Putative nucleolar protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIZ4_LEIBR

TriTrypDb:

LbrM.31.0300 , LBRM2903_310009600

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	13
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HIZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIZ4

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	15
GO:0006139	nucleobase-containing compound metabolic process	3	15
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009451	RNA modification	5	15
GO:0009987	cellular process	1	15
GO:0016070	RNA metabolic process	5	15
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0032259	methylation	2	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0042254	ribosome biogenesis	5	11
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0043414	macromolecule methylation	3	15
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0046483	heterocycle metabolic process	3	15
GO:0071704	organic substance metabolic process	2	15
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	15
GO:1901360	organic cyclic compound metabolic process	3	15
GO:0000154	rRNA modification	6	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006364	rRNA processing	8	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	15
GO:0003824	catalytic activity	1	15
GO:0005488	binding	1	15
GO:0008168	methyltransferase activity	4	15
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	15
GO:0016741	transferase activity, transferring one-carbon groups	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15
GO:0008169	C-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity	6	1
GO:0016434	rRNA (cytosine) methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.442
CLV_C14_Caspase3-7	65	69	PF00656	0.513
CLV_NRD_NRD_1	124	126	PF00675	0.479
CLV_NRD_NRD_1	265	267	PF00675	0.225
CLV_NRD_NRD_1	41	43	PF00675	0.542
CLV_NRD_NRD_1	474	476	PF00675	0.233
CLV_NRD_NRD_1	507	509	PF00675	0.243
CLV_NRD_NRD_1	609	611	PF00675	0.650
CLV_NRD_NRD_1	620	622	PF00675	0.613
CLV_PCSK_KEX2_1	123	125	PF00082	0.471
CLV_PCSK_KEX2_1	264	266	PF00082	0.225
CLV_PCSK_KEX2_1	274	276	PF00082	0.253
CLV_PCSK_KEX2_1	473	475	PF00082	0.236
CLV_PCSK_KEX2_1	507	509	PF00082	0.243
CLV_PCSK_KEX2_1	555	557	PF00082	0.654
CLV_PCSK_KEX2_1	609	611	PF00082	0.697
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.225
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.253
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.246
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.706
CLV_PCSK_SKI1_1	124	128	PF00082	0.456
CLV_PCSK_SKI1_1	144	148	PF00082	0.425
CLV_PCSK_SKI1_1	19	23	PF00082	0.543
CLV_PCSK_SKI1_1	3	7	PF00082	0.604
CLV_PCSK_SKI1_1	400	404	PF00082	0.236
CLV_PCSK_SKI1_1	417	421	PF00082	0.236
CLV_PCSK_SKI1_1	42	46	PF00082	0.613
CLV_PCSK_SKI1_1	436	440	PF00082	0.269
CLV_Separin_Metazoa	212	216	PF03568	0.431
DEG_APCC_DBOX_1	214	222	PF00400	0.407
DEG_ODPH_VHL_1	324	335	PF01847	0.425
DEG_SCF_SKP2-CKS1_1	583	590	PF00560	0.502
DEG_SPOP_SBC_1	545	549	PF00917	0.661
