TPR_MLP1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIZ8_LEIBR

TriTrypDb:

LbrM.31.0340 , LBRM2903_310010100

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HIZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIZ8

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036159	inner dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.693
CLV_C14_Caspase3-7	4	8	PF00656	0.525
CLV_C14_Caspase3-7	436	440	PF00656	0.312
CLV_C14_Caspase3-7	675	679	PF00656	0.412
CLV_C14_Caspase3-7	821	825	PF00656	0.378
CLV_MEL_PAP_1	459	465	PF00089	0.348
CLV_NRD_NRD_1	148	150	PF00675	0.408
CLV_NRD_NRD_1	183	185	PF00675	0.426
CLV_NRD_NRD_1	186	188	PF00675	0.429
CLV_NRD_NRD_1	211	213	PF00675	0.423
CLV_NRD_NRD_1	339	341	PF00675	0.665
CLV_NRD_NRD_1	474	476	PF00675	0.493
CLV_NRD_NRD_1	479	481	PF00675	0.523
CLV_NRD_NRD_1	48	50	PF00675	0.400
CLV_NRD_NRD_1	510	512	PF00675	0.481
CLV_NRD_NRD_1	618	620	PF00675	0.385
CLV_NRD_NRD_1	682	684	PF00675	0.562
CLV_NRD_NRD_1	738	740	PF00675	0.444
CLV_PCSK_FUR_1	321	325	PF00082	0.635
CLV_PCSK_FUR_1	339	343	PF00082	0.673
CLV_PCSK_FUR_1	680	684	PF00082	0.558
CLV_PCSK_KEX2_1	148	150	PF00082	0.519
CLV_PCSK_KEX2_1	323	325	PF00082	0.638
CLV_PCSK_KEX2_1	339	341	PF00082	0.525
CLV_PCSK_KEX2_1	461	463	PF00082	0.503
CLV_PCSK_KEX2_1	47	49	PF00082	0.404
CLV_PCSK_KEX2_1	479	481	PF00082	0.301
CLV_PCSK_KEX2_1	504	506	PF00082	0.380
CLV_PCSK_KEX2_1	525	527	PF00082	0.495
CLV_PCSK_KEX2_1	587	589	PF00082	0.516
CLV_PCSK_KEX2_1	620	622	PF00082	0.383
CLV_PCSK_KEX2_1	682	684	PF00082	0.532
CLV_PCSK_KEX2_1	738	740	PF00082	0.492
CLV_PCSK_KEX2_1	75	77	PF00082	0.404
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.638
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.491
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.503
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.380
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.495
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.484
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.512
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.404
CLV_PCSK_PC7_1	475	481	PF00082	0.330
CLV_PCSK_SKI1_1	170	174	PF00082	0.454
CLV_PCSK_SKI1_1	23	27	PF00082	0.416
CLV_PCSK_SKI1_1	570	574	PF00082	0.552
CLV_PCSK_SKI1_1	621	625	PF00082	0.409
CLV_PCSK_SKI1_1	631	635	PF00082	0.445
CLV_PCSK_SKI1_1	686	690	PF00082	0.540
CLV_PCSK_SKI1_1	723	727	PF00082	0.512
CLV_PCSK_SKI1_1	730	734	PF00082	0.408
CLV_PCSK_SKI1_1	846	850	PF00082	0.451
DEG_APCC_DBOX_1	109	117	PF00400	0.512
DEG_APCC_DBOX_1	46	54	PF00400	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.578
DEG_SPOP_SBC_1	413	417	PF00917	0.424
DOC_CYCLIN_RxL_1	45	55	PF00134	0.395
DOC_CYCLIN_RxL_1	567	577	PF00134	0.274
DOC_MAPK_gen_1	119	127	PF00069	0.289
