NARG2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIX3_LEIBR

TriTrypDb:

LbrM.31.0090 , LBRM2903_310008500

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.472
CLV_NRD_NRD_1	168	170	PF00675	0.399
CLV_NRD_NRD_1	177	179	PF00675	0.467
CLV_NRD_NRD_1	312	314	PF00675	0.638
CLV_NRD_NRD_1	70	72	PF00675	0.465
CLV_PCSK_KEX2_1	168	170	PF00082	0.400
CLV_PCSK_KEX2_1	179	181	PF00082	0.443
CLV_PCSK_KEX2_1	31	33	PF00082	0.448
CLV_PCSK_KEX2_1	311	313	PF00082	0.684
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.484
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.448
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.693
CLV_PCSK_SKI1_1	133	137	PF00082	0.501
CLV_PCSK_SKI1_1	143	147	PF00082	0.336
CLV_PCSK_SKI1_1	229	233	PF00082	0.441
CLV_PCSK_SKI1_1	35	39	PF00082	0.475
CLV_PCSK_SKI1_1	367	371	PF00082	0.570
CLV_Separin_Metazoa	68	72	PF03568	0.472
DEG_APCC_DBOX_1	242	250	PF00400	0.495
DEG_APCC_DBOX_1	445	453	PF00400	0.566
DEG_SPOP_SBC_1	330	334	PF00917	0.773
DOC_CYCLIN_RxL_1	364	371	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.510
DOC_MAPK_gen_1	35	45	PF00069	0.451
DOC_MAPK_MEF2A_6	156	165	PF00069	0.455
DOC_MAPK_MEF2A_6	229	238	PF00069	0.380
DOC_MAPK_RevD_3	358	373	PF00069	0.579
DOC_PP1_RVXF_1	154	160	PF00149	0.446
DOC_PP2B_LxvP_1	422	425	PF13499	0.553
DOC_PP4_FxxP_1	144	147	PF00568	0.392
DOC_PP4_FxxP_1	273	276	PF00568	0.491
DOC_USP7_MATH_1	274	278	PF00917	0.426
DOC_USP7_MATH_1	331	335	PF00917	0.769
DOC_USP7_MATH_1	374	378	PF00917	0.287
DOC_USP7_MATH_1	392	396	PF00917	0.312
DOC_USP7_MATH_1	431	435	PF00917	0.472
DOC_USP7_MATH_1	484	488	PF00917	0.615
DOC_USP7_UBL2_3	31	35	PF12436	0.466
DOC_WW_Pin1_4	157	162	PF00397	0.441
DOC_WW_Pin1_4	258	263	PF00397	0.601
DOC_WW_Pin1_4	91	96	PF00397	0.564
LIG_14-3-3_CanoR_1	255	262	PF00244	0.521
LIG_14-3-3_CanoR_1	32	38	PF00244	0.529
LIG_14-3-3_CanoR_1	470	476	PF00244	0.451
LIG_Actin_WH2_2	242	257	PF00022	0.401
LIG_AP2alpha_1	379	383	PF02296	0.434
LIG_AP2alpha_2	184	186	PF02296	0.453
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_CSL_BTD_1	158	161	PF09270	0.435
LIG_deltaCOP1_diTrp_1	244	250	PF00928	0.390
LIG_deltaCOP1_diTrp_1	458	464	PF00928	0.324
LIG_FHA_1	102	108	PF00498	0.428
LIG_FHA_1	130	136	PF00498	0.449
LIG_FHA_1	230	236	PF00498	0.399
LIG_FHA_1	419	425	PF00498	0.476
LIG_FHA_1	430	436	PF00498	0.546
LIG_FHA_1	85	91	PF00498	0.506
LIG_FHA_2	115	121	PF00498	0.512
LIG_FHA_2	259	265	PF00498	0.632
LIG_FHA_2	279	285	PF00498	0.377
LIG_FHA_2	298	304	PF00498	0.625
LIG_FHA_2	335	341	PF00498	0.768
LIG_FHA_2	407	413	PF00498	0.485
LIG_FHA_2	477	483	PF00498	0.603
LIG_LIR_Apic_2	189	195	PF02991	0.394
LIG_LIR_Apic_2	271	276	PF02991	0.615
LIG_LIR_Gen_1	23	34	PF02991	0.318
LIG_LIR_Gen_1	293	304	PF02991	0.621
LIG_LIR_Gen_1	377	386	PF02991	0.444
LIG_LIR_Nem_3	170	176	PF02991	0.524
LIG_LIR_Nem_3	23	29	PF02991	0.309
LIG_LIR_Nem_3	293	299	PF02991	0.552
LIG_LIR_Nem_3	303	309	PF02991	0.558
LIG_LIR_Nem_3	377	382	PF02991	0.380
LIG_Pex14_1	459	463	PF04695	0.510
LIG_Pex14_2	379	383	PF04695	0.434
LIG_Pex14_2	51	55	PF04695	0.459
LIG_SH2_CRK	192	196	PF00017	0.532
LIG_SH2_CRK	26	30	PF00017	0.421
LIG_SH2_GRB2like	150	153	PF00017	0.419
LIG_SH2_NCK_1	26	30	PF00017	0.294
LIG_SH2_SRC	439	442	PF00017	0.314
LIG_SH2_STAP1	306	310	PF00017	0.551
LIG_SH2_STAP1	60	64	PF00017	0.453
LIG_SH2_STAT5	100	103	PF00017	0.419
LIG_SH2_STAT5	225	228	PF00017	0.425
LIG_SH2_STAT5	237	240	PF00017	0.311
LIG_SH2_STAT5	439	442	PF00017	0.474
LIG_SH2_STAT5	463	466	PF00017	0.525
LIG_SH2_STAT5	60	63	PF00017	0.421
LIG_SH3_3	155	161	PF00018	0.411
LIG_SH3_3	425	431	PF00018	0.558
LIG_SH3_3	442	448	PF00018	0.510
LIG_TRAF2_1	337	340	PF00917	0.561
MOD_CDK_SPK_2	157	162	PF00069	0.441
MOD_CK1_1	332	338	PF00069	0.750
MOD_CK2_1	114	120	PF00069	0.480
MOD_CK2_1	258	264	PF00069	0.629
MOD_CK2_1	288	294	PF00069	0.595
MOD_CK2_1	297	303	PF00069	0.543
MOD_CK2_1	334	340	PF00069	0.565
MOD_CK2_1	374	380	PF00069	0.374
MOD_CK2_1	406	412	PF00069	0.428
MOD_CK2_1	476	482	PF00069	0.528
MOD_CMANNOS	247	250	PF00535	0.378
MOD_GlcNHglycan	204	207	PF01048	0.502
MOD_GlcNHglycan	290	293	PF01048	0.662
MOD_GlcNHglycan	315	318	PF01048	0.700
MOD_GlcNHglycan	353	357	PF01048	0.414
MOD_GSK3_1	101	108	PF00069	0.473
MOD_GSK3_1	110	117	PF00069	0.421
MOD_GSK3_1	184	191	PF00069	0.477
MOD_GSK3_1	196	203	PF00069	0.426
MOD_GSK3_1	250	257	PF00069	0.451
MOD_GSK3_1	274	281	PF00069	0.577
MOD_GSK3_1	284	291	PF00069	0.477
MOD_GSK3_1	330	337	PF00069	0.675
MOD_GSK3_1	348	355	PF00069	0.582
MOD_GSK3_1	429	436	PF00069	0.588
MOD_NEK2_1	186	191	PF00069	0.421
MOD_NEK2_1	278	283	PF00069	0.460
MOD_NEK2_1	305	310	PF00069	0.577
MOD_NEK2_1	352	357	PF00069	0.564
MOD_NEK2_1	418	423	PF00069	0.488
MOD_NEK2_1	471	476	PF00069	0.443
MOD_NEK2_2	250	255	PF00069	0.371
MOD_NEK2_2	374	379	PF00069	0.281
MOD_NEK2_2	433	438	PF00069	0.494
MOD_PIKK_1	334	340	PF00454	0.766
MOD_PIKK_1	447	453	PF00454	0.550
MOD_PIKK_1	84	90	PF00454	0.560
MOD_PKA_2	167	173	PF00069	0.473
MOD_PKA_2	254	260	PF00069	0.491
MOD_PKA_2	297	303	PF00069	0.587
MOD_Plk_1	284	290	PF00069	0.539
MOD_Plk_2-3	114	120	PF00069	0.454
MOD_Plk_2-3	78	84	PF00069	0.489
MOD_Plk_4	114	120	PF00069	0.439
MOD_Plk_4	150	156	PF00069	0.411
MOD_Plk_4	193	199	PF00069	0.536
MOD_Plk_4	274	280	PF00069	0.438
MOD_Plk_4	284	290	PF00069	0.351
MOD_Plk_4	305	311	PF00069	0.579
MOD_Plk_4	374	380	PF00069	0.481
MOD_Plk_4	45	51	PF00069	0.371
MOD_Plk_4	471	477	PF00069	0.528
MOD_Plk_4	6	12	PF00069	0.653
MOD_ProDKin_1	157	163	PF00069	0.447
MOD_ProDKin_1	258	264	PF00069	0.604
MOD_ProDKin_1	91	97	PF00069	0.554
MOD_SUMO_rev_2	205	215	PF00179	0.460
MOD_SUMO_rev_2	366	375	PF00179	0.543
MOD_SUMO_rev_2	76	82	PF00179	0.491
TRG_DiLeu_BaEn_1	114	119	PF01217	0.572
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.454
TRG_ENDOCYTIC_2	173	176	PF00928	0.533
TRG_ENDOCYTIC_2	26	29	PF00928	0.421
TRG_ER_diArg_1	365	368	PF00400	0.321
TRG_NLS_MonoExtC_3	132	137	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U9	Leptomonas seymouri	69%	100%
A0A0S4J099	Bodo saltans	26%	100%
A0A0S4JY56	Bodo saltans	45%	96%
A0A3Q8ICB7	Leishmania donovani	82%	100%
A4I6A2	Leishmania infantum	82%	100%
C9ZM74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	83%
C9ZWU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	91%
E9B1F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q6Q5	Leishmania major	81%	100%