Adenosine deaminase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenosine deaminase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJ19_LEIBR

TriTrypDb:

LbrM.31.0560 , LBRM2903_310012400 , LBRM2903_310012500

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ19

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003824	catalytic activity	1	9
GO:0004000	adenosine deaminase activity	4	9
GO:0005488	binding	1	9
GO:0016787	hydrolase activity	2	9
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	9
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	9
GO:0019239	deaminase activity	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0008251	tRNA-specific adenosine deaminase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.560
CLV_C14_Caspase3-7	167	171	PF00656	0.362
CLV_C14_Caspase3-7	566	570	PF00656	0.486
CLV_NRD_NRD_1	114	116	PF00675	0.551
CLV_NRD_NRD_1	143	145	PF00675	0.370
CLV_NRD_NRD_1	158	160	PF00675	0.221
CLV_NRD_NRD_1	186	188	PF00675	0.323
CLV_NRD_NRD_1	325	327	PF00675	0.301
CLV_NRD_NRD_1	368	370	PF00675	0.618
CLV_NRD_NRD_1	430	432	PF00675	0.685
CLV_NRD_NRD_1	483	485	PF00675	0.694
CLV_PCSK_FUR_1	366	370	PF00082	0.618
CLV_PCSK_KEX2_1	114	116	PF00082	0.551
CLV_PCSK_KEX2_1	143	145	PF00082	0.370
CLV_PCSK_KEX2_1	158	160	PF00082	0.221
CLV_PCSK_KEX2_1	186	188	PF00082	0.364
CLV_PCSK_KEX2_1	324	326	PF00082	0.301
CLV_PCSK_KEX2_1	368	370	PF00082	0.642
CLV_PCSK_KEX2_1	432	434	PF00082	0.645
CLV_PCSK_KEX2_1	483	485	PF00082	0.694
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.645
CLV_PCSK_PC7_1	479	485	PF00082	0.707
CLV_PCSK_SKI1_1	143	147	PF00082	0.399
CLV_PCSK_SKI1_1	274	278	PF00082	0.294
CLV_PCSK_SKI1_1	398	402	PF00082	0.574
DEG_APCC_DBOX_1	325	333	PF00400	0.465
DEG_APCC_KENBOX_2	514	518	PF00400	0.466
DEG_Nend_UBRbox_2	1	3	PF02207	0.792
DEG_SCF_TRCP1_1	413	419	PF00400	0.546
DEG_SPOP_SBC_1	6	10	PF00917	0.504
DOC_ANK_TNKS_1	186	193	PF00023	0.406
DOC_CDC14_PxL_1	17	25	PF14671	0.358
DOC_CYCLIN_RxL_1	140	150	PF00134	0.596
DOC_MAPK_DCC_7	324	334	PF00069	0.528
DOC_MAPK_gen_1	114	121	PF00069	0.492
DOC_MAPK_gen_1	158	164	PF00069	0.448
DOC_MAPK_gen_1	312	321	PF00069	0.501
DOC_MAPK_MEF2A_6	114	121	PF00069	0.434
DOC_MAPK_MEF2A_6	209	216	PF00069	0.430
DOC_MAPK_MEF2A_6	506	513	PF00069	0.412
DOC_MAPK_NFAT4_5	506	514	PF00069	0.416
DOC_PP1_RVXF_1	572	578	PF00149	0.714
DOC_PP2B_LxvP_1	89	92	PF13499	0.413
DOC_PP4_FxxP_1	330	333	PF00568	0.501
DOC_USP7_MATH_1	104	108	PF00917	0.576
DOC_USP7_MATH_1	109	113	PF00917	0.471
DOC_USP7_MATH_1	169	173	PF00917	0.568
DOC_USP7_MATH_1	198	202	PF00917	0.406
DOC_USP7_MATH_1	230	234	PF00917	0.566
