Putative FG-GAP repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intergrin alpha chain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIX5_LEIBR

TriTrypDb:

LbrM.31.0110 , LBRM2903_310008800

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HIX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	734	738	PF00656	0.412
CLV_C14_Caspase3-7	77	81	PF00656	0.314
CLV_NRD_NRD_1	205	207	PF00675	0.721
CLV_NRD_NRD_1	305	307	PF00675	0.535
CLV_PCSK_KEX2_1	146	148	PF00082	0.615
CLV_PCSK_KEX2_1	204	206	PF00082	0.730
CLV_PCSK_KEX2_1	305	307	PF00082	0.571
CLV_PCSK_KEX2_1	771	773	PF00082	0.447
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.615
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.468
CLV_PCSK_SKI1_1	65	69	PF00082	0.502
DEG_APCC_DBOX_1	272	280	PF00400	0.512
DEG_APCC_DBOX_1	693	701	PF00400	0.396
DEG_APCC_DBOX_1	712	720	PF00400	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DEG_ODPH_VHL_1	2	15	PF01847	0.580
DEG_SCF_FBW7_1	26	31	PF00400	0.380
DEG_SCF_FBW7_1	323	330	PF00400	0.415
DEG_SPOP_SBC_1	28	32	PF00917	0.550
DOC_CDC14_PxL_1	137	145	PF14671	0.422
DOC_CKS1_1	164	169	PF01111	0.519
DOC_CKS1_1	25	30	PF01111	0.382
DOC_CKS1_1	324	329	PF01111	0.321
DOC_CKS1_1	404	409	PF01111	0.407
DOC_CKS1_1	51	56	PF01111	0.313
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	755	761	PF00134	0.413
DOC_MAPK_DCC_7	752	762	PF00069	0.413
DOC_MAPK_DCC_7	98	108	PF00069	0.349
DOC_MAPK_gen_1	179	188	PF00069	0.438
DOC_MAPK_gen_1	302	312	PF00069	0.465
DOC_MAPK_gen_1	694	702	PF00069	0.372
DOC_MAPK_MEF2A_6	273	280	PF00069	0.469
DOC_MAPK_MEF2A_6	683	691	PF00069	0.351
DOC_MAPK_MEF2A_6	718	727	PF00069	0.329
DOC_MAPK_MEF2A_6	752	759	PF00069	0.437
DOC_MAPK_NFAT4_5	273	281	PF00069	0.471
DOC_MAPK_RevD_3	758	772	PF00069	0.449
DOC_PP1_RVXF_1	495	501	PF00149	0.396
DOC_PP2B_LxvP_1	138	141	PF13499	0.425
DOC_PP2B_LxvP_1	727	730	PF13499	0.379
DOC_PP2B_LxvP_1	755	758	PF13499	0.449
DOC_PP4_FxxP_1	702	705	PF00568	0.412
DOC_PP4_FxxP_1	92	95	PF00568	0.362
DOC_PP4_MxPP_1	251	254	PF00568	0.403
DOC_USP7_MATH_1	224	228	PF00917	0.418
DOC_USP7_MATH_1	272	276	PF00917	0.397
DOC_USP7_MATH_1	291	295	PF00917	0.475
DOC_USP7_MATH_1	630	634	PF00917	0.371
DOC_WW_Pin1_4	163	168	PF00397	0.461
DOC_WW_Pin1_4	186	191	PF00397	0.384
DOC_WW_Pin1_4	205	210	PF00397	0.526
DOC_WW_Pin1_4	24	29	PF00397	0.550
DOC_WW_Pin1_4	266	271	PF00397	0.464
DOC_WW_Pin1_4	323	328	PF00397	0.326
DOC_WW_Pin1_4	403	408	PF00397	0.331
DOC_WW_Pin1_4	422	427	PF00397	0.302
DOC_WW_Pin1_4	449	454	PF00397	0.370
DOC_WW_Pin1_4	50	55	PF00397	0.306
DOC_WW_Pin1_4	620	625	PF00397	0.369
DOC_WW_Pin1_4	650	655	PF00397	0.441
DOC_WW_Pin1_4	99	104	PF00397	0.330
LIG_14-3-3_CanoR_1	197	203	PF00244	0.468
LIG_14-3-3_CanoR_1	273	277	PF00244	0.487
LIG_14-3-3_CanoR_1	305	312	PF00244	0.421
LIG_14-3-3_CanoR_1	45	51	PF00244	0.248
LIG_14-3-3_CanoR_1	497	501	PF00244	0.390
LIG_14-3-3_CanoR_1	575	581	PF00244	0.260
LIG_14-3-3_CanoR_1	718	724	PF00244	0.341
LIG_14-3-3_CanoR_1	96	101	PF00244	0.446
LIG_BH_BH3_1	296	312	PF00452	0.345
LIG_BIR_III_2	675	679	PF00653	0.272
LIG_BRCT_BRCA1_1	344	348	PF00533	0.292
LIG_BRCT_BRCA1_1	424	428	PF00533	0.413
LIG_BRCT_BRCA1_1	652	656	PF00533	0.420
LIG_BRCT_BRCA1_1	739	743	PF00533	0.402
LIG_FHA_1	120	126	PF00498	0.310
LIG_FHA_1	285	291	PF00498	0.384
LIG_FHA_1	305	311	PF00498	0.357
LIG_FHA_1	324	330	PF00498	0.328
LIG_FHA_1	370	376	PF00498	0.341
LIG_FHA_1	404	410	PF00498	0.396
LIG_FHA_1	461	467	PF00498	0.429
LIG_FHA_1	51	57	PF00498	0.332
LIG_FHA_1	514	520	PF00498	0.329
LIG_FHA_1	581	587	PF00498	0.366
LIG_FHA_1	633	639	PF00498	0.426
LIG_FHA_1	664	670	PF00498	0.373
LIG_FHA_1	705	711	PF00498	0.405
LIG_FHA_1	734	740	PF00498	0.389
LIG_FHA_1	752	758	PF00498	0.263
LIG_FHA_2	170	176	PF00498	0.512
LIG_FHA_2	187	193	PF00498	0.326
LIG_FHA_2	290	296	PF00498	0.559
LIG_FHA_2	328	334	PF00498	0.413
LIG_FHA_2	452	458	PF00498	0.408
LIG_FHA_2	497	503	PF00498	0.315
LIG_FHA_2	656	662	PF00498	0.422
LIG_FHA_2	670	676	PF00498	0.248
LIG_FHA_2	81	87	PF00498	0.399
LIG_Integrin_isoDGR_2	568	570	PF01839	0.556
LIG_Integrin_RGD_1	663	665	PF01839	0.508
LIG_LIR_Apic_2	48	54	PF02991	0.335
LIG_LIR_Apic_2	99	103	PF02991	0.339
LIG_LIR_Gen_1	217	226	PF02991	0.447
LIG_LIR_Gen_1	383	392	PF02991	0.335
LIG_LIR_Gen_1	623	632	PF02991	0.423
LIG_LIR_Gen_1	71	79	PF02991	0.395
LIG_LIR_Gen_1	717	727	PF02991	0.336
LIG_LIR_LC3C_4	606	609	PF02991	0.317
LIG_LIR_Nem_3	217	223	PF02991	0.448
LIG_LIR_Nem_3	32	38	PF02991	0.454
LIG_LIR_Nem_3	383	389	PF02991	0.337
LIG_LIR_Nem_3	499	503	PF02991	0.318
LIG_LIR_Nem_3	533	537	PF02991	0.419
LIG_LIR_Nem_3	653	659	PF02991	0.382
LIG_LIR_Nem_3	670	674	PF02991	0.249
LIG_LIR_Nem_3	71	75	PF02991	0.349
LIG_LIR_Nem_3	717	723	PF02991	0.345
LIG_LIR_Nem_3	740	746	PF02991	0.309
LIG_MLH1_MIPbox_1	344	348	PF16413	0.292
LIG_NRBOX	8	14	PF00104	0.584
LIG_PDZ_Class_2	780	785	PF00595	0.727
LIG_Pex14_2	428	432	PF04695	0.392
LIG_Pex14_2	667	671	PF04695	0.416
LIG_Pex14_2	743	747	PF04695	0.328
LIG_PTB_Apo_2	234	241	PF02174	0.413
LIG_PTB_Apo_2	679	686	PF02174	0.352
LIG_PTB_Phospho_1	679	685	PF10480	0.392
LIG_SH2_CRK	100	104	PF00017	0.344
LIG_SH2_CRK	220	224	PF00017	0.441
LIG_SH2_CRK	35	39	PF00017	0.453
LIG_SH2_CRK	51	55	PF00017	0.394
LIG_SH2_CRK	720	724	PF00017	0.341
