Folliculin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vesicle coat protein involved in Golgi to plasma membrane transport, putative

Species:

Leishmania braziliensis

UniProt:

A4HIY5_LEIBR

TriTrypDb:

LbrM.31.0210 , LBRM2903_310006300

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005765	lysosomal membrane	7	1
GO:0005774	vacuolar membrane	5	1
GO:0005815	microtubule organizing center	2	1
GO:0005819	spindle	5	1
GO:0005829	cytosol	2	1
GO:0005929	cilium	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098852	lytic vacuole membrane	6	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HIY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIY5

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	1
GO:0009967	positive regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010647	positive regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023056	positive regulation of signaling	4	1
GO:0032006	regulation of TOR signaling	6	1
GO:0032008	positive regulation of TOR signaling	7	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048584	positive regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902533	positive regulation of intracellular signal transduction	6	1
GO:1903432	regulation of TORC1 signaling	7	1
GO:1904263	positive regulation of TORC1 signaling	8	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	10
GO:0008047	enzyme activator activity	3	10
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.561
CLV_NRD_NRD_1	114	116	PF00675	0.335
CLV_NRD_NRD_1	144	146	PF00675	0.438
CLV_NRD_NRD_1	172	174	PF00675	0.410
CLV_NRD_NRD_1	424	426	PF00675	0.542
CLV_PCSK_KEX2_1	113	115	PF00082	0.336
CLV_PCSK_KEX2_1	144	146	PF00082	0.382
CLV_PCSK_KEX2_1	172	174	PF00082	0.410
CLV_PCSK_KEX2_1	424	426	PF00082	0.542
CLV_PCSK_KEX2_1	580	582	PF00082	0.507
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.355
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.507
CLV_PCSK_PC7_1	110	116	PF00082	0.335
CLV_PCSK_PC7_1	168	174	PF00082	0.447
CLV_PCSK_SKI1_1	177	181	PF00082	0.447
CLV_PCSK_SKI1_1	31	35	PF00082	0.621
CLV_PCSK_SKI1_1	314	318	PF00082	0.488
CLV_PCSK_SKI1_1	364	368	PF00082	0.529
CLV_PCSK_SKI1_1	375	379	PF00082	0.390
CLV_PCSK_SKI1_1	40	44	PF00082	0.513
CLV_PCSK_SKI1_1	449	453	PF00082	0.544
CLV_PCSK_SKI1_1	49	53	PF00082	0.418
CLV_PCSK_SKI1_1	536	540	PF00082	0.488
DEG_APCC_DBOX_1	114	122	PF00400	0.447
DEG_APCC_DBOX_1	172	180	PF00400	0.480
DEG_APCC_DBOX_1	39	47	PF00400	0.605
DEG_APCC_DBOX_1	580	588	PF00400	0.503
DEG_Kelch_Keap1_1	559	564	PF01344	0.518
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_SCF_FBW7_1	507	514	PF00400	0.671
DOC_AGCK_PIF_2	24	29	PF00069	0.561
DOC_CKS1_1	508	513	PF01111	0.679
DOC_CYCLIN_RxL_1	271	282	PF00134	0.687
DOC_CYCLIN_RxL_1	310	318	PF00134	0.483
DOC_CYCLIN_RxL_1	34	47	PF00134	0.585
DOC_CYCLIN_RxL_1	371	381	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.571
DOC_MAPK_gen_1	110	120	PF00069	0.333
DOC_PP1_RVXF_1	272	279	PF00149	0.696
DOC_PP1_RVXF_1	362	369	PF00149	0.406
DOC_PP2B_LxvP_1	183	186	PF13499	0.458
DOC_PP2B_LxvP_1	2	5	PF13499	0.349
DOC_PP2B_LxvP_1	377	380	PF13499	0.329
DOC_PP4_FxxP_1	102	105	PF00568	0.447
DOC_PP4_FxxP_1	120	123	PF00568	0.447
DOC_USP7_MATH_1	175	179	PF00917	0.389
DOC_USP7_MATH_1	193	197	PF00917	0.565
DOC_USP7_MATH_1	224	228	PF00917	0.557
DOC_USP7_MATH_1	300	304	PF00917	0.413
DOC_USP7_MATH_1	33	37	PF00917	0.404
DOC_USP7_MATH_1	360	364	PF00917	0.489
DOC_USP7_MATH_1	427	431	PF00917	0.647
DOC_USP7_MATH_1	511	515	PF00917	0.748
DOC_USP7_MATH_1	516	520	PF00917	0.742
DOC_USP7_MATH_1	527	531	PF00917	0.700
DOC_USP7_MATH_1	556	560	PF00917	0.732
DOC_USP7_MATH_1	574	578	PF00917	0.680
DOC_WW_Pin1_4	378	383	PF00397	0.530
DOC_WW_Pin1_4	387	392	PF00397	0.600
DOC_WW_Pin1_4	507	512	PF00397	0.781
DOC_WW_Pin1_4	520	525	PF00397	0.586
DOC_WW_Pin1_4	582	587	PF00397	0.721
LIG_14-3-3_CanoR_1	177	186	PF00244	0.344
LIG_14-3-3_CanoR_1	254	262	PF00244	0.693
LIG_14-3-3_CanoR_1	364	369	PF00244	0.449
LIG_14-3-3_CanoR_1	449	454	PF00244	0.542
LIG_14-3-3_CanoR_1	526	533	PF00244	0.704
LIG_14-3-3_CanoR_1	545	549	PF00244	0.669
LIG_14-3-3_CanoR_1	570	574	PF00244	0.769
LIG_Actin_WH2_2	410	426	PF00022	0.558
LIG_APCC_ABBAyCdc20_2	274	280	PF00400	0.703
LIG_BRCT_BRCA1_1	98	102	PF00533	0.370
LIG_Clathr_ClatBox_1	276	280	PF01394	0.709
LIG_Clathr_ClatBox_1	396	400	PF01394	0.556
LIG_DCNL_PONY_1	1	4	PF03556	0.375
LIG_FHA_1	137	143	PF00498	0.227
LIG_FHA_1	178	184	PF00498	0.424
LIG_FHA_1	381	387	PF00498	0.623
LIG_FHA_1	438	444	PF00498	0.575
LIG_FHA_2	297	303	PF00498	0.548
LIG_FHA_2	323	329	PF00498	0.549
LIG_FHA_2	437	443	PF00498	0.740
LIG_FHA_2	76	82	PF00498	0.541
LIG_GBD_Chelix_1	335	343	PF00786	0.421
LIG_LIR_Apic_2	338	344	PF02991	0.439
LIG_LIR_Apic_2	354	360	PF02991	0.441
LIG_LIR_Apic_2	99	105	PF02991	0.447
LIG_LIR_Gen_1	11	20	PF02991	0.432
LIG_LIR_Gen_1	124	130	PF02991	0.374
LIG_LIR_Gen_1	136	143	PF02991	0.277
LIG_LIR_Gen_1	157	164	PF02991	0.372
LIG_LIR_Gen_1	21	32	PF02991	0.451
LIG_LIR_Gen_1	374	384	PF02991	0.607
LIG_LIR_Nem_3	11	15	PF02991	0.437
LIG_LIR_Nem_3	124	128	PF02991	0.374
LIG_LIR_Nem_3	136	141	PF02991	0.277
LIG_LIR_Nem_3	157	161	PF02991	0.362
LIG_LIR_Nem_3	21	27	PF02991	0.434
LIG_LIR_Nem_3	28	32	PF02991	0.474
LIG_LIR_Nem_3	374	379	PF02991	0.578
LIG_LIR_Nem_3	546	552	PF02991	0.496
LIG_LIR_Nem_3	67	71	PF02991	0.319
LIG_NRBOX	178	184	PF00104	0.363
LIG_PCNA_PIPBox_1	370	379	PF02747	0.321
LIG_PCNA_yPIPBox_3	364	377	PF02747	0.462
LIG_Pex14_1	291	295	PF04695	0.382
LIG_Pex14_2	116	120	PF04695	0.447
LIG_Pex14_2	8	12	PF04695	0.506
LIG_Rb_pABgroove_1	391	399	PF01858	0.567
LIG_SH2_CRK	158	162	PF00017	0.441
LIG_SH2_CRK	341	345	PF00017	0.548
LIG_SH2_CRK	357	361	PF00017	0.434
LIG_SH2_CRK	493	497	PF00017	0.558
LIG_SH2_CRK	549	553	PF00017	0.638
LIG_SH2_GRB2like	68	71	PF00017	0.528
LIG_SH2_NCK_1	158	162	PF00017	0.441
LIG_SH2_NCK_1	341	345	PF00017	0.590
LIG_SH2_SRC	89	92	PF00017	0.591
LIG_SH2_STAP1	158	162	PF00017	0.480
LIG_SH2_STAP1	22	26	PF00017	0.544
LIG_SH2_STAP1	361	365	PF00017	0.464
LIG_SH2_STAT3	588	591	PF00017	0.709
LIG_SH2_STAT5	134	137	PF00017	0.480
LIG_SH2_STAT5	26	29	PF00017	0.526
LIG_SH2_STAT5	341	344	PF00017	0.548
LIG_SH2_STAT5	376	379	PF00017	0.579
LIG_SH2_STAT5	457	460	PF00017	0.559
LIG_SH2_STAT5	486	489	PF00017	0.521
LIG_SH2_STAT5	597	600	PF00017	0.673
LIG_SH2_STAT5	68	71	PF00017	0.528
LIG_SH3_3	210	216	PF00018	0.559
LIG_SH3_3	281	287	PF00018	0.560
LIG_SH3_3	376	382	PF00018	0.580
LIG_SH3_3	505	511	PF00018	0.769
LIG_SUMO_SIM_par_1	180	187	PF11976	0.227
LIG_SUMO_SIM_par_1	438	445	PF11976	0.492
LIG_TRAF2_1	198	201	PF00917	0.589
LIG_TRAF2_1	498	501	PF00917	0.670
LIG_TRAF2_1	82	85	PF00917	0.521
LIG_TRFH_1	341	345	PF08558	0.590
LIG_UBA3_1	267	274	PF00899	0.447
LIG_UBA3_1	42	49	PF00899	0.379
LIG_WRC_WIRS_1	365	370	PF05994	0.397
LIG_WRC_WIRS_1	599	604	PF05994	0.685
LIG_WRC_WIRS_1	97	102	PF05994	0.447
MOD_CDC14_SPxK_1	523	526	PF00782	0.713
MOD_CDK_SPxK_1	520	526	PF00069	0.698
MOD_CK1_1	136	142	PF00069	0.323
MOD_CK1_1	192	198	PF00069	0.614
MOD_CK1_1	465	471	PF00069	0.658
MOD_CK1_1	528	534	PF00069	0.668
MOD_CK1_1	547	553	PF00069	0.609
MOD_CK1_1	555	561	PF00069	0.597
MOD_CK1_1	572	578	PF00069	0.658
MOD_CK1_1	79	85	PF00069	0.512
MOD_CK2_1	121	127	PF00069	0.413
MOD_CK2_1	175	181	PF00069	0.370
MOD_CK2_1	296	302	PF00069	0.538
MOD_CK2_1	436	442	PF00069	0.749
MOD_CK2_1	495	501	PF00069	0.690
MOD_CK2_1	558	564	PF00069	0.739
MOD_CK2_1	75	81	PF00069	0.469
MOD_GlcNHglycan	191	194	PF01048	0.683
MOD_GlcNHglycan	195	198	PF01048	0.581
MOD_GlcNHglycan	302	305	PF01048	0.550
MOD_GlcNHglycan	317	320	PF01048	0.404
MOD_GlcNHglycan	469	472	PF01048	0.643
MOD_GlcNHglycan	512	516	PF01048	0.679
MOD_GlcNHglycan	527	530	PF01048	0.686
MOD_GlcNHglycan	541	544	PF01048	0.690
MOD_GlcNHglycan	549	552	PF01048	0.653
MOD_GlcNHglycan	554	557	PF01048	0.529
MOD_GlcNHglycan	558	561	PF01048	0.670
MOD_GlcNHglycan	57	60	PF01048	0.575
MOD_GlcNHglycan	91	94	PF01048	0.525
MOD_GSK3_1	144	151	PF00069	0.417
MOD_GSK3_1	177	184	PF00069	0.468
MOD_GSK3_1	189	196	PF00069	0.572
MOD_GSK3_1	296	303	PF00069	0.599
MOD_GSK3_1	331	338	PF00069	0.456
MOD_GSK3_1	339	346	PF00069	0.558