DOC_USP7_MATH_1	402	406	PF00917	0.755
DOC_USP7_MATH_1	439	443	PF00917	0.675
DOC_USP7_MATH_1	529	533	PF00917	0.715
DOC_USP7_MATH_1	59	63	PF00917	0.702
DOC_USP7_MATH_1	590	594	PF00917	0.566
DOC_USP7_MATH_1	6	10	PF00917	0.545
DOC_USP7_MATH_1	66	70	PF00917	0.715
DOC_WW_Pin1_4	24	29	PF00397	0.542
DOC_WW_Pin1_4	540	545	PF00397	0.609
LIG_14-3-3_CanoR_1	264	270	PF00244	0.436
LIG_14-3-3_CanoR_1	324	330	PF00244	0.534
LIG_14-3-3_CanoR_1	368	378	PF00244	0.484
LIG_14-3-3_CanoR_1	483	489	PF00244	0.714
LIG_Actin_WH2_2	193	211	PF00022	0.406
LIG_BRCT_BRCA1_1	89	93	PF00533	0.253
LIG_deltaCOP1_diTrp_1	311	316	PF00928	0.560
LIG_EH1_1	504	512	PF00400	0.406
LIG_FHA_1	209	215	PF00498	0.564
LIG_FHA_1	250	256	PF00498	0.406
LIG_FHA_1	286	292	PF00498	0.488
LIG_FHA_1	308	314	PF00498	0.537
LIG_FHA_2	454	460	PF00498	0.520
LIG_FHA_2	485	491	PF00498	0.663
LIG_FHA_2	543	549	PF00498	0.494
LIG_FHA_2	566	572	PF00498	0.744
LIG_FHA_2	6	12	PF00498	0.768
LIG_LIR_Apic_2	328	333	PF02991	0.500
LIG_LIR_Apic_2	448	454	PF02991	0.489
LIG_LIR_Gen_1	279	287	PF02991	0.406
LIG_LIR_Gen_1	344	352	PF02991	0.406
LIG_LIR_Gen_1	419	428	PF02991	0.682
LIG_LIR_Nem_3	279	284	PF02991	0.406
LIG_LIR_Nem_3	344	349	PF02991	0.522
LIG_LIR_Nem_3	419	424	PF02991	0.718
LIG_LIR_Nem_3	442	447	PF02991	0.773
LIG_RPA_C_Fungi	154	166	PF08784	0.253
LIG_SH2_CRK	281	285	PF00017	0.491
LIG_SH2_NCK_1	533	537	PF00017	0.772
LIG_SH2_PTP2	116	119	PF00017	0.529
LIG_SH2_SRC	533	536	PF00017	0.506
LIG_SH2_STAP1	180	184	PF00017	0.491
LIG_SH2_STAT3	561	564	PF00017	0.449
LIG_SH2_STAT5	116	119	PF00017	0.476
LIG_SH3_3	375	381	PF00018	0.656
LIG_SxIP_EBH_1	483	497	PF03271	0.481
LIG_TRAF2_1	69	72	PF00917	0.629
LIG_UBA3_1	509	515	PF00899	0.428
MOD_CK1_1	120	126	PF00069	0.369
MOD_CK1_1	233	239	PF00069	0.405
MOD_CK1_1	267	273	PF00069	0.335
MOD_CK1_1	387	393	PF00069	0.483
MOD_CK1_1	411	417	PF00069	0.687
MOD_CK1_1	486	492	PF00069	0.593
MOD_CK1_1	523	529	PF00069	0.652
MOD_CK1_1	542	548	PF00069	0.635
MOD_CK1_1	7	13	PF00069	0.493
MOD_CK2_1	369	375	PF00069	0.646
MOD_CK2_1	387	393	PF00069	0.320
MOD_CK2_1	431	437	PF00069	0.775
MOD_CK2_1	484	490	PF00069	0.713
MOD_CK2_1	5	11	PF00069	0.765
MOD_CK2_1	534	540	PF00069	0.620
MOD_CK2_1	66	72	PF00069	0.668
MOD_Cter_Amidation	322	325	PF01082	0.357
MOD_GlcNHglycan	106	110	PF01048	0.593
MOD_GlcNHglycan	122	125	PF01048	0.302
MOD_GlcNHglycan	170	174	PF01048	0.491
MOD_GlcNHglycan	232	235	PF01048	0.388
MOD_GlcNHglycan	389	392	PF01048	0.538
MOD_GlcNHglycan	413	416	PF01048	0.574
MOD_GlcNHglycan	440	444	PF01048	0.684
MOD_GlcNHglycan	529	532	PF01048	0.746
MOD_GlcNHglycan	565	568	PF01048	0.723
MOD_GlcNHglycan	72	76	PF01048	0.636
