Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MFS/sugar transport protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIW8_LEIBR

TriTrypDb:

LbrM.31.0040 , LBRM2903_310007900 , LBRM2903_310008000

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HIW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIW8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	305	307	PF00675	0.378
CLV_NRD_NRD_1	41	43	PF00675	0.531
CLV_NRD_NRD_1	5	7	PF00675	0.423
CLV_PCSK_FUR_1	161	165	PF00082	0.318
CLV_PCSK_KEX2_1	163	165	PF00082	0.382
CLV_PCSK_KEX2_1	297	299	PF00082	0.313
CLV_PCSK_KEX2_1	305	307	PF00082	0.371
CLV_PCSK_KEX2_1	5	7	PF00082	0.430
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.371
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.331
CLV_PCSK_SKI1_1	333	337	PF00082	0.403
CLV_PCSK_SKI1_1	339	343	PF00082	0.302
CLV_PCSK_SKI1_1	465	469	PF00082	0.361
CLV_PCSK_SKI1_1	523	527	PF00082	0.255
DEG_APCC_DBOX_1	101	109	PF00400	0.275
DEG_APCC_DBOX_1	5	13	PF00400	0.578
DEG_MDM2_SWIB_1	433	440	PF02201	0.273
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_CDC14_PxL_1	92	100	PF14671	0.399
DOC_CKS1_1	477	482	PF01111	0.452
DOC_MAPK_gen_1	163	173	PF00069	0.528
DOC_MAPK_gen_1	411	420	PF00069	0.537
DOC_MAPK_gen_1	5	11	PF00069	0.584
DOC_MAPK_gen_1	544	553	PF00069	0.588
DOC_MAPK_MEF2A_6	164	173	PF00069	0.534
DOC_MAPK_MEF2A_6	414	422	PF00069	0.484
DOC_MAPK_MEF2A_6	446	455	PF00069	0.330
DOC_MAPK_MEF2A_6	465	474	PF00069	0.328
DOC_PP2B_PxIxI_1	168	174	PF00149	0.481
DOC_PP4_FxxP_1	21	24	PF00568	0.559
DOC_PP4_FxxP_1	351	354	PF00568	0.312
DOC_USP7_MATH_1	402	406	PF00917	0.541
DOC_USP7_MATH_1	423	427	PF00917	0.330
DOC_USP7_MATH_1	454	458	PF00917	0.318
DOC_USP7_MATH_1	508	512	PF00917	0.392
DOC_USP7_UBL2_3	446	450	PF12436	0.310
DOC_WW_Pin1_4	227	232	PF00397	0.531
DOC_WW_Pin1_4	327	332	PF00397	0.630
DOC_WW_Pin1_4	476	481	PF00397	0.443
DOC_WW_Pin1_4	557	562	PF00397	0.620
LIG_14-3-3_CanoR_1	137	143	PF00244	0.204
LIG_14-3-3_CanoR_1	298	307	PF00244	0.551
LIG_14-3-3_CanoR_1	310	314	PF00244	0.695
LIG_14-3-3_CanoR_1	319	323	PF00244	0.603
LIG_14-3-3_CanoR_1	361	365	PF00244	0.286
LIG_Actin_WH2_2	451	467	PF00022	0.289
LIG_APCC_ABBA_1	329	334	PF00400	0.535
LIG_eIF4E_1	521	527	PF01652	0.234
LIG_FHA_1	107	113	PF00498	0.313
LIG_FHA_1	13	19	PF00498	0.546
LIG_FHA_1	186	192	PF00498	0.436
LIG_FHA_1	207	213	PF00498	0.382
LIG_FHA_1	319	325	PF00498	0.542
LIG_FHA_1	369	375	PF00498	0.316
LIG_FHA_1	469	475	PF00498	0.445
LIG_FHA_1	548	554	PF00498	0.613
