Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIX7_LEIBR

TriTrypDb:

LbrM.31.0130 , LBRM2903_310009000

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.631
CLV_C14_Caspase3-7	238	242	PF00656	0.487
CLV_C14_Caspase3-7	248	252	PF00656	0.590
CLV_C14_Caspase3-7	348	352	PF00656	0.362
CLV_C14_Caspase3-7	41	45	PF00656	0.630
CLV_NRD_NRD_1	1	3	PF00675	0.686
CLV_NRD_NRD_1	138	140	PF00675	0.526
CLV_NRD_NRD_1	269	271	PF00675	0.614
CLV_NRD_NRD_1	320	322	PF00675	0.530
CLV_NRD_NRD_1	365	367	PF00675	0.508
CLV_NRD_NRD_1	496	498	PF00675	0.405
CLV_NRD_NRD_1	511	513	PF00675	0.506
CLV_NRD_NRD_1	575	577	PF00675	0.519
CLV_NRD_NRD_1	595	597	PF00675	0.534
CLV_NRD_NRD_1	604	606	PF00675	0.544
CLV_PCSK_FUR_1	318	322	PF00082	0.547
CLV_PCSK_FUR_1	573	577	PF00082	0.531
CLV_PCSK_FUR_1	7	11	PF00082	0.664
CLV_PCSK_KEX2_1	138	140	PF00082	0.614
CLV_PCSK_KEX2_1	268	270	PF00082	0.600
CLV_PCSK_KEX2_1	320	322	PF00082	0.508
CLV_PCSK_KEX2_1	472	474	PF00082	0.507
CLV_PCSK_KEX2_1	496	498	PF00082	0.445
CLV_PCSK_KEX2_1	511	513	PF00082	0.466
CLV_PCSK_KEX2_1	519	521	PF00082	0.489
CLV_PCSK_KEX2_1	575	577	PF00082	0.532
CLV_PCSK_KEX2_1	586	588	PF00082	0.494
CLV_PCSK_KEX2_1	595	597	PF00082	0.429
CLV_PCSK_KEX2_1	604	606	PF00082	0.484
CLV_PCSK_KEX2_1	9	11	PF00082	0.681
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.614
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.507
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.373
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.566
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.662
CLV_PCSK_PC7_1	264	270	PF00082	0.580
CLV_PCSK_SKI1_1	38	42	PF00082	0.756
CLV_PCSK_SKI1_1	532	536	PF00082	0.586
CLV_PCSK_SKI1_1	575	579	PF00082	0.510
CLV_PCSK_SKI1_1	586	590	PF00082	0.678
CLV_PCSK_SKI1_1	652	656	PF00082	0.475
CLV_PCSK_SKI1_1	91	95	PF00082	0.492
DEG_APCC_DBOX_1	474	482	PF00400	0.416
DEG_APCC_DBOX_1	574	582	PF00400	0.440
DEG_APCC_DBOX_1	801	809	PF00400	0.612
DEG_Nend_UBRbox_1	1	4	PF02207	0.494
DEG_SCF_TRCP1_1	737	743	PF00400	0.407
DEG_SPOP_SBC_1	153	157	PF00917	0.498
DEG_SPOP_SBC_1	233	237	PF00917	0.673
DOC_CKS1_1	179	184	PF01111	0.511
DOC_MAPK_gen_1	458	467	PF00069	0.450
DOC_MAPK_gen_1	472	480	PF00069	0.375
DOC_MAPK_gen_1	687	695	PF00069	0.399
DOC_MAPK_MEF2A_6	357	364	PF00069	0.447
DOC_MAPK_MEF2A_6	486	493	PF00069	0.338
DOC_PIKK_1	772	780	PF02985	0.519
DOC_PP1_RVXF_1	370	377	PF00149	0.511
DOC_PP2B_LxvP_1	210	213	PF13499	0.675
DOC_USP7_MATH_1	153	157	PF00917	0.608
DOC_USP7_MATH_1	160	164	PF00917	0.571
DOC_USP7_MATH_1	171	175	PF00917	0.639
DOC_USP7_MATH_1	233	237	PF00917	0.677
DOC_USP7_MATH_1	240	244	PF00917	0.654
DOC_USP7_MATH_1	302	306	PF00917	0.674
DOC_USP7_MATH_1	350	354	PF00917	0.523
DOC_USP7_MATH_1	804	808	PF00917	0.679
DOC_USP7_MATH_1	82	86	PF00917	0.710
DOC_USP7_UBL2_3	30	34	PF12436	0.630
DOC_USP7_UBL2_3	582	586	PF12436	0.595
DOC_WW_Pin1_4	101	106	PF00397	0.692
DOC_WW_Pin1_4	128	133	PF00397	0.571
DOC_WW_Pin1_4	154	159	PF00397	0.704
DOC_WW_Pin1_4	169	174	PF00397	0.567
DOC_WW_Pin1_4	178	183	PF00397	0.634
DOC_WW_Pin1_4	280	285	PF00397	0.590
DOC_WW_Pin1_4	72	77	PF00397	0.714
DOC_WW_Pin1_4	797	802	PF00397	0.543
LIG_14-3-3_CanoR_1	200	206	PF00244	0.692
LIG_14-3-3_CanoR_1	268	274	PF00244	0.636
LIG_14-3-3_CanoR_1	303	307	PF00244	0.511
LIG_14-3-3_CanoR_1	357	363	PF00244	0.508
LIG_14-3-3_CanoR_1	453	461	PF00244	0.374
LIG_14-3-3_CanoR_1	616	622	PF00244	0.530
LIG_14-3-3_CanoR_1	652	660	PF00244	0.506
LIG_14-3-3_CanoR_1	690	696	PF00244	0.476
LIG_14-3-3_CanoR_1	754	762	PF00244	0.434
LIG_14-3-3_CanoR_1	766	770	PF00244	0.575
LIG_14-3-3_CanoR_1	788	797	PF00244	0.553
LIG_14-3-3_CanoR_1	802	810	PF00244	0.738
LIG_Actin_WH2_2	590	606	PF00022	0.384
LIG_Actin_WH2_2	646	663	PF00022	0.335
LIG_BIR_III_4	241	245	PF00653	0.503
LIG_BRCT_BRCA1_1	201	205	PF00533	0.699
LIG_BRCT_BRCA1_1	47	51	PF00533	0.599
LIG_EVH1_1	210	214	PF00568	0.649
LIG_FHA_1	118	124	PF00498	0.610
LIG_FHA_1	226	232	PF00498	0.673
LIG_FHA_1	252	258	PF00498	0.577
LIG_FHA_1	310	316	PF00498	0.632
LIG_FHA_1	466	472	PF00498	0.411
LIG_FHA_1	488	494	PF00498	0.341
LIG_FHA_1	616	622	PF00498	0.625
LIG_FHA_1	694	700	PF00498	0.506
LIG_FHA_1	790	796	PF00498	0.425
LIG_FHA_2	311	317	PF00498	0.449
LIG_FHA_2	381	387	PF00498	0.472
LIG_FHA_2	39	45	PF00498	0.575
LIG_FHA_2	51	57	PF00498	0.568
LIG_FHA_2	534	540	PF00498	0.577
LIG_FHA_2	653	659	PF00498	0.506
LIG_FHA_2	696	702	PF00498	0.489
LIG_FHA_2	766	772	PF00498	0.505
LIG_GBD_Chelix_1	86	94	PF00786	0.506
LIG_Integrin_isoDGR_2	773	775	PF01839	0.488
LIG_LIR_Gen_1	381	390	PF02991	0.436
LIG_LIR_Nem_3	409	414	PF02991	0.460
LIG_NRBOX	428	434	PF00104	0.514
LIG_RPA_C_Fungi	492	504	PF08784	0.362
LIG_SH2_CRK	179	183	PF00017	0.512
LIG_SH2_CRK	411	415	PF00017	0.527
