Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIZ2_LEIBR

TriTrypDb:

LbrM.31.0280 , LBRM2903_310009400

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HIZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034389	lipid droplet organization	5	1
GO:0044238	primary metabolic process	2	1
GO:0070925	organelle assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140042	lipid droplet formation	6	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.567
CLV_NRD_NRD_1	304	306	PF00675	0.594
CLV_NRD_NRD_1	478	480	PF00675	0.540
CLV_NRD_NRD_1	496	498	PF00675	0.405
CLV_NRD_NRD_1	8	10	PF00675	0.592
CLV_PCSK_KEX2_1	304	306	PF00082	0.594
CLV_PCSK_KEX2_1	470	472	PF00082	0.572
CLV_PCSK_KEX2_1	478	480	PF00082	0.530
CLV_PCSK_KEX2_1	496	498	PF00082	0.405
CLV_PCSK_KEX2_1	508	510	PF00082	0.493
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.411
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.482
CLV_PCSK_SKI1_1	143	147	PF00082	0.570
CLV_PCSK_SKI1_1	304	308	PF00082	0.523
CLV_PCSK_SKI1_1	322	326	PF00082	0.534
CLV_PCSK_SKI1_1	385	389	PF00082	0.593
CLV_PCSK_SKI1_1	399	403	PF00082	0.638
CLV_PCSK_SKI1_1	471	475	PF00082	0.522
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DEG_SPOP_SBC_1	203	207	PF00917	0.363
DOC_CKS1_1	472	477	PF01111	0.604
DOC_MAPK_gen_1	380	389	PF00069	0.370
DOC_MAPK_MEF2A_6	296	303	PF00069	0.399
DOC_MAPK_MEF2A_6	340	348	PF00069	0.438
DOC_MAPK_MEF2A_6	351	358	PF00069	0.394
DOC_MAPK_MEF2A_6	73	82	PF00069	0.404
DOC_MAPK_MEF2A_6	9	17	PF00069	0.590
DOC_PP1_RVXF_1	303	310	PF00149	0.403
DOC_PP1_RVXF_1	383	390	PF00149	0.427
DOC_PP4_FxxP_1	148	151	PF00568	0.517
DOC_PP4_FxxP_1	311	314	PF00568	0.388
DOC_PP4_FxxP_1	352	355	PF00568	0.368
DOC_USP7_MATH_1	270	274	PF00917	0.490
DOC_USP7_MATH_1	373	377	PF00917	0.332
DOC_USP7_MATH_1	421	425	PF00917	0.444
DOC_USP7_MATH_1	50	54	PF00917	0.679
DOC_WW_Pin1_4	210	215	PF00397	0.488
DOC_WW_Pin1_4	350	355	PF00397	0.447
DOC_WW_Pin1_4	4	9	PF00397	0.781
DOC_WW_Pin1_4	471	476	PF00397	0.633
DOC_WW_Pin1_4	501	506	PF00397	0.788
LIG_14-3-3_CanoR_1	204	214	PF00244	0.494
LIG_14-3-3_CanoR_1	399	406	PF00244	0.460
LIG_14-3-3_CanoR_1	478	487	PF00244	0.791
LIG_14-3-3_CanoR_1	496	502	PF00244	0.619
LIG_14-3-3_CanoR_1	60	65	PF00244	0.669
LIG_Actin_WH2_2	483	498	PF00022	0.737
LIG_Actin_WH2_2	58	75	PF00022	0.700
LIG_BRCT_BRCA1_1	260	264	PF00533	0.316
LIG_BRCT_BRCA1_1	329	333	PF00533	0.520
LIG_BRCT_BRCA1_1	497	501	PF00533	0.765
LIG_EH1_1	32	40	PF00400	0.518
LIG_FHA_1	116	122	PF00498	0.450
LIG_FHA_1	153	159	PF00498	0.546
LIG_FHA_1	197	203	PF00498	0.393
LIG_FHA_1	351	357	PF00498	0.474
LIG_FHA_1	389	395	PF00498	0.370
LIG_FHA_1	406	412	PF00498	0.339
LIG_FHA_1	452	458	PF00498	0.611
LIG_FHA_1	472	478	PF00498	0.712
LIG_FHA_1	490	496	PF00498	0.731