LIG_FHA_1	574	580	PF00498	0.663
LIG_LIR_Gen_1	121	129	PF02991	0.302
LIG_LIR_Gen_1	141	152	PF02991	0.388
LIG_LIR_Gen_1	209	219	PF02991	0.280
LIG_LIR_Gen_1	343	354	PF02991	0.338
LIG_LIR_Gen_1	80	90	PF02991	0.594
LIG_LIR_Nem_3	141	147	PF02991	0.343
LIG_LIR_Nem_3	165	170	PF02991	0.546
LIG_LIR_Nem_3	257	262	PF02991	0.324
LIG_LIR_Nem_3	302	307	PF02991	0.498
LIG_LIR_Nem_3	343	349	PF02991	0.338
LIG_LIR_Nem_3	432	436	PF02991	0.474
LIG_LIR_Nem_3	485	491	PF02991	0.510
LIG_LIR_Nem_3	519	525	PF02991	0.382
LIG_LIR_Nem_3	80	85	PF02991	0.538
LIG_MYND_1	96	100	PF01753	0.206
LIG_NRBOX	385	391	PF00104	0.312
LIG_Pex14_1	77	81	PF04695	0.587
LIG_Pex14_2	17	21	PF04695	0.537
LIG_Pex14_2	336	340	PF04695	0.410
LIG_Pex14_2	342	346	PF04695	0.350
LIG_Pex14_2	364	368	PF04695	0.301
LIG_Pex14_2	430	434	PF04695	0.283
LIG_PTB_Apo_2	356	363	PF02174	0.448
LIG_SH2_CRK	144	148	PF00017	0.312
LIG_SH2_CRK	195	199	PF00017	0.271
LIG_SH2_CRK	264	268	PF00017	0.322
LIG_SH2_NCK_1	483	487	PF00017	0.507
LIG_SH2_STAP1	140	144	PF00017	0.369
LIG_SH2_STAP1	195	199	PF00017	0.326
LIG_SH2_STAP1	395	399	PF00017	0.281
LIG_SH2_STAP1	483	487	PF00017	0.507
LIG_SH2_STAT3	400	403	PF00017	0.540
LIG_SH2_STAT5	118	121	PF00017	0.348
LIG_SH2_STAT5	128	131	PF00017	0.367
LIG_SH2_STAT5	148	151	PF00017	0.348
LIG_SH2_STAT5	301	304	PF00017	0.563
LIG_SH2_STAT5	350	353	PF00017	0.315
LIG_SH2_STAT5	400	403	PF00017	0.572
LIG_SH3_1	264	270	PF00018	0.327
LIG_SH3_2	41	46	PF14604	0.640
LIG_SH3_3	225	231	PF00018	0.518
LIG_SH3_3	264	270	PF00018	0.341
LIG_SH3_3	27	33	PF00018	0.603
LIG_SH3_3	38	44	PF00018	0.629
LIG_SH3_3	448	454	PF00018	0.369
LIG_SH3_3	537	543	PF00018	0.352
LIG_SUMO_SIM_anti_2	196	203	PF11976	0.247
LIG_TRAF2_1	561	564	PF00917	0.679
LIG_TYR_ITIM	142	147	PF00017	0.373
LIG_TYR_ITSM	300	307	PF00017	0.486
LIG_UBA3_1	155	163	PF00899	0.303
LIG_UBA3_1	289	297	PF00899	0.274
LIG_UBA3_1	525	532	PF00899	0.239
LIG_WRC_WIRS_1	120	125	PF05994	0.345
LIG_WRC_WIRS_1	430	435	PF05994	0.369
LIG_WW_3	39	43	PF00397	0.682
MOD_CDC14_SPxK_1	330	333	PF00782	0.538
MOD_CDK_SPK_2	476	481	PF00069	0.443
MOD_CDK_SPxK_1	327	333	PF00069	0.535
MOD_CK1_1	110	116	PF00069	0.410
MOD_CK1_1	122	128	PF00069	0.400
MOD_CK1_1	405	411	PF00069	0.604
MOD_CK1_1	492	498	PF00069	0.289
MOD_CK1_1	503	509	PF00069	0.328
MOD_CK2_1	127	133	PF00069	0.299
MOD_CK2_1	227	233	PF00069	0.577
MOD_CK2_1	557	563	PF00069	0.747
MOD_GlcNHglycan	233	237	PF01048	0.349
MOD_GlcNHglycan	36	39	PF01048	0.490
MOD_GlcNHglycan	425	428	PF01048	0.340
