Putative cytoskeleton-associated protein CAP5.5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton-associated protein CAP5.5, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ23_LEIBR

TriTrypDb:

LbrM.31.0600 , LBRM2903_310012900

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 39
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	4
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HJ23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ23

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	41
GO:0006807	nitrogen compound metabolic process	2	41
GO:0008152	metabolic process	1	41
GO:0019538	protein metabolic process	3	41
GO:0043170	macromolecule metabolic process	3	41
GO:0044238	primary metabolic process	2	41
GO:0071704	organic substance metabolic process	2	41
GO:1901564	organonitrogen compound metabolic process	3	41

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	41
GO:0004175	endopeptidase activity	4	41
GO:0004197	cysteine-type endopeptidase activity	5	41
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	41
GO:0008233	peptidase activity	3	41
GO:0008234	cysteine-type peptidase activity	4	41
GO:0016787	hydrolase activity	2	41
GO:0140096	catalytic activity, acting on a protein	2	41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.405
CLV_PCSK_KEX2_1	14	16	PF00082	0.447
CLV_PCSK_KEX2_1	337	339	PF00082	0.453
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.448
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.526
CLV_PCSK_SKI1_1	306	310	PF00082	0.432
CLV_PCSK_SKI1_1	410	414	PF00082	0.506
CLV_PCSK_SKI1_1	55	59	PF00082	0.253
CLV_PCSK_SKI1_1	72	76	PF00082	0.325
DEG_MDM2_SWIB_1	148	156	PF02201	0.365
DOC_CKS1_1	181	186	PF01111	0.479
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.249
DOC_MAPK_MEF2A_6	387	395	PF00069	0.417
DOC_PP1_RVXF_1	336	343	PF00149	0.535
DOC_PP2B_LxvP_1	348	351	PF13499	0.287
DOC_PP4_FxxP_1	21	24	PF00568	0.218
DOC_PP4_FxxP_1	295	298	PF00568	0.402
DOC_USP7_MATH_1	175	179	PF00917	0.566
DOC_USP7_MATH_1	238	242	PF00917	0.534
DOC_USP7_MATH_1	261	265	PF00917	0.443
DOC_USP7_MATH_1	322	326	PF00917	0.411
DOC_USP7_MATH_1	375	379	PF00917	0.502
DOC_USP7_MATH_1	453	457	PF00917	0.456
DOC_USP7_MATH_1	91	95	PF00917	0.397
DOC_USP7_UBL2_3	116	120	PF12436	0.463
DOC_WW_Pin1_4	180	185	PF00397	0.481
DOC_WW_Pin1_4	59	64	PF00397	0.472
LIG_14-3-3_CanoR_1	15	22	PF00244	0.475
LIG_14-3-3_CanoR_1	213	219	PF00244	0.509
LIG_BIR_II_1	1	5	PF00653	0.246
LIG_BRCT_BRCA1_1	345	349	PF00533	0.237
LIG_BRCT_BRCA1_1	377	381	PF00533	0.440
LIG_BRCT_BRCA1_1	444	448	PF00533	0.407
LIG_FHA_1	181	187	PF00498	0.413
LIG_FHA_1	215	221	PF00498	0.521
LIG_FHA_1	324	330	PF00498	0.405
LIG_FHA_1	447	453	PF00498	0.516
LIG_FHA_1	5	11	PF00498	0.337
LIG_FHA_2	127	133	PF00498	0.500
LIG_FHA_2	319	325	PF00498	0.409