LIG_FHA_1	54	60	PF00498	0.697
LIG_FHA_2	205	211	PF00498	0.357
LIG_FHA_2	244	250	PF00498	0.292
LIG_FHA_2	61	67	PF00498	0.705
LIG_LIR_Apic_2	147	151	PF02991	0.515
LIG_LIR_Apic_2	368	373	PF02991	0.409
LIG_LIR_Gen_1	181	191	PF02991	0.467
LIG_LIR_Gen_1	317	325	PF02991	0.355
LIG_LIR_Gen_1	347	356	PF02991	0.391
LIG_LIR_Gen_1	408	417	PF02991	0.491
LIG_LIR_Gen_1	484	495	PF02991	0.740
LIG_LIR_Nem_3	181	187	PF02991	0.475
LIG_LIR_Nem_3	317	321	PF02991	0.345
LIG_LIR_Nem_3	330	336	PF02991	0.381
LIG_LIR_Nem_3	347	352	PF02991	0.292
LIG_LIR_Nem_3	408	412	PF02991	0.391
LIG_LIR_Nem_3	484	490	PF02991	0.695
LIG_LYPXL_S_1	311	315	PF13949	0.502
LIG_LYPXL_yS_3	312	315	PF13949	0.302
LIG_NRBOX	302	308	PF00104	0.350
LIG_NRBOX	427	433	PF00104	0.492
LIG_NRBOX	85	91	PF00104	0.240
LIG_Pex14_1	316	320	PF04695	0.496
LIG_Pex14_1	400	404	PF04695	0.442
LIG_Pex14_2	186	190	PF04695	0.324
LIG_Pex14_2	277	281	PF04695	0.371
LIG_Pex14_2	416	420	PF04695	0.240
LIG_SH2_STAP1	237	241	PF00017	0.376
LIG_SH2_STAT5	237	240	PF00017	0.397
LIG_SH2_STAT5	320	323	PF00017	0.452
LIG_SH2_STAT5	434	437	PF00017	0.578
LIG_SH2_STAT5	503	506	PF00017	0.605
LIG_SH2_STAT5	62	65	PF00017	0.696
LIG_SH3_1	10	16	PF00018	0.589
LIG_SH3_2	335	340	PF14604	0.376
LIG_SH3_3	10	16	PF00018	0.769
LIG_SH3_3	208	214	PF00018	0.420
LIG_SH3_3	329	335	PF00018	0.462
LIG_SH3_3	455	461	PF00018	0.599
LIG_SH3_3	469	475	PF00018	0.551
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.519
LIG_SUMO_SIM_anti_2	341	347	PF11976	0.356
LIG_SUMO_SIM_anti_2	408	414	PF11976	0.396
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.326
LIG_SUMO_SIM_par_1	253	261	PF11976	0.292
LIG_SUMO_SIM_par_1	73	79	PF11976	0.538
LIG_SUMO_SIM_par_1	87	92	PF11976	0.377
LIG_TRAF2_1	246	249	PF00917	0.481
LIG_Vh1_VBS_1	75	93	PF01044	0.240
LIG_WRC_WIRS_1	406	411	PF05994	0.325
LIG_WRC_WIRS_1	61	66	PF05994	0.706
LIG_WRPW_2	295	298	PF00400	0.318
MOD_CDC14_SPxK_1	7	10	PF00782	0.612
MOD_CDK_SPK_2	210	215	PF00069	0.488
MOD_CDK_SPK_2	4	9	PF00069	0.614
MOD_CDK_SPxK_1	4	10	PF00069	0.613
MOD_CDK_SPxK_1	501	507	PF00069	0.790
MOD_CDK_SPxxK_3	471	478	PF00069	0.633
MOD_CDK_SPxxK_3	501	508	PF00069	0.693
MOD_CK1_1	100	106	PF00069	0.431
MOD_CK1_1	185	191	PF00069	0.501
MOD_CK1_1	376	382	PF00069	0.305
MOD_CK1_1	489	495	PF00069	0.733
MOD_CK1_1	53	59	PF00069	0.539
MOD_CK2_1	204	210	PF00069	0.486
MOD_CK2_1	243	249	PF00069	0.414
MOD_DYRK1A_RPxSP_1	471	475	PF00069	0.606
MOD_GlcNHglycan	169	172	PF01048	0.593
MOD_GlcNHglycan	17	20	PF01048	0.374
MOD_GlcNHglycan	207	210	PF01048	0.688
MOD_GlcNHglycan	322	325	PF01048	0.713
MOD_GlcNHglycan	329	332	PF01048	0.659
MOD_GlcNHglycan	374	378	PF01048	0.539
MOD_GlcNHglycan	66	70	PF01048	0.419
MOD_GlcNHglycan	92	96	PF01048	0.486
MOD_GSK3_1	190	197	PF00069	0.395
