Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ25_LEIBR

TriTrypDb:

LbrM.31.0630 , LBRM2903_310013100

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0097196	Shu complex	2	1

Expansion

Sequence features

A4HJ25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ25

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	139	143	PF00082	0.623
CLV_PCSK_KEX2_1	141	143	PF00082	0.615
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.629
DEG_COP1_1	115	122	PF00400	0.476
DEG_SCF_FBW7_1	80	86	PF00400	0.608
DEG_SPOP_SBC_1	186	190	PF00917	0.426
DOC_CKS1_1	213	218	PF01111	0.621
DOC_CKS1_1	80	85	PF01111	0.531
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.615
DOC_MAPK_DCC_7	114	124	PF00069	0.623
DOC_MAPK_gen_1	114	124	PF00069	0.623
DOC_MAPK_gen_1	141	151	PF00069	0.540
DOC_MAPK_MEF2A_6	117	124	PF00069	0.672
DOC_PP1_RVXF_1	92	98	PF00149	0.406
DOC_PP2B_LxvP_1	192	195	PF13499	0.646
DOC_USP7_MATH_1	154	158	PF00917	0.536
DOC_USP7_MATH_1	186	190	PF00917	0.426
DOC_USP7_MATH_1	21	25	PF00917	0.575
DOC_USP7_MATH_1	83	87	PF00917	0.591
DOC_WW_Pin1_4	212	217	PF00397	0.622
DOC_WW_Pin1_4	79	84	PF00397	0.529
LIG_14-3-3_CanoR_1	145	151	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	16	20	PF00533	0.534
LIG_BRCT_BRCA1_1	46	50	PF00533	0.474
LIG_Clathr_ClatBox_1	122	126	PF01394	0.482
LIG_eIF4E_1	196	202	PF01652	0.616
LIG_FHA_1	114	120	PF00498	0.498
LIG_FHA_1	180	186	PF00498	0.635
LIG_FHA_1	209	215	PF00498	0.557
LIG_FHA_1	220	226	PF00498	0.621
LIG_FHA_2	215	221	PF00498	0.584
LIG_KLC1_Yacidic_2	96	101	PF13176	0.475
LIG_LIR_Gen_1	193	204	PF02991	0.510
LIG_LIR_Gen_1	71	81	PF02991	0.637
LIG_LIR_Gen_1	96	105	PF02991	0.451
LIG_LIR_Nem_3	193	199	PF02991	0.540
LIG_LIR_Nem_3	71	77	PF02991	0.644
LIG_LIR_Nem_3	96	100	PF02991	0.456
LIG_MLH1_MIPbox_1	16	20	PF16413	0.534
LIG_PAM2_1	10	22	PF00658	0.558
LIG_SH2_CRK	74	78	PF00017	0.635
LIG_SH2_NCK_1	74	78	PF00017	0.652
LIG_SH2_PTP2	178	181	PF00017	0.493
LIG_SH2_SRC	99	102	PF00017	0.472
LIG_SH2_STAT5	161	164	PF00017	0.609
LIG_SH2_STAT5	178	181	PF00017	0.537
LIG_SH2_STAT5	231	234	PF00017	0.621
LIG_SH2_STAT5	99	102	PF00017	0.453
LIG_SH3_2	80	85	PF14604	0.447
LIG_SH3_3	129	135	PF00018	0.562
LIG_SH3_3	222	228	PF00018	0.595
LIG_SH3_3	23	29	PF00018	0.662
LIG_SH3_3	74	80	PF00018	0.573
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.453
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.476
LIG_SUMO_SIM_par_1	120	128	PF11976	0.491
LIG_TYR_ITSM	70	77	PF00017	0.548
MOD_CDK_SPxK_1	79	85	PF00069	0.447
MOD_CK1_1	10	16	PF00069	0.490
MOD_CK1_1	157	163	PF00069	0.683
MOD_CK1_1	60	66	PF00069	0.361
MOD_CK2_1	157	163	PF00069	0.544
MOD_CK2_1	83	89	PF00069	0.547
MOD_Cter_Amidation	139	142	PF01082	0.620
MOD_GlcNHglycan	208	211	PF01048	0.599
MOD_GSK3_1	10	17	PF00069	0.543
MOD_GSK3_1	150	157	PF00069	0.575
MOD_GSK3_1	186	193	PF00069	0.450
MOD_GSK3_1	208	215	PF00069	0.641
MOD_GSK3_1	53	60	PF00069	0.506
MOD_GSK3_1	68	75	PF00069	0.626
MOD_GSK3_1	79	86	PF00069	0.593
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	113	118	PF00069	0.686
MOD_NEK2_1	130	135	PF00069	0.440
MOD_NEK2_1	14	19	PF00069	0.402
MOD_NEK2_1	150	155	PF00069	0.492
MOD_PIKK_1	187	193	PF00454	0.651
MOD_PKA_2	113	119	PF00069	0.550
MOD_PKA_2	144	150	PF00069	0.476
MOD_Plk_1	14	20	PF00069	0.456
MOD_Plk_1	69	75	PF00069	0.617
MOD_Plk_1	88	94	PF00069	0.548
MOD_Plk_4	118	124	PF00069	0.619
MOD_Plk_4	14	20	PF00069	0.480
MOD_Plk_4	157	163	PF00069	0.563
MOD_Plk_4	60	66	PF00069	0.519
MOD_Plk_4	69	75	PF00069	0.474
MOD_ProDKin_1	212	218	PF00069	0.620
MOD_ProDKin_1	79	85	PF00069	0.531
TRG_ENDOCYTIC_2	178	181	PF00928	0.493
TRG_ENDOCYTIC_2	196	199	PF00928	0.620
TRG_ENDOCYTIC_2	74	77	PF00928	0.567
TRG_ER_diArg_1	238	241	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3G7	Leptomonas seymouri	69%	100%
A0A1X0NJ44	Trypanosomatidae	42%	100%
A0A3Q8IIC3	Leishmania donovani	85%	100%
A0A422P024	Trypanosoma rangeli	43%	100%
A4I6E7	Leishmania infantum	85%	100%
C9ZN54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B1J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q6L6	Leishmania major	83%	100%
V5BN46	Trypanosoma cruzi	46%	100%