Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 4, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ03_LEIBR

TriTrypDb:

LbrM.31.0400 , LBRM2903_310010600 , LBRM2903_310010700

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	8
GO:0099080	supramolecular complex	2	8
GO:0099081	supramolecular polymer	3	8
GO:0099512	supramolecular fiber	4	8
GO:0099513	polymeric cytoskeletal fiber	5	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

A4HJ03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ03

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007019	microtubule depolymerization	5	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0051261	protein depolymerization	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.539
CLV_NRD_NRD_1	22	24	PF00675	0.509
CLV_NRD_NRD_1	252	254	PF00675	0.307
CLV_NRD_NRD_1	400	402	PF00675	0.354
CLV_NRD_NRD_1	429	431	PF00675	0.280
CLV_NRD_NRD_1	620	622	PF00675	0.634
CLV_NRD_NRD_1	624	626	PF00675	0.623
CLV_NRD_NRD_1	629	631	PF00675	0.578
CLV_NRD_NRD_1	632	634	PF00675	0.577
CLV_NRD_NRD_1	678	680	PF00675	0.552
CLV_NRD_NRD_1	69	71	PF00675	0.539
CLV_NRD_NRD_1	711	713	PF00675	0.634
CLV_PCSK_FUR_1	627	631	PF00082	0.622
CLV_PCSK_FUR_1	708	712	PF00082	0.541
CLV_PCSK_KEX2_1	211	213	PF00082	0.611
CLV_PCSK_KEX2_1	22	24	PF00082	0.509
CLV_PCSK_KEX2_1	254	256	PF00082	0.301
CLV_PCSK_KEX2_1	400	402	PF00082	0.354
CLV_PCSK_KEX2_1	429	431	PF00082	0.280
CLV_PCSK_KEX2_1	624	626	PF00082	0.633
CLV_PCSK_KEX2_1	628	630	PF00082	0.584
CLV_PCSK_KEX2_1	678	680	PF00082	0.595
CLV_PCSK_KEX2_1	69	71	PF00082	0.519
CLV_PCSK_KEX2_1	710	712	PF00082	0.640
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.611
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.326
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.535
CLV_PCSK_PC7_1	624	630	PF00082	0.616
CLV_PCSK_SKI1_1	315	319	PF00082	0.279
CLV_PCSK_SKI1_1	493	497	PF00082	0.332
CLV_PCSK_SKI1_1	554	558	PF00082	0.314
CLV_PCSK_SKI1_1	757	761	PF00082	0.595
CLV_PCSK_SKI1_1	816	820	PF00082	0.450
CLV_Separin_Metazoa	521	525	PF03568	0.280
DEG_APCC_DBOX_1	776	784	PF00400	0.445
DEG_Nend_UBRbox_2	1	3	PF02207	0.506
DEG_ODPH_VHL_1	257	269	PF01847	0.274
DEG_SPOP_SBC_1	538	542	PF00917	0.216
DEG_SPOP_SBC_1	714	718	PF00917	0.538
DEG_SPOP_SBC_1	818	822	PF00917	0.392
DOC_ANK_TNKS_1	254	261	PF00023	0.307
DOC_CKS1_1	157	162	PF01111	0.491
DOC_CKS1_1	765	770	PF01111	0.431
DOC_CYCLIN_RxL_1	490	500	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	587	593	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	844	847	PF00134	0.480
