Thiol-dependent reductase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thiol-dependent reductase 1

Species:

Leishmania braziliensis

UniProt:

A4HJ18_LEIBR

TriTrypDb:

LbrM.31.0550 , LBRM2903_310012300

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ18

PDB structure(s): 4ags_A , 4ags_B , 4ags_C

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0015035	protein-disulfide reductase activity	3	6
GO:0015036	disulfide oxidoreductase activity	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	6
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	6
GO:0019153	protein-disulfide reductase (glutathione) activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	2
GO:0015038	glutathione disulfide oxidoreductase activity	5	2
GO:0016209	antioxidant activity	1	2
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	2
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0045174	glutathione dehydrogenase (ascorbate) activity	2	2
GO:0050661	NADP binding	4	1
GO:0070402	NADPH binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1
GO:0005515	protein binding	2	1
GO:0042802	identical protein binding	3	1
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.530
CLV_NRD_NRD_1	65	67	PF00675	0.277
CLV_PCSK_KEX2_1	125	127	PF00082	0.428
CLV_PCSK_KEX2_1	438	440	PF00082	0.520
CLV_PCSK_KEX2_1	65	67	PF00082	0.491
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.428
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.432
CLV_PCSK_SKI1_1	126	130	PF00082	0.469
CLV_PCSK_SKI1_1	170	174	PF00082	0.424
CLV_PCSK_SKI1_1	253	257	PF00082	0.324
CLV_PCSK_SKI1_1	303	307	PF00082	0.418
CLV_PCSK_SKI1_1	394	398	PF00082	0.514
CLV_PCSK_SKI1_1	4	8	PF00082	0.483
CLV_PCSK_SKI1_1	427	431	PF00082	0.485
CLV_PCSK_SKI1_1	438	442	PF00082	0.494
CLV_PCSK_SKI1_1	66	70	PF00082	0.477
DEG_SCF_FBW7_1	396	401	PF00400	0.277
DEG_SCF_FBW7_2	283	289	PF00400	0.530
DOC_CDC14_PxL_1	277	285	PF14671	0.277
DOC_CKS1_1	283	288	PF01111	0.428
DOC_CKS1_1	421	426	PF01111	0.433
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.399
DOC_MAPK_DCC_7	52	60	PF00069	0.428
DOC_MAPK_gen_1	437	443	PF00069	0.542
DOC_MAPK_MEF2A_6	52	60	PF00069	0.428
DOC_PP1_RVXF_1	166	172	PF00149	0.408
DOC_WW_Pin1_4	282	287	PF00397	0.418
DOC_WW_Pin1_4	394	399	PF00397	0.339
DOC_WW_Pin1_4	420	425	PF00397	0.433
LIG_14-3-3_CanoR_1	126	136	PF00244	0.346
LIG_14-3-3_CanoR_1	198	202	PF00244	0.497
LIG_14-3-3_CanoR_1	253	258	PF00244	0.359
LIG_14-3-3_CanoR_1	392	397	PF00244	0.339
LIG_Actin_WH2_2	156	172	PF00022	0.491
LIG_APCC_ABBA_1	239	244	PF00400	0.497
LIG_BRCT_BRCA1_1	338	342	PF00533	0.433
LIG_deltaCOP1_diTrp_1	269	274	PF00928	0.277
LIG_EH1_1	331	339	PF00400	0.530
LIG_eIF4E_1	332	338	PF01652	0.497
LIG_FHA_1	307	313	PF00498	0.586
LIG_FHA_1	333	339	PF00498	0.423
LIG_FHA_1	395	401	PF00498	0.361
LIG_FHA_1	55	61	PF00498	0.458
LIG_FHA_2	154	160	PF00498	0.530
LIG_FHA_2	430	436	PF00498	0.593
LIG_GBD_Chelix_1	34	42	PF00786	0.491
LIG_Integrin_RGD_1	314	316	PF01839	0.606
LIG_LIR_Gen_1	269	277	PF02991	0.277
LIG_LIR_Gen_1	30	38	PF02991	0.518
LIG_LIR_Gen_1	351	359	PF02991	0.504
LIG_LIR_Gen_1	401	412	PF02991	0.434
LIG_LIR_Nem_3	213	218	PF02991	0.580
LIG_LIR_Nem_3	269	274	PF02991	0.453
LIG_LIR_Nem_3	30	34	PF02991	0.473
