LeishMANIAdb
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CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL-TRIO domain-containing protein
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HJ11_LEIBR
TriTrypDb:
LbrM.31.0480 , LBRM2903_310011300 *
Length:
993

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0012505 endomembrane system 2 1
GO:0044232 organelle membrane contact site 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0140284 endoplasmic reticulum-endosome membrane contact site 3 1

Expansion

Sequence features

A4HJ11
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 24 28 PF00656 0.560
CLV_C14_Caspase3-7 408 412 PF00656 0.801
CLV_C14_Caspase3-7 574 578 PF00656 0.494
CLV_C14_Caspase3-7 63 67 PF00656 0.521
CLV_NRD_NRD_1 122 124 PF00675 0.513
CLV_NRD_NRD_1 436 438 PF00675 0.708
CLV_NRD_NRD_1 50 52 PF00675 0.490
CLV_NRD_NRD_1 502 504 PF00675 0.611
CLV_NRD_NRD_1 565 567 PF00675 0.585
CLV_NRD_NRD_1 609 611 PF00675 0.508
CLV_NRD_NRD_1 68 70 PF00675 0.499
CLV_NRD_NRD_1 693 695 PF00675 0.547
CLV_NRD_NRD_1 799 801 PF00675 0.376
CLV_NRD_NRD_1 857 859 PF00675 0.647
CLV_NRD_NRD_1 915 917 PF00675 0.556
CLV_PCSK_KEX2_1 16 18 PF00082 0.600
CLV_PCSK_KEX2_1 49 51 PF00082 0.505
CLV_PCSK_KEX2_1 502 504 PF00082 0.626
CLV_PCSK_KEX2_1 565 567 PF00082 0.585
CLV_PCSK_KEX2_1 609 611 PF00082 0.489
CLV_PCSK_KEX2_1 693 695 PF00082 0.547
CLV_PCSK_KEX2_1 799 801 PF00082 0.376
CLV_PCSK_KEX2_1 857 859 PF00082 0.639
CLV_PCSK_KEX2_1 915 917 PF00082 0.585
CLV_PCSK_KEX2_1 988 990 PF00082 0.605
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.600
CLV_PCSK_PC1ET2_1 988 990 PF00082 0.605
CLV_PCSK_PC7_1 689 695 PF00082 0.529
CLV_PCSK_SKI1_1 13 17 PF00082 0.559
CLV_PCSK_SKI1_1 182 186 PF00082 0.408
CLV_PCSK_SKI1_1 236 240 PF00082 0.570
CLV_PCSK_SKI1_1 256 260 PF00082 0.267
CLV_PCSK_SKI1_1 549 553 PF00082 0.593
CLV_PCSK_SKI1_1 56 60 PF00082 0.504
CLV_PCSK_SKI1_1 566 570 PF00082 0.651
CLV_PCSK_SKI1_1 609 613 PF00082 0.505
CLV_PCSK_SKI1_1 679 683 PF00082 0.472
DEG_APCC_DBOX_1 181 189 PF00400 0.261
DEG_APCC_DBOX_1 415 423 PF00400 0.667
DEG_APCC_DBOX_1 693 701 PF00400 0.515
DEG_MDM2_SWIB_1 590 598 PF02201 0.496
DEG_Nend_Nbox_1 1 3 PF02207 0.531
DEG_SPOP_SBC_1 542 546 PF00917 0.537
DOC_ANK_TNKS_1 662 669 PF00023 0.358