MOD_GSK3_1	105	112	PF00069	0.429
MOD_GSK3_1	169	176	PF00069	0.503
MOD_GSK3_1	229	236	PF00069	0.435
MOD_GSK3_1	263	270	PF00069	0.475
MOD_GSK3_1	276	283	PF00069	0.224
MOD_GSK3_1	303	310	PF00069	0.438
MOD_GSK3_1	394	401	PF00069	0.459
MOD_GSK3_1	439	446	PF00069	0.697
MOD_GSK3_1	523	530	PF00069	0.721
MOD_GSK3_1	540	547	PF00069	0.605
MOD_GSK3_1	565	572	PF00069	0.747
MOD_GSK3_1	590	597	PF00069	0.493
MOD_N-GLC_1	303	308	PF02516	0.438
MOD_N-GLC_1	411	416	PF02516	0.627
MOD_NEK2_1	208	213	PF00069	0.486
MOD_NEK2_1	216	221	PF00069	0.398
MOD_NEK2_1	222	227	PF00069	0.363
MOD_NEK2_1	305	310	PF00069	0.357
MOD_NEK2_1	342	347	PF00069	0.445
MOD_NEK2_1	394	399	PF00069	0.555
MOD_NEK2_1	422	427	PF00069	0.480
MOD_NEK2_1	552	557	PF00069	0.644
MOD_NEK2_1	563	568	PF00069	0.408
MOD_NEK2_1	576	581	PF00069	0.642
MOD_NEK2_1	87	92	PF00069	0.450
MOD_NEK2_2	109	114	PF00069	0.379
MOD_NEK2_2	384	389	PF00069	0.293
MOD_NEK2_2	590	595	PF00069	0.489
MOD_PIKK_1	285	291	PF00454	0.224
MOD_PIKK_1	552	558	PF00454	0.663
MOD_PIKK_1	577	583	PF00454	0.448
MOD_PK_1	335	341	PF00069	0.363
MOD_PKA_1	325	331	PF00069	0.347
MOD_PKA_1	431	437	PF00069	0.510
MOD_PKA_1	483	489	PF00069	0.714
MOD_PKA_2	173	179	PF00069	0.435
MOD_PKA_2	208	214	PF00069	0.491
MOD_PKA_2	263	269	PF00069	0.423
MOD_PKA_2	325	331	PF00069	0.340
MOD_PKA_2	483	489	PF00069	0.714
MOD_Plk_1	109	115	PF00069	0.363
MOD_Plk_1	249	255	PF00069	0.224
MOD_Plk_1	303	309	PF00069	0.438
MOD_Plk_1	439	445	PF00069	0.510
MOD_Plk_1	550	556	PF00069	0.705
MOD_Plk_4	325	331	PF00069	0.310
MOD_Plk_4	423	429	PF00069	0.483
MOD_Plk_4	460	466	PF00069	0.668
MOD_Plk_4	534	540	PF00069	0.641
MOD_ProDKin_1	24	30	PF00069	0.542
MOD_ProDKin_1	540	546	PF00069	0.608
MOD_SUMO_for_1	204	207	PF00179	0.224
MOD_SUMO_rev_2	425	434	PF00179	0.728
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.624
TRG_ENDOCYTIC_2	116	119	PF00928	0.460
TRG_ENDOCYTIC_2	180	183	PF00928	0.438
TRG_ENDOCYTIC_2	281	284	PF00928	0.385
TRG_ER_diArg_1	113	115	PF00400	0.574
TRG_ER_diArg_1	142	144	PF00400	0.485
TRG_ER_diArg_1	185	187	PF00400	0.491
TRG_ER_diArg_1	324	326	PF00400	0.357
TRG_ER_diArg_1	365	368	PF00400	0.576
TRG_ER_diArg_1	418	421	PF00400	0.657
TRG_ER_diArg_1	482	484	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	126	131	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P680	Leptomonas seymouri	42%	100%
A0A3Q8IGD9	Leishmania donovani	71%	100%
A0A422NGA7	Trypanosoma rangeli	32%	98%
A4I8P1	Leishmania infantum	71%	100%
D0A4L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
E9B3K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q4J9	Leishmania major	70%	100%