DOC_MAPK_DCC_7	762	771	PF00069	0.440
DOC_MAPK_gen_1	242	250	PF00069	0.507
DOC_MAPK_gen_1	363	372	PF00069	0.421
DOC_MAPK_gen_1	452	459	PF00069	0.210
DOC_MAPK_gen_1	508	514	PF00069	0.280
DOC_MAPK_gen_1	633	645	PF00069	0.533
DOC_MAPK_gen_1	744	753	PF00069	0.608
DOC_MAPK_MEF2A_6	244	252	PF00069	0.459
DOC_MAPK_MEF2A_6	315	322	PF00069	0.280
DOC_MAPK_MEF2A_6	365	374	PF00069	0.411
DOC_MAPK_MEF2A_6	442	451	PF00069	0.347
DOC_MAPK_MEF2A_6	97	106	PF00069	0.484
DOC_PP2B_LxvP_1	587	590	PF13499	0.629
DOC_PP2B_LxvP_1	844	847	PF13499	0.480
DOC_PP4_FxxP_1	158	161	PF00568	0.487
DOC_PP4_FxxP_1	34	37	PF00568	0.483
DOC_USP7_MATH_1	140	144	PF00917	0.648
DOC_USP7_MATH_1	537	541	PF00917	0.292
DOC_USP7_MATH_1	648	652	PF00917	0.545
DOC_USP7_MATH_1	714	718	PF00917	0.644
DOC_USP7_MATH_1	723	727	PF00917	0.599
DOC_USP7_MATH_1	807	811	PF00917	0.451
DOC_USP7_MATH_1	818	822	PF00917	0.426
DOC_USP7_MATH_1	849	853	PF00917	0.479
DOC_USP7_MATH_1	88	92	PF00917	0.481
DOC_WW_Pin1_4	136	141	PF00397	0.563
DOC_WW_Pin1_4	143	148	PF00397	0.581
DOC_WW_Pin1_4	156	161	PF00397	0.532
DOC_WW_Pin1_4	171	176	PF00397	0.585
DOC_WW_Pin1_4	186	191	PF00397	0.617
DOC_WW_Pin1_4	231	236	PF00397	0.583
DOC_WW_Pin1_4	32	37	PF00397	0.489
DOC_WW_Pin1_4	710	715	PF00397	0.620
DOC_WW_Pin1_4	761	766	PF00397	0.476
DOC_WW_Pin1_4	850	855	PF00397	0.548
LIG_14-3-3_CanoR_1	135	140	PF00244	0.598
LIG_14-3-3_CanoR_1	193	197	PF00244	0.703
LIG_14-3-3_CanoR_1	215	220	PF00244	0.621
LIG_14-3-3_CanoR_1	247	251	PF00244	0.437
LIG_14-3-3_CanoR_1	584	590	PF00244	0.525
LIG_14-3-3_CanoR_1	678	687	PF00244	0.623
LIG_14-3-3_CanoR_1	712	721	PF00244	0.547
LIG_14-3-3_CanoR_1	777	781	PF00244	0.358
LIG_Actin_WH2_2	116	131	PF00022	0.515
LIG_Actin_WH2_2	379	397	PF00022	0.209
LIG_Actin_WH2_2	801	818	PF00022	0.421
LIG_BRCT_BRCA1_1	102	106	PF00533	0.504
LIG_BRCT_BRCA1_1	220	224	PF00533	0.517
LIG_BRCT_BRCA1_1	729	733	PF00533	0.481
LIG_EVH1_1	845	849	PF00568	0.474
LIG_FHA_1	123	129	PF00498	0.522
LIG_FHA_1	137	143	PF00498	0.514
LIG_FHA_1	231	237	PF00498	0.574
LIG_FHA_1	247	253	PF00498	0.479
LIG_FHA_1	317	323	PF00498	0.319
LIG_FHA_1	458	464	PF00498	0.343
LIG_FHA_1	518	524	PF00498	0.354
LIG_FHA_1	531	537	PF00498	0.354
LIG_FHA_1	657	663	PF00498	0.509
LIG_FHA_1	777	783	PF00498	0.408
LIG_FHA_1	865	871	PF00498	0.576
LIG_FHA_2	144	150	PF00498	0.510
LIG_FHA_2	214	220	PF00498	0.517
LIG_FHA_2	284	290	PF00498	0.315
LIG_FHA_2	303	309	PF00498	0.297
LIG_FHA_2	344	350	PF00498	0.282
LIG_FHA_2	433	439	PF00498	0.315
LIG_FHA_2	482	488	PF00498	0.280