LIG_SH2_GRB2like	415	418	PF00017	0.341
LIG_SH2_STAP1	434	438	PF00017	0.486
LIG_SH2_STAP1	450	454	PF00017	0.355
LIG_SH2_STAP1	517	521	PF00017	0.512
LIG_SH2_STAP1	617	621	PF00017	0.542
LIG_SH2_STAT3	666	669	PF00017	0.485
LIG_SH2_STAT5	617	620	PF00017	0.521
LIG_SH2_STAT5	790	793	PF00017	0.527
LIG_SH3_3	104	110	PF00018	0.701
LIG_SH3_3	147	153	PF00018	0.540
LIG_SH3_3	208	214	PF00018	0.675
LIG_SH3_3	798	804	PF00018	0.534
LIG_SUMO_SIM_par_1	488	494	PF11976	0.471
LIG_TRAF2_1	704	707	PF00917	0.545
LIG_WW_3	212	216	PF00397	0.659
MOD_CDC14_SPxK_1	283	286	PF00782	0.617
MOD_CDK_SPK_2	797	802	PF00069	0.595
MOD_CDK_SPxK_1	280	286	PF00069	0.608
MOD_CK1_1	101	107	PF00069	0.713
MOD_CK1_1	111	117	PF00069	0.518
MOD_CK1_1	163	169	PF00069	0.712
MOD_CK1_1	226	232	PF00069	0.645
MOD_CK1_1	272	278	PF00069	0.661
MOD_CK1_1	311	317	PF00069	0.449
MOD_CK1_1	345	351	PF00069	0.367
MOD_CK1_1	403	409	PF00069	0.384
MOD_CK1_1	445	451	PF00069	0.454
MOD_CK1_1	58	64	PF00069	0.624
MOD_CK1_1	612	618	PF00069	0.536
MOD_CK1_1	622	628	PF00069	0.409
MOD_CK1_1	735	741	PF00069	0.484
MOD_CK1_1	757	763	PF00069	0.400
MOD_CK2_1	15	21	PF00069	0.613
MOD_CK2_1	380	386	PF00069	0.471
MOD_CK2_1	453	459	PF00069	0.517
MOD_CK2_1	652	658	PF00069	0.507
MOD_CK2_1	765	771	PF00069	0.347
MOD_GlcNHglycan	100	103	PF01048	0.713
MOD_GlcNHglycan	141	144	PF01048	0.603
MOD_GlcNHglycan	173	176	PF01048	0.522
MOD_GlcNHglycan	225	228	PF01048	0.546
MOD_GlcNHglycan	241	245	PF01048	0.464
MOD_GlcNHglycan	247	250	PF01048	0.610
MOD_GlcNHglycan	348	351	PF01048	0.489
MOD_GlcNHglycan	405	408	PF01048	0.477
MOD_GlcNHglycan	621	624	PF01048	0.542
MOD_GlcNHglycan	737	740	PF01048	0.691
MOD_GSK3_1	128	135	PF00069	0.564
MOD_GSK3_1	159	166	PF00069	0.578
MOD_GSK3_1	272	279	PF00069	0.610
MOD_GSK3_1	342	349	PF00069	0.554
MOD_GSK3_1	36	43	PF00069	0.657
MOD_GSK3_1	376	383	PF00069	0.472
MOD_GSK3_1	424	431	PF00069	0.495
MOD_GSK3_1	615	622	PF00069	0.626
MOD_GSK3_1	691	698	PF00069	0.486
MOD_GSK3_1	728	735	PF00069	0.471
MOD_GSK3_1	753	760	PF00069	0.528
MOD_GSK3_1	94	101	PF00069	0.666
MOD_LATS_1	794	800	PF00433	0.617
MOD_N-GLC_1	233	238	PF02516	0.650
MOD_N-GLC_1	251	256	PF02516	0.597
MOD_NEK2_1	245	250	PF00069	0.486
MOD_NEK2_1	271	276	PF00069	0.565
MOD_NEK2_1	310	315	PF00069	0.610
MOD_NEK2_1	380	385	PF00069	0.469
MOD_NEK2_1	480	485	PF00069	0.560
MOD_NEK2_1	660	665	PF00069	0.527
MOD_NEK2_2	95	100	PF00069	0.508
MOD_PIKK_1	166	172	PF00454	0.675
MOD_PIKK_1	226	232	PF00454	0.691
MOD_PIKK_1	272	278	PF00454	0.645
MOD_PIKK_1	292	298	PF00454	0.513
MOD_PIKK_1	424	430	PF00454	0.507
MOD_PIKK_1	480	486	PF00454	0.538
MOD_PIKK_1	55	61	PF00454	0.675
MOD_PIKK_1	721	727	PF00454	0.415
MOD_PK_1	342	348	PF00069	0.374
MOD_PKA_1	139	145	PF00069	0.519
MOD_PKA_1	269	275	PF00069	0.593
MOD_PKA_2	199	205	PF00069	0.577
MOD_PKA_2	223	229	PF00069	0.660
MOD_PKA_2	245	251	PF00069	0.542
MOD_PKA_2	269	275	PF00069	0.723
MOD_PKA_2	276	282	PF00069	0.621
MOD_PKA_2	302	308	PF00069	0.673
MOD_PKA_2	615	621	PF00069	0.487
MOD_PKA_2	660	666	PF00069	0.550
MOD_PKA_2	672	678	PF00069	0.371
MOD_PKA_2	753	759	PF00069	0.468
MOD_PKA_2	765	771	PF00069	0.462
MOD_PKA_2	795	801	PF00069	0.515
MOD_Plk_1	324	330	PF00069	0.365
MOD_Plk_1	331	337	PF00069	0.338
MOD_Plk_1	380	386	PF00069	0.507
MOD_Plk_1	487	493	PF00069	0.393
MOD_Plk_1	757	763	PF00069	0.521
MOD_Plk_2-3	13	19	PF00069	0.658
MOD_Plk_2-3	199	205	PF00069	0.638
MOD_Plk_2-3	251	257	PF00069	0.587
MOD_Plk_2-3	765	771	PF00069	0.584
MOD_Plk_4	331	337	PF00069	0.355
MOD_Plk_4	428	434	PF00069	0.496
MOD_Plk_4	765	771	PF00069	0.504
MOD_ProDKin_1	101	107	PF00069	0.690
MOD_ProDKin_1	128	134	PF00069	0.574
MOD_ProDKin_1	154	160	PF00069	0.708
MOD_ProDKin_1	169	175	PF00069	0.583
MOD_ProDKin_1	178	184	PF00069	0.633
MOD_ProDKin_1	280	286	PF00069	0.590
MOD_ProDKin_1	72	78	PF00069	0.718
MOD_ProDKin_1	797	803	PF00069	0.544
MOD_SUMO_for_1	115	118	PF00179	0.544
MOD_SUMO_rev_2	368	374	PF00179	0.510
MOD_SUMO_rev_2	381	390	PF00179	0.455
MOD_SUMO_rev_2	579	588	PF00179	0.596
MOD_SUMO_rev_2	620	627	PF00179	0.355
TRG_DiLeu_BaEn_1	765	770	PF01217	0.461
TRG_ENDOCYTIC_2	411	414	PF00928	0.465
TRG_ER_diArg_1	268	270	PF00400	0.592
TRG_ER_diArg_1	317	320	PF00400	0.521
TRG_ER_diArg_1	573	576	PF00400	0.516
TRG_ER_diArg_1	594	596	PF00400	0.541
TRG_ER_diArg_1	603	605	PF00400	0.546
TRG_ER_diArg_1	70	73	PF00400	0.540
TRG_NES_CRM1_1	479	494	PF08389	0.336
TRG_NLS_MonoCore_2	137	142	PF00514	0.520
TRG_NLS_MonoExtN_4	138	143	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE76	Leptomonas seymouri	54%	100%
A0A0S4JTA5	Bodo saltans	25%	100%
A0A1X0NJ20	Trypanosomatidae	28%	91%
A0A3Q8IFY0	Leishmania donovani	72%	98%
A4I6A6	Leishmania infantum	72%	98%
E9B1G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4Q6Q1	Leishmania major	70%	100%