DOC_CYCLIN_RxL_1	430	444	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.449
DOC_MAPK_gen_1	184	193	PF00069	0.374
DOC_MAPK_gen_1	205	213	PF00069	0.385
DOC_MAPK_gen_1	250	258	PF00069	0.436
DOC_MAPK_gen_1	284	292	PF00069	0.425
DOC_MAPK_gen_1	393	403	PF00069	0.425
DOC_MAPK_gen_1	473	479	PF00069	0.449
DOC_MAPK_gen_1	495	505	PF00069	0.527
DOC_MAPK_MEF2A_6	284	292	PF00069	0.425
DOC_PP2B_LxvP_1	235	238	PF13499	0.449
DOC_PP2B_LxvP_1	403	406	PF13499	0.425
DOC_PP2B_LxvP_1	594	597	PF13499	0.736
DOC_PP4_FxxP_1	486	489	PF00568	0.425
DOC_USP7_MATH_1	314	318	PF00917	0.527
DOC_USP7_MATH_1	620	624	PF00917	0.612
DOC_USP7_MATH_2	281	287	PF00917	0.425
DOC_USP7_UBL2_3	27	31	PF12436	0.673
DOC_USP7_UBL2_3	586	590	PF12436	0.717
DOC_WW_Pin1_4	146	151	PF00397	0.583
DOC_WW_Pin1_4	32	37	PF00397	0.469
DOC_WW_Pin1_4	584	589	PF00397	0.619
DOC_WW_Pin1_4	596	601	PF00397	0.502
LIG_14-3-3_CanoR_1	144	150	PF00244	0.536
LIG_14-3-3_CanoR_1	19	24	PF00244	0.642
LIG_14-3-3_CanoR_1	257	262	PF00244	0.449
LIG_14-3-3_CanoR_1	365	370	PF00244	0.436
LIG_14-3-3_CanoR_1	430	438	PF00244	0.452
LIG_14-3-3_CanoR_1	556	566	PF00244	0.574
LIG_14-3-3_CanoR_1	593	597	PF00244	0.527
LIG_14-3-3_CanoR_1	621	625	PF00244	0.496
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_eIF4E_1	222	228	PF01652	0.230
LIG_FHA_1	166	172	PF00498	0.542
LIG_FHA_1	188	194	PF00498	0.407
LIG_FHA_1	20	26	PF00498	0.498
LIG_FHA_1	253	259	PF00498	0.437
LIG_FHA_1	341	347	PF00498	0.464
LIG_FHA_1	351	357	PF00498	0.461
LIG_FHA_1	377	383	PF00498	0.453
LIG_FHA_1	408	414	PF00498	0.493
LIG_FHA_2	177	183	PF00498	0.423
LIG_FHA_2	382	388	PF00498	0.475
LIG_FHA_2	81	87	PF00498	0.493
LIG_LIR_Gen_1	209	218	PF02991	0.336
LIG_LIR_Gen_1	223	232	PF02991	0.356
LIG_LIR_Gen_1	283	293	PF02991	0.425
LIG_LIR_Gen_1	389	398	PF02991	0.542
LIG_LIR_Gen_1	90	95	PF02991	0.580
LIG_LIR_Nem_3	209	213	PF02991	0.375
LIG_LIR_Nem_3	223	227	PF02991	0.467
LIG_LIR_Nem_3	283	288	PF02991	0.425
LIG_LIR_Nem_3	317	321	PF02991	0.290
LIG_LIR_Nem_3	389	394	PF02991	0.500
LIG_LIR_Nem_3	90	94	PF02991	0.578
LIG_MAD2	331	339	PF02301	0.464
LIG_PCNA_PIPBox_1	229	238	PF02747	0.364
LIG_PCNA_yPIPBox_3	167	176	PF02747	0.462
LIG_REV1ctd_RIR_1	517	527	PF16727	0.436
LIG_SH2_NCK_1	425	429	PF00017	0.392
LIG_SH2_SRC	425	428	PF00017	0.392
LIG_SH2_STAP1	391	395	PF00017	0.436
LIG_SH2_STAT3	310	313	PF00017	0.425
LIG_SH2_STAT3	345	348	PF00017	0.425
LIG_SH2_STAT5	210	213	PF00017	0.411
LIG_SH2_STAT5	305	308	PF00017	0.448
LIG_SH2_STAT5	345	348	PF00017	0.425
LIG_SH2_STAT5	451	454	PF00017	0.436
LIG_SH2_STAT5	509	512	PF00017	0.492
LIG_SH3_3	358	364	PF00018	0.449
LIG_SH3_3	594	600	PF00018	0.548
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.406
LIG_SUMO_SIM_par_1	217	223	PF11976	0.398
LIG_TRAF2_1	179	182	PF00917	0.332
LIG_TRAF2_1	325	328	PF00917	0.450
LIG_TRAF2_1	55	58	PF00917	0.771
LIG_TRAF2_1	62	65	PF00917	0.722
LIG_TRAF2_1	97	100	PF00917	0.575
LIG_TYR_ITSM	387	394	PF00017	0.479
MOD_CDK_SPxK_1	584	590	PF00069	0.619
MOD_CDK_SPxxK_3	596	603	PF00069	0.617
