Tau95 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIW4_LEIBR

TriTrypDb:

LbrM.30.3810 , LBRM2903_210018400

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000127	transcription factor TFIIIC complex	4	11
GO:0005667	transcription regulator complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0090576	RNA polymerase III transcription regulator complex	3	11

Expansion

Sequence features

A4HIW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIW4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006352	DNA-templated transcription initiation	6	11
GO:0006384	transcription initiation at RNA polymerase III promoter	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.664
CLV_C14_Caspase3-7	257	261	PF00656	0.549
CLV_C14_Caspase3-7	272	276	PF00656	0.645
CLV_C14_Caspase3-7	414	418	PF00656	0.406
CLV_C14_Caspase3-7	444	448	PF00656	0.273
CLV_NRD_NRD_1	148	150	PF00675	0.485
CLV_NRD_NRD_1	211	213	PF00675	0.627
CLV_NRD_NRD_1	239	241	PF00675	0.519
CLV_NRD_NRD_1	243	245	PF00675	0.492
CLV_NRD_NRD_1	506	508	PF00675	0.400
CLV_NRD_NRD_1	537	539	PF00675	0.503
CLV_NRD_NRD_1	549	551	PF00675	0.470
CLV_NRD_NRD_1	599	601	PF00675	0.537
CLV_NRD_NRD_1	603	605	PF00675	0.552
CLV_NRD_NRD_1	61	63	PF00675	0.648
CLV_NRD_NRD_1	635	637	PF00675	0.466
CLV_PCSK_FUR_1	209	213	PF00082	0.673
CLV_PCSK_FUR_1	237	241	PF00082	0.591
CLV_PCSK_KEX2_1	134	136	PF00082	0.640
CLV_PCSK_KEX2_1	148	150	PF00082	0.459
CLV_PCSK_KEX2_1	208	210	PF00082	0.591
CLV_PCSK_KEX2_1	211	213	PF00082	0.592
CLV_PCSK_KEX2_1	239	241	PF00082	0.536
CLV_PCSK_KEX2_1	243	245	PF00082	0.500
CLV_PCSK_KEX2_1	506	508	PF00082	0.400
CLV_PCSK_KEX2_1	537	539	PF00082	0.428
CLV_PCSK_KEX2_1	549	551	PF00082	0.435
CLV_PCSK_KEX2_1	599	601	PF00082	0.476
CLV_PCSK_KEX2_1	603	605	PF00082	0.505
CLV_PCSK_KEX2_1	61	63	PF00082	0.619
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.640
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.622
CLV_PCSK_PC7_1	239	245	PF00082	0.399
CLV_PCSK_PC7_1	533	539	PF00082	0.517
CLV_PCSK_PC7_1	599	605	PF00082	0.482
CLV_PCSK_SKI1_1	148	152	PF00082	0.664
CLV_PCSK_SKI1_1	212	216	PF00082	0.679
CLV_PCSK_SKI1_1	528	532	PF00082	0.484
CLV_PCSK_SKI1_1	549	553	PF00082	0.261
DEG_APCC_DBOX_1	147	155	PF00400	0.610
DEG_APCC_DBOX_1	549	557	PF00400	0.464
DEG_SCF_FBW7_1	35	40	PF00400	0.621
DEG_SCF_FBW7_1	80	85	PF00400	0.497
DEG_SPOP_SBC_1	280	284	PF00917	0.662
DEG_SPOP_SBC_1	39	43	PF00917	0.668
DOC_CDC14_PxL_1	315	323	PF14671	0.576
DOC_CKS1_1	309	314	PF01111	0.627
DOC_CYCLIN_RxL_1	146	155	PF00134	0.466
