Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ02_LEIBR

TriTrypDb:

LbrM.31.0390 , LBRM2903_310010500

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HJ02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.540
CLV_NRD_NRD_1	170	172	PF00675	0.562
CLV_NRD_NRD_1	197	199	PF00675	0.448
CLV_NRD_NRD_1	313	315	PF00675	0.363
CLV_NRD_NRD_1	323	325	PF00675	0.375
CLV_NRD_NRD_1	73	75	PF00675	0.456
CLV_PCSK_FUR_1	311	315	PF00082	0.358
CLV_PCSK_FUR_1	321	325	PF00082	0.384
CLV_PCSK_KEX2_1	166	168	PF00082	0.410
CLV_PCSK_KEX2_1	197	199	PF00082	0.448
CLV_PCSK_KEX2_1	313	315	PF00082	0.365
CLV_PCSK_KEX2_1	323	325	PF00082	0.379
CLV_PCSK_KEX2_1	73	75	PF00082	0.403
CLV_PCSK_SKI1_1	208	212	PF00082	0.410
CLV_PCSK_SKI1_1	313	317	PF00082	0.302
CLV_PCSK_SKI1_1	91	95	PF00082	0.474
DEG_APCC_DBOX_1	197	205	PF00400	0.248
DEG_Nend_UBRbox_1	1	4	PF02207	0.582
DOC_CKS1_1	22	27	PF01111	0.473
DOC_MAPK_gen_1	73	84	PF00069	0.258
DOC_PP1_RVXF_1	75	81	PF00149	0.372
DOC_USP7_MATH_1	118	122	PF00917	0.334
DOC_USP7_MATH_1	123	127	PF00917	0.340
DOC_WW_Pin1_4	18	23	PF00397	0.474
DOC_WW_Pin1_4	265	270	PF00397	0.372
DOC_WW_Pin1_4	56	61	PF00397	0.274
LIG_14-3-3_CanoR_1	154	159	PF00244	0.220
LIG_14-3-3_CanoR_1	197	202	PF00244	0.274
LIG_14-3-3_CanoR_1	91	100	PF00244	0.280
LIG_Actin_WH2_2	302	318	PF00022	0.553
LIG_EH1_1	269	277	PF00400	0.210
LIG_EH1_1	295	303	PF00400	0.320
LIG_FHA_1	146	152	PF00498	0.372
LIG_FHA_1	209	215	PF00498	0.226
LIG_FHA_1	227	233	PF00498	0.327
LIG_FHA_1	32	38	PF00498	0.328
LIG_FHA_1	92	98	PF00498	0.274
LIG_FHA_2	104	110	PF00498	0.416
LIG_FHA_2	226	232	PF00498	0.268
LIG_IRF3_LxIS_1	37	44	PF10401	0.230
LIG_LIR_Gen_1	157	162	PF02991	0.272
LIG_LIR_Gen_1	244	252	PF02991	0.274
LIG_LIR_Nem_3	157	161	PF02991	0.272
LIG_LIR_Nem_3	244	250	PF02991	0.201
LIG_LIR_Nem_3	44	50	PF02991	0.304
LIG_LIR_Nem_3	8	13	PF02991	0.474
LIG_NRBOX	37	43	PF00104	0.240
LIG_PDZ_Class_2	335	340	PF00595	0.565
LIG_Pex14_2	218	222	PF04695	0.274
LIG_SH2_CRK	115	119	PF00017	0.431
LIG_SH2_CRK	247	251	PF00017	0.201
LIG_SH2_CRK	278	282	PF00017	0.243
LIG_SH2_NCK_1	278	282	PF00017	0.212
LIG_SH2_NCK_1	296	300	PF00017	0.464
LIG_SH2_STAP1	243	247	PF00017	0.201
LIG_SH2_STAT3	252	255	PF00017	0.285
LIG_SH2_STAT5	130	133	PF00017	0.402
LIG_SH2_STAT5	181	184	PF00017	0.285
LIG_SH2_STAT5	243	246	PF00017	0.274
LIG_SH2_STAT5	262	265	PF00017	0.274
LIG_SH2_STAT5	296	299	PF00017	0.320
LIG_SH2_STAT5	49	52	PF00017	0.277
