Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ08_LEIBR

TriTrypDb:

LbrM.31.0450 , LBRM2903_270012800

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 3
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HJ08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.424
CLV_C14_Caspase3-7	167	171	PF00656	0.396
CLV_C14_Caspase3-7	461	465	PF00656	0.666
CLV_C14_Caspase3-7	74	78	PF00656	0.440
CLV_NRD_NRD_1	15	17	PF00675	0.551
CLV_NRD_NRD_1	376	378	PF00675	0.642
CLV_NRD_NRD_1	448	450	PF00675	0.486
CLV_NRD_NRD_1	474	476	PF00675	0.663
CLV_PCSK_FUR_1	374	378	PF00082	0.470
CLV_PCSK_FUR_1	472	476	PF00082	0.664
CLV_PCSK_KEX2_1	15	17	PF00082	0.676
CLV_PCSK_KEX2_1	376	378	PF00082	0.642
CLV_PCSK_KEX2_1	474	476	PF00082	0.663
CLV_PCSK_PC7_1	11	17	PF00082	0.679
CLV_PCSK_SKI1_1	15	19	PF00082	0.600
CLV_PCSK_SKI1_1	377	381	PF00082	0.642
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SPOP_SBC_1	109	113	PF00917	0.396
DEG_SPOP_SBC_1	224	228	PF00917	0.579
DEG_SPOP_SBC_1	241	245	PF00917	0.518
DEG_SPOP_SBC_1	252	256	PF00917	0.576
DOC_CDC14_PxL_1	387	395	PF14671	0.663
DOC_MAPK_gen_1	178	188	PF00069	0.571
DOC_MAPK_gen_1	339	348	PF00069	0.662
DOC_MAPK_gen_1	472	481	PF00069	0.858
DOC_MAPK_JIP1_4	342	348	PF00069	0.662
DOC_PP1_SILK_1	377	382	PF00149	0.842
DOC_PP2B_LxvP_1	186	189	PF13499	0.496
DOC_USP7_MATH_1	211	215	PF00917	0.389
DOC_USP7_MATH_1	313	317	PF00917	0.669
DOC_USP7_MATH_1	438	442	PF00917	0.687
DOC_USP7_MATH_1	73	77	PF00917	0.513
DOC_USP7_UBL2_3	302	306	PF12436	0.548
DOC_WW_Pin1_4	365	370	PF00397	0.839
DOC_WW_Pin1_4	441	446	PF00397	0.684
DOC_WW_Pin1_4	465	470	PF00397	0.855
LIG_14-3-3_CanoR_1	401	411	PF00244	0.678
LIG_14-3-3_CanoR_1	453	459	PF00244	0.706
LIG_14-3-3_CanoR_1	472	482	PF00244	0.784
LIG_14-3-3_CanoR_1	57	63	PF00244	0.537
LIG_Actin_WH2_2	41	59	PF00022	0.398
LIG_BRCT_BRCA1_1	477	481	PF00533	0.851
LIG_deltaCOP1_diTrp_1	118	123	PF00928	0.474
LIG_eIF4E_1	215	221	PF01652	0.524
LIG_FHA_1	277	283	PF00498	0.434
LIG_FHA_1	293	299	PF00498	0.265
LIG_FHA_1	417	423	PF00498	0.737
LIG_FHA_1	442	448	PF00498	0.752
LIG_FHA_1	474	480	PF00498	0.857
LIG_FHA_2	158	164	PF00498	0.421
LIG_FHA_2	165	171	PF00498	0.386
LIG_FHA_2	234	240	PF00498	0.440
LIG_FHA_2	405	411	PF00498	0.676
LIG_GBD_Chelix_1	290	298	PF00786	0.527
LIG_LIR_Gen_1	285	294	PF02991	0.527