MOD_GSK3_1	258	265	PF00069	0.276
MOD_GSK3_1	266	273	PF00069	0.361
MOD_GSK3_1	279	286	PF00069	0.369
MOD_GSK3_1	350	357	PF00069	0.359
MOD_GSK3_1	388	395	PF00069	0.374
MOD_GSK3_1	486	493	PF00069	0.738
MOD_GSK3_1	497	504	PF00069	0.723
MOD_GSK3_1	50	57	PF00069	0.668
MOD_GSK3_1	60	67	PF00069	0.680
MOD_GSK3_1	96	103	PF00069	0.495
MOD_N-GLC_1	365	370	PF02516	0.536
MOD_N-GLC_1	501	506	PF02516	0.588
MOD_NEK2_1	158	163	PF00069	0.476
MOD_NEK2_1	190	195	PF00069	0.425
MOD_NEK2_1	258	263	PF00069	0.275
MOD_NEK2_1	280	285	PF00069	0.365
MOD_NEK2_1	365	370	PF00069	0.394
MOD_NEK2_1	388	393	PF00069	0.367
MOD_NEK2_1	42	47	PF00069	0.551
MOD_NEK2_1	420	425	PF00069	0.490
MOD_NEK2_1	490	495	PF00069	0.730
MOD_NEK2_1	64	69	PF00069	0.692
MOD_NEK2_1	97	102	PF00069	0.468
MOD_NEK2_2	196	201	PF00069	0.435
MOD_PIKK_1	490	496	PF00454	0.731
MOD_PKA_2	152	158	PF00069	0.492
MOD_PKA_2	203	209	PF00069	0.361
MOD_PKA_2	327	333	PF00069	0.349
MOD_PKA_2	480	486	PF00069	0.699
MOD_PKA_2	495	501	PF00069	0.749
MOD_PKB_1	479	487	PF00069	0.603
MOD_Plk_1	258	264	PF00069	0.288
MOD_Plk_1	266	272	PF00069	0.370
MOD_Plk_1	365	371	PF00069	0.335
MOD_Plk_1	490	496	PF00069	0.714
MOD_Plk_1	54	60	PF00069	0.554
MOD_Plk_2-3	451	457	PF00069	0.722
MOD_Plk_4	258	264	PF00069	0.340
MOD_Plk_4	405	411	PF00069	0.356
MOD_Plk_4	60	66	PF00069	0.709
MOD_Plk_4	76	82	PF00069	0.276
MOD_ProDKin_1	210	216	PF00069	0.485
MOD_ProDKin_1	350	356	PF00069	0.447
MOD_ProDKin_1	4	10	PF00069	0.781
MOD_ProDKin_1	471	477	PF00069	0.634
MOD_ProDKin_1	501	507	PF00069	0.790
MOD_SUMO_for_1	233	236	PF00179	0.476
MOD_SUMO_rev_2	147	155	PF00179	0.369
MOD_SUMO_rev_2	500	510	PF00179	0.611
TRG_DiLeu_BaEn_1	34	39	PF01217	0.520
TRG_DiLeu_BaEn_4	455	461	PF01217	0.599
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.270
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.369
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.512
TRG_ENDOCYTIC_2	312	315	PF00928	0.368
TRG_ENDOCYTIC_2	318	321	PF00928	0.387
TRG_ENDOCYTIC_2	349	352	PF00928	0.346
TRG_ENDOCYTIC_2	487	490	PF00928	0.753
TRG_ENDOCYTIC_2	62	65	PF00928	0.707
TRG_ER_diArg_1	303	305	PF00400	0.395
TRG_ER_diArg_1	360	363	PF00400	0.346
TRG_ER_diArg_1	440	443	PF00400	0.538
TRG_ER_diArg_1	477	479	PF00400	0.792
TRG_ER_diArg_1	495	497	PF00400	0.582
TRG_ER_diLys_1	507	510	PF00400	0.682
TRG_NES_CRM1_1	26	40	PF08389	0.703
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.751
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U6	Leptomonas seymouri	53%	100%
A0A1X0NJH4	Trypanosomatidae	36%	100%
A0A3Q8IEM5	Leishmania donovani	74%	100%
A4I6A9	Leishmania infantum	74%	100%
E9B1G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q6P7	Leishmania major	72%	100%
V5BN41	Trypanosoma cruzi	39%	100%