LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJ26_LEIBR
TriTrypDb:
LbrM.31.0640 , LBRM2903_310013300 *
Length:
395

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 7
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4HJ26
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ26

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 181 183 PF00675 0.322
CLV_NRD_NRD_1 28 30 PF00675 0.362
CLV_NRD_NRD_1 353 355 PF00675 0.507
CLV_PCSK_KEX2_1 125 127 PF00082 0.299
CLV_PCSK_KEX2_1 181 183 PF00082 0.322
CLV_PCSK_KEX2_1 192 194 PF00082 0.345
CLV_PCSK_KEX2_1 375 377 PF00082 0.503
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.347
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.326
CLV_PCSK_PC1ET2_1 375 377 PF00082 0.503
CLV_PCSK_SKI1_1 256 260 PF00082 0.219
CLV_PCSK_SKI1_1 332 336 PF00082 0.371
CLV_PCSK_SKI1_1 97 101 PF00082 0.331
DEG_Nend_Nbox_1 1 3 PF02207 0.525
DOC_CYCLIN_RxL_1 8 16 PF00134 0.327
DOC_MAPK_gen_1 131 140 PF00069 0.219
DOC_MAPK_gen_1 236 245 PF00069 0.217
DOC_MAPK_gen_1 375 382 PF00069 0.411
DOC_MAPK_MEF2A_6 236 245 PF00069 0.217
DOC_USP7_MATH_1 160 164 PF00917 0.289
DOC_USP7_MATH_1 270 274 PF00917 0.281
DOC_USP7_MATH_1 278 282 PF00917 0.327
DOC_WW_Pin1_4 201 206 PF00397 0.266
DOC_WW_Pin1_4 22 27 PF00397 0.308
DOC_WW_Pin1_4 31 36 PF00397 0.308
DOC_WW_Pin1_4 390 395 PF00397 0.470
LIG_14-3-3_CanoR_1 126 132 PF00244 0.310
LIG_14-3-3_CanoR_1 181 185 PF00244 0.245
LIG_14-3-3_CanoR_1 3 8 PF00244 0.455
LIG_14-3-3_CanoR_1 354 358 PF00244 0.464
LIG_14-3-3_CanoR_1 39 43 PF00244 0.318
LIG_Actin_WH2_2 24 41 PF00022 0.288
LIG_APCC_ABBA_1 243 248 PF00400 0.305
LIG_BIR_III_4 148 152 PF00653 0.290
LIG_BRCT_BRCA1_1 280 284 PF00533 0.326
LIG_CaM_IQ_9 117 133 PF13499 0.288
LIG_deltaCOP1_diTrp_1 266 274 PF00928 0.331
LIG_DLG_GKlike_1 3 10 PF00625 0.362
LIG_eIF4E_1 95 101 PF01652 0.288
LIG_FHA_1 23 29 PF00498 0.219
LIG_FHA_1 47 53 PF00498 0.275
LIG_FHA_1 60 66 PF00498 0.335
LIG_FHA_1 94 100 PF00498 0.391
LIG_FHA_2 102 108 PF00498 0.326
LIG_FHA_2 362 368 PF00498 0.540
LIG_FHA_2 381 387 PF00498 0.457
LIG_GBD_Chelix_1 316 324 PF00786 0.362
LIG_IRF3_LxIS_1 117 123 PF10401 0.326
LIG_LIR_Gen_1 133 144 PF02991 0.272
LIG_LIR_Gen_1 72 80 PF02991 0.312
LIG_LIR_Gen_1 94 101 PF02991 0.333
LIG_LIR_Nem_3 111 116 PF02991 0.258
LIG_LIR_Nem_3 266 271 PF02991 0.353
LIG_LIR_Nem_3 281 287 PF02991 0.331
LIG_LIR_Nem_3 336 341 PF02991 0.426
LIG_LIR_Nem_3 72 76 PF02991 0.312
LIG_LIR_Nem_3 94 98 PF02991 0.502
LIG_MAD2 11 19 PF02301 0.302
LIG_PCNA_yPIPBox_3 131 144 PF02747 0.264
LIG_PDZ_Class_1 390 395 PF00595 0.470
LIG_Pex14_1 109 113 PF04695 0.288
LIG_Pex14_2 369 373 PF04695 0.428
LIG_PTAP_UEV_1 279 284 PF05743 0.219
LIG_SH2_CRK 73 77 PF00017 0.288
LIG_SH2_CRK 85 89 PF00017 0.288
LIG_SH2_CRK 95 99 PF00017 0.303
LIG_SH2_SRC 246 249 PF00017 0.293