DOC_CYCLIN_RxL_1	522	534	PF00134	0.487
DOC_CYCLIN_RxL_1	546	555	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	566	572	PF00134	0.477
DOC_MAPK_gen_1	156	166	PF00069	0.460
DOC_MAPK_gen_1	503	512	PF00069	0.511
DOC_MAPK_gen_1	549	556	PF00069	0.405
DOC_MAPK_MEF2A_6	229	236	PF00069	0.498
DOC_MAPK_MEF2A_6	24	33	PF00069	0.538
DOC_MAPK_MEF2A_6	506	514	PF00069	0.509
DOC_MAPK_MEF2A_6	563	570	PF00069	0.407
DOC_MAPK_NFAT4_5	229	237	PF00069	0.649
DOC_PP2B_LxvP_1	18	21	PF13499	0.494
DOC_PP2B_LxvP_1	566	569	PF13499	0.495
DOC_PP2B_PxIxI_1	385	391	PF00149	0.341
DOC_PP4_FxxP_1	72	75	PF00568	0.539
DOC_USP7_MATH_1	188	192	PF00917	0.682
DOC_USP7_MATH_1	214	218	PF00917	0.573
DOC_USP7_MATH_1	22	26	PF00917	0.687
DOC_USP7_MATH_1	280	284	PF00917	0.729
DOC_USP7_MATH_1	317	321	PF00917	0.599
DOC_USP7_MATH_1	354	358	PF00917	0.430
DOC_USP7_MATH_1	392	396	PF00917	0.399
DOC_USP7_MATH_1	488	492	PF00917	0.281
DOC_USP7_MATH_1	610	614	PF00917	0.310
DOC_USP7_MATH_1	654	658	PF00917	0.658
DOC_WW_Pin1_4	308	313	PF00397	0.614
DOC_WW_Pin1_4	33	38	PF00397	0.635
DOC_WW_Pin1_4	4	9	PF00397	0.773
DOC_WW_Pin1_4	517	522	PF00397	0.501
DOC_WW_Pin1_4	78	83	PF00397	0.608
LIG_14-3-3_CanoR_1	159	165	PF00244	0.540
LIG_14-3-3_CanoR_1	24	30	PF00244	0.567
LIG_14-3-3_CanoR_1	281	286	PF00244	0.491
LIG_14-3-3_CanoR_1	506	514	PF00244	0.353
LIG_14-3-3_CanoR_1	549	554	PF00244	0.462
LIG_Actin_WH2_2	493	508	PF00022	0.341
LIG_AP2alpha_2	247	249	PF02296	0.478
LIG_BRCT_BRCA1_1	124	128	PF00533	0.627
LIG_BRCT_BRCA1_1	682	686	PF00533	0.557
LIG_CtBP_PxDLS_1	594	598	PF00389	0.488
LIG_eIF4E_1	227	233	PF01652	0.473
LIG_EVH1_2	328	332	PF00568	0.292
LIG_FHA_1	161	167	PF00498	0.555
LIG_FHA_1	248	254	PF00498	0.544
LIG_FHA_1	280	286	PF00498	0.670
LIG_FHA_1	304	310	PF00498	0.595
LIG_FHA_1	34	40	PF00498	0.621
LIG_FHA_1	385	391	PF00498	0.316
LIG_FHA_1	467	473	PF00498	0.273
LIG_FHA_2	11	17	PF00498	0.531
LIG_FHA_2	550	556	PF00498	0.399
LIG_GBD_Chelix_1	441	449	PF00786	0.406
LIG_LIR_Apic_2	71	75	PF02991	0.546
LIG_LIR_Gen_1	213	223	PF02991	0.643
LIG_LIR_Gen_1	25	33	PF02991	0.649
LIG_LIR_Gen_1	304	315	PF02991	0.639
LIG_LIR_Gen_1	494	505	PF02991	0.431
LIG_LIR_Gen_1	683	693	PF02991	0.517
LIG_LIR_Nem_3	213	218	PF02991	0.507
LIG_LIR_Nem_3	25	29	PF02991	0.608
LIG_LIR_Nem_3	304	310	PF02991	0.527
LIG_LIR_Nem_3	494	500	PF02991	0.428
LIG_LIR_Nem_3	683	689	PF02991	0.518
LIG_NRBOX	526	532	PF00104	0.452
LIG_NRBOX	622	628	PF00104	0.489
LIG_PCNA_PIPBox_1	221	230	PF02747	0.500
LIG_PCNA_yPIPBox_3	221	229	PF02747	0.503
LIG_PTB_Apo_2	222	229	PF02174	0.629