DOC_MAPK_gen_1	148	158	PF00069	0.473
DOC_MAPK_gen_1	318	328	PF00069	0.546
DOC_MAPK_gen_1	475	484	PF00069	0.616
DOC_MAPK_gen_1	511	517	PF00069	0.530
DOC_MAPK_gen_1	550	559	PF00069	0.397
DOC_MAPK_gen_1	568	575	PF00069	0.459
DOC_MAPK_gen_1	637	644	PF00069	0.449
DOC_MAPK_gen_1	682	691	PF00069	0.488
DOC_MAPK_MEF2A_6	321	330	PF00069	0.422
DOC_MAPK_MEF2A_6	550	559	PF00069	0.496
DOC_MAPK_MEF2A_6	653	661	PF00069	0.546
DOC_MAPK_RevD_3	325	341	PF00069	0.423
DOC_PIKK_1	360	368	PF02985	0.509
DOC_PP1_RVXF_1	46	53	PF00149	0.398
DOC_PP1_RVXF_1	756	763	PF00149	0.545
DOC_USP7_UBL2_3	286	290	PF12436	0.606
DOC_USP7_UBL2_3	546	550	PF12436	0.515
DOC_USP7_UBL2_3	686	690	PF12436	0.428
DOC_USP7_UBL2_3	711	715	PF12436	0.675
DOC_USP7_UBL2_3	726	730	PF12436	0.435
LIG_14-3-3_CanoR_1	112	117	PF00244	0.498
LIG_14-3-3_CanoR_1	351	358	PF00244	0.689
LIG_14-3-3_CanoR_1	411	421	PF00244	0.521
LIG_14-3-3_CanoR_1	511	517	PF00244	0.420
LIG_14-3-3_CanoR_1	653	661	PF00244	0.607
LIG_14-3-3_CanoR_1	738	742	PF00244	0.426
LIG_Actin_WH2_2	118	133	PF00022	0.390
LIG_Actin_WH2_2	246	262	PF00022	0.462
LIG_Actin_WH2_2	524	539	PF00022	0.340
LIG_Clathr_ClatBox_1	556	560	PF01394	0.349
LIG_Clathr_ClatBox_1	580	584	PF01394	0.494
LIG_Clathr_ClatBox_1	607	611	PF01394	0.455
LIG_FHA_1	171	177	PF00498	0.491
LIG_FHA_1	195	201	PF00498	0.488
LIG_FHA_1	24	30	PF00498	0.413
LIG_FHA_1	272	278	PF00498	0.512
LIG_FHA_1	297	303	PF00498	0.586
LIG_FHA_1	388	394	PF00498	0.479
LIG_FHA_1	413	419	PF00498	0.551
LIG_FHA_1	559	565	PF00498	0.367
LIG_FHA_1	622	628	PF00498	0.505
LIG_FHA_1	65	71	PF00498	0.380
LIG_FHA_1	692	698	PF00498	0.448
LIG_FHA_1	738	744	PF00498	0.465
LIG_FHA_1	780	786	PF00498	0.503
LIG_FHA_2	130	136	PF00498	0.467
LIG_FHA_2	19	25	PF00498	0.449
LIG_FHA_2	229	235	PF00498	0.458
LIG_FHA_2	278	284	PF00498	0.539
LIG_FHA_2	28	34	PF00498	0.437
LIG_FHA_2	331	337	PF00498	0.562
LIG_FHA_2	351	357	PF00498	0.437
LIG_FHA_2	362	368	PF00498	0.470
LIG_FHA_2	469	475	PF00498	0.469
LIG_FHA_2	485	491	PF00498	0.339
LIG_FHA_2	537	543	PF00498	0.561
LIG_FHA_2	580	586	PF00498	0.498
LIG_FHA_2	98	104	PF00498	0.521
LIG_Integrin_RGD_1	673	675	PF01839	0.514
LIG_LIR_Gen_1	223	233	PF02991	0.382
LIG_LIR_Gen_1	777	786	PF02991	0.395
LIG_LIR_LC3C_4	224	229	PF02991	0.287
LIG_LIR_Nem_3	210	214	PF02991	0.398
LIG_LIR_Nem_3	223	228	PF02991	0.343
LIG_LIR_Nem_3	777	781	PF02991	0.396
LIG_NRBOX	568	574	PF00104	0.280
LIG_PDZ_Class_3	854	859	PF00595	0.512
LIG_PTB_Apo_2	448	455	PF02174	0.425
LIG_SH2_CRK	211	215	PF00017	0.408
LIG_SH2_NCK_1	778	782	PF00017	0.463
LIG_SH2_SRC	246	249	PF00017	0.426
LIG_SH2_STAP1	795	799	PF00017	0.465
LIG_SH2_STAT3	279	282	PF00017	0.513
LIG_SH2_STAT3	705	708	PF00017	0.356
LIG_SH2_STAT5	279	282	PF00017	0.574