MOD_CK1_1	368	374	PF00069	0.362
MOD_CK1_1	455	461	PF00069	0.464
MOD_CK1_1	528	534	PF00069	0.540
MOD_CK1_1	549	555	PF00069	0.714
MOD_CK1_1	584	590	PF00069	0.615
MOD_CK2_1	176	182	PF00069	0.430
MOD_CK2_1	386	392	PF00069	0.527
MOD_CK2_1	80	86	PF00069	0.702
MOD_CK2_1	94	100	PF00069	0.521
MOD_GlcNHglycan	334	338	PF01048	0.303
MOD_GlcNHglycan	407	410	PF01048	0.294
MOD_GlcNHglycan	440	443	PF01048	0.253
MOD_GlcNHglycan	548	551	PF01048	0.712
MOD_GSK3_1	11	18	PF00069	0.564
MOD_GSK3_1	142	149	PF00069	0.587
MOD_GSK3_1	248	255	PF00069	0.533
MOD_GSK3_1	32	39	PF00069	0.592
MOD_GSK3_1	407	414	PF00069	0.427
MOD_GSK3_1	499	506	PF00069	0.494
MOD_GSK3_1	525	532	PF00069	0.484
MOD_GSK3_1	535	542	PF00069	0.648
MOD_GSK3_1	544	551	PF00069	0.521
MOD_GSK3_1	592	599	PF00069	0.686
MOD_N-GLC_1	80	85	PF02516	0.627
MOD_NEK2_1	174	179	PF00069	0.624
MOD_NEK2_1	228	233	PF00069	0.456
MOD_NEK2_1	248	253	PF00069	0.504
MOD_NEK2_1	333	338	PF00069	0.476
MOD_NEK2_1	350	355	PF00069	0.360
MOD_NEK2_1	376	381	PF00069	0.459
MOD_NEK2_1	438	443	PF00069	0.462
MOD_NEK2_1	503	508	PF00069	0.465
MOD_PIKK_1	429	435	PF00454	0.469
MOD_PK_1	415	421	PF00069	0.425
MOD_PKA_1	11	17	PF00069	0.514
MOD_PKA_1	42	48	PF00069	0.619
MOD_PKA_1	525	531	PF00069	0.394
MOD_PKA_2	251	257	PF00069	0.425
MOD_PKA_2	429	435	PF00069	0.436
MOD_PKA_2	529	535	PF00069	0.390
MOD_PKA_2	557	563	PF00069	0.679
MOD_PKA_2	592	598	PF00069	0.542
MOD_PKA_2	608	614	PF00069	0.500
MOD_Plk_1	415	421	PF00069	0.420
MOD_Plk_4	228	234	PF00069	0.445
MOD_Plk_4	314	320	PF00069	0.464
MOD_Plk_4	341	347	PF00069	0.422
MOD_Plk_4	455	461	PF00069	0.425
MOD_ProDKin_1	146	152	PF00069	0.584
MOD_ProDKin_1	32	38	PF00069	0.469
MOD_ProDKin_1	584	590	PF00069	0.619
MOD_ProDKin_1	596	602	PF00069	0.502
MOD_SUMO_for_1	117	120	PF00179	0.463
MOD_SUMO_for_1	197	200	PF00179	0.429
MOD_SUMO_rev_2	111	119	PF00179	0.471
TRG_DiLeu_BaEn_1	209	214	PF01217	0.380
TRG_DiLeu_BaEn_1	223	228	PF01217	0.355
TRG_DiLeu_BaEn_2	239	245	PF01217	0.472
TRG_DiLeu_BaEn_3	462	468	PF01217	0.458
TRG_ENDOCYTIC_2	210	213	PF00928	0.351
TRG_ENDOCYTIC_2	224	227	PF00928	0.318
TRG_ENDOCYTIC_2	391	394	PF00928	0.422
TRG_ENDOCYTIC_2	425	428	PF00928	0.423
TRG_ER_diArg_1	122	125	PF00400	0.469
TRG_ER_diArg_1	507	509	PF00400	0.440
TRG_NLS_MonoExtC_3	553	558	PF00514	0.665
TRG_NLS_MonoExtN_4	554	559	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P967	Leptomonas seymouri	77%	100%
A0A0S4KG56	Bodo saltans	65%	100%
A0A1X0NJV9	Trypanosomatidae	71%	100%
A0A3Q8IJ07	Leishmania donovani	27%	99%
A0A3Q8IJS8	Leishmania donovani	80%	100%
A0A422N5J0	Trypanosoma rangeli	70%	100%
A4I6B1	Leishmania infantum	79%	100%
C9ZN38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AEB6	Leishmania major	27%	100%
E9AHJ5	Leishmania infantum	27%	99%
E9B1G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q08J23	Homo sapiens	25%	81%
Q1HFZ0	Mus musculus	25%	83%
Q28E61	Xenopus tropicalis	24%	78%
Q4Q6P5	Leishmania major	82%	100%
Q4V7N2	Xenopus laevis	26%	90%
V5BIK5	Trypanosoma cruzi	66%	100%