LIG_PTB_Apo_2	471	478	PF02174	0.292
LIG_PTB_Phospho_1	222	228	PF10480	0.638
LIG_SH2_CRK	130	134	PF00017	0.492
LIG_SH2_CRK	161	165	PF00017	0.575
LIG_SH2_CRK	541	545	PF00017	0.460
LIG_SH2_NCK_1	380	384	PF00017	0.195
LIG_SH2_NCK_1	489	493	PF00017	0.411
LIG_SH2_NCK_1	497	501	PF00017	0.378
LIG_SH2_PTP2	26	29	PF00017	0.640
LIG_SH2_SRC	343	346	PF00017	0.406
LIG_SH2_STAP1	497	501	PF00017	0.250
LIG_SH2_STAP1	619	623	PF00017	0.431
LIG_SH2_STAT5	130	133	PF00017	0.491
LIG_SH2_STAT5	161	164	PF00017	0.519
LIG_SH2_STAT5	26	29	PF00017	0.640
LIG_SH2_STAT5	470	473	PF00017	0.273
LIG_SH2_STAT5	567	570	PF00017	0.395
LIG_SH3_3	130	136	PF00018	0.492
LIG_SH3_3	26	32	PF00018	0.575
LIG_SH3_3	323	329	PF00018	0.348
LIG_SUMO_SIM_par_1	386	391	PF11976	0.341
LIG_TRAF2_1	391	394	PF00917	0.465
LIG_TRAF2_1	644	647	PF00917	0.572
LIG_TRAF2_1	688	691	PF00917	0.469
LIG_TRAF2_2	569	574	PF00917	0.460
MOD_CK1_1	113	119	PF00069	0.736
MOD_CK1_1	120	126	PF00069	0.738
MOD_CK1_1	25	31	PF00069	0.654
MOD_CK1_1	283	289	PF00069	0.667
MOD_CK1_1	357	363	PF00069	0.300
MOD_CK1_1	411	417	PF00069	0.341
MOD_CK1_1	491	497	PF00069	0.352
MOD_CK1_1	613	619	PF00069	0.471
MOD_CK1_1	657	663	PF00069	0.629
MOD_CK1_1	676	682	PF00069	0.501
MOD_CK1_1	89	95	PF00069	0.658
MOD_CK2_1	10	16	PF00069	0.526
MOD_CK2_1	388	394	PF00069	0.460
MOD_CK2_1	549	555	PF00069	0.414
MOD_CK2_1	659	665	PF00069	0.711
MOD_CK2_1	679	685	PF00069	0.563
MOD_GlcNHglycan	104	109	PF01048	0.587
MOD_GlcNHglycan	116	119	PF01048	0.699
MOD_GlcNHglycan	121	125	PF01048	0.593
MOD_GlcNHglycan	167	170	PF01048	0.557
MOD_GlcNHglycan	176	179	PF01048	0.588
MOD_GlcNHglycan	190	193	PF01048	0.749
MOD_GlcNHglycan	268	271	PF01048	0.790
MOD_GlcNHglycan	285	288	PF01048	0.543
MOD_GlcNHglycan	356	359	PF01048	0.398
MOD_GlcNHglycan	373	378	PF01048	0.409
MOD_GlcNHglycan	390	393	PF01048	0.427
MOD_GlcNHglycan	42	45	PF01048	0.688
MOD_GlcNHglycan	451	454	PF01048	0.292
MOD_GlcNHglycan	490	493	PF01048	0.365
MOD_GlcNHglycan	54	57	PF01048	0.625
MOD_GlcNHglycan	672	678	PF01048	0.625
MOD_GlcNHglycan	682	685	PF01048	0.577
MOD_GlcNHglycan	686	689	PF01048	0.479
MOD_GlcNHglycan	90	94	PF01048	0.747
MOD_GSK3_1	110	117	PF00069	0.747
MOD_GSK3_1	165	172	PF00069	0.672
MOD_GSK3_1	276	283	PF00069	0.728
MOD_GSK3_1	31	38	PF00069	0.550
MOD_GSK3_1	384	391	PF00069	0.427
MOD_GSK3_1	393	400	PF00069	0.436
MOD_GSK3_1	408	415	PF00069	0.405
MOD_GSK3_1	6	13	PF00069	0.701
MOD_GSK3_1	613	620	PF00069	0.394
MOD_GSK3_1	652	659	PF00069	0.615
MOD_GSK3_1	676	683	PF00069	0.681
MOD_GSK3_1	78	85	PF00069	0.588
MOD_LATS_1	547	553	PF00433	0.460