LIG_FHA_2	61	67	PF00498	0.538
LIG_FHA_2	655	661	PF00498	0.612
LIG_FHA_2	765	771	PF00498	0.480
LIG_FHA_2	797	803	PF00498	0.347
LIG_FHA_2	820	826	PF00498	0.430
LIG_Integrin_isoDGR_2	238	240	PF01839	0.503
LIG_LIR_Gen_1	103	112	PF02991	0.481
LIG_LIR_Gen_1	340	347	PF02991	0.326
LIG_LIR_Gen_1	359	366	PF02991	0.421
LIG_LIR_Gen_1	416	426	PF02991	0.284
LIG_LIR_Gen_1	462	469	PF02991	0.469
LIG_LIR_Nem_3	340	344	PF02991	0.381
LIG_LIR_Nem_3	359	364	PF02991	0.341
LIG_LIR_Nem_3	373	378	PF02991	0.409
LIG_LIR_Nem_3	416	422	PF02991	0.291
LIG_LIR_Nem_3	462	468	PF02991	0.361
LIG_LIR_Nem_3	873	879	PF02991	0.458
LIG_MLH1_MIPbox_1	730	734	PF16413	0.484
LIG_MYND_1	842	846	PF01753	0.485
LIG_NRBOX	381	387	PF00104	0.326
LIG_Pex14_2	296	300	PF04695	0.338
LIG_PTB_Apo_2	377	384	PF02174	0.280
LIG_PTB_Phospho_1	377	383	PF10480	0.315
LIG_REV1ctd_RIR_1	731	741	PF16727	0.488
LIG_SH2_CRK	341	345	PF00017	0.381
LIG_SH2_CRK	383	387	PF00017	0.453
LIG_SH2_GRB2like	310	313	PF00017	0.209
LIG_SH2_NCK_1	341	345	PF00017	0.274
LIG_SH2_SRC	310	313	PF00017	0.372
LIG_SH2_STAP1	555	559	PF00017	0.326
LIG_SH2_STAT5	294	297	PF00017	0.314
LIG_SH2_STAT5	310	313	PF00017	0.389
LIG_SH2_STAT5	341	344	PF00017	0.338
LIG_SH2_STAT5	353	356	PF00017	0.326
LIG_SH2_STAT5	378	381	PF00017	0.405
LIG_SH2_STAT5	83	86	PF00017	0.495
LIG_SH3_1	253	259	PF00018	0.307
LIG_SH3_1	762	768	PF00018	0.456
LIG_SH3_2	617	622	PF14604	0.593
LIG_SH3_3	154	160	PF00018	0.560
LIG_SH3_3	162	168	PF00018	0.611
LIG_SH3_3	253	259	PF00018	0.360
LIG_SH3_3	34	40	PF00018	0.527
LIG_SH3_3	52	58	PF00018	0.544
LIG_SH3_3	614	620	PF00018	0.718
LIG_SH3_3	748	754	PF00018	0.575
LIG_SH3_3	762	768	PF00018	0.473
LIG_SH3_3	843	849	PF00018	0.557
LIG_SH3_3	874	880	PF00018	0.452
LIG_SH3_4	365	372	PF00018	0.209
LIG_SH3_CIN85_PxpxPR_1	36	41	PF14604	0.492
LIG_SUMO_SIM_par_1	316	321	PF11976	0.280
LIG_SUMO_SIM_par_1	390	396	PF11976	0.280
LIG_SUMO_SIM_par_1	494	500	PF11976	0.280
LIG_SUMO_SIM_par_1	767	772	PF11976	0.440
LIG_SxIP_EBH_1	678	692	PF03271	0.516
LIG_TRAF2_1	287	290	PF00917	0.280
LIG_UBA3_1	360	365	PF00899	0.208
LIG_UBA3_1	495	499	PF00899	0.326
LIG_WW_2	37	40	PF00397	0.538
LIG_WW_2	846	849	PF00397	0.466
MOD_CDK_SPK_2	710	715	PF00069	0.545
MOD_CDK_SPxxK_3	186	193	PF00069	0.581
MOD_CK1_1	121	127	PF00069	0.560
MOD_CK1_1	143	149	PF00069	0.570
MOD_CK1_1	218	224	PF00069	0.758
MOD_CK1_1	323	329	PF00069	0.430
MOD_CK1_1	337	343	PF00069	0.299
MOD_CK1_1	440	446	PF00069	0.323
MOD_CK1_1	517	523	PF00069	0.326
MOD_CK1_1	540	546	PF00069	0.331
MOD_CK1_1	563	569	PF00069	0.573
