TATE DNA transposons

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATE DNA transposons

Species:

Leishmania braziliensis

UniProt:

A4HIW1_LEIBR

TriTrypDb:

LbrM.30.3780 , LBRM2903_110018000

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIW1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015074	DNA integration	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.421
CLV_NRD_NRD_1	124	126	PF00675	0.416
CLV_NRD_NRD_1	152	154	PF00675	0.417
CLV_NRD_NRD_1	474	476	PF00675	0.707
CLV_NRD_NRD_1	622	624	PF00675	0.574
CLV_PCSK_KEX2_1	123	125	PF00082	0.424
CLV_PCSK_KEX2_1	152	154	PF00082	0.417
CLV_PCSK_KEX2_1	27	29	PF00082	0.637
CLV_PCSK_KEX2_1	43	45	PF00082	0.355
CLV_PCSK_KEX2_1	473	475	PF00082	0.709
CLV_PCSK_KEX2_1	48	50	PF00082	0.513
CLV_PCSK_KEX2_1	621	623	PF00082	0.552
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.637
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.355
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.513
CLV_PCSK_PC7_1	44	50	PF00082	0.610
CLV_PCSK_SKI1_1	125	129	PF00082	0.472
CLV_PCSK_SKI1_1	15	19	PF00082	0.703
CLV_PCSK_SKI1_1	160	164	PF00082	0.372
CLV_PCSK_SKI1_1	183	187	PF00082	0.400
CLV_PCSK_SKI1_1	314	318	PF00082	0.498
CLV_PCSK_SKI1_1	347	351	PF00082	0.568
CLV_PCSK_SKI1_1	48	52	PF00082	0.495
CLV_PCSK_SKI1_1	523	527	PF00082	0.565
CLV_PCSK_SKI1_1	70	74	PF00082	0.533
DEG_APCC_DBOX_1	267	275	PF00400	0.610
DOC_CKS1_1	221	226	PF01111	0.572
DOC_MAPK_gen_1	157	167	PF00069	0.399
DOC_MAPK_gen_1	353	363	PF00069	0.592
DOC_MAPK_MEF2A_6	160	167	PF00069	0.394
DOC_MAPK_MEF2A_6	308	317	PF00069	0.435
DOC_PP1_RVXF_1	358	364	PF00149	0.598
DOC_PP2B_LxvP_1	38	41	PF13499	0.631
DOC_PP4_FxxP_1	115	118	PF00568	0.631
DOC_PP4_FxxP_1	482	485	PF00568	0.774
DOC_PP4_FxxP_1	57	60	PF00568	0.573
DOC_PP4_FxxP_1	605	608	PF00568	0.544
DOC_USP7_MATH_1	593	597	PF00917	0.588
DOC_USP7_UBL2_3	308	312	PF12436	0.436
DOC_WW_Pin1_4	220	225	PF00397	0.568
DOC_WW_Pin1_4	262	267	PF00397	0.441
DOC_WW_Pin1_4	27	32	PF00397	0.618
LIG_14-3-3_CanoR_1	124	130	PF00244	0.412
LIG_14-3-3_CanoR_1	196	201	PF00244	0.412
LIG_14-3-3_CanoR_1	205	209	PF00244	0.411
LIG_14-3-3_CanoR_1	304	308	PF00244	0.568
LIG_14-3-3_CanoR_1	325	331	PF00244	0.411
LIG_14-3-3_CanoