Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIZ0_LEIBR

TriTrypDb:

LbrM.31.0260 , LBRM2903_310007000

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.492
CLV_NRD_NRD_1	265	267	PF00675	0.723
CLV_NRD_NRD_1	457	459	PF00675	0.459
CLV_NRD_NRD_1	466	468	PF00675	0.463
CLV_NRD_NRD_1	493	495	PF00675	0.390
CLV_PCSK_KEX2_1	457	459	PF00082	0.459
CLV_PCSK_KEX2_1	465	467	PF00082	0.441
CLV_PCSK_SKI1_1	387	391	PF00082	0.488
CLV_PCSK_SKI1_1	478	482	PF00082	0.430
DEG_APCC_DBOX_1	136	144	PF00400	0.368
DEG_SPOP_SBC_1	271	275	PF00917	0.712
DOC_CKS1_1	37	42	PF01111	0.331
DOC_MAPK_gen_1	134	142	PF00069	0.425
DOC_MAPK_gen_1	465	472	PF00069	0.291
DOC_MAPK_gen_1	494	501	PF00069	0.446
DOC_MAPK_MEF2A_6	478	485	PF00069	0.412
DOC_PP1_RVXF_1	482	488	PF00149	0.269
DOC_PP2B_LxvP_1	192	195	PF13499	0.478
DOC_PP2B_LxvP_1	206	209	PF13499	0.393
DOC_PP4_FxxP_1	119	122	PF00568	0.442
DOC_PP4_FxxP_1	179	182	PF00568	0.348
DOC_PP4_FxxP_1	238	241	PF00568	0.585
DOC_USP7_MATH_1	272	276	PF00917	0.743
DOC_USP7_MATH_1	298	302	PF00917	0.584
DOC_USP7_MATH_1	328	332	PF00917	0.635
DOC_USP7_MATH_1	551	555	PF00917	0.611
DOC_USP7_MATH_1	561	565	PF00917	0.649
DOC_WW_Pin1_4	178	183	PF00397	0.347
DOC_WW_Pin1_4	252	257	PF00397	0.769
DOC_WW_Pin1_4	274	279	PF00397	0.564
DOC_WW_Pin1_4	283	288	PF00397	0.476
DOC_WW_Pin1_4	294	299	PF00397	0.511
DOC_WW_Pin1_4	319	324	PF00397	0.688
DOC_WW_Pin1_4	342	347	PF00397	0.595
DOC_WW_Pin1_4	36	41	PF00397	0.335
DOC_WW_Pin1_4	557	562	PF00397	0.660
LIG_14-3-3_CanoR_1	103	111	PF00244	0.474
LIG_14-3-3_CanoR_1	458	464	PF00244	0.455
LIG_14-3-3_CanoR_1	484	490	PF00244	0.411
LIG_Clathr_ClatBox_1	16	20	PF01394	0.433
LIG_CtBP_PxDLS_1	278	282	PF00389	0.524
LIG_eIF4E_1	359	365	PF01652	0.553
LIG_FHA_1	103	109	PF00498	0.413
LIG_FHA_1	172	178	PF00498	0.356
LIG_FHA_1	225	231	PF00498	0.467
LIG_FHA_1	234	240	PF00498	0.566
LIG_FHA_1	274	280	PF00498	0.535
LIG_FHA_1	287	293	PF00498	0.466
LIG_FHA_1	433	439	PF00498	0.499
LIG_FHA_2	245	251	PF00498	0.539
LIG_LIR_Apic_2	178	182	PF02991	0.347
LIG_LIR_Apic_2	236	241	PF02991	0.578
LIG_LIR_Gen_1	32	43	PF02991	0.321
LIG_LIR_Gen_1	450	460	PF02991	0.335
LIG_LIR_Gen_1	67	73	PF02991	0.363
LIG_LIR_LC3C_4	479	483	PF02991	0.264
LIG_LIR_Nem_3	150	155	PF02991	0.340
LIG_LIR_Nem_3	32	38	PF02991	0.341
LIG_LIR_Nem_3	450	455	PF02991	0.477
LIG_LIR_Nem_3	67	72	PF02991	0.368
LIG_LIR_Nem_3	83	88	PF02991	0.343
LIG_PDZ_Class_1	561	566	PF00595	0.622
LIG_Pex14_1	151	155	PF04695	0.328
LIG_SH2_CRK	44	48	PF00017	0.324
LIG_SH2_SRC	474	477	PF00017	0.416
LIG_SH2_STAP1	44	48	PF00017	0.324
LIG_SH2_STAT3	118	121	PF00017	0.395
LIG_SH2_STAT5	118	121	PF00017	0.395
LIG_SH2_STAT5	155	158	PF00017	0.314
LIG_SH2_STAT5	205	208	PF00017	0.382
LIG_SH2_STAT5	221	224	PF00017	0.358
LIG_SH2_STAT5	359	362	PF00017	0.488
LIG_SH2_STAT5	363	366	PF00017	0.497
LIG_SH2_STAT5	378	381	PF00017	0.680
LIG_SH2_STAT5	452	455	PF00017	0.483
LIG_SH2_STAT5	461	464	PF00017	0.443
LIG_SH2_STAT5	474	477	PF00017	0.408
LIG_SH2_STAT5	530	533	PF00017	0.383
LIG_SH2_STAT5	85	88	PF00017	0.324
LIG_SH3_3	227	233	PF00018	0.505
LIG_SH3_3	265	271	PF00018	0.686
LIG_SH3_3	320	326	PF00018	0.684
LIG_SH3_3	532	538	PF00018	0.431
LIG_SH3_3	60	66	PF00018	0.390
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.486
LIG_SUMO_SIM_anti_2	479	484	PF11976	0.335
LIG_SUMO_SIM_par_1	15	20	PF11976	0.518
LIG_SUMO_SIM_par_1	171	178	PF11976	0.361
LIG_SUMO_SIM_par_1	221	227	PF11976	0.446
LIG_SUMO_SIM_par_1	286	291	PF11976	0.504
LIG_SUMO_SIM_par_1	497	503	PF11976	0.384
LIG_TRAF2_1	169	172	PF00917	0.334
LIG_WRC_WIRS_1	351	356	PF05994	0.551
LIG_WW_3	345	349	PF00397	0.525
MOD_CDC14_SPxK_1	560	563	PF00782	0.669
MOD_CDK_SPK_2	252	257	PF00069	0.675
MOD_CDK_SPxK_1	342	348	PF00069	0.526
MOD_CDK_SPxK_1	557	563	PF00069	0.664
MOD_CK1_1	255	261	PF00069	0.644
MOD_CK1_1	262	268	PF00069	0.596
MOD_CK1_1	273	279	PF00069	0.718
MOD_CK1_1	286	292	PF00069	0.507
MOD_CK1_1	297	303	PF00069	0.552
MOD_CK1_1	309	315	PF00069	0.709
MOD_CK1_1	322	328	PF00069	0.604
MOD_CK1_1	331	337	PF00069	0.637
MOD_CK1_1	398	404	PF00069	0.523
MOD_CK1_1	520	526	PF00069	0.379
MOD_CK2_1	194	200	PF00069	0.420
MOD_CK2_1	377	383	PF00069	0.410
MOD_CK2_1	551	557	PF00069	0.495
MOD_GlcNHglycan	10	13	PF01048	0.476
MOD_GlcNHglycan	147	150	PF01048	0.481
MOD_GlcNHglycan	233	236	PF01048	0.549
MOD_GlcNHglycan	257	260	PF01048	0.683
MOD_GlcNHglycan	281	284	PF01048	0.656
MOD_GlcNHglycan	300	303	PF01048	0.607
MOD_GlcNHglycan	326	329	PF01048	0.603
MOD_GlcNHglycan	335	338	PF01048	0.653
MOD_GSK3_1	147	154	PF00069	0.461
MOD_GSK3_1	171	178	PF00069	0.362
MOD_GSK3_1	255	262	PF00069	0.613
MOD_GSK3_1	266	273	PF00069	0.630
MOD_GSK3_1	279	286	PF00069	0.527
MOD_GSK3_1	290	297	PF00069	0.693
MOD_GSK3_1	306	313	PF00069	0.585
MOD_GSK3_1	324	331	PF00069	0.633
MOD_GSK3_1	512	519	PF00069	0.385
MOD_GSK3_1	549	556	PF00069	0.604
MOD_GSK3_1	557	564	PF00069	0.601
MOD_GSK3_1	98	105	PF00069	0.481
MOD_N-GLC_1	279	284	PF02516	0.548
MOD_N-GLC_1	310	315	PF02516	0.585
MOD_N-GLC_1	331	336	PF02516	0.684
MOD_N-GLC_1	432	437	PF02516	0.481
MOD_NEK2_1	281	286	PF00069	0.569
MOD_NEK2_1	431	436	PF00069	0.411
MOD_NEK2_1	517	522	PF00069	0.285
MOD_NEK2_1	73	78	PF00069	0.353
MOD_NEK2_2	211	216	PF00069	0.395
MOD_NEK2_2	233	238	PF00069	0.558
MOD_NMyristoyl	1	7	PF02799	0.573
MOD_PIKK_1	224	230	PF00454	0.444
MOD_PIKK_1	300	306	PF00454	0.521
MOD_PKA_1	266	272	PF00069	0.604
MOD_PKA_2	102	108	PF00069	0.398
MOD_PKA_2	262	268	PF00069	0.817
MOD_PKA_2	92	98	PF00069	0.350
MOD_PKB_1	25	33	PF00069	0.311
MOD_PKB_1	348	356	PF00069	0.572
MOD_Plk_4	147	153	PF00069	0.471
MOD_Plk_4	233	239	PF00069	0.577
MOD_Plk_4	451	457	PF00069	0.332
MOD_Plk_4	497	503	PF00069	0.448
MOD_Plk_4	517	523	PF00069	0.241
MOD_ProDKin_1	178	184	PF00069	0.347
MOD_ProDKin_1	252	258	PF00069	0.771
MOD_ProDKin_1	274	280	PF00069	0.563
MOD_ProDKin_1	283	289	PF00069	0.476
MOD_ProDKin_1	294	300	PF00069	0.511
MOD_ProDKin_1	319	325	PF00069	0.688
MOD_ProDKin_1	342	348	PF00069	0.597
MOD_ProDKin_1	36	42	PF00069	0.331
MOD_ProDKin_1	557	563	PF00069	0.664
MOD_SUMO_rev_2	11	17	PF00179	0.528
MOD_SUMO_rev_2	500	507	PF00179	0.381
TRG_ENDOCYTIC_2	221	224	PF00928	0.358
TRG_ENDOCYTIC_2	44	47	PF00928	0.324
TRG_ENDOCYTIC_2	452	455	PF00928	0.472
TRG_ENDOCYTIC_2	85	88	PF00928	0.324
TRG_ER_diArg_1	25	28	PF00400	0.366
TRG_ER_diArg_1	456	458	PF00400	0.445
TRG_ER_diArg_1	464	467	PF00400	0.453
TRG_NES_CRM1_1	358	374	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.440
TRG_PTS1	563	566	PF00515	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS69	Leptomonas seymouri	61%	96%
A0A3Q8IEE2	Leishmania donovani	84%	100%
A4I4P4	Leishmania infantum	84%	100%
E9AE47	Leishmania major	82%	98%
E9ALN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%