NLE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIZ5_LEIBR

TriTrypDb:

LbrM.31.0310 , LBRM2903_310009700

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HIZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.438
CLV_C14_Caspase3-7	45	49	PF00656	0.269
CLV_MEL_PAP_1	273	279	PF00089	0.307
CLV_NRD_NRD_1	173	175	PF00675	0.537
CLV_NRD_NRD_1	84	86	PF00675	0.355
CLV_PCSK_KEX2_1	175	177	PF00082	0.505
CLV_PCSK_KEX2_1	84	86	PF00082	0.374
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.505
CLV_PCSK_PC7_1	80	86	PF00082	0.472
CLV_PCSK_SKI1_1	181	185	PF00082	0.308
CLV_PCSK_SKI1_1	270	274	PF00082	0.308
DEG_APCC_DBOX_1	358	366	PF00400	0.413
DOC_MAPK_gen_1	258	265	PF00069	0.507
DOC_MAPK_MEF2A_6	258	265	PF00069	0.507
DOC_PP4_FxxP_1	355	358	PF00568	0.417
DOC_PP4_FxxP_1	39	42	PF00568	0.391
DOC_USP7_MATH_1	186	190	PF00917	0.403
DOC_USP7_MATH_1	233	237	PF00917	0.432
DOC_USP7_MATH_1	323	327	PF00917	0.578
DOC_USP7_MATH_1	35	39	PF00917	0.279
DOC_USP7_MATH_1	385	389	PF00917	0.258
DOC_USP7_UBL2_3	171	175	PF12436	0.592
DOC_WW_Pin1_4	95	100	PF00397	0.312
LIG_14-3-3_CanoR_1	399	408	PF00244	0.389
LIG_14-3-3_CanoR_1	84	90	PF00244	0.357
LIG_APCC_ABBA_1	108	113	PF00400	0.382
LIG_Clathr_ClatBox_1	405	409	PF01394	0.337
LIG_Clathr_ClatBox_1	92	96	PF01394	0.328
LIG_DLG_GKlike_1	85	92	PF00625	0.276
LIG_eIF4E_1	378	384	PF01652	0.295
LIG_eIF4E_1	73	79	PF01652	0.339
LIG_FHA_1	200	206	PF00498	0.468
LIG_FHA_1	214	220	PF00498	0.468
LIG_FHA_1	238	244	PF00498	0.436
LIG_FHA_1	390	396	PF00498	0.322
LIG_FHA_1	401	407	PF00498	0.391
LIG_FHA_1	411	417	PF00498	0.296
LIG_FHA_1	74	80	PF00498	0.268
LIG_FHA_1	96	102	PF00498	0.375
LIG_FHA_2	175	181	PF00498	0.501
LIG_FHA_2	262	268	PF00498	0.437
LIG_FHA_2	43	49	PF00498	0.200
LIG_LIR_Apic_2	27	33	PF02991	0.307
LIG_LIR_Apic_2	354	358	PF02991	0.422
LIG_LIR_Apic_2	36	42	PF02991	0.221
LIG_LIR_Gen_1	245	250	PF02991	0.357
LIG_LIR_Gen_1	88	97	PF02991	0.261
LIG_LIR_Nem_3	88	92	PF02991	0.337
LIG_NRBOX	204	210	PF00104	0.175
LIG_PCNA_yPIPBox_3	51	64	PF02747	0.175
LIG_PTB_Apo_2	91	98	PF02174	0.347
LIG_PTB_Phospho_1	91	97	PF10480	0.349
LIG_SH2_CRK	30	34	PF00017	0.320
LIG_SH2_STAP1	134	138	PF00017	0.422
LIG_SH2_STAP1	363	367	PF00017	0.294
LIG_SH2_STAP1	89	93	PF00017	0.279
LIG_SH2_STAT3	421	424	PF00017	0.454
LIG_SH2_STAT5	421	424	PF00017	0.402
LIG_SH2_STAT5	73	76	PF00017	0.260
LIG_SH2_STAT5	97	100	PF00017	0.315
LIG_SH3_3	115	121	PF00018	0.422
LIG_SH3_3	158	164	PF00018	0.327
LIG_Sin3_3	126	133	PF02671	0.429
LIG_SUMO_SIM_par_1	403	410	PF11976	0.350
LIG_SUMO_SIM_par_1	413	420	PF11976	0.307
LIG_TRAF2_1	88	91	PF00917	0.369
LIG_TYR_ITIM	87	92	PF00017	0.277
LIG_WRC_WIRS_1	149	154	PF05994	0.463
LIG_WRC_WIRS_1	22	27	PF05994	0.260
LIG_WRC_WIRS_1	262	267	PF05994	0.326
LIG_WRC_WIRS_1	352	357	PF05994	0.378
MOD_CK1_1	14	20	PF00069	0.497
MOD_CK1_1	201	207	PF00069	0.440
MOD_CK1_1	236	242	PF00069	0.474
MOD_CK1_1	275	281	PF00069	0.442
MOD_CK1_1	334	340	PF00069	0.434
MOD_CK1_1	379	385	PF00069	0.391
MOD_CK2_1	85	91	PF00069	0.355
MOD_Cter_Amidation	172	175	PF01082	0.593
MOD_GlcNHglycan	13	16	PF01048	0.539