LIG_SH2_CRK	753	757	PF00017	0.413
LIG_SH2_STAP1	22	26	PF00017	0.385
LIG_SH2_STAP1	220	224	PF00017	0.511
LIG_SH2_STAP1	685	689	PF00017	0.407
LIG_SH2_STAP1	753	757	PF00017	0.434
LIG_SH2_STAT3	22	25	PF00017	0.384
LIG_SH2_STAT5	121	124	PF00017	0.309
LIG_SH2_STAT5	137	140	PF00017	0.394
LIG_SH2_STAT5	346	349	PF00017	0.310
LIG_SH2_STAT5	572	575	PF00017	0.305
LIG_SH2_STAT5	617	620	PF00017	0.391
LIG_SH2_STAT5	625	628	PF00017	0.401
LIG_SH2_STAT5	746	749	PF00017	0.407
LIG_SH2_STAT5	753	756	PF00017	0.387
LIG_SH3_3	161	167	PF00018	0.450
LIG_SH3_3	529	535	PF00018	0.337
LIG_SH3_3	64	70	PF00018	0.414
LIG_SH3_3	709	715	PF00018	0.441
LIG_SH3_3	772	778	PF00018	0.570
LIG_SH3_3	85	91	PF00018	0.434
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.500
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.339
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.342
LIG_SUMO_SIM_par_1	115	122	PF11976	0.394
LIG_SUMO_SIM_par_1	582	588	PF11976	0.420
LIG_TYR_ITIM	751	756	PF00017	0.413
LIG_WRC_WIRS_1	656	661	PF05994	0.454
LIG_WRC_WIRS_1	69	74	PF05994	0.420
MOD_CDK_SPK_2	50	55	PF00069	0.306
MOD_CDK_SPxxK_3	266	273	PF00069	0.457
MOD_CDK_SPxxK_3	650	657	PF00069	0.442
MOD_CK1_1	198	204	PF00069	0.512
MOD_CK1_1	266	272	PF00069	0.498
MOD_CK1_1	294	300	PF00069	0.530
MOD_CK2_1	169	175	PF00069	0.509
MOD_CK2_1	186	192	PF00069	0.318
MOD_CK2_1	289	295	PF00069	0.570
MOD_CK2_1	310	316	PF00069	0.416
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.509
MOD_GlcNHglycan	35	38	PF01048	0.570
MOD_GlcNHglycan	42	45	PF01048	0.581
MOD_GlcNHglycan	449	452	PF01048	0.580
MOD_GlcNHglycan	480	483	PF01048	0.588
MOD_GlcNHglycan	516	519	PF01048	0.538
MOD_GlcNHglycan	577	580	PF01048	0.578
MOD_GlcNHglycan	641	644	PF01048	0.627
MOD_GlcNHglycan	762	765	PF01048	0.475
MOD_GSK3_1	24	31	PF00069	0.421
MOD_GSK3_1	285	292	PF00069	0.541
MOD_GSK3_1	323	330	PF00069	0.387
MOD_GSK3_1	342	349	PF00069	0.236
MOD_GSK3_1	390	397	PF00069	0.374
MOD_GSK3_1	447	454	PF00069	0.342
MOD_GSK3_1	456	463	PF00069	0.368
MOD_GSK3_1	46	53	PF00069	0.319
MOD_GSK3_1	526	533	PF00069	0.343
MOD_GSK3_1	731	738	PF00069	0.352
MOD_LATS_1	94	100	PF00433	0.456
MOD_N-GLC_1	169	174	PF02516	0.638
MOD_N-GLC_1	28	33	PF02516	0.643
MOD_N-GLC_1	395	400	PF02516	0.579
MOD_N-GLC_1	478	483	PF02516	0.617
MOD_N-GLC_1	681	686	PF02516	0.502
MOD_N-GLC_2	639	641	PF02516	0.584
MOD_NEK2_1	284	289	PF00069	0.476
MOD_NEK2_1	342	347	PF00069	0.294
MOD_NEK2_1	369	374	PF00069	0.403
MOD_NEK2_1	390	395	PF00069	0.330
MOD_NEK2_1	40	45	PF00069	0.334
MOD_NEK2_1	421	426	PF00069	0.369
MOD_NEK2_1	513	518	PF00069	0.317
MOD_NEK2_1	607	612	PF00069	0.294
MOD_NEK2_1	681	686	PF00069	0.332
MOD_NEK2_1	719	724	PF00069	0.343
MOD_NEK2_1	735	740	PF00069	0.278
MOD_NEK2_1	760	765	PF00069	0.392
MOD_PIKK_1	29	35	PF00454	0.492
MOD_PIKK_1	70	76	PF00454	0.337
MOD_PKA_2	198	204	PF00069	0.574
MOD_PKA_2	272	278	PF00069	0.463
MOD_PKA_2	285	291	PF00069	0.521
MOD_PKA_2	304	310	PF00069	0.342
MOD_PKA_2	496	502	PF00069	0.378
MOD_PKA_2	523	529	PF00069	0.403
MOD_PKA_2	574	580	PF00069	0.435
MOD_Plk_1	184	190	PF00069	0.504
MOD_Plk_1	294	300	PF00069	0.540
MOD_Plk_1	414	420	PF00069	0.450
MOD_Plk_1	669	675	PF00069	0.414
MOD_Plk_1	681	687	PF00069	0.269
MOD_Plk_2-3	414	420	PF00069	0.450
MOD_Plk_2-3	496	502	PF00069	0.348
MOD_Plk_4	169	175	PF00069	0.532
MOD_Plk_4	294	300	PF00069	0.496
MOD_Plk_4	342	348	PF00069	0.292
MOD_Plk_4	46	52	PF00069	0.314
MOD_Plk_4	480	486	PF00069	0.256
MOD_Plk_4	526	532	PF00069	0.371
MOD_Plk_4	538	544	PF00069	0.360
MOD_Plk_4	589	595	PF00069	0.324
MOD_Plk_4	751	757	PF00069	0.403
MOD_ProDKin_1	163	169	PF00069	0.466
MOD_ProDKin_1	186	192	PF00069	0.386
MOD_ProDKin_1	205	211	PF00069	0.526
MOD_ProDKin_1	24	30	PF00069	0.548
MOD_ProDKin_1	266	272	PF00069	0.460
MOD_ProDKin_1	323	329	PF00069	0.328
MOD_ProDKin_1	403	409	PF00069	0.329
MOD_ProDKin_1	422	428	PF00069	0.305
MOD_ProDKin_1	449	455	PF00069	0.369
MOD_ProDKin_1	50	56	PF00069	0.305
MOD_ProDKin_1	620	626	PF00069	0.368
MOD_ProDKin_1	650	656	PF00069	0.440
MOD_ProDKin_1	99	105	PF00069	0.335
MOD_SUMO_for_1	256	259	PF00179	0.419
MOD_SUMO_rev_2	130	134	PF00179	0.347
MOD_SUMO_rev_2	227	236	PF00179	0.494
MOD_SUMO_rev_2	313	319	PF00179	0.437
MOD_SUMO_rev_2	470	475	PF00179	0.405
MOD_SUMO_rev_2	585	591	PF00179	0.397
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.245
TRG_ENDOCYTIC_2	137	140	PF00928	0.431
TRG_ENDOCYTIC_2	220	223	PF00928	0.443
TRG_ENDOCYTIC_2	35	38	PF00928	0.459
TRG_ENDOCYTIC_2	625	628	PF00928	0.385
TRG_ENDOCYTIC_2	720	723	PF00928	0.320
TRG_ENDOCYTIC_2	753	756	PF00928	0.413
TRG_ER_diArg_1	178	181	PF00400	0.419
TRG_ER_diArg_1	204	206	PF00400	0.553
TRG_ER_diArg_1	304	306	PF00400	0.323
TRG_ER_diArg_1	694	697	PF00400	0.380
TRG_ER_diArg_1	698	701	PF00400	0.415
TRG_NES_CRM1_1	717	733	PF08389	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U3	Leptomonas seymouri	69%	100%
A0A0S4JVN8	Bodo saltans	41%	90%
A0A1X0NSW9	Trypanosomatidae	48%	89%
A0A3S7X408	Leishmania donovani	82%	100%
A0A422NXM6	Trypanosoma rangeli	46%	92%
A4I6A4	Leishmania infantum	82%	100%
C9ZTY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	93%
E9B1F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q6Q3	Leishmania major	83%	100%
V5AJ13	Trypanosoma cruzi	46%	95%