LIG_LIR_Gen_1	295	303	PF02991	0.363
LIG_LIR_Gen_1	363	369	PF02991	0.667
LIG_LIR_Gen_1	383	391	PF02991	0.591
LIG_LIR_Nem_3	132	138	PF02991	0.540
LIG_LIR_Nem_3	204	210	PF02991	0.435
LIG_LIR_Nem_3	279	284	PF02991	0.514
LIG_LIR_Nem_3	285	290	PF02991	0.442
LIG_LIR_Nem_3	295	299	PF02991	0.278
LIG_LIR_Nem_3	305	311	PF02991	0.516
LIG_LIR_Nem_3	363	367	PF02991	0.671
LIG_LIR_Nem_3	388	393	PF02991	0.662
LIG_LIR_Nem_3	452	458	PF02991	0.683
LIG_LIR_Nem_3	93	98	PF02991	0.554
LIG_LYPXL_S_1	389	393	PF13949	0.446
LIG_LYPXL_yS_3	390	393	PF13949	0.663
LIG_SH2_CRK	183	187	PF00017	0.550
LIG_SH2_NCK_1	192	196	PF00017	0.416
LIG_SH2_STAP1	39	43	PF00017	0.379
LIG_SH2_STAP1	9	13	PF00017	0.461
LIG_SH2_STAT3	122	125	PF00017	0.495
LIG_SH2_STAT5	215	218	PF00017	0.367
LIG_SH2_STAT5	95	98	PF00017	0.445
LIG_SH3_3	337	343	PF00018	0.663
LIG_SH3_3	67	73	PF00018	0.485
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.287
LIG_SUMO_SIM_par_1	219	234	PF11976	0.403
LIG_SUMO_SIM_par_1	45	51	PF11976	0.352
LIG_TRAF2_1	268	271	PF00917	0.619
LIG_WRC_WIRS_1	361	366	PF05994	0.841
LIG_WRC_WIRS_1	49	54	PF05994	0.367
MOD_CDK_SPxK_1	365	371	PF00069	0.837
MOD_CDK_SPxxK_3	465	472	PF00069	0.855
MOD_CK1_1	113	119	PF00069	0.484
MOD_CK1_1	159	165	PF00069	0.591
MOD_CK1_1	200	206	PF00069	0.467
MOD_CK1_1	231	237	PF00069	0.433
MOD_CK1_1	260	266	PF00069	0.626
MOD_CK1_1	321	327	PF00069	0.819
MOD_CK1_1	341	347	PF00069	0.599
MOD_CK1_1	350	356	PF00069	0.734
MOD_CK1_1	357	363	PF00069	0.648
MOD_CK1_1	402	408	PF00069	0.788
MOD_CK1_1	428	434	PF00069	0.699
MOD_CK1_1	441	447	PF00069	0.687
MOD_CK1_1	457	463	PF00069	0.787
MOD_CK1_1	55	61	PF00069	0.370
MOD_CK2_1	1	7	PF00069	0.510
MOD_CK2_1	203	209	PF00069	0.560
MOD_CK2_1	233	239	PF00069	0.437
MOD_Cter_Amidation	176	179	PF01082	0.739
MOD_Cter_Amidation	374	377	PF01082	0.641
MOD_GlcNHglycan	145	148	PF01048	0.667
MOD_GlcNHglycan	152	155	PF01048	0.685
MOD_GlcNHglycan	315	318	PF01048	0.525
MOD_GlcNHglycan	323	326	PF01048	0.596
MOD_GlcNHglycan	404	407	PF01048	0.598
MOD_GlcNHglycan	412	416	PF01048	0.496
MOD_GlcNHglycan	441	444	PF01048	0.487
MOD_GSK3_1	109	116	PF00069	0.525
MOD_GSK3_1	139	146	PF00069	0.534
MOD_GSK3_1	184	191	PF00069	0.430
MOD_GSK3_1	197	204	PF00069	0.507
MOD_GSK3_1	222	229	PF00069	0.581
MOD_GSK3_1	230	237	PF00069	0.509
MOD_GSK3_1	240	247	PF00069	0.489