MOD_CK1_1	585	591	PF00069	0.528
MOD_CK1_1	611	617	PF00069	0.661
MOD_CK1_1	655	661	PF00069	0.644
MOD_CK1_1	681	687	PF00069	0.721
MOD_CK1_1	764	770	PF00069	0.492
MOD_CK1_1	852	858	PF00069	0.597
MOD_CK1_1	863	869	PF00069	0.507
MOD_CK1_1	9	15	PF00069	0.507
MOD_CK1_1	91	97	PF00069	0.463
MOD_CK2_1	213	219	PF00069	0.546
MOD_CK2_1	283	289	PF00069	0.326
MOD_CK2_1	310	316	PF00069	0.332
MOD_CK2_1	343	349	PF00069	0.280
MOD_CK2_1	370	376	PF00069	0.421
MOD_CK2_1	432	438	PF00069	0.280
MOD_CK2_1	481	487	PF00069	0.326
MOD_CK2_1	654	660	PF00069	0.584
MOD_CK2_1	769	775	PF00069	0.384
MOD_CK2_1	866	872	PF00069	0.469
MOD_CK2_1	9	15	PF00069	0.507
MOD_DYRK1A_RPxSP_1	715	719	PF00069	0.537
MOD_GlcNHglycan	114	117	PF01048	0.592
MOD_GlcNHglycan	180	184	PF01048	0.493
MOD_GlcNHglycan	196	199	PF01048	0.652
MOD_GlcNHglycan	322	325	PF01048	0.338
MOD_GlcNHglycan	336	339	PF01048	0.372
MOD_GlcNHglycan	601	604	PF01048	0.586
MOD_GlcNHglycan	693	696	PF01048	0.609
MOD_GlcNHglycan	862	865	PF01048	0.558
MOD_GSK3_1	118	125	PF00069	0.561
MOD_GSK3_1	136	143	PF00069	0.641
MOD_GSK3_1	215	222	PF00069	0.693
MOD_GSK3_1	316	323	PF00069	0.315
MOD_GSK3_1	339	346	PF00069	0.282
MOD_GSK3_1	428	435	PF00069	0.293
MOD_GSK3_1	46	53	PF00069	0.482
MOD_GSK3_1	563	570	PF00069	0.534
MOD_GSK3_1	648	655	PF00069	0.642
MOD_GSK3_1	678	685	PF00069	0.727
MOD_GSK3_1	69	76	PF00069	0.555
MOD_GSK3_1	710	717	PF00069	0.668
MOD_GSK3_1	723	730	PF00069	0.691
MOD_GSK3_1	757	764	PF00069	0.710
MOD_GSK3_1	796	803	PF00069	0.367
MOD_GSK3_1	859	866	PF00069	0.640
MOD_LATS_1	631	637	PF00433	0.537
MOD_N-GLC_1	171	176	PF02516	0.492
MOD_N-GLC_1	491	496	PF02516	0.326
MOD_N-GLC_1	549	554	PF02516	0.272
MOD_N-GLC_1	648	653	PF02516	0.636
MOD_N-GLC_1	679	684	PF02516	0.637
MOD_N-GLC_2	403	405	PF02516	0.326
MOD_NEK2_1	123	128	PF00069	0.549
MOD_NEK2_1	318	323	PF00069	0.350
MOD_NEK2_1	370	375	PF00069	0.331
MOD_NEK2_1	459	464	PF00069	0.354
MOD_NEK2_1	514	519	PF00069	0.326
MOD_NEK2_1	523	528	PF00069	0.326
MOD_NEK2_1	654	659	PF00069	0.544
MOD_NEK2_1	733	738	PF00069	0.550
MOD_NEK2_1	819	824	PF00069	0.453
MOD_NEK2_2	310	315	PF00069	0.410
MOD_NEK2_2	325	330	PF00069	0.284
MOD_NEK2_2	445	450	PF00069	0.280
MOD_NEK2_2	723	728	PF00069	0.503
MOD_OFUCOSY	829	834	PF10250	0.489
MOD_PK_1	560	566	PF00069	0.456
MOD_PK_1	73	79	PF00069	0.510
MOD_PKA_1	633	639	PF00069	0.546
MOD_PKA_1	678	684	PF00069	0.535
MOD_PKA_1	69	75	PF00069	0.545
MOD_PKA_1	691	697	PF00069	0.481
MOD_PKA_2	192	198	PF00069	0.629
MOD_PKA_2	222	228	PF00069	0.659
MOD_PKA_2	246	252	PF00069	0.369