LIG_SH2_SRC 287 290 PF00017 0.288
LIG_SH2_STAP1 113 117 PF00017 0.190
LIG_SH2_STAP1 246 250 PF00017 0.288
LIG_SH2_STAP1 73 77 PF00017 0.288
LIG_SH2_STAP1 85 89 PF00017 0.288
LIG_SH2_STAP1 95 99 PF00017 0.288
LIG_SH2_STAT5 116 119 PF00017 0.290
LIG_SH2_STAT5 309 312 PF00017 0.393
LIG_SH2_STAT5 33 36 PF00017 0.326
LIG_SH2_STAT5 95 98 PF00017 0.343
LIG_SH3_1 277 283 PF00018 0.288
LIG_SH3_3 277 283 PF00018 0.326
LIG_SH3_3 73 79 PF00018 0.314
LIG_SUMO_SIM_anti_2 96 105 PF11976 0.356
LIG_SUMO_SIM_par_1 96 105 PF11976 0.329
LIG_WRC_WIRS_1 271 276 PF05994 0.250
MOD_CDK_SPxxK_3 22 29 PF00069 0.308
MOD_CK1_1 162 168 PF00069 0.334
MOD_CK1_1 210 216 PF00069 0.340
MOD_CK1_1 349 355 PF00069 0.448
MOD_CK1_1 361 367 PF00069 0.456
MOD_CK2_1 162 168 PF00069 0.219
MOD_CK2_1 361 367 PF00069 0.513
MOD_CK2_1 380 386 PF00069 0.523
MOD_GlcNHglycan 148 152 PF01048 0.271
MOD_GlcNHglycan 176 179 PF01048 0.296
MOD_GlcNHglycan 201 204 PF01048 0.290
MOD_GlcNHglycan 256 259 PF01048 0.359
MOD_GlcNHglycan 280 283 PF01048 0.232
MOD_GlcNHglycan 348 351 PF01048 0.574
MOD_GlcNHglycan 62 65 PF01048 0.219
MOD_GSK3_1 121 128 PF00069 0.326
MOD_GSK3_1 159 166 PF00069 0.361
MOD_GSK3_1 195 202 PF00069 0.301
MOD_GSK3_1 246 253 PF00069 0.325
MOD_GSK3_1 34 41 PF00069 0.345
MOD_GSK3_1 349 356 PF00069 0.467
MOD_GSK3_1 386 393 PF00069 0.551
MOD_N-GLC_2 385 387 PF02516 0.467
MOD_NEK2_1 120 125 PF00069 0.326
MOD_NEK2_1 13 18 PF00069 0.459
MOD_NEK2_1 173 178 PF00069 0.379
MOD_NEK2_1 180 185 PF00069 0.336
MOD_NEK2_1 195 200 PF00069 0.288
MOD_NEK2_1 2 7 PF00069 0.460
MOD_NEK2_1 38 43 PF00069 0.331
MOD_NEK2_2 246 251 PF00069 0.326
MOD_PIKK_1 125 131 PF00454 0.299
MOD_PKA_1 125 131 PF00069 0.299
MOD_PKA_2 125 131 PF00069 0.299
MOD_PKA_2 166 172 PF00069 0.348
MOD_PKA_2 180 186 PF00069 0.262
MOD_PKA_2 2 8 PF00069 0.469
MOD_PKA_2 213 219 PF00069 0.416
MOD_PKA_2 353 359 PF00069 0.542
MOD_PKA_2 38 44 PF00069 0.288
MOD_Plk_1 246 252 PF00069 0.340
MOD_Plk_4 13 19 PF00069 0.386
MOD_Plk_4 270 276 PF00069 0.250
MOD_Plk_4 319 325 PF00069 0.501
MOD_ProDKin_1 201 207 PF00069 0.266
MOD_ProDKin_1 22 28 PF00069 0.308
MOD_ProDKin_1 31 37 PF00069 0.308
MOD_SUMO_rev_2 55 63 PF00179 0.315
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.269
TRG_ENDOCYTIC_2 73 76 PF00928 0.288
TRG_ENDOCYTIC_2 85 88 PF00928 0.288
TRG_ENDOCYTIC_2 95 98 PF00928 0.303
TRG_ER_diArg_1 180 182 PF00400 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P958 Leptomonas seymouri 59% 100%
A0A3Q8IGS5 Leishmania donovani 28% 91%
A0A3S7X466 Leishmania donovani 80% 100%
A4I6E8 Leishmania infantum 80% 100%
A4I8U9 Leishmania infantum 28% 91%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 95%
Q4Q4A6 Leishmania major 26% 100%
Q4Q6L5 Leishmania major 78% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS