Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIX6_LEIBR

TriTrypDb:

LbrM.31.0120 , LBRM2903_310008900

Length:

131

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HIX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.757
CLV_NRD_NRD_1	17	19	PF00675	0.467
CLV_NRD_NRD_1	3	5	PF00675	0.466
CLV_NRD_NRD_1	32	34	PF00675	0.298
CLV_PCSK_KEX2_1	102	104	PF00082	0.757
CLV_PCSK_KEX2_1	17	19	PF00082	0.465
CLV_PCSK_KEX2_1	3	5	PF00082	0.470
CLV_PCSK_KEX2_1	31	33	PF00082	0.398
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.357
CLV_PCSK_PC7_1	13	19	PF00082	0.371
CLV_PCSK_SKI1_1	125	129	PF00082	0.738
CLV_PCSK_SKI1_1	68	72	PF00082	0.492
CLV_PCSK_SKI1_1	89	93	PF00082	0.616
DEG_APCC_DBOX_1	55	63	PF00400	0.636
DEG_Nend_Nbox_1	1	3	PF02207	0.690
DOC_CYCLIN_yClb1_LxF_4	66	71	PF00134	0.240
DOC_MAPK_gen_1	3	9	PF00069	0.651
DOC_MAPK_gen_1	56	64	PF00069	0.634
DOC_PP1_MyPhoNE_1	58	65	PF00149	0.651
DOC_PP1_RVXF_1	66	72	PF00149	0.240
DOC_USP7_MATH_1	23	27	PF00917	0.635
DOC_USP7_MATH_2	106	112	PF00917	0.339
DOC_USP7_MATH_2	93	99	PF00917	0.373
DOC_WW_Pin1_4	113	118	PF00397	0.481
LIG_14-3-3_CanoR_1	49	54	PF00244	0.637
LIG_Actin_WH2_2	84	99	PF00022	0.430
LIG_FHA_1	80	86	PF00498	0.378
LIG_LIR_Apic_2	82	86	PF02991	0.357
LIG_LIR_Gen_1	116	127	PF02991	0.513
LIG_LIR_Nem_3	116	122	PF02991	0.512
LIG_NRBOX	4	10	PF00104	0.680
LIG_Pex14_1	67	71	PF04695	0.413
LIG_Pex14_1	79	83	PF04695	0.378
LIG_Pex14_2	73	77	PF04695	0.363
LIG_SH2_CRK	83	87	PF00017	0.477
LIG_SH2_NCK_1	83	87	PF00017	0.531
LIG_SH3_1	13	19	PF00018	0.571
LIG_SH3_3	13	19	PF00018	0.670
LIG_UBA3_1	36	42	PF00899	0.661
MOD_CK2_1	95	101	PF00069	0.490
MOD_Cter_Amidation	29	32	PF01082	0.362
MOD_GSK3_1	17	24	PF00069	0.707
MOD_GSK3_1	75	82	PF00069	0.391
MOD_N-GLC_1	49	54	PF02516	0.489
MOD_NEK2_2	23	28	PF00069	0.658
MOD_PKA_1	17	23	PF00069	0.681
MOD_PKA_2	17	23	PF00069	0.665
MOD_Plk_1	49	55	PF00069	0.689
MOD_Plk_2-3	95	101	PF00069	0.437
MOD_ProDKin_1	113	119	PF00069	0.480
MOD_SUMO_rev_2	124	129	PF00179	0.370
TRG_ER_diArg_1	102	104	PF00400	0.546
TRG_ER_diArg_1	16	18	PF00400	0.661
TRG_ER_diArg_1	2	4	PF00400	0.615
TRG_ER_diArg_1	32	34	PF00400	0.663
TRG_ER_diArg_1	44	47	PF00400	0.632
TRG_NLS_Bipartite_1	17	32	PF00514	0.574
TRG_NLS_MonoExtC_3	27	32	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP6	Leptomonas seymouri	72%	100%
A0A0S4JY38	Bodo saltans	43%	82%
A0A3Q8IG61	Leishmania donovani	80%	100%
A4I6A5	Leishmania infantum	80%	100%
C9ZN31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	97%
E9B1G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q6Q2	Leishmania major	78%	100%