MOD_N-GLC_1	114	119	PF02516	0.714
MOD_NEK2_1	332	337	PF00069	0.421
MOD_NEK2_1	408	413	PF00069	0.371
MOD_NEK2_1	449	454	PF00069	0.406
MOD_NEK2_1	52	57	PF00069	0.695
MOD_PIKK_1	143	149	PF00454	0.581
MOD_PK_1	281	287	PF00069	0.423
MOD_PKA_1	549	555	PF00069	0.406
MOD_PKA_2	113	119	PF00069	0.525
MOD_PKA_2	170	176	PF00069	0.692
MOD_PKA_2	276	282	PF00069	0.782
MOD_PKA_2	436	442	PF00069	0.341
MOD_PKA_2	505	511	PF00069	0.359
MOD_PKA_2	549	555	PF00069	0.390
MOD_PKA_2	613	619	PF00069	0.445
MOD_PKB_1	513	521	PF00069	0.507
MOD_Plk_1	303	309	PF00069	0.660
MOD_Plk_1	392	398	PF00069	0.409
MOD_Plk_1	673	679	PF00069	0.734
MOD_Plk_1	684	690	PF00069	0.747
MOD_Plk_4	128	134	PF00069	0.491
MOD_Plk_4	393	399	PF00069	0.386
MOD_Plk_4	436	442	PF00069	0.341
MOD_Plk_4	522	528	PF00069	0.421
MOD_Plk_4	549	555	PF00069	0.344
MOD_Plk_4	68	74	PF00069	0.525
MOD_ProDKin_1	308	314	PF00069	0.609
MOD_ProDKin_1	33	39	PF00069	0.638
MOD_ProDKin_1	4	10	PF00069	0.776
MOD_ProDKin_1	517	523	PF00069	0.494
MOD_ProDKin_1	78	84	PF00069	0.611
MOD_SUMO_rev_2	269	276	PF00179	0.575
TRG_DiLeu_BaEn_1	219	224	PF01217	0.669
TRG_DiLeu_BaEn_2	62	68	PF01217	0.679
TRG_DiLeu_BaEn_4	393	399	PF01217	0.406
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.635
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.406
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.341
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.470
TRG_ENDOCYTIC_2	130	133	PF00928	0.491
TRG_ENDOCYTIC_2	161	164	PF00928	0.568
TRG_ENDOCYTIC_2	26	29	PF00928	0.559
TRG_ENDOCYTIC_2	497	500	PF00928	0.431
TRG_ENDOCYTIC_2	541	544	PF00928	0.545
TRG_ENDOCYTIC_2	567	570	PF00928	0.374
TRG_ER_diArg_1	209	212	PF00400	0.620
TRG_ER_diArg_1	236	239	PF00400	0.562
TRG_ER_diArg_1	242	244	PF00400	0.477
TRG_ER_diArg_1	479	482	PF00400	0.305
TRG_ER_diArg_1	505	507	PF00400	0.536
TRG_ER_diArg_1	512	515	PF00400	0.495
TRG_ER_diArg_1	536	538	PF00400	0.520
TRG_ER_diArg_1	549	551	PF00400	0.490
TRG_ER_diArg_1	633	636	PF00400	0.540
TRG_NLS_MonoCore_2	207	212	PF00514	0.668
TRG_NLS_MonoExtC_3	207	212	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	636	641	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I9	Leptomonas seymouri	50%	93%
A0A1X0NZE8	Trypanosomatidae	32%	100%
A0A3S7WWK4	Leishmania donovani	83%	99%
A0A422NAG1	Trypanosoma rangeli	35%	100%
D0A185	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGX8	Leishmania infantum	84%	99%
E9AV94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QC86	Leishmania major	80%	100%
V5B9M4	Trypanosoma cruzi	38%	100%