2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diphthamide synthesis protein

Species:

Leishmania braziliensis

UniProt:

A4HIY1_LEIBR

TriTrypDb:

LbrM.31.0170 , LBRM2903_310005900

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIY1

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	11
GO:0006448	regulation of translational elongation	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010608	post-transcriptional regulation of gene expression	6	11
GO:0017182	peptidyl-diphthamide metabolic process	7	11
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018202	peptidyl-histidine modification	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0019538	protein metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0034248	regulation of amide metabolic process	5	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1900247	regulation of cytoplasmic translational elongation	8	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.450
CLV_NRD_NRD_1	249	251	PF00675	0.230
CLV_NRD_NRD_1	44	46	PF00675	0.475
CLV_PCSK_KEX2_1	249	251	PF00082	0.271
CLV_PCSK_KEX2_1	290	292	PF00082	0.338
CLV_PCSK_KEX2_1	36	38	PF00082	0.311
CLV_PCSK_KEX2_1	44	46	PF00082	0.311
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.318
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.329
CLV_PCSK_SKI1_1	290	294	PF00082	0.255
CLV_PCSK_SKI1_1	304	308	PF00082	0.188
CLV_PCSK_SKI1_1	33	37	PF00082	0.354
CLV_PCSK_SKI1_1	332	336	PF00082	0.228
CLV_PCSK_SKI1_1	45	49	PF00082	0.328
DEG_APCC_DBOX_1	158	166	PF00400	0.511
DEG_APCC_DBOX_1	290	298	PF00400	0.461
DEG_Nend_UBRbox_2	1	3	PF02207	0.436
DOC_CYCLIN_RxL_1	15	25	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.428
DOC_MAPK_gen_1	287	296	PF00069	0.446
DOC_MAPK_gen_1	39	48	PF00069	0.337
DOC_MAPK_HePTP_8	284	296	PF00069	0.446
DOC_MAPK_HePTP_8	38	50	PF00069	0.297
DOC_MAPK_MEF2A_6	287	296	PF00069	0.446
DOC_MAPK_MEF2A_6	41	50	PF00069	0.294
DOC_PP2B_LxvP_1	21	24	PF13499	0.351
DOC_PP4_FxxP_1	170	173	PF00568	0.415
DOC_PP4_FxxP_1	330	333	PF00568	0.428
DOC_PP4_FxxP_1	57	60	PF00568	0.428
DOC_SPAK_OSR1_1	210	214	PF12202	0.510
DOC_SPAK_OSR1_1	28	32	PF12202	0.320
DOC_USP7_MATH_1	68	72	PF00917	0.467
DOC_USP7_MATH_2	197	203	PF00917	0.360
DOC_WW_Pin1_4	189	194	PF00397	0.415
DOC_WW_Pin1_4	333	338	PF00397	0.446
LIG_14-3-3_CanoR_1	180	188	PF00244	0.446
LIG_14-3-3_CanoR_1	291	295	PF00244	0.493
LIG_APCC_ABBA_1	119	124	PF00400	0.415
LIG_BRCT_BRCA1_1	297	301	PF00533	0.428
LIG_CaM_IQ_9	4	20	PF13499	0.486
LIG_deltaCOP1_diTrp_1	325	330	PF00928	0.428
LIG_eIF4E_1	102	108	PF01652	0.415
LIG_FHA_1	182	188	PF00498	0.549
LIG_FHA_1	291	297	PF00498	0.450
LIG_FHA_2	67	73	PF00498	0.418
LIG_LIR_Apic_2	167	173	PF02991	0.427
LIG_LIR_Gen_1	261	269	PF02991	0.430
LIG_LIR_Gen_1	312	322	PF02991	0.428
LIG_LIR_Nem_3	261	265	PF02991	0.463
LIG_LIR_Nem_3	312	317	PF02991	0.439
LIG_MYND_1	333	337	PF01753	0.428
LIG_Pex14_1	326	330	PF04695	0.428
LIG_Pex14_1	349	353	PF04695	0.446
LIG_PTB_Apo_2	114	121	PF02174	0.443
LIG_PTB_Phospho_1	114	120	PF10480	0.443
LIG_SH2_NCK_1	240	244	PF00017	0.461
LIG_SH2_NCK_1	358	362	PF00017	0.255
LIG_SH2_PTP2	120	123	PF00017	0.415
LIG_SH2_PTP2	314	317	PF00017	0.446
LIG_SH2_STAP1	338	342	PF00017	0.428
LIG_SH2_STAT5	120	123	PF00017	0.429
LIG_SH2_STAT5	205	208	PF00017	0.415
LIG_SH2_STAT5	314	317	PF00017	0.446
LIG_SH2_STAT5	368	371	PF00017	0.427
LIG_SH3_3	171	177	PF00018	0.428
LIG_SH3_3	314	320	PF00018	0.447
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.510
LIG_SUMO_SIM_par_1	105	112	PF11976	0.415
LIG_SUMO_SIM_par_1	292	299	PF11976	0.510
LIG_SUMO_SIM_par_1	71	78	PF11976	0.418
LIG_UBA3_1	107	111	PF00899	0.415
LIG_UBA3_1	296	304	PF00899	0.441
LIG_WRC_WIRS_1	213	218	PF05994	0.428
MOD_CDK_SPK_2	189	194	PF00069	0.471
MOD_CK1_1	236	242	PF00069	0.485
MOD_CK2_1	180	186	PF00069	0.446
MOD_CK2_1	333	339	PF00069	0.446
MOD_CK2_1	66	72	PF00069	0.415
