Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ12_LEIBR

TriTrypDb:

LbrM.31.0490 , LBRM2903_310011400

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004497	monooxygenase activity	3	1
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0020037	heme binding	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0046914	transition metal ion binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.591
CLV_C14_Caspase3-7	277	281	PF00656	0.395
CLV_NRD_NRD_1	155	157	PF00675	0.389
CLV_NRD_NRD_1	33	35	PF00675	0.511
CLV_NRD_NRD_1	593	595	PF00675	0.427
CLV_PCSK_KEX2_1	155	157	PF00082	0.389
CLV_PCSK_KEX2_1	33	35	PF00082	0.517
CLV_PCSK_KEX2_1	351	353	PF00082	0.605
CLV_PCSK_KEX2_1	528	530	PF00082	0.434
CLV_PCSK_KEX2_1	593	595	PF00082	0.427
CLV_PCSK_KEX2_1	632	634	PF00082	0.352
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.580
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.504
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.305
CLV_PCSK_PC7_1	29	35	PF00082	0.545
CLV_PCSK_PC7_1	524	530	PF00082	0.441
CLV_PCSK_SKI1_1	101	105	PF00082	0.621
CLV_PCSK_SKI1_1	38	42	PF00082	0.765
CLV_PCSK_SKI1_1	538	542	PF00082	0.416
CLV_PCSK_SKI1_1	624	628	PF00082	0.278
CLV_PCSK_SKI1_1	629	633	PF00082	0.281
CLV_PCSK_SKI1_1	80	84	PF00082	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.617
DEG_SCF_FBW7_1	497	504	PF00400	0.457
DOC_CDC14_PxL_1	367	375	PF14671	0.264
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	618	621	PF00134	0.404
DOC_MAPK_gen_1	286	295	PF00069	0.257
DOC_MAPK_MEF2A_6	289	297	PF00069	0.399
DOC_PP1_RVXF_1	135	141	PF00149	0.556
DOC_PP1_RVXF_1	200	207	PF00149	0.367
DOC_PP2B_LxvP_1	13	16	PF13499	0.590
DOC_PP2B_LxvP_1	190	193	PF13499	0.475
DOC_PP2B_LxvP_1	618	621	PF13499	0.409
DOC_PP4_FxxP_1	309	312	PF00568	0.455
DOC_PP4_FxxP_1	617	620	PF00568	0.427
DOC_PP4_MxPP_1	185	188	PF00568	0.582
DOC_SPAK_OSR1_1	400	404	PF12202	0.283
DOC_USP7_MATH_1	142	146	PF00917	0.543
DOC_USP7_MATH_1	276	280	PF00917	0.630
DOC_USP7_MATH_1	300	304	PF00917	0.402
DOC_USP7_MATH_1	335	339	PF00917	0.609
DOC_USP7_MATH_1	357	361	PF00917	0.555
DOC_USP7_MATH_1	366	370	PF00917	0.449
DOC_USP7_MATH_1	408	412	PF00917	0.623
DOC_USP7_MATH_1	416	420	PF00917	0.522
DOC_USP7_MATH_1	637	641	PF00917	0.472
DOC_USP7_MATH_1	657	661	PF00917	0.623
DOC_WW_Pin1_4	170	175	PF00397	0.382
DOC_WW_Pin1_4	358	363	PF00397	0.583
DOC_WW_Pin1_4	40	45	PF00397	0.488
DOC_WW_Pin1_4	406	411	PF00397	0.577
DOC_WW_Pin1_4	476	481	PF00397	0.409
DOC_WW_Pin1_4	497	502	PF00397	0.451
LIG_14-3-3_CanoR_1	155	163	PF00244	0.492
LIG_14-3-3_CanoR_1	21	27	PF00244	0.698
LIG_14-3-3_CanoR_1	301	306	PF00244	0.473
LIG_14-3-3_CanoR_1	380	387	PF00244	0.540