MOD_GlcNHglycan	186	189	PF01048	0.387
MOD_GlcNHglycan	19	22	PF01048	0.404
MOD_GlcNHglycan	277	280	PF01048	0.333
MOD_GlcNHglycan	287	290	PF01048	0.261
MOD_GlcNHglycan	325	328	PF01048	0.568
MOD_GlcNHglycan	333	336	PF01048	0.438
MOD_GlcNHglycan	355	358	PF01048	0.315
MOD_GlcNHglycan	377	381	PF01048	0.560
MOD_GSK3_1	10	17	PF00069	0.470
MOD_GSK3_1	163	170	PF00069	0.420
MOD_GSK3_1	186	193	PF00069	0.335
MOD_GSK3_1	233	240	PF00069	0.505
MOD_GSK3_1	385	392	PF00069	0.292
MOD_GSK3_1	400	407	PF00069	0.333
MOD_GSK3_1	422	429	PF00069	0.343
MOD_GSK3_1	435	442	PF00069	0.327
MOD_N-GLC_1	433	438	PF02516	0.317
MOD_NEK2_1	128	133	PF00069	0.432
MOD_NEK2_1	184	189	PF00069	0.321
MOD_NEK2_1	199	204	PF00069	0.294
MOD_NEK2_1	208	213	PF00069	0.459
MOD_NEK2_1	231	236	PF00069	0.453
MOD_NEK2_1	26	31	PF00069	0.285
MOD_NEK2_1	331	336	PF00069	0.346
MOD_NEK2_1	343	348	PF00069	0.318
MOD_NEK2_1	398	403	PF00069	0.441
MOD_NEK2_1	417	422	PF00069	0.222
MOD_NEK2_1	53	58	PF00069	0.170
MOD_NEK2_2	114	119	PF00069	0.422
MOD_NEK2_2	148	153	PF00069	0.451
MOD_NEK2_2	21	26	PF00069	0.391
MOD_NEK2_2	237	242	PF00069	0.422
MOD_PIKK_1	163	169	PF00454	0.472
MOD_PK_1	190	196	PF00069	0.324
MOD_PKA_1	174	180	PF00069	0.538
MOD_PKA_2	275	281	PF00069	0.319
MOD_PKA_2	398	404	PF00069	0.370
MOD_Plk_1	237	243	PF00069	0.436
MOD_Plk_1	35	41	PF00069	0.260
MOD_Plk_1	389	395	PF00069	0.306
MOD_Plk_1	417	423	PF00069	0.296
MOD_Plk_4	104	110	PF00069	0.313
MOD_Plk_4	201	207	PF00069	0.345
MOD_Plk_4	21	27	PF00069	0.279
MOD_Plk_4	363	369	PF00069	0.334
MOD_Plk_4	379	385	PF00069	0.273
MOD_Plk_4	417	423	PF00069	0.347
MOD_Plk_4	53	59	PF00069	0.175
MOD_Plk_4	74	80	PF00069	0.339
MOD_ProDKin_1	95	101	PF00069	0.314
MOD_SUMO_rev_2	429	436	PF00179	0.350
TRG_ENDOCYTIC_2	89	92	PF00928	0.294
TRG_ER_diArg_1	176	179	PF00400	0.573
TRG_ER_diArg_1	340	343	PF00400	0.311
TRG_NES_CRM1_1	48	61	PF08389	0.279
TRG_NLS_MonoExtC_3	173	178	PF00514	0.497
TRG_NLS_MonoExtN_4	171	178	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U0	Leptomonas seymouri	81%	97%
A0A0S4JA64	Bodo saltans	24%	76%
A0A1X0NJ30	Trypanosomatidae	62%	98%
A0A3S5IQK0	Trypanosoma rangeli	63%	86%
A0A3S7X417	Leishmania donovani	87%	92%
A1CH75	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	21%	92%
A1CXL0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	22%	92%
A2QI22	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	21%	91%
A3LQ86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	21%	96%
A4I6B2	Leishmania infantum	87%	92%
A4R2Q6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	93%
A5DL92	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	22%	99%
A6R3K5	Ajellomyces capsulatus (strain NAm1 / WU24)	23%	91%
A6S0T8	Botryotinia fuckeliana (strain B05.10)	24%	94%
A7ECP3	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	24%	94%
A7RHG8	Nematostella vectensis	29%	100%
A8IR43	Chlamydomonas reinhardtii	28%	100%
A8PD13	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	26%	100%
A8QB65	Brugia malayi	23%	100%
A9UP22	Monosiga brevicollis	27%	100%
B0DWM8	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	27%	99%