DOC_CKS1_1 638 643 PF01111 0.535
DOC_CYCLIN_RxL_1 603 614 PF00134 0.488
DOC_CYCLIN_yClb1_LxF_4 564 569 PF00134 0.582
DOC_CYCLIN_yClb5_NLxxxL_5 107 115 PF00134 0.261
DOC_MAPK_gen_1 13 21 PF00069 0.488
DOC_MAPK_gen_1 603 613 PF00069 0.485
DOC_MAPK_gen_1 857 865 PF00069 0.613
DOC_MAPK_MEF2A_6 732 739 PF00069 0.335
DOC_MAPK_MEF2A_6 84 92 PF00069 0.383
DOC_MAPK_MEF2A_6 858 867 PF00069 0.509
DOC_MAPK_RevD_3 422 438 PF00069 0.470
DOC_MAPK_RevD_3 901 916 PF00069 0.454
DOC_PP1_RVXF_1 563 570 PF00149 0.576
DOC_PP1_RVXF_1 619 625 PF00149 0.362
DOC_PP1_RVXF_1 677 683 PF00149 0.461
DOC_PP2B_LxvP_1 664 667 PF13499 0.608
DOC_PP4_FxxP_1 2 5 PF00568 0.499
DOC_USP7_MATH_1 362 366 PF00917 0.617
DOC_USP7_MATH_1 377 381 PF00917 0.536
DOC_USP7_MATH_1 402 406 PF00917 0.675
DOC_USP7_MATH_1 541 545 PF00917 0.647
DOC_USP7_MATH_1 733 737 PF00917 0.332
DOC_USP7_MATH_1 791 795 PF00917 0.511
DOC_WW_Pin1_4 228 233 PF00397 0.375
DOC_WW_Pin1_4 288 293 PF00397 0.766
DOC_WW_Pin1_4 316 321 PF00397 0.637
DOC_WW_Pin1_4 572 577 PF00397 0.491
DOC_WW_Pin1_4 637 642 PF00397 0.586
DOC_WW_Pin1_4 924 929 PF00397 0.775
LIG_14-3-3_CanoR_1 143 149 PF00244 0.411
LIG_14-3-3_CanoR_1 190 199 PF00244 0.270
LIG_14-3-3_CanoR_1 236 245 PF00244 0.460
LIG_14-3-3_CanoR_1 250 258 PF00244 0.495
LIG_14-3-3_CanoR_1 421 430 PF00244 0.494
LIG_14-3-3_CanoR_1 502 511 PF00244 0.507
LIG_14-3-3_CanoR_1 610 616 PF00244 0.450
LIG_14-3-3_CanoR_1 621 625 PF00244 0.476
LIG_14-3-3_CanoR_1 69 73 PF00244 0.495
LIG_14-3-3_CanoR_1 693 697 PF00244 0.402
LIG_14-3-3_CanoR_1 746 752 PF00244 0.630
LIG_14-3-3_CanoR_1 764 768 PF00244 0.317
LIG_14-3-3_CanoR_1 983 988 PF00244 0.668
LIG_Actin_WH2_2 127 145 PF00022 0.411
LIG_Actin_WH2_2 732 748 PF00022 0.578
LIG_Actin_WH2_2 967 985 PF00022 0.463
LIG_APCC_ABBA_1 19 24 PF00400 0.340
LIG_APCC_ABBA_1 643 648 PF00400 0.472
LIG_BRCT_BRCA1_1 157 161 PF00533 0.411
LIG_BRCT_BRCA1_1 694 698 PF00533 0.479
LIG_CaM_NSCaTE_8 677 684 PF13499 0.578
LIG_Clathr_ClatBox_1 597 601 PF01394 0.483
LIG_CSL_BTD_1 614 617 PF09270 0.514
LIG_CtBP_PxDLS_1 219 223 PF00389 0.411
LIG_CtBP_PxDLS_1 831 835 PF00389 0.662
LIG_deltaCOP1_diTrp_1 27 33 PF00928 0.439
LIG_deltaCOP1_diTrp_1 454 463 PF00928 0.594
LIG_deltaCOP1_diTrp_1 676 682 PF00928 0.478
LIG_EH1_1 553 561 PF00400 0.508