MOD_Cter_Amidation	288	291	PF01082	0.261
MOD_GlcNHglycan	222	226	PF01048	0.311
MOD_GlcNHglycan	87	92	PF01048	0.228
MOD_GSK3_1	102	109	PF00069	0.417
MOD_LATS_1	288	294	PF00433	0.406
MOD_NEK2_1	132	137	PF00069	0.439
MOD_NEK2_1	154	159	PF00069	0.444
MOD_NEK2_1	188	193	PF00069	0.415
MOD_NEK2_1	55	60	PF00069	0.390
MOD_NEK2_2	106	111	PF00069	0.415
MOD_PIKK_1	233	239	PF00454	0.360
MOD_PKA_1	290	296	PF00069	0.488
MOD_PKA_2	290	296	PF00069	0.548
MOD_PKA_2	320	326	PF00069	0.430
MOD_Plk_1	221	227	PF00069	0.406
MOD_Plk_1	77	83	PF00069	0.417
MOD_Plk_4	199	205	PF00069	0.461
MOD_Plk_4	212	218	PF00069	0.431
MOD_Plk_4	290	296	PF00069	0.448
MOD_ProDKin_1	189	195	PF00069	0.415
MOD_ProDKin_1	333	339	PF00069	0.446
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.428
TRG_ENDOCYTIC_2	120	123	PF00928	0.415
TRG_ENDOCYTIC_2	314	317	PF00928	0.455
TRG_ER_diArg_1	248	250	PF00400	0.471
TRG_ER_diArg_1	44	46	PF00400	0.475
TRG_NES_CRM1_1	112	126	PF08389	0.428
TRG_NES_CRM1_1	153	168	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHA4	Leptomonas seymouri	91%	100%
A0A0S4JS33	Bodo saltans	70%	94%
A0A1D8PL26	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	71%
A0A1X0P135	Trypanosomatidae	76%	100%
A0A3Q8IRF6	Leishmania donovani	95%	100%
A0A3R7MRI9	Trypanosoma rangeli	74%	100%
A0A8C2MDK8	Cricetulus griseus	50%	85%
A4I4N6	Leishmania infantum	95%	100%
A4QN59	Danio rerio	27%	75%
A7SKJ3	Nematostella vectensis	25%	70%
A7SLX5	Nematostella vectensis	50%	80%
C9ZLC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AE39	Leishmania major	95%	100%
E9ALP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O58832	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O59713	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	86%
P0CN18	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	38%	71%
P0CN19	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	38%	71%
P0CN20	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	72%
P0CN21	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	72%
P32461	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	70%
P40487	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	88%
P49958	Caenorhabditis elegans	49%	94%
Q002B5	Cricetulus griseus	27%	76%
Q08DM2	Bos taurus	29%	76%
Q09454	Caenorhabditis elegans	27%	78%
Q10206	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	74%
Q3SYT1	Bos taurus	51%	85%
Q3T7C9	Penaeus vannamei	47%	88%
Q4I5M4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	22%	70%
Q4IQ72	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	49%	81%
Q4WN99	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	21%	66%
Q4X0S7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	52%	84%
Q54PW5	Dictyostelium discoideum	51%	79%
Q567W6	Danio rerio	50%	98%
Q568Y2	Rattus norvegicus	30%	76%
Q57907	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q59MG1	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	88%
Q59SJ9	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	71%
Q5AZJ7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	50%	87%
Q5NCQ5	Mus musculus	50%	85%
Q5RE82	Pongo abelii	29%	76%
Q5ZHX9	Gallus gallus	50%	91%
Q5ZKI2	Gallus gallus	31%	78%
Q6BPU5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	48%	89%
Q6C0S8	Yarrowia lipolytica (strain CLIB 122 / E 150)	48%	85%
Q6CGE7	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	78%
Q6CLC9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	47%	88%
Q6DE00	Xenopus laevis	27%	78%
Q6FTG1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	45%	87%
Q6GPQ5	Xenopus laevis	53%	85%
Q75AZ9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	46%	88%
Q7SC98	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	49%	81%
Q8SUZ5	Encephalitozoon cuniculi (strain GB-M1)	41%	100%
Q9BQC3	Homo sapiens	28%	76%
Q9BZG8	Homo sapiens	51%	84%
Q9CR25	Mus musculus	28%	76%