LIG_14-3-3_CanoR_1	438	444	PF00244	0.383
LIG_14-3-3_CanoR_1	661	669	PF00244	0.536
LIG_APCC_ABBA_1	293	298	PF00400	0.373
LIG_BRCT_BRCA1_1	202	206	PF00533	0.486
LIG_Clathr_ClatBox_1	553	557	PF01394	0.345
LIG_CtBP_PxDLS_1	174	178	PF00389	0.451
LIG_FHA_1	114	120	PF00498	0.749
LIG_FHA_1	2	8	PF00498	0.640
LIG_FHA_1	30	36	PF00498	0.596
LIG_FHA_1	448	454	PF00498	0.490
LIG_FHA_1	502	508	PF00498	0.446
LIG_FHA_1	546	552	PF00498	0.384
LIG_FHA_2	566	572	PF00498	0.423
LIG_IRF3_LxIS_1	241	248	PF10401	0.237
LIG_LIR_Apic_2	308	312	PF02991	0.467
LIG_LIR_Gen_1	220	231	PF02991	0.516
LIG_LIR_Gen_1	548	556	PF02991	0.420
LIG_LIR_LC3C_4	257	261	PF02991	0.260
LIG_LIR_Nem_3	133	138	PF02991	0.484
LIG_LIR_Nem_3	220	226	PF02991	0.504
LIG_LIR_Nem_3	361	367	PF02991	0.556
LIG_LIR_Nem_3	469	475	PF02991	0.367
LIG_LIR_Nem_3	548	553	PF02991	0.415
LIG_LIR_Nem_3	568	573	PF02991	0.391
LIG_MYND_1	175	179	PF01753	0.450
LIG_MYND_1	616	620	PF01753	0.417
LIG_NRBOX	562	568	PF00104	0.436
LIG_Pex14_2	131	135	PF04695	0.476
LIG_Pex14_2	305	309	PF04695	0.475
LIG_SH2_CRK	242	246	PF00017	0.394
LIG_SH2_NCK_1	412	416	PF00017	0.460
LIG_SH2_PTP2	550	553	PF00017	0.404
LIG_SH2_PTP2	625	628	PF00017	0.267
LIG_SH2_STAP1	231	235	PF00017	0.494
LIG_SH2_STAP1	412	416	PF00017	0.460
LIG_SH2_STAP1	488	492	PF00017	0.410
LIG_SH2_STAT5	200	203	PF00017	0.463
LIG_SH2_STAT5	432	435	PF00017	0.353
LIG_SH2_STAT5	475	478	PF00017	0.380
LIG_SH2_STAT5	50	53	PF00017	0.544
LIG_SH2_STAT5	550	553	PF00017	0.404
LIG_SH2_STAT5	625	628	PF00017	0.328
LIG_SH3_3	116	122	PF00018	0.548
LIG_SH3_3	185	191	PF00018	0.507
LIG_SH3_3	365	371	PF00018	0.419
LIG_SUMO_SIM_anti_2	602	609	PF11976	0.300
LIG_SUMO_SIM_par_1	552	557	PF11976	0.347
LIG_TRAF2_1	327	330	PF00917	0.434
LIG_TRAF2_1	587	590	PF00917	0.320
LIG_TYR_ITIM	623	628	PF00017	0.423
LIG_UBA3_1	197	202	PF00899	0.427
LIG_WRC_WIRS_1	567	572	PF05994	0.444
LIG_WW_3	186	190	PF00397	0.511
MOD_CDK_SPK_2	358	363	PF00069	0.558
MOD_CDK_SPxxK_3	40	47	PF00069	0.477
MOD_CK1_1	464	470	PF00069	0.457
MOD_CK1_1	479	485	PF00069	0.293
MOD_CK1_1	545	551	PF00069	0.357
MOD_CK1_1	596	602	PF00069	0.397
MOD_CK1_1	660	666	PF00069	0.563
MOD_CK2_1	111	117	PF00069	0.700
MOD_CK2_1	310	316	PF00069	0.435
MOD_CK2_1	393	399	PF00069	0.343
MOD_CK2_1	439	445	PF00069	0.465
MOD_CK2_1	516	522	PF00069	0.491
MOD_CK2_1	565	571	PF00069	0.429
MOD_CK2_1	596	602	PF00069	0.385
MOD_Cter_Amidation	349	352	PF01082	0.521
MOD_GlcNHglycan	113	116	PF01048	0.711
MOD_GlcNHglycan	146	149	PF01048	0.661
MOD_GlcNHglycan	158	161	PF01048	0.569
MOD_GlcNHglycan	247	250	PF01048	0.360
MOD_GlcNHglycan	256	259	PF01048	0.450
MOD_GlcNHglycan	353	356	PF01048	0.660
MOD_GlcNHglycan	368	371	PF01048	0.399
MOD_GlcNHglycan	418	421	PF01048	0.497