LIG_eIF4E_1 179 185 PF01652 0.261
LIG_FAT_LD_1 477 485 PF03623 0.519
LIG_FHA_1 125 131 PF00498 0.423
LIG_FHA_1 143 149 PF00498 0.364
LIG_FHA_1 176 182 PF00498 0.358
LIG_FHA_1 278 284 PF00498 0.602
LIG_FHA_1 333 339 PF00498 0.547
LIG_FHA_1 365 371 PF00498 0.633
LIG_FHA_1 617 623 PF00498 0.452
LIG_FHA_1 63 69 PF00498 0.509
LIG_FHA_1 736 742 PF00498 0.373
LIG_FHA_1 818 824 PF00498 0.296
LIG_FHA_2 189 195 PF00498 0.358
LIG_FHA_2 237 243 PF00498 0.563
LIG_FHA_2 291 297 PF00498 0.558
LIG_FHA_2 317 323 PF00498 0.774
LIG_FHA_2 548 554 PF00498 0.702
LIG_FHA_2 572 578 PF00498 0.462
LIG_FHA_2 61 67 PF00498 0.520
LIG_FHA_2 714 720 PF00498 0.491
LIG_FHA_2 833 839 PF00498 0.541
LIG_FHA_2 92 98 PF00498 0.411
LIG_LIR_Apic_2 887 892 PF02991 0.469
LIG_LIR_Gen_1 231 241 PF02991 0.435
LIG_LIR_Gen_1 27 35 PF02991 0.442
LIG_LIR_Gen_1 303 312 PF02991 0.565
LIG_LIR_Gen_1 324 333 PF02991 0.735
LIG_LIR_Gen_1 371 377 PF02991 0.618
LIG_LIR_Gen_1 393 402 PF02991 0.690
LIG_LIR_Gen_1 429 440 PF02991 0.604
LIG_LIR_Gen_1 462 471 PF02991 0.555
LIG_LIR_Gen_1 592 600 PF02991 0.500
LIG_LIR_Gen_1 695 704 PF02991 0.466
LIG_LIR_Gen_1 815 826 PF02991 0.451
LIG_LIR_Nem_3 158 164 PF02991 0.411
LIG_LIR_Nem_3 231 237 PF02991 0.455
LIG_LIR_Nem_3 27 32 PF02991 0.440
LIG_LIR_Nem_3 324 330 PF02991 0.717
LIG_LIR_Nem_3 371 375 PF02991 0.615
LIG_LIR_Nem_3 393 399 PF02991 0.686
LIG_LIR_Nem_3 429 435 PF02991 0.601
LIG_LIR_Nem_3 462 466 PF02991 0.511
LIG_LIR_Nem_3 525 529 PF02991 0.530
LIG_LIR_Nem_3 57 62 PF02991 0.507
LIG_LIR_Nem_3 592 597 PF02991 0.495
LIG_LIR_Nem_3 640 646 PF02991 0.432
LIG_LIR_Nem_3 674 680 PF02991 0.487
LIG_LIR_Nem_3 695 701 PF02991 0.454
LIG_LIR_Nem_3 815 821 PF02991 0.551
LIG_LIR_Nem_3 866 870 PF02991 0.473
LIG_MLH1_MIPbox_1 157 161 PF16413 0.411
LIG_MYND_3 474 478 PF01753 0.647
LIG_NRBOX 476 482 PF00104 0.555
LIG_NRBOX 902 908 PF00104 0.460
LIG_Pex14_1 29 33 PF04695 0.439
LIG_Pex14_2 590 594 PF04695 0.481
LIG_PTB_Apo_2 33 40 PF02174 0.468
LIG_SH2_CRK 432 436 PF00017 0.693
LIG_SH2_CRK 662 666 PF00017 0.502
LIG_SH2_CRK 678 682 PF00017 0.349
LIG_SH2_GRB2like 287 290 PF00017 0.580
LIG_SH2_GRB2like 306 309 PF00017 0.489
LIG_SH2_GRB2like 91 94 PF00017 0.411
LIG_SH2_NCK_1 889 893 PF00017 0.615
LIG_SH2_SRC 25 28 PF00017 0.447