LIG_SUMO_SIM_anti_2	694	699	PF11976	0.485
LIG_SUMO_SIM_anti_2	813	819	PF11976	0.486
LIG_SUMO_SIM_anti_2	839	846	PF11976	0.477
LIG_SUMO_SIM_par_1	579	585	PF11976	0.495
LIG_SUMO_SIM_par_1	739	745	PF11976	0.329
LIG_SUMO_SIM_par_1	784	790	PF11976	0.531
LIG_SUMO_SIM_par_1	829	834	PF11976	0.462
LIG_TRAF2_1	270	273	PF00917	0.500
LIG_TRAF2_1	280	283	PF00917	0.506
LIG_TRAF2_1	403	406	PF00917	0.408
LIG_TRAF2_1	471	474	PF00917	0.488
LIG_TRAF2_1	527	530	PF00917	0.460
LIG_TRAF2_1	582	585	PF00917	0.425
LIG_TRAF2_1	615	618	PF00917	0.403
LIG_TRAF2_1	837	840	PF00917	0.431
LIG_UBA3_1	516	525	PF00899	0.418
LIG_UBA3_1	580	587	PF00899	0.499
LIG_UBA3_1	607	613	PF00899	0.395
LIG_UBA3_1	688	693	PF00899	0.544
MOD_CK1_1	317	323	PF00069	0.699
MOD_CK1_1	419	425	PF00069	0.462
MOD_CK1_1	734	740	PF00069	0.539
MOD_CK1_1	80	86	PF00069	0.579
MOD_CK2_1	18	24	PF00069	0.448
MOD_CK2_1	228	234	PF00069	0.438
MOD_CK2_1	263	269	PF00069	0.519
MOD_CK2_1	27	33	PF00069	0.408
MOD_CK2_1	277	283	PF00069	0.396
MOD_CK2_1	330	336	PF00069	0.684
MOD_CK2_1	350	356	PF00069	0.435
MOD_CK2_1	414	420	PF00069	0.517
MOD_CK2_1	468	474	PF00069	0.458
MOD_CK2_1	485	491	PF00069	0.390
MOD_CK2_1	524	530	PF00069	0.436
MOD_CK2_1	538	544	PF00069	0.548
MOD_CK2_1	579	585	PF00069	0.409
MOD_CK2_1	66	72	PF00069	0.409
MOD_CK2_1	97	103	PF00069	0.546
MOD_GlcNHglycan	216	221	PF01048	0.528
MOD_GlcNHglycan	263	266	PF01048	0.467
MOD_GlcNHglycan	420	424	PF01048	0.435
MOD_GlcNHglycan	733	736	PF01048	0.576
MOD_GSK3_1	23	30	PF00069	0.415
MOD_GSK3_1	259	266	PF00069	0.566
MOD_GSK3_1	383	390	PF00069	0.600
MOD_GSK3_1	412	419	PF00069	0.390
MOD_GSK3_1	520	527	PF00069	0.430
MOD_GSK3_1	64	71	PF00069	0.472
MOD_N-GLC_1	18	23	PF02516	0.457
MOD_N-GLC_1	277	282	PF02516	0.575
MOD_N-GLC_1	631	636	PF02516	0.518
MOD_NEK2_1	164	169	PF00069	0.553
MOD_NEK2_1	18	23	PF00069	0.462
MOD_NEK2_1	259	264	PF00069	0.484
MOD_NEK2_1	330	335	PF00069	0.683
MOD_NEK2_1	396	401	PF00069	0.511
MOD_NEK2_1	484	489	PF00069	0.393
MOD_NEK2_1	510	515	PF00069	0.542
MOD_NEK2_1	520	525	PF00069	0.413
MOD_NEK2_1	536	541	PF00069	0.379
MOD_NEK2_1	691	696	PF00069	0.424
MOD_NEK2_1	70	75	PF00069	0.472
MOD_NEK2_1	746	751	PF00069	0.542
MOD_NEK2_1	823	828	PF00069	0.440
MOD_PIKK_1	170	176	PF00454	0.512
MOD_PIKK_1	194	200	PF00454	0.515
MOD_PIKK_1	296	302	PF00454	0.630
MOD_PIKK_1	64	70	PF00454	0.390
MOD_PIKK_1	652	658	PF00454	0.502
MOD_PIKK_1	718	724	PF00454	0.632
MOD_PIKK_1	779	785	PF00454	0.503
MOD_PIKK_1	97	103	PF00454	0.440
MOD_PK_1	112	118	PF00069	0.495
MOD_PK_1	39	45	PF00069	0.410
MOD_PK_1	511	517	PF00069	0.291
MOD_PKA_1	461	467	PF00069	0.410
MOD_PKA_1	511	517	PF00069	0.505
MOD_PKA_1	524	530	PF00069	0.435
MOD_PKA_2	111	117	PF00069	0.478
MOD_PKA_2	317	323	PF00069	0.618