LIG_SH3_3	19	25	PF00018	0.474
LIG_SH3_3	227	233	PF00018	0.201
LIG_SH3_3	82	88	PF00018	0.274
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.317
LIG_SUMO_SIM_par_1	38	45	PF11976	0.319
LIG_TRFH_1	265	269	PF08558	0.372
LIG_TYR_ITIM	276	281	PF00017	0.243
LIG_WRC_WIRS_1	119	124	PF05994	0.264
MOD_CK1_1	121	127	PF00069	0.333
MOD_CK1_1	268	274	PF00069	0.274
MOD_CK1_1	31	37	PF00069	0.380
MOD_CK2_1	95	101	PF00069	0.322
MOD_GlcNHglycan	126	129	PF01048	0.558
MOD_GlcNHglycan	182	185	PF01048	0.572
MOD_GlcNHglycan	208	211	PF01048	0.478
MOD_GlcNHglycan	317	321	PF01048	0.370
MOD_GlcNHglycan	50	53	PF01048	0.474
MOD_GlcNHglycan	60	63	PF01048	0.474
MOD_GlcNHglycan	97	100	PF01048	0.547
MOD_GSK3_1	103	110	PF00069	0.436
MOD_GSK3_1	202	209	PF00069	0.347
MOD_GSK3_1	241	248	PF00069	0.274
MOD_GSK3_1	261	268	PF00069	0.160
MOD_GSK3_1	28	35	PF00069	0.284
MOD_GSK3_1	91	98	PF00069	0.288
MOD_N-GLC_1	124	129	PF02516	0.550
MOD_N-GLC_2	287	289	PF02516	0.457
MOD_NEK2_1	162	167	PF00069	0.210
MOD_NEK2_1	261	266	PF00069	0.323
MOD_NEK2_1	78	83	PF00069	0.354
MOD_PIKK_1	191	197	PF00454	0.247
MOD_PKA_1	197	203	PF00069	0.248
MOD_PKA_2	107	113	PF00069	0.445
MOD_PKA_2	197	203	PF00069	0.248
MOD_Plk_4	245	251	PF00069	0.274
MOD_Plk_4	32	38	PF00069	0.324
MOD_ProDKin_1	18	24	PF00069	0.474
MOD_ProDKin_1	265	271	PF00069	0.372
MOD_ProDKin_1	56	62	PF00069	0.274
TRG_ENDOCYTIC_2	119	122	PF00928	0.264
TRG_ENDOCYTIC_2	243	246	PF00928	0.285
TRG_ENDOCYTIC_2	247	250	PF00928	0.264
TRG_ENDOCYTIC_2	278	281	PF00928	0.274
TRG_ENDOCYTIC_2	47	50	PF00928	0.372
TRG_ER_diArg_1	196	198	PF00400	0.248
TRG_ER_diArg_1	313	315	PF00400	0.563
TRG_ER_diArg_1	321	324	PF00400	0.583
TRG_ER_diArg_1	73	75	PF00400	0.210
TRG_NLS_MonoExtC_3	170	175	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T7	Leptomonas seymouri	60%	100%
A0A0N1I377	Leptomonas seymouri	25%	100%
A0A0S4J3I3	Bodo saltans	23%	100%
A0A3Q8IGC2	Leishmania donovani	25%	100%
A0A3S7X427	Leishmania donovani	79%	100%
A4HL28	Leishmania braziliensis	26%	100%
A4I6C1	Leishmania infantum	79%	100%
A4I8K9	Leishmania infantum	26%	100%
E9B1H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B3G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q4N1	Leishmania major	26%	99%
Q4Q6N5	Leishmania major	79%	100%
Q4QH78	Leishmania major	21%	100%
Q4V8Y6	Danio rerio	25%	100%
Q6NS19	Xenopus laevis	26%	100%
Q969X5	Homo sapiens	24%	100%
Q9DC16	Mus musculus	23%	100%