MOD_GSK3_1	360	367	PF00069	0.466
MOD_GSK3_1	437	444	PF00069	0.682
MOD_GSK3_1	458	465	PF00069	0.558
MOD_GSK3_1	503	510	PF00069	0.625
MOD_GSK3_1	516	523	PF00069	0.532
MOD_GSK3_1	539	546	PF00069	0.648
MOD_GSK3_1	552	559	PF00069	0.523
MOD_GSK3_1	569	576	PF00069	0.710
MOD_GSK3_1	75	82	PF00069	0.474
MOD_GSK3_1	96	103	PF00069	0.428
MOD_N-GLC_1	34	39	PF02516	0.408
MOD_N-GLC_1	436	441	PF02516	0.681
MOD_N-GLC_1	79	84	PF02516	0.514
MOD_NEK2_1	100	105	PF00069	0.471
MOD_NEK2_1	247	252	PF00069	0.573
MOD_NEK2_1	296	301	PF00069	0.606
MOD_NEK2_1	335	340	PF00069	0.395
MOD_NEK2_1	366	371	PF00069	0.482
MOD_NEK2_1	386	391	PF00069	0.351
MOD_NEK2_1	474	479	PF00069	0.564
MOD_NEK2_1	525	530	PF00069	0.643
MOD_NEK2_1	539	544	PF00069	0.608
MOD_NEK2_1	573	578	PF00069	0.556
MOD_NEK2_2	544	549	PF00069	0.720
MOD_PIKK_1	144	150	PF00454	0.447
MOD_PIKK_1	366	372	PF00454	0.453
MOD_PIKK_1	474	480	PF00454	0.459
MOD_PK_1	34	40	PF00069	0.653
MOD_PK_1	413	419	PF00069	0.445
MOD_PKA_1	144	150	PF00069	0.422
MOD_PKA_2	144	150	PF00069	0.422
MOD_PKA_2	412	418	PF00069	0.575
MOD_PKA_2	525	531	PF00069	0.748
MOD_PKA_2	544	550	PF00069	0.738
MOD_PKA_2	569	575	PF00069	0.728
MOD_Plk_1	34	40	PF00069	0.551
MOD_Plk_1	436	442	PF00069	0.758
MOD_Plk_1	462	468	PF00069	0.672
MOD_Plk_1	503	509	PF00069	0.683
MOD_Plk_2-3	181	187	PF00069	0.227
MOD_Plk_2-3	442	448	PF00069	0.650
MOD_Plk_4	34	40	PF00069	0.643
MOD_Plk_4	343	349	PF00069	0.510
MOD_Plk_4	449	455	PF00069	0.532
MOD_Plk_4	47	53	PF00069	0.508
MOD_Plk_4	528	534	PF00069	0.631
MOD_Plk_4	544	550	PF00069	0.561
MOD_Plk_4	96	102	PF00069	0.379
MOD_ProDKin_1	378	384	PF00069	0.534
MOD_ProDKin_1	387	393	PF00069	0.592
MOD_ProDKin_1	507	513	PF00069	0.778
MOD_ProDKin_1	520	526	PF00069	0.588
MOD_ProDKin_1	582	588	PF00069	0.722
TRG_DiLeu_BaEn_1	47	52	PF01217	0.624
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.572
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.569
TRG_ENDOCYTIC_2	125	128	PF00928	0.447
TRG_ENDOCYTIC_2	158	161	PF00928	0.355
TRG_ENDOCYTIC_2	26	29	PF00928	0.482
TRG_ENDOCYTIC_2	376	379	PF00928	0.569
TRG_ENDOCYTIC_2	493	496	PF00928	0.508
TRG_ENDOCYTIC_2	549	552	PF00928	0.669
TRG_ER_diArg_1	114	116	PF00400	0.335
TRG_ER_diArg_1	143	145	PF00400	0.430
TRG_ER_diArg_1	423	425	PF00400	0.547
TRG_ER_diArg_1	488	491	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V0	Leptomonas seymouri	59%	97%
A0A1X0NZX4	Trypanosomatidae	27%	100%
A0A3Q8IF87	Leishmania donovani	84%	99%
A0A3R7KI94	Trypanosoma rangeli	30%	100%
A4I4N9	Leishmania infantum	85%	99%
C9ZLC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AE42	Leishmania major	82%	99%
E9ALP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5ATT7	Trypanosoma cruzi	31%	100%