LIG_SH2_SRC 646 649 PF00017 0.452
LIG_SH2_SRC 770 773 PF00017 0.512
LIG_SH2_STAP1 234 238 PF00017 0.482
LIG_SH2_STAP1 432 436 PF00017 0.693
LIG_SH2_STAT3 439 442 PF00017 0.444
LIG_SH2_STAT3 782 785 PF00017 0.525
LIG_SH2_STAT5 179 182 PF00017 0.347
LIG_SH2_STAT5 244 247 PF00017 0.462
LIG_SH2_STAT5 25 28 PF00017 0.447
LIG_SH2_STAT5 287 290 PF00017 0.653
LIG_SH2_STAT5 31 34 PF00017 0.438
LIG_SH2_STAT5 439 442 PF00017 0.533
LIG_SH2_STAT5 62 65 PF00017 0.507
LIG_SH2_STAT5 646 649 PF00017 0.452
LIG_SH2_STAT5 670 673 PF00017 0.410
LIG_SH2_STAT5 747 750 PF00017 0.530
LIG_SH2_STAT5 770 773 PF00017 0.512
LIG_SH2_STAT5 79 82 PF00017 0.411
LIG_SH2_STAT5 91 94 PF00017 0.411
LIG_SH3_1 889 895 PF00018 0.444
LIG_SH3_3 177 183 PF00018 0.411
LIG_SH3_3 272 278 PF00018 0.504
LIG_SH3_3 347 353 PF00018 0.583
LIG_SH3_3 396 402 PF00018 0.705
LIG_SH3_3 697 703 PF00018 0.513
LIG_SH3_3 775 781 PF00018 0.483
LIG_SH3_3 889 895 PF00018 0.444
LIG_SH3_3 956 962 PF00018 0.574
LIG_SUMO_SIM_par_1 334 339 PF11976 0.629
LIG_SUMO_SIM_par_1 364 371 PF11976 0.525
LIG_SUMO_SIM_par_1 555 561 PF11976 0.501
LIG_SUMO_SIM_par_1 595 601 PF11976 0.500
LIG_TRAF2_1 320 323 PF00917 0.653
LIG_TRAF2_1 426 429 PF00917 0.741
LIG_TRAF2_1 716 719 PF00917 0.389
LIG_TRAF2_1 812 815 PF00917 0.468
LIG_TYR_ITIM 686 691 PF00017 0.475
LIG_UBA3_1 839 848 PF00899 0.641
MOD_CDK_SPxxK_3 637 644 PF00069 0.583
MOD_CK1_1 175 181 PF00069 0.487
MOD_CK1_1 290 296 PF00069 0.762
MOD_CK1_1 314 320 PF00069 0.562
MOD_CK1_1 321 327 PF00069 0.608
MOD_CK1_1 379 385 PF00069 0.766
MOD_CK1_1 412 418 PF00069 0.763
MOD_CK1_1 544 550 PF00069 0.531
MOD_CK1_1 877 883 PF00069 0.493
MOD_CK1_1 914 920 PF00069 0.654
MOD_CK1_1 937 943 PF00069 0.634
MOD_CK1_1 951 957 PF00069 0.510
MOD_CK1_1 963 969 PF00069 0.457
MOD_CK2_1 188 194 PF00069 0.261
MOD_CK2_1 236 242 PF00069 0.564
MOD_CK2_1 254 260 PF00069 0.309
MOD_CK2_1 316 322 PF00069 0.784
MOD_CK2_1 422 428 PF00069 0.735
MOD_CK2_1 488 494 PF00069 0.601
MOD_CK2_1 651 657 PF00069 0.484
MOD_CK2_1 713 719 PF00069 0.492
MOD_CK2_1 832 838 PF00069 0.573
MOD_CK2_1 966 972 PF00069 0.638
MOD_GlcNHglycan 174 177 PF01048 0.405
MOD_GlcNHglycan 199 202 PF01048 0.402
MOD_GlcNHglycan 364 367 PF01048 0.544
MOD_GlcNHglycan 379 382 PF01048 0.523
MOD_GlcNHglycan 581 584 PF01048 0.462
