C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIX2_LEIBR

TriTrypDb:

LbrM.31.0080 , LBRM2903_310008400

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIX2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.747
CLV_NRD_NRD_1	110	112	PF00675	0.616
CLV_PCSK_KEX2_1	110	112	PF00082	0.606
CLV_PCSK_KEX2_1	216	218	PF00082	0.660
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.573
DOC_USP7_MATH_1	197	201	PF00917	0.742
DOC_USP7_MATH_1	203	207	PF00917	0.686
DOC_USP7_MATH_1	219	223	PF00917	0.646
DOC_USP7_UBL2_3	204	208	PF12436	0.573
DOC_USP7_UBL2_3	212	216	PF12436	0.638
LIG_14-3-3_CanoR_1	128	136	PF00244	0.529
LIG_BIR_III_4	8	12	PF00653	0.762
LIG_BRCT_BRCA1_1	138	142	PF00533	0.484
LIG_CaM_IQ_9	133	149	PF13499	0.536
LIG_FHA_2	120	126	PF00498	0.588
LIG_FHA_2	167	173	PF00498	0.646
LIG_FHA_2	3	9	PF00498	0.504
LIG_LIR_Nem_3	79	85	PF02991	0.497
LIG_PTB_Apo_2	55	62	PF02174	0.675
LIG_PTB_Phospho_1	55	61	PF10480	0.674
LIG_SH2_CRK	16	20	PF00017	0.554
LIG_SH2_CRK	61	65	PF00017	0.709
LIG_SH2_NCK_1	16	20	PF00017	0.703
LIG_SH2_NCK_1	40	44	PF00017	0.647
LIG_SH2_NCK_1	61	65	PF00017	0.678
LIG_SH2_STAT3	7	10	PF00017	0.690
LIG_SH3_3	172	178	PF00018	0.642
LIG_SH3_3	66	72	PF00018	0.682
LIG_SH3_4	208	215	PF00018	0.559
LIG_TRAF2_1	179	182	PF00917	0.622
MOD_CK2_1	119	125	PF00069	0.594
MOD_GlcNHglycan	86	89	PF01048	0.720
MOD_GSK3_1	17	24	PF00069	0.514
MOD_GSK3_1	219	226	PF00069	0.557
MOD_N-GLC_1	21	26	PF02516	0.703
MOD_N-GLC_1	223	228	PF02516	0.551
MOD_NEK2_1	136	141	PF00069	0.537
MOD_NEK2_1	2	7	PF00069	0.508
MOD_OFUCOSY	133	140	PF10250	0.474
MOD_PIKK_1	119	125	PF00454	0.540
MOD_PKA_2	127	133	PF00069	0.470
MOD_PKA_2	17	23	PF00069	0.695
MOD_SUMO_for_1	179	182	PF00179	0.560
MOD_SUMO_for_1	184	187	PF00179	0.544
MOD_SUMO_for_1	192	195	PF00179	0.627
MOD_SUMO_rev_2	181	190	PF00179	0.627
TRG_ENDOCYTIC_2	93	96	PF00928	0.641
TRG_ER_diArg_1	109	111	PF00400	0.678
TRG_NLS_MonoExtN_4	108	115	PF00514	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA54	Leptomonas seymouri	71%	100%
A0A1X0P7C1	Trypanosomatidae	42%	100%
A0A3Q8ISC2	Leishmania donovani	80%	100%
A4I6A1	Leishmania infantum	80%	100%
E9B1F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	96%
Q4Q6Q6	Leishmania major	80%	100%