MOD_GlcNHglycan	47	52	PF01048	0.459
MOD_GlcNHglycan	495	498	PF01048	0.371
MOD_GlcNHglycan	502	505	PF01048	0.385
MOD_GSK3_1	106	113	PF00069	0.356
MOD_GSK3_1	227	234	PF00069	0.578
MOD_GSK3_1	250	257	PF00069	0.446
MOD_GSK3_1	318	325	PF00069	0.608
MOD_GSK3_1	340	347	PF00069	0.252
MOD_GSK3_1	366	373	PF00069	0.361
MOD_GSK3_1	374	381	PF00069	0.313
MOD_GSK3_1	489	496	PF00069	0.493
MOD_GSK3_1	499	506	PF00069	0.303
MOD_GSK3_1	509	516	PF00069	0.309
MOD_GSK3_1	73	80	PF00069	0.590
MOD_N-GLC_1	322	327	PF02516	0.319
MOD_N-GLC_1	357	362	PF02516	0.494
MOD_N-GLC_1	557	562	PF02516	0.417
MOD_N-GLC_2	461	463	PF02516	0.213
MOD_NEK2_1	106	111	PF00069	0.305
MOD_NEK2_1	254	259	PF00069	0.449
MOD_NEK2_1	293	298	PF00069	0.410
MOD_NEK2_1	322	327	PF00069	0.531
MOD_NEK2_1	340	345	PF00069	0.430
MOD_NEK2_1	357	362	PF00069	0.379
MOD_NEK2_1	368	373	PF00069	0.358
MOD_NEK2_1	374	379	PF00069	0.295
MOD_NEK2_1	440	445	PF00069	0.490
MOD_NEK2_1	482	487	PF00069	0.560
MOD_NEK2_1	509	514	PF00069	0.357
MOD_NEK2_2	429	434	PF00069	0.301
MOD_NEK2_2	454	459	PF00069	0.305
MOD_PIKK_1	110	116	PF00454	0.304
MOD_PIKK_1	374	380	PF00454	0.269
MOD_PKA_2	309	315	PF00069	0.643
MOD_PKA_2	318	324	PF00069	0.552
MOD_PKA_2	360	366	PF00069	0.290
MOD_Plk_1	357	363	PF00069	0.297
MOD_Plk_1	547	553	PF00069	0.665
MOD_Plk_4	194	200	PF00069	0.381
MOD_Plk_4	206	212	PF00069	0.306
MOD_Plk_4	250	256	PF00069	0.404
MOD_Plk_4	378	384	PF00069	0.275
MOD_Plk_4	429	435	PF00069	0.497
MOD_Plk_4	454	460	PF00069	0.298
MOD_Plk_4	73	79	PF00069	0.609
MOD_ProDKin_1	227	233	PF00069	0.530
MOD_ProDKin_1	327	333	PF00069	0.629
MOD_ProDKin_1	476	482	PF00069	0.449
MOD_ProDKin_1	557	563	PF00069	0.619
MOD_SUMO_for_1	162	165	PF00179	0.485
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.404
TRG_ENDOCYTIC_2	144	147	PF00928	0.377
TRG_ENDOCYTIC_2	195	198	PF00928	0.357
TRG_ENDOCYTIC_2	213	216	PF00928	0.311
TRG_ENDOCYTIC_2	304	307	PF00928	0.504
TRG_ENDOCYTIC_2	350	353	PF00928	0.321
TRG_ENDOCYTIC_2	449	452	PF00928	0.339
TRG_ER_diArg_1	304	306	PF00400	0.635
TRG_ER_diArg_1	5	7	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	57%	100%
A0A0N1I3H1	Leptomonas seymouri	29%	85%
A0A3Q8IF44	Leishmania donovani	81%	100%
A0A3Q8ILR5	Leishmania donovani	26%	100%
A4HL09	Leishmania braziliensis	27%	100%
A4I8J0	Leishmania infantum	26%	100%
E9AHK6	Leishmania infantum	81%	100%
E9B1F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B3F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q4Q0	Leishmania major	25%	98%
Q4Q6R0	Leishmania major	77%	100%