MOD_PKA_2	350	356	PF00069	0.684
MOD_PKA_2	461	467	PF00069	0.369
MOD_PKA_2	510	516	PF00069	0.534
MOD_PKA_2	536	542	PF00069	0.578
MOD_PKA_2	652	658	PF00069	0.597
MOD_PKA_2	698	704	PF00069	0.344
MOD_PKA_2	737	743	PF00069	0.398
MOD_PKA_2	97	103	PF00069	0.472
MOD_PKB_1	110	118	PF00069	0.509
MOD_PKB_1	619	627	PF00069	0.447
MOD_Plk_1	277	283	PF00069	0.561
MOD_Plk_1	330	336	PF00069	0.549
MOD_Plk_1	452	458	PF00069	0.453
MOD_Plk_1	631	637	PF00069	0.520
MOD_Plk_1	691	697	PF00069	0.450
MOD_Plk_1	80	86	PF00069	0.461
MOD_Plk_1	823	829	PF00069	0.465
MOD_Plk_2-3	103	109	PF00069	0.311
MOD_Plk_2-3	332	338	PF00069	0.539
MOD_Plk_2-3	579	585	PF00069	0.441
MOD_Plk_2-3	710	716	PF00069	0.604
MOD_Plk_2-3	77	83	PF00069	0.523
MOD_Plk_4	511	517	PF00069	0.361
MOD_SUMO_for_1	125	128	PF00179	0.502
MOD_SUMO_for_1	358	361	PF00179	0.694
MOD_SUMO_for_1	466	469	PF00179	0.479
MOD_SUMO_for_1	689	692	PF00179	0.427
MOD_SUMO_rev_2	128	133	PF00179	0.394
MOD_SUMO_rev_2	162	169	PF00179	0.566
MOD_SUMO_rev_2	469	478	PF00179	0.550
MOD_SUMO_rev_2	541	548	PF00179	0.460
MOD_SUMO_rev_2	616	622	PF00179	0.425
TRG_DiLeu_BaEn_1	618	623	PF01217	0.397
TRG_DiLeu_BaEn_4	473	479	PF01217	0.464
TRG_DiLeu_BaEn_4	755	761	PF01217	0.546
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.505
TRG_ENDOCYTIC_2	161	164	PF00928	0.458
TRG_ENDOCYTIC_2	211	214	PF00928	0.409
TRG_ENDOCYTIC_2	778	781	PF00928	0.525
TRG_ER_diArg_1	339	342	PF00400	0.569
TRG_ER_diArg_1	47	49	PF00400	0.406
TRG_ER_diArg_1	478	480	PF00400	0.436
TRG_ER_diArg_1	619	622	PF00400	0.380
TRG_ER_diArg_1	680	683	PF00400	0.559
TRG_NES_CRM1_1	553	565	PF08389	0.427
TRG_NES_CRM1_1	821	836	PF08389	0.464
TRG_NLS_Bipartite_1	511	528	PF00514	0.289
TRG_NLS_MonoExtC_3	183	188	PF00514	0.399
TRG_NLS_MonoExtC_3	523	529	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	526	530	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	588	593	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	606	611	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	758	763	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP4	Leptomonas seymouri	76%	100%
A0A0S4KP09	Bodo saltans	30%	100%
A0A1X0NJ74	Trypanosomatidae	49%	100%
A0A3Q8IFA9	Leishmania donovani	87%	100%
A0A422MZK1	Trypanosoma rangeli	49%	100%
A4I6B5	Leishmania infantum	88%	100%
A8IQE0	Chlamydomonas reinhardtii	30%	96%
C9ZN73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D3Z8K2	Rattus norvegicus	30%	92%
E1BM70	Bos taurus	29%	91%
E2R1I5	Canis lupus familiaris	30%	91%
E9B1H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P0CK98	Danio rerio	29%	91%
Q0V9R4	Xenopus tropicalis	31%	91%
Q4Q6P1	Leishmania major	87%	100%
Q9D5Y1	Mus musculus	30%	92%
Q9UFE4	Homo sapiens	29%	91%
V5DEU3	Trypanosoma cruzi	50%	100%