MOD_GSK3_1	250	257	PF00069	0.511
MOD_GSK3_1	344	351	PF00069	0.781
MOD_GSK3_1	353	360	PF00069	0.656
MOD_GSK3_1	395	402	PF00069	0.778
MOD_GSK3_1	425	432	PF00069	0.702
MOD_GSK3_1	454	461	PF00069	0.803
MOD_GSK3_1	473	480	PF00069	0.767
MOD_GSK3_1	48	55	PF00069	0.538
MOD_GSK3_1	99	106	PF00069	0.553
MOD_N-GLC_1	260	265	PF02516	0.692
MOD_N-GLC_1	276	281	PF02516	0.587
MOD_N-GLC_1	344	349	PF02516	0.549
MOD_N-GLC_1	464	469	PF02516	0.469
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	105	110	PF00069	0.427
MOD_NEK2_1	157	162	PF00069	0.432
MOD_NEK2_1	223	228	PF00069	0.408
MOD_NEK2_1	330	335	PF00069	0.662
MOD_NEK2_1	348	353	PF00069	0.600
MOD_NEK2_1	411	416	PF00069	0.679
MOD_NEK2_1	458	463	PF00069	0.797
MOD_NEK2_1	473	478	PF00069	0.813
MOD_NEK2_1	52	57	PF00069	0.554
MOD_NEK2_1	99	104	PF00069	0.460
MOD_PIKK_1	254	260	PF00454	0.486
MOD_PIKK_1	330	336	PF00454	0.662
MOD_PIKK_1	56	62	PF00454	0.483
MOD_PK_1	475	481	PF00069	0.854
MOD_PKA_1	449	455	PF00069	0.682
MOD_PKA_1	474	480	PF00069	0.857
MOD_PKA_2	338	344	PF00069	0.833
MOD_PKA_2	375	381	PF00069	0.841
MOD_PKA_2	400	406	PF00069	0.679
MOD_PKA_2	473	479	PF00069	0.704
MOD_PKA_2	56	62	PF00069	0.543
MOD_PKB_1	472	480	PF00069	0.859
MOD_Plk_1	201	207	PF00069	0.437
MOD_Plk_1	276	282	PF00069	0.293
MOD_Plk_1	344	350	PF00069	0.663
MOD_Plk_1	39	45	PF00069	0.467
MOD_Plk_1	52	58	PF00069	0.479
MOD_Plk_4	100	106	PF00069	0.529
MOD_Plk_4	211	217	PF00069	0.444
MOD_Plk_4	276	282	PF00069	0.434
MOD_Plk_4	292	298	PF00069	0.265
MOD_Plk_4	416	422	PF00069	0.677
MOD_Plk_4	477	483	PF00069	0.845
MOD_ProDKin_1	365	371	PF00069	0.837
MOD_ProDKin_1	441	447	PF00069	0.684
MOD_ProDKin_1	465	471	PF00069	0.853
MOD_SUMO_rev_2	459	468	PF00179	0.668
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.436
TRG_ENDOCYTIC_2	128	131	PF00928	0.560
TRG_ENDOCYTIC_2	183	186	PF00928	0.469
TRG_ENDOCYTIC_2	207	210	PF00928	0.492
TRG_ENDOCYTIC_2	215	218	PF00928	0.417
TRG_ENDOCYTIC_2	384	387	PF00928	0.651
TRG_ENDOCYTIC_2	390	393	PF00928	0.644
TRG_ER_diArg_1	15	17	PF00400	0.539
TRG_ER_diArg_1	374	377	PF00400	0.670
TRG_ER_diArg_1	471	474	PF00400	0.844

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICK3	Leishmania donovani	58%	94%
E9AD43	Leishmania major	58%	100%
E9AHD6	Leishmania infantum	58%	94%
E9AYW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	95%