MOD_GlcNHglycan 786 789 PF01048 0.632
MOD_GlcNHglycan 849 852 PF01048 0.472
MOD_GlcNHglycan 889 892 PF01048 0.718
MOD_GlcNHglycan 918 921 PF01048 0.742
MOD_GlcNHglycan 965 968 PF01048 0.683
MOD_GSK3_1 124 131 PF00069 0.375
MOD_GSK3_1 171 178 PF00069 0.411
MOD_GSK3_1 250 257 PF00069 0.424
MOD_GSK3_1 295 302 PF00069 0.649
MOD_GSK3_1 307 314 PF00069 0.709
MOD_GSK3_1 371 378 PF00069 0.725
MOD_GSK3_1 385 392 PF00069 0.532
MOD_GSK3_1 530 537 PF00069 0.481
MOD_GSK3_1 543 550 PF00069 0.493
MOD_GSK3_1 60 67 PF00069 0.581
MOD_GSK3_1 616 623 PF00069 0.491
MOD_GSK3_1 741 748 PF00069 0.600
MOD_GSK3_1 843 850 PF00069 0.397
MOD_GSK3_1 914 921 PF00069 0.593
MOD_GSK3_1 924 931 PF00069 0.624
MOD_GSK3_1 966 973 PF00069 0.709
MOD_N-GLC_1 137 142 PF02516 0.513
MOD_N-GLC_1 171 176 PF02516 0.411
MOD_N-GLC_1 288 293 PF02516 0.718
MOD_N-GLC_1 307 312 PF02516 0.570
MOD_N-GLC_1 314 319 PF02516 0.535
MOD_N-GLC_1 547 552 PF02516 0.551
MOD_N-GLC_2 226 228 PF02516 0.517
MOD_NEK2_1 113 118 PF00069 0.411
MOD_NEK2_1 155 160 PF00069 0.411
MOD_NEK2_1 197 202 PF00069 0.411
MOD_NEK2_1 375 380 PF00069 0.729
MOD_NEK2_1 409 414 PF00069 0.657
MOD_NEK2_1 430 435 PF00069 0.558
MOD_NEK2_1 54 59 PF00069 0.488
MOD_NEK2_1 571 576 PF00069 0.489
MOD_NEK2_1 611 616 PF00069 0.485
MOD_NEK2_1 64 69 PF00069 0.503
MOD_NEK2_1 771 776 PF00069 0.408
MOD_NEK2_1 816 821 PF00069 0.545
MOD_NEK2_1 843 848 PF00069 0.496
MOD_NEK2_1 874 879 PF00069 0.522
MOD_NEK2_1 885 890 PF00069 0.611
MOD_NEK2_1 929 934 PF00069 0.555
MOD_NEK2_1 935 940 PF00069 0.509
MOD_NEK2_1 970 975 PF00069 0.732
MOD_PIKK_1 496 502 PF00454 0.584
MOD_PIKK_1 512 518 PF00454 0.395
MOD_PIKK_1 771 777 PF00454 0.553
MOD_PIKK_1 781 787 PF00454 0.522
MOD_PK_1 137 143 PF00069 0.261
MOD_PKA_1 502 508 PF00069 0.511
MOD_PKA_1 847 853 PF00069 0.419
MOD_PKA_2 142 148 PF00069 0.411
MOD_PKA_2 155 161 PF00069 0.411
MOD_PKA_2 502 508 PF00069 0.511
MOD_PKA_2 620 626 PF00069 0.501
MOD_PKA_2 68 74 PF00069 0.492
MOD_PKA_2 692 698 PF00069 0.373
MOD_PKA_2 745 751 PF00069 0.623
MOD_PKA_2 763 769 PF00069 0.328
MOD_PKA_2 914 920 PF00069 0.692
MOD_PKA_2 97 103 PF00069 0.261
MOD_PKB_1 916 924 PF00069 0.616
MOD_Plk_1 137 143 PF00069 0.411
MOD_Plk_1 295 301 PF00069 0.603
MOD_Plk_1 321 327 PF00069 0.635
MOD_Plk_1 410 416 PF00069 0.744
