PIH1_CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania braziliensis

UniProt:

A4HIY9_LEIBR

TriTrypDb:

LbrM.31.0250 , LBRM2903_310006900

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIY9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0022607	cellular component assembly	4	13
GO:0043933	protein-containing complex organization	4	13
GO:0065003	protein-containing complex assembly	5	13
GO:0070286	axonemal dynein complex assembly	6	13
GO:0071840	cellular component organization or biogenesis	2	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0051087	protein-folding chaperone binding	3	13
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.618
CLV_C14_Caspase3-7	244	248	PF00656	0.538
CLV_NRD_NRD_1	119	121	PF00675	0.531
CLV_NRD_NRD_1	90	92	PF00675	0.613
CLV_PCSK_KEX2_1	22	24	PF00082	0.413
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.413
CLV_PCSK_SKI1_1	148	152	PF00082	0.581
CLV_PCSK_SKI1_1	19	23	PF00082	0.527
CLV_PCSK_SKI1_1	254	258	PF00082	0.340
CLV_Separin_Metazoa	204	208	PF03568	0.474
DEG_APCC_DBOX_1	201	209	PF00400	0.558
DOC_CYCLIN_RxL_1	251	258	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.665
DOC_MAPK_gen_1	254	261	PF00069	0.505
DOC_MAPK_MEF2A_6	254	261	PF00069	0.481
DOC_PP2B_LxvP_1	233	236	PF13499	0.474
DOC_PP2B_LxvP_1	78	81	PF13499	0.522
DOC_PP4_FxxP_1	163	166	PF00568	0.424
DOC_PP4_FxxP_1	21	24	PF00568	0.501
DOC_USP7_MATH_1	155	159	PF00917	0.565
DOC_USP7_MATH_1	41	45	PF00917	0.625
DOC_USP7_MATH_1	81	85	PF00917	0.570
DOC_USP7_MATH_1	99	103	PF00917	0.720
LIG_14-3-3_CanoR_1	148	153	PF00244	0.572
LIG_14-3-3_CanoR_1	207	212	PF00244	0.528
LIG_14-3-3_CanoR_1	224	228	PF00244	0.361
LIG_Actin_WH2_2	211	226	PF00022	0.485
LIG_BRCT_BRCA1_1	38	42	PF00533	0.633
LIG_FHA_1	198	204	PF00498	0.508
LIG_FHA_1	256	262	PF00498	0.492
LIG_FHA_2	106	112	PF00498	0.480
LIG_FHA_2	160	166	PF00498	0.423
LIG_FHA_2	242	248	PF00498	0.538
LIG_FHA_2	70	76	PF00498	0.571
LIG_LIR_Apic_2	162	166	PF02991	0.506
LIG_LIR_Apic_2	20	24	PF02991	0.464
LIG_LIR_Nem_3	179	185	PF02991	0.461
LIG_PCNA_PIPBox_1	109	118	PF02747	0.509
LIG_PCNA_yPIPBox_3	109	121	PF02747	0.516
LIG_PDZ_Class_2	270	275	PF00595	0.559
LIG_SH2_STAP1	221	225	PF00017	0.461
LIG_SH2_STAT5	182	185	PF00017	0.428
LIG_SH2_STAT5	232	235	PF00017	0.432
LIG_SH3_3	200	206	PF00018	0.456
LIG_SH3_3	95	101	PF00018	0.569
LIG_TRAF2_1	162	165	PF00917	0.563
MOD_CK1_1	17	23	PF00069	0.511
MOD_CK1_1	193	199	PF00069	0.479
MOD_CK2_1	159	165	PF00069	0.566
MOD_CK2_1	207	213	PF00069	0.474
MOD_CK2_1	3	9	PF00069	0.508
MOD_CK2_1	99	105	PF00069	0.569
MOD_GlcNHglycan	101	104	PF01048	0.677
MOD_GlcNHglycan	176	179	PF01048	0.323
MOD_GlcNHglycan	192	195	PF01048	0.176
MOD_GlcNHglycan	3	6	PF01048	0.514
MOD_GlcNHglycan	38	41	PF01048	0.620
MOD_GlcNHglycan	43	46	PF01048	0.675
MOD_GlcNHglycan	48	51	PF01048	0.681
MOD_GSK3_1	10	17	PF00069	0.581
MOD_GSK3_1	144	151	PF00069	0.725
MOD_GSK3_1	155	162	PF00069	0.430
MOD_GSK3_1	185	192	PF00069	0.464
MOD_GSK3_1	193	200	PF00069	0.445
MOD_GSK3_1	36	43	PF00069	0.498
MOD_N-GLC_1	17	22	PF02516	0.563
MOD_N-GLC_1	174	179	PF02516	0.235
MOD_NEK2_1	1	6	PF00069	0.423
MOD_NEK2_1	14	19	PF00069	0.691
MOD_NEK2_1	223	228	PF00069	0.469
MOD_PIKK_1	105	111	PF00454	0.619
MOD_PK_1	207	213	PF00069	0.474
MOD_PKA_2	223	229	PF00069	0.408
MOD_PKA_2	99	105	PF00069	0.686
MOD_Plk_1	17	23	PF00069	0.492
MOD_Plk_2-3	159	165	PF00069	0.566
MOD_Plk_4	10	16	PF00069	0.490
MOD_Plk_4	148	154	PF00069	0.684
MOD_Plk_4	166	172	PF00069	0.356
MOD_Plk_4	69	75	PF00069	0.483
MOD_SUMO_rev_2	264	274	PF00179	0.576
TRG_ENDOCYTIC_2	182	185	PF00928	0.448
TRG_ER_diArg_1	117	120	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH00	Leptomonas seymouri	62%	99%
A0A0S4IJ87	Bodo saltans	37%	100%
A0A0S4JAL6	Bodo saltans	35%	100%
A0A1X0NZY8	Trypanosomatidae	32%	100%
A0A3Q8IIW1	Leishmania donovani	85%	98%
A0A422NNL4	Trypanosoma rangeli	38%	100%
A4I4P3	Leishmania infantum	85%	98%
C9ZLD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AE46	Leishmania major	81%	99%
E9ALN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
V5BBV3	Trypanosoma cruzi	38%	100%