LIG_LIR_Apic_2	102	106	PF02991	0.514
LIG_LIR_Apic_2	20	24	PF02991	0.426
LIG_LIR_Gen_1	124	132	PF02991	0.487
LIG_LIR_Gen_1	204	212	PF02991	0.458
LIG_LIR_Gen_1	378	389	PF02991	0.426
LIG_LIR_Gen_1	399	407	PF02991	0.321
LIG_LIR_Nem_3	108	113	PF02991	0.452
LIG_LIR_Nem_3	124	128	PF02991	0.448
LIG_LIR_Nem_3	204	210	PF02991	0.431
LIG_LIR_Nem_3	214	219	PF02991	0.499
LIG_LIR_Nem_3	346	352	PF02991	0.358
LIG_LIR_Nem_3	378	384	PF02991	0.463
LIG_LIR_Nem_3	399	404	PF02991	0.305
LIG_LIR_Nem_3	445	451	PF02991	0.449
LIG_PCNA_yPIPBox_3	77	90	PF02747	0.407
LIG_PDZ_Class_1	479	484	PF00595	0.250
LIG_Pex14_2	148	152	PF04695	0.485
LIG_Pex14_2	277	281	PF04695	0.460
LIG_Pex14_2	99	103	PF04695	0.349
LIG_SH2_CRK	118	122	PF00017	0.465
LIG_SH2_CRK	125	129	PF00017	0.470
LIG_SH2_CRK	401	405	PF00017	0.204
LIG_SH2_CRK	416	420	PF00017	0.272
LIG_SH2_NCK_1	125	129	PF00017	0.534
LIG_SH2_NCK_1	207	211	PF00017	0.406
LIG_SH2_NCK_1	416	420	PF00017	0.272
LIG_SH2_SRC	207	210	PF00017	0.567
LIG_SH2_STAP1	216	220	PF00017	0.530
LIG_SH2_STAT3	251	254	PF00017	0.504
LIG_SH2_STAT5	191	194	PF00017	0.511
LIG_SH2_STAT5	216	219	PF00017	0.430
LIG_SH2_STAT5	287	290	PF00017	0.460
LIG_SH2_STAT5	420	423	PF00017	0.291
LIG_SH2_STAT5	451	454	PF00017	0.307
LIG_SH2_STAT5	478	481	PF00017	0.425
LIG_SH2_STAT5	89	92	PF00017	0.472
LIG_SH2_STAT5	9	12	PF00017	0.368
LIG_SH3_3	21	27	PF00018	0.218
LIG_SH3_3	232	238	PF00018	0.530
LIG_SH3_3	371	377	PF00018	0.527
LIG_SUMO_SIM_anti_2	221	228	PF11976	0.407
LIG_SUMO_SIM_par_1	221	228	PF11976	0.411
LIG_SUMO_SIM_par_1	315	321	PF11976	0.262
LIG_SUMO_SIM_par_1	328	333	PF11976	0.224
LIG_SUMO_SIM_par_1	350	355	PF11976	0.362
LIG_TRAF2_1	62	65	PF00917	0.403
LIG_UBA3_1	329	337	PF00899	0.495
LIG_UBA3_1	352	359	PF00899	0.325
LIG_UBA3_1	424	431	PF00899	0.226
MOD_CDK_SPxxK_3	59	66	PF00069	0.519
MOD_CK1_1	250	256	PF00069	0.440
MOD_CK1_1	443	449	PF00069	0.407
MOD_CK2_1	161	167	PF00069	0.513
MOD_CK2_1	318	324	PF00069	0.398
MOD_CK2_1	354	360	PF00069	0.427
MOD_CK2_1	59	65	PF00069	0.431
MOD_CMANNOS	278	281	PF00535	0.268
MOD_GlcNHglycan	142	145	PF01048	0.276
MOD_GlcNHglycan	16	19	PF01048	0.439
MOD_GlcNHglycan	173	176	PF01048	0.272
MOD_GlcNHglycan	203	206	PF01048	0.294
MOD_GlcNHglycan	241	244	PF01048	0.321
MOD_GlcNHglycan	314	317	PF01048	0.481
MOD_GlcNHglycan	444	448	PF01048	0.416
MOD_GlcNHglycan	479	482	PF01048	0.430
MOD_GSK3_1	126	133	PF00069	0.463
MOD_GSK3_1	157	164	PF00069	0.525
MOD_GSK3_1	171	178	PF00069	0.464
MOD_GSK3_1	250	257	PF00069	0.455
MOD_GSK3_1	31	38	PF00069	0.388
MOD_GSK3_1	318	325	PF00069	0.379
MOD_GSK3_1	442	449	PF00069	0.519
MOD_N-GLC_1	368	373	PF02516	0.493
MOD_NEK2_1	140	145	PF00069	0.490
MOD_NEK2_1	309	314	PF00069	0.432
MOD_NEK2_1	318	323	PF00069	0.376
MOD_NEK2_1	330	335	PF00069	0.371
MOD_NEK2_1	35	40	PF00069	0.449
MOD_NEK2_1	354	359	PF00069	0.349
