Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MFS/sugar transport protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIW8_LEIBR

TriTrypDb:

LbrM.31.0040 , LBRM2903_310007900 , LBRM2903_310008000

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

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Expansion

Sequence features

A4HIW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIW8

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	305	307	PF00675	0.378
CLV_NRD_NRD_1	41	43	PF00675	0.531
CLV_NRD_NRD_1	5	7	PF00675	0.423
CLV_PCSK_FUR_1	161	165	PF00082	0.318
CLV_PCSK_KEX2_1	163	165	PF00082	0.382
CLV_PCSK_KEX2_1	297	299	PF00082	0.313
CLV_PCSK_KEX2_1	305	307	PF00082	0.371
CLV_PCSK_KEX2_1	5	7	PF00082	0.430
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.371
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.331

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	57%	100%
A0A0N1I3H1	Leptomonas seymouri	29%	85%
A0A3Q8IF44	Leishmania donovani	81%	100%
A0A3Q8ILR5	Leishmania donovani	26%	100%
A4HL09	Leishmania braziliensis	27%	100%
A4I8J0	Leishmania infantum	26%	100%
E9AHK6	Leishmania infantum	81%	100%
E9B1F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B3F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q4Q0	Leishmania major	25%	98%

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