Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIY8_LEIBR

TriTrypDb:

LbrM.31.0240 , LBRM2903_310006800

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.614
CLV_C14_Caspase3-7	226	230	PF00656	0.369
CLV_NRD_NRD_1	325	327	PF00675	0.737
CLV_PCSK_FUR_1	117	121	PF00082	0.472
CLV_PCSK_KEX2_1	119	121	PF00082	0.446
CLV_PCSK_KEX2_1	218	220	PF00082	0.558
CLV_PCSK_KEX2_1	324	326	PF00082	0.734
CLV_PCSK_KEX2_1	334	336	PF00082	0.755
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.472
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.558
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.750
CLV_PCSK_PC7_1	115	121	PF00082	0.514
CLV_PCSK_SKI1_1	261	265	PF00082	0.368
CLV_PCSK_SKI1_1	301	305	PF00082	0.682
CLV_PCSK_SKI1_1	91	95	PF00082	0.451
DEG_APCC_DBOX_1	231	239	PF00400	0.603
DEG_APCC_DBOX_1	68	76	PF00400	0.586
DEG_Nend_UBRbox_4	1	3	PF02207	0.444
DEG_SCF_FBW7_2	303	308	PF00400	0.734
DOC_MAPK_gen_1	218	224	PF00069	0.503
DOC_MAPK_gen_1	261	267	PF00069	0.485
DOC_USP7_MATH_1	25	29	PF00917	0.732
DOC_USP7_MATH_1	276	280	PF00917	0.582
DOC_USP7_MATH_1	46	50	PF00917	0.636
DOC_WW_Pin1_4	301	306	PF00397	0.698
LIG_Actin_WH2_2	231	248	PF00022	0.591
LIG_Clathr_ClatBox_1	195	199	PF01394	0.598
LIG_eIF4E_1	260	266	PF01652	0.553
LIG_FHA_1	123	129	PF00498	0.480
LIG_FHA_1	46	52	PF00498	0.649
LIG_FHA_1	74	80	PF00498	0.536
LIG_FHA_1	88	94	PF00498	0.368
LIG_LIR_Gen_1	163	173	PF02991	0.491
LIG_LIR_Gen_1	311	320	PF02991	0.698
LIG_LIR_Nem_3	163	169	PF02991	0.492
LIG_LIR_Nem_3	257	263	PF02991	0.468
LIG_LIR_Nem_3	311	317	PF02991	0.674
LIG_LRP6_Inhibitor_1	217	223	PF00058	0.561
LIG_NRP_CendR_1	334	337	PF00754	0.718
LIG_SH2_CRK	260	264	PF00017	0.482
LIG_SH2_CRK	314	318	PF00017	0.706
LIG_SH2_STAT3	38	41	PF00017	0.766
LIG_SH2_STAT5	38	41	PF00017	0.741
LIG_SH2_STAT5	8	11	PF00017	0.588
LIG_TRAF2_1	64	67	PF00917	0.619
LIG_TRAF2_1	98	101	PF00917	0.573
LIG_TYR_ITIM	258	263	PF00017	0.510
LIG_UBA3_1	264	272	PF00899	0.493
MOD_CK1_1	184	190	PF00069	0.536
MOD_CK2_1	276	282	PF00069	0.592
MOD_CK2_1	95	101	PF00069	0.571
MOD_Cter_Amidation	322	325	PF01082	0.707
MOD_GlcNHglycan	14	17	PF01048	0.704
MOD_GlcNHglycan	155	158	PF01048	0.511
MOD_GlcNHglycan	22	25	PF01048	0.601
MOD_GlcNHglycan	250	253	PF01048	0.535
MOD_GlcNHglycan	329	332	PF01048	0.653
MOD_GlcNHglycan	48	51	PF01048	0.647
MOD_GSK3_1	180	187	PF00069	0.415
MOD_GSK3_1	206	213	PF00069	0.512
MOD_GSK3_1	244	251	PF00069	0.519
MOD_GSK3_1	25	32	PF00069	0.742
MOD_GSK3_1	297	304	PF00069	0.627
MOD_GSK3_1	75	82	PF00069	0.607
MOD_GSK3_1	8	15	PF00069	0.599
MOD_N-GLC_1	87	92	PF02516	0.442
MOD_NEK2_1	180	185	PF00069	0.588
MOD_NEK2_1	245	250	PF00069	0.552
MOD_NEK2_1	75	80	PF00069	0.572
MOD_NEK2_1	87	92	PF00069	0.496
MOD_NEK2_1	95	100	PF00069	0.272
MOD_PIKK_1	123	129	PF00454	0.600
MOD_PIKK_1	93	99	PF00454	0.530
MOD_PKA_2	181	187	PF00069	0.602
MOD_Plk_1	87	93	PF00069	0.504
MOD_Plk_4	276	282	PF00069	0.540
MOD_ProDKin_1	301	307	PF00069	0.700
MOD_SUMO_rev_2	253	263	PF00179	0.459
MOD_SUMO_rev_2	308	313	PF00179	0.720
MOD_SUMO_rev_2	78	87	PF00179	0.498
MOD_SUMO_rev_2	96	105	PF00179	0.370
TRG_DiLeu_BaEn_1	54	59	PF01217	0.624
TRG_DiLeu_BaEn_4	164	170	PF01217	0.339
TRG_ENDOCYTIC_2	260	263	PF00928	0.483
TRG_ENDOCYTIC_2	314	317	PF00928	0.666
TRG_ER_diArg_1	114	117	PF00400	0.513
TRG_ER_diArg_1	334	337	PF00400	0.768
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC73	Leptomonas seymouri	67%	100%
A0A0S4J6B5	Bodo saltans	31%	71%
A0A1X0P000	Trypanosomatidae	31%	93%
A0A3S7X2L2	Leishmania donovani	88%	100%
A4I4P2	Leishmania infantum	88%	100%
C9ZLD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
E9AE45	Leishmania major	86%	100%
E9ALP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BKZ3	Trypanosoma cruzi	30%	93%