MOD_PIKK_1	250	256	PF00454	0.470
MOD_PIKK_1	282	288	PF00454	0.354
MOD_PIKK_1	323	329	PF00454	0.397
MOD_PIKK_1	330	336	PF00454	0.344
MOD_PIKK_1	4	10	PF00454	0.276
MOD_PKA_1	14	20	PF00069	0.371
MOD_PKA_2	14	20	PF00069	0.340
MOD_PKA_2	239	245	PF00069	0.482
MOD_PKA_2	4	10	PF00069	0.253
MOD_Plk_1	273	279	PF00069	0.471
MOD_Plk_1	282	288	PF00069	0.469
MOD_Plk_1	323	329	PF00069	0.390
MOD_Plk_1	343	349	PF00069	0.580
MOD_Plk_1	443	449	PF00069	0.358
MOD_Plk_2-3	31	37	PF00069	0.397
MOD_Plk_2-3	458	464	PF00069	0.264
MOD_Plk_4	175	181	PF00069	0.454
MOD_Plk_4	187	193	PF00069	0.509
MOD_Plk_4	214	220	PF00069	0.490
MOD_Plk_4	273	279	PF00069	0.464
MOD_Plk_4	344	350	PF00069	0.239
MOD_Plk_4	35	41	PF00069	0.440
MOD_Plk_4	474	480	PF00069	0.438
MOD_ProDKin_1	180	186	PF00069	0.481
MOD_ProDKin_1	59	65	PF00069	0.472
MOD_SUMO_rev_2	62	68	PF00179	0.425
TRG_DiLeu_BaEn_2	378	384	PF01217	0.478
TRG_DiLeu_LyEn_5	108	113	PF01217	0.349
TRG_ENDOCYTIC_2	118	121	PF00928	0.472
TRG_ENDOCYTIC_2	125	128	PF00928	0.468
TRG_ENDOCYTIC_2	207	210	PF00928	0.461
TRG_ENDOCYTIC_2	401	404	PF00928	0.332
TRG_ENDOCYTIC_2	71	74	PF00928	0.492
TRG_ER_FFAT_1	336	347	PF00635	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	35%	69%
A0A0N1IGQ2	Leptomonas seymouri	32%	69%
A0A0N1ILF1	Leptomonas seymouri	34%	70%
A0A1X0NJ61	Trypanosomatidae	37%	85%
A0A1X0NW84	Trypanosomatidae	34%	70%
A0A1X0NW85	Trypanosomatidae	35%	71%
A0A1X0NWW1	Trypanosomatidae	36%	67%
A0A3Q8IDD4	Leishmania donovani	31%	69%
A0A3S7WW71	Leishmania donovani	33%	70%
A0A3S7X470	Leishmania donovani	69%	67%
A0A422MYX0	Trypanosoma rangeli	35%	67%
A4HE81	Leishmania braziliensis	32%	69%
A4HJ24	Leishmania braziliensis	33%	68%
A4HYW2	Leishmania infantum	32%	70%
A4I1J4	Leishmania infantum	31%	69%
A4I6E4	Leishmania infantum	68%	67%
A8MX76	Homo sapiens	23%	71%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	71%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	66%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	95%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	67%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	83%
E8NHQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9AIH3	Leishmania braziliensis	32%	70%
E9AIH6	Leishmania braziliensis	30%	89%
E9AUQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	74%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	70%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	88%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	69%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	68%
Q4Q6L7	Leishmania major	33%	66%
Q4Q6L9	Leishmania major	67%	100%
Q4Q9U3	Leishmania major	32%	100%
Q4QCS5	Leishmania major	30%	100%
Q4QCS7	Leishmania major	33%	100%
V5AYJ1	Trypanosoma cruzi	36%	68%
V5BA05	Trypanosoma cruzi	37%	73%
V5BEL3	Trypanosoma cruzi	34%	70%