B0W517	Culex quinquefasciatus	28%	100%
B0Y5V6	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	92%
B2B5V0	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	25%	92%
B2VZH2	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	25%	97%
B3MJV8	Drosophila ananassae	27%	100%
B3N534	Drosophila erecta	28%	100%
B3RQN1	Trichoplax adhaerens	23%	100%
B4GT01	Drosophila persimilis	28%	100%
B4HWV6	Drosophila sechellia	29%	100%
B4JPT9	Drosophila grimshawi	27%	100%
B4KKN1	Drosophila mojavensis	26%	100%
B4LS78	Drosophila virilis	28%	100%
B4MU54	Drosophila willistoni	28%	100%
B4P116	Drosophila yakuba	28%	100%
B4Q9T6	Drosophila simulans	29%	100%
B5DG67	Salmo salar	27%	100%
B7PY76	Ixodes scapularis	25%	100%
C3XVT5	Branchiostoma floridae	23%	100%
C9ZN39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	99%
D3TLL6	Glossina morsitans morsitans	25%	100%
E9B1G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	82%
G0SFB5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	24%	91%
O24076	Medicago sativa	25%	100%
P25387	Chlamydomonas reinhardtii	24%	100%
P61480	Rattus norvegicus	26%	100%
P61964	Homo sapiens	24%	100%
P61965	Mus musculus	24%	100%
Q0CLJ4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	23%	93%
Q0UXP3	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	95%
Q0VC24	Bos taurus	26%	100%
Q17BB0	Aedes aegypti	27%	100%
Q1DJF7	Coccidioides immitis (strain RS)	24%	96%
Q28I85	Xenopus tropicalis	26%	100%
Q29KQ0	Drosophila pseudoobscura pseudoobscura	28%	100%
Q2GXT0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	23%	93%
Q2HJH6	Bos taurus	26%	100%
Q2KIG2	Bos taurus	24%	100%
Q2UGK1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	22%	92%
Q498M4	Rattus norvegicus	24%	100%
Q4Q6P4	Leishmania major	87%	100%
Q4WP10	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	92%
Q54W52	Dictyostelium discoideum	23%	97%
Q5APF0	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	96%
Q5B4R1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	92%
Q5BJ90	Xenopus tropicalis	27%	100%
Q5RE95	Pongo abelii	24%	100%
Q5REE6	Pongo abelii	27%	100%
Q5RF51	Pongo abelii	25%	100%
Q6BLS5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	96%
Q6CU59	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6FKK3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	98%
Q6NX08	Danio rerio	28%	100%
Q6PE01	Mus musculus	27%	100%
Q756D0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
Q7QJ33	Anopheles gambiae	28%	100%
Q7T0P4	Xenopus laevis	26%	100%
Q86VZ2	Homo sapiens	24%	100%
Q8H594	Oryza sativa subsp. japonica	27%	100%
Q96DI7	Homo sapiens	27%	100%
Q9C2I5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	92%
Q9D7H2	Mus musculus	24%	100%
Q9GZL7	Homo sapiens	27%	100%
Q9JJA4	Mus musculus	26%	100%
Q9LF27	Arabidopsis thaliana	27%	100%
Q9M2Z2	Arabidopsis thaliana	23%	100%
Q9SZQ5	Arabidopsis thaliana	25%	100%
Q9URY0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9V3J8	Drosophila melanogaster	24%	100%
Q9VKQ3	Drosophila melanogaster	29%	100%
V5AYL2	Trypanosoma cruzi	63%	88%