MOD_GlcNHglycan	447	450	PF01048	0.518
MOD_GlcNHglycan	51	54	PF01048	0.529
MOD_GlcNHglycan	535	538	PF01048	0.516
MOD_GlcNHglycan	58	61	PF01048	0.436
MOD_GlcNHglycan	595	598	PF01048	0.669
MOD_GlcNHglycan	639	642	PF01048	0.508
MOD_GlcNHglycan	662	665	PF01048	0.646
MOD_GlcNHglycan	668	672	PF01048	0.682
MOD_GSK3_1	101	108	PF00069	0.669
MOD_GSK3_1	144	151	PF00069	0.533
MOD_GSK3_1	296	303	PF00069	0.450
MOD_GSK3_1	333	340	PF00069	0.621
MOD_GSK3_1	447	454	PF00069	0.543
MOD_GSK3_1	461	468	PF00069	0.501
MOD_GSK3_1	497	504	PF00069	0.383
MOD_GSK3_1	541	548	PF00069	0.317
MOD_GSK3_1	633	640	PF00069	0.472
MOD_GSK3_1	85	92	PF00069	0.532
MOD_N-GLC_2	332	334	PF02516	0.432
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	111	116	PF00069	0.698
MOD_NEK2_1	20	25	PF00069	0.509
MOD_NEK2_1	245	250	PF00069	0.331
MOD_NEK2_1	259	264	PF00069	0.338
MOD_NEK2_1	296	301	PF00069	0.354
MOD_NEK2_1	339	344	PF00069	0.753
MOD_NEK2_1	465	470	PF00069	0.375
MOD_NEK2_1	541	546	PF00069	0.394
MOD_NEK2_2	200	205	PF00069	0.322
MOD_PIKK_1	217	223	PF00454	0.300
MOD_PKA_1	351	357	PF00069	0.515
MOD_PKA_1	38	44	PF00069	0.483
MOD_PKA_1	593	599	PF00069	0.560
MOD_PKA_1	632	638	PF00069	0.378
MOD_PKA_2	1	7	PF00069	0.613
MOD_PKA_2	104	110	PF00069	0.633
MOD_PKA_2	143	149	PF00069	0.560
MOD_PKA_2	20	26	PF00069	0.401
MOD_PKA_2	300	306	PF00069	0.473
MOD_PKA_2	351	357	PF00069	0.515
MOD_PKA_2	379	385	PF00069	0.492
MOD_PKA_2	451	457	PF00069	0.513
MOD_PKA_2	593	599	PF00069	0.636
MOD_PKA_2	632	638	PF00069	0.519
MOD_PKA_2	660	666	PF00069	0.545
MOD_Plk_1	287	293	PF00069	0.397
MOD_Plk_1	89	95	PF00069	0.615
MOD_Plk_4	259	265	PF00069	0.392
MOD_Plk_4	371	377	PF00069	0.376
MOD_Plk_4	461	467	PF00069	0.477
MOD_Plk_4	8	14	PF00069	0.556
MOD_ProDKin_1	170	176	PF00069	0.388
MOD_ProDKin_1	358	364	PF00069	0.565
MOD_ProDKin_1	40	46	PF00069	0.479
MOD_ProDKin_1	406	412	PF00069	0.584
MOD_ProDKin_1	476	482	PF00069	0.418
MOD_ProDKin_1	497	503	PF00069	0.445
MOD_SUMO_rev_2	31	41	PF00179	0.625
TRG_DiLeu_BaEn_1	603	608	PF01217	0.293
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.424
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.388
TRG_ENDOCYTIC_2	242	245	PF00928	0.509
TRG_ENDOCYTIC_2	550	553	PF00928	0.404
TRG_ENDOCYTIC_2	574	577	PF00928	0.432
TRG_ENDOCYTIC_2	625	628	PF00928	0.424
TRG_ER_diArg_1	155	158	PF00400	0.529
TRG_ER_diArg_1	33	36	PF00400	0.495
TRG_ER_FFAT_2	48	56	PF00635	0.555
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T2	Leptomonas seymouri	44%	100%
A0A3S7X435	Leishmania donovani	73%	100%
A4I6K2	Leishmania infantum	73%	100%
E9B1I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q6M6	Leishmania major	72%	100%
V5AYQ1	Trypanosoma cruzi	30%	100%