LIG_LIR_Nem_3	351	357	PF02991	0.504
LIG_LIR_Nem_3	401	407	PF02991	0.417
LIG_MLH1_MIPbox_1	338	342	PF16413	0.277
LIG_MYND_3	55	59	PF01753	0.530
LIG_PCNA_TLS_4	96	103	PF02747	0.530
LIG_Pex14_1	270	274	PF04695	0.399
LIG_Pex14_2	406	410	PF04695	0.465
LIG_PTB_Apo_2	326	333	PF02174	0.530
LIG_PTB_Phospho_1	326	332	PF10480	0.530
LIG_REV1ctd_RIR_1	371	381	PF16727	0.530
LIG_REV1ctd_RIR_1	404	410	PF16727	0.399
LIG_SH2_CRK	31	35	PF00017	0.501
LIG_SH2_GRB2like	235	238	PF00017	0.458
LIG_SH2_STAP1	235	239	PF00017	0.530
LIG_SH2_STAP1	31	35	PF00017	0.533
LIG_SH2_STAP1	404	408	PF00017	0.458
LIG_SH2_STAT5	101	104	PF00017	0.384
LIG_SH2_STAT5	150	153	PF00017	0.432
LIG_SH2_STAT5	232	235	PF00017	0.362
LIG_SH2_STAT5	300	303	PF00017	0.409
LIG_SH2_STAT5	332	335	PF00017	0.432
LIG_SH2_STAT5	77	80	PF00017	0.385
LIG_SH2_STAT5	9	12	PF00017	0.548
LIG_SH3_3	257	263	PF00018	0.509
LIG_SH3_3	307	313	PF00018	0.418
LIG_SH3_3	57	63	PF00018	0.258
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.375
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.405
LIG_TRAF2_1	432	435	PF00917	0.581
LIG_TYR_ITIM	29	34	PF00017	0.464
LIG_UBA3_1	386	394	PF00899	0.436
LIG_UBA3_1	440	446	PF00899	0.385
MOD_CDK_SPxxK_3	420	427	PF00069	0.433
MOD_CK1_1	127	133	PF00069	0.277
MOD_CK1_1	276	282	PF00069	0.373
MOD_CK2_1	197	203	PF00069	0.418
MOD_CK2_1	429	435	PF00069	0.561
MOD_GlcNHglycan	121	124	PF01048	0.519
MOD_GlcNHglycan	126	129	PF01048	0.528
MOD_GlcNHglycan	131	134	PF01048	0.365
MOD_GlcNHglycan	221	224	PF01048	0.564
MOD_GlcNHglycan	286	289	PF01048	0.530
MOD_GlcNHglycan	91	94	PF01048	0.548
MOD_GSK3_1	197	204	PF00069	0.380
MOD_GSK3_1	332	339	PF00069	0.356
MOD_GSK3_1	394	401	PF00069	0.339
MOD_N-GLC_1	142	147	PF02516	0.530
MOD_N-GLC_2	80	82	PF02516	0.356
MOD_NEK2_1	129	134	PF00069	0.277
MOD_NEK2_1	78	83	PF00069	0.528
MOD_NEK2_1	89	94	PF00069	0.436
MOD_PIKK_1	101	107	PF00454	0.339
MOD_PIKK_1	291	297	PF00454	0.455
MOD_PKA_1	253	259	PF00069	0.277
MOD_PKA_1	27	33	PF00069	0.277
MOD_PKA_2	197	203	PF00069	0.385
MOD_PKA_2	51	57	PF00069	0.385
MOD_Plk_1	153	159	PF00069	0.465
MOD_Plk_4	197	203	PF00069	0.305
MOD_Plk_4	306	312	PF00069	0.590
MOD_Plk_4	336	342	PF00069	0.495
MOD_Plk_4	68	74	PF00069	0.526
MOD_ProDKin_1	282	288	PF00069	0.418
MOD_ProDKin_1	394	400	PF00069	0.339
MOD_ProDKin_1	420	426	PF00069	0.433
MOD_SUMO_for_1	348	351	PF00179	0.458
MOD_SUMO_rev_2	21	30	PF00179	0.485
MOD_SUMO_rev_2	345	350	PF00179	0.474
TRG_DiLeu_BaEn_2	321	327	PF01217	0.530
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.530
TRG_ENDOCYTIC_2	179	182	PF00928	0.385
TRG_ENDOCYTIC_2	215	218	PF00928	0.606
TRG_ENDOCYTIC_2	271	274	PF00928	0.458
TRG_ENDOCYTIC_2	31	34	PF00928	0.440
TRG_ENDOCYTIC_2	404	407	PF00928	0.391
TRG_ENDOCYTIC_2	46	49	PF00928	0.315
TRG_ER_diArg_1	245	248	PF00400	0.428
TRG_ER_diArg_1	65	67	PF00400	0.277
TRG_ER_diArg_1	96	99	PF00400	0.287
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IX62	Bodo saltans	40%	94%
A0A0S4KHM5	Bodo saltans	39%	93%
A0A1X0P247	Trypanosomatidae	44%	100%
A0A3S7X699	Leishmania donovani	80%	100%
A0A422NGA2	Trypanosoma rangeli	49%	100%
A4I8P2	Leishmania infantum	80%	100%
E9B3K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q70GE8	Leishmania major	81%	100%
V5DBY4	Trypanosoma cruzi	46%	100%