Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ17_LEIBR

TriTrypDb:

LbrM.31.0540 , LBRM2903_310012200

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.294
CLV_C14_Caspase3-7	27	31	PF00656	0.575
CLV_C14_Caspase3-7	275	279	PF00656	0.318
CLV_C14_Caspase3-7	295	299	PF00656	0.477
CLV_C14_Caspase3-7	309	313	PF00656	0.457
CLV_MEL_PAP_1	38	44	PF00089	0.454
CLV_NRD_NRD_1	329	331	PF00675	0.539
CLV_NRD_NRD_1	89	91	PF00675	0.636
CLV_PCSK_KEX2_1	329	331	PF00082	0.539
CLV_PCSK_KEX2_1	89	91	PF00082	0.665
CLV_PCSK_SKI1_1	117	121	PF00082	0.326
CLV_PCSK_SKI1_1	128	132	PF00082	0.349
CLV_PCSK_SKI1_1	158	162	PF00082	0.324
CLV_PCSK_SKI1_1	44	48	PF00082	0.370
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DOC_MAPK_gen_1	13	21	PF00069	0.412
DOC_MAPK_MEF2A_6	15	23	PF00069	0.458
DOC_MAPK_MEF2A_6	2	11	PF00069	0.476
DOC_PP2B_LxvP_1	193	196	PF13499	0.680
DOC_PP2B_LxvP_1	207	210	PF13499	0.330
DOC_PP4_FxxP_1	243	246	PF00568	0.478
DOC_SPAK_OSR1_1	242	246	PF12202	0.450
DOC_USP7_MATH_1	210	214	PF00917	0.458
DOC_USP7_MATH_1	246	250	PF00917	0.370
DOC_USP7_MATH_1	31	35	PF00917	0.535
DOC_USP7_MATH_1	52	56	PF00917	0.455
DOC_WW_Pin1_4	184	189	PF00397	0.659
DOC_WW_Pin1_4	50	55	PF00397	0.498
DOC_WW_Pin1_4	95	100	PF00397	0.645
LIG_14-3-3_CanoR_1	147	155	PF00244	0.463
LIG_14-3-3_CanoR_1	175	184	PF00244	0.410
LIG_14-3-3_CanoR_1	314	322	PF00244	0.329
LIG_14-3-3_CanoR_1	6	12	PF00244	0.491
LIG_14-3-3_CanoR_1	89	99	PF00244	0.630
LIG_14-3-3_CterR_2	336	338	PF00244	0.566
LIG_APCC_ABBAyCdc20_2	73	79	PF00400	0.420
LIG_CtBP_PxDLS_1	273	277	PF00389	0.319
LIG_DLG_GKlike_1	272	280	PF00625	0.333
LIG_eIF4E_1	322	328	PF01652	0.398
LIG_FHA_1	200	206	PF00498	0.289
LIG_FHA_1	278	284	PF00498	0.567
LIG_FHA_1	318	324	PF00498	0.440
LIG_FHA_1	80	86	PF00498	0.581
LIG_FHA_1	91	97	PF00498	0.667
LIG_FHA_2	198	204	PF00498	0.481
LIG_GBD_Chelix_1	323	331	PF00786	0.419
LIG_LIR_Apic_2	240	246	PF02991	0.286
LIG_LIR_Nem_3	168	174	PF02991	0.417
LIG_NBox_RRM_1	250	260	PF00076	0.244
LIG_PTB_Apo_2	300	307	PF02174	0.463
LIG_PTB_Phospho_1	300	306	PF10480	0.456
LIG_RPA_C_Fungi	30	42	PF08784	0.481
LIG_SH2_GRB2like	305	308	PF00017	0.396
LIG_SH2_SRC	310	313	PF00017	0.340
LIG_SH2_STAT5	265	268	PF00017	0.399
LIG_SH2_STAT5	310	313	PF00017	0.484
LIG_SH2_STAT5	322	325	PF00017	0.416
LIG_SH3_3	131	137	PF00018	0.385
LIG_SH3_3	54	60	PF00018	0.512
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.469
LIG_SUMO_SIM_par_1	159	164	PF11976	0.426
LIG_WRC_WIRS_1	247	252	PF05994	0.322
MOD_CK1_1	191	197	PF00069	0.554
MOD_CK1_1	213	219	PF00069	0.445
MOD_CK1_1	267	273	PF00069	0.438
MOD_CK1_1	292	298	PF00069	0.376
MOD_CK1_1	98	104	PF00069	0.628
MOD_CK2_1	161	167	PF00069	0.422
MOD_GlcNHglycan	163	166	PF01048	0.427
MOD_GlcNHglycan	212	215	PF01048	0.452
MOD_GlcNHglycan	298	301	PF01048	0.448
MOD_GSK3_1	161	168	PF00069	0.354
MOD_GSK3_1	180	187	PF00069	0.518
MOD_GSK3_1	221	228	PF00069	0.479
MOD_GSK3_1	260	267	PF00069	0.434
MOD_GSK3_1	272	279	PF00069	0.462
MOD_GSK3_1	289	296	PF00069	0.352
MOD_GSK3_1	313	320	PF00069	0.433
MOD_GSK3_1	98	105	PF00069	0.636
MOD_N-GLC_1	184	189	PF02516	0.652
MOD_N-GLC_1	191	196	PF02516	0.689
MOD_N-GLC_1	317	322	PF02516	0.532
MOD_NEK2_1	161	166	PF00069	0.391
MOD_NEK2_1	276	281	PF00069	0.429
MOD_NEK2_1	289	294	PF00069	0.337
MOD_NEK2_1	323	328	PF00069	0.403
MOD_NEK2_1	9	14	PF00069	0.507
MOD_PIKK_1	313	319	PF00454	0.349
MOD_PKA_2	296	302	PF00069	0.402
MOD_PKA_2	31	37	PF00069	0.538
MOD_PKA_2	313	319	PF00069	0.380
MOD_PKA_2	40	46	PF00069	0.511
MOD_PKA_2	85	91	PF00069	0.545
MOD_PKB_1	90	98	PF00069	0.656
MOD_Plk_1	102	108	PF00069	0.603
MOD_Plk_1	191	197	PF00069	0.688
MOD_Plk_1	317	323	PF00069	0.535
MOD_Plk_4	246	252	PF00069	0.441
MOD_Plk_4	289	295	PF00069	0.357
MOD_Plk_4	323	329	PF00069	0.410
MOD_ProDKin_1	184	190	PF00069	0.661
MOD_ProDKin_1	50	56	PF00069	0.494
MOD_ProDKin_1	95	101	PF00069	0.642
TRG_DiLeu_BaEn_1	240	245	PF01217	0.398
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.333
TRG_ENDOCYTIC_2	110	113	PF00928	0.383
TRG_ER_diArg_1	328	330	PF00400	0.546
TRG_ER_diArg_1	73	76	PF00400	0.631
TRG_ER_diArg_1	89	92	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRG0	Leptomonas seymouri	56%	98%
A0A0S4JMI8	Bodo saltans	30%	100%
A0A1X0P0V8	Trypanosomatidae	42%	100%
A0A3Q8IJV7	Leishmania donovani	83%	100%
A0A422NG71	Trypanosoma rangeli	46%	100%
A4I8P3	Leishmania infantum	83%	100%
D0A4L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B3K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4J5	Leishmania major	84%	100%
V5BFZ0	Trypanosoma cruzi	45%	100%