MOD_PKA_2	428	434	PF00069	0.313
MOD_PKA_2	481	487	PF00069	0.280
MOD_PKA_2	514	520	PF00069	0.327
MOD_PKA_2	523	529	PF00069	0.326
MOD_PKA_2	585	591	PF00069	0.519
MOD_PKA_2	623	629	PF00069	0.582
MOD_PKA_2	678	684	PF00069	0.660
MOD_PKA_2	69	75	PF00069	0.506
MOD_PKA_2	714	720	PF00069	0.599
MOD_PKA_2	736	742	PF00069	0.491
MOD_PKA_2	776	782	PF00069	0.412
MOD_Plk_1	283	289	PF00069	0.326
MOD_Plk_1	46	52	PF00069	0.521
MOD_Plk_1	491	497	PF00069	0.326
MOD_Plk_1	549	555	PF00069	0.297
MOD_Plk_1	648	654	PF00069	0.595
MOD_Plk_1	73	79	PF00069	0.552
MOD_Plk_1	749	755	PF00069	0.557
MOD_Plk_1	769	775	PF00069	0.410
MOD_Plk_1	871	877	PF00069	0.454
MOD_Plk_2-3	284	290	PF00069	0.280
MOD_Plk_4	339	345	PF00069	0.326
MOD_Plk_4	370	376	PF00069	0.385
MOD_Plk_4	491	497	PF00069	0.326
MOD_Plk_4	530	536	PF00069	0.295
MOD_Plk_4	800	806	PF00069	0.435
MOD_Plk_4	852	858	PF00069	0.551
MOD_Plk_4	866	872	PF00069	0.540
MOD_ProDKin_1	136	142	PF00069	0.564
MOD_ProDKin_1	143	149	PF00069	0.579
MOD_ProDKin_1	156	162	PF00069	0.528
MOD_ProDKin_1	171	177	PF00069	0.585
MOD_ProDKin_1	186	192	PF00069	0.595
MOD_ProDKin_1	231	237	PF00069	0.581
MOD_ProDKin_1	32	38	PF00069	0.489
MOD_ProDKin_1	710	716	PF00069	0.619
MOD_ProDKin_1	761	767	PF00069	0.461
MOD_ProDKin_1	850	856	PF00069	0.550
MOD_SUMO_for_1	210	213	PF00179	0.583
MOD_SUMO_rev_2	606	614	PF00179	0.518
MOD_SUMO_rev_2	739	745	PF00179	0.591
TRG_DiLeu_BaEn_1	417	422	PF01217	0.280
TRG_ENDOCYTIC_2	341	344	PF00928	0.326
TRG_ENDOCYTIC_2	383	386	PF00928	0.469
TRG_ER_diArg_1	21	23	PF00400	0.508
TRG_ER_diArg_1	252	255	PF00400	0.305
TRG_ER_diArg_1	400	402	PF00400	0.280
TRG_ER_diArg_1	584	587	PF00400	0.518
TRG_ER_diArg_1	623	625	PF00400	0.649
TRG_ER_diArg_1	627	630	PF00400	0.609
TRG_ER_diArg_1	677	679	PF00400	0.571
TRG_ER_diArg_1	710	712	PF00400	0.640
TRG_ER_diArg_1	813	816	PF00400	0.406
TRG_ER_diArg_1	838	841	PF00400	0.481
TRG_NES_CRM1_1	776	789	PF08389	0.441
TRG_NLS_MonoCore_2	620	625	PF00514	0.539
TRG_NLS_MonoCore_2	626	631	PF00514	0.531
TRG_NLS_MonoExtC_3	620	625	PF00514	0.546
TRG_NLS_MonoExtC_3	626	632	PF00514	0.529
TRG_NLS_MonoExtN_4	618	625	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	746	750	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	792	796	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGE8	Leptomonas seymouri	52%	94%
A0A3Q8IG71	Leishmania donovani	72%	100%
A4H7F1	Leishmania braziliensis	42%	100%
A4I6C2	Leishmania infantum	72%	93%
E9B1I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q6N4	Leishmania major	69%	100%