MOD_Plk_1 428 434 PF00069 0.451
MOD_Plk_1 54 60 PF00069 0.491
MOD_Plk_1 547 553 PF00069 0.552
MOD_Plk_1 741 747 PF00069 0.587
MOD_Plk_2-3 254 260 PF00069 0.354
MOD_Plk_2-3 713 719 PF00069 0.540
MOD_Plk_4 128 134 PF00069 0.411
MOD_Plk_4 137 143 PF00069 0.411
MOD_Plk_4 175 181 PF00069 0.411
MOD_Plk_4 295 301 PF00069 0.625
MOD_Plk_4 332 338 PF00069 0.560
MOD_Plk_4 382 388 PF00069 0.653
MOD_Plk_4 430 436 PF00069 0.464
MOD_Plk_4 735 741 PF00069 0.569
MOD_Plk_4 819 825 PF00069 0.385
MOD_Plk_4 960 966 PF00069 0.528
MOD_ProDKin_1 228 234 PF00069 0.371
MOD_ProDKin_1 288 294 PF00069 0.761
MOD_ProDKin_1 316 322 PF00069 0.625
MOD_ProDKin_1 572 578 PF00069 0.489
MOD_ProDKin_1 637 643 PF00069 0.580
MOD_ProDKin_1 924 930 PF00069 0.773
MOD_SUMO_for_1 475 478 PF00179 0.551
MOD_SUMO_rev_2 116 126 PF00179 0.416
MOD_SUMO_rev_2 253 258 PF00179 0.358
MOD_SUMO_rev_2 726 734 PF00179 0.382
TRG_DiLeu_BaEn_1 208 213 PF01217 0.261
TRG_DiLeu_BaEn_1 676 681 PF01217 0.584
TRG_DiLeu_BaLyEn_6 180 185 PF01217 0.411
TRG_DiLeu_BaLyEn_6 607 612 PF01217 0.480
TRG_DiLeu_BaLyEn_6 660 665 PF01217 0.354
TRG_DiLeu_LyEn_5 676 681 PF01217 0.584
TRG_ENDOCYTIC_2 234 237 PF00928 0.492
TRG_ENDOCYTIC_2 306 309 PF00928 0.815
TRG_ENDOCYTIC_2 31 34 PF00928 0.438
TRG_ENDOCYTIC_2 432 435 PF00928 0.606
TRG_ENDOCYTIC_2 662 665 PF00928 0.451
TRG_ENDOCYTIC_2 678 681 PF00928 0.460
TRG_ENDOCYTIC_2 688 691 PF00928 0.415
TRG_ER_diArg_1 48 51 PF00400 0.459
TRG_ER_diArg_1 501 503 PF00400 0.619
TRG_ER_diArg_1 564 566 PF00400 0.593
TRG_ER_diArg_1 608 610 PF00400 0.500
TRG_ER_diArg_1 798 800 PF00400 0.366
TRG_ER_diArg_1 915 918 PF00400 0.555
TRG_NES_CRM1_1 260 270 PF08389 0.517
TRG_NES_CRM1_1 637 648 PF08389 0.436
TRG_NES_CRM1_1 815 829 PF08389 0.467
TRG_Pf-PMV_PEXEL_1 182 187 PF00026 0.261
TRG_Pf-PMV_PEXEL_1 190 194 PF00026 0.229
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.342
TRG_Pf-PMV_PEXEL_1 565 570 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 633 637 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P961 Leptomonas seymouri 57% 100%
A0A3S5H7P3 Leishmania donovani 74% 100%
A4I6K1 Leishmania infantum 74% 100%
E9B1I7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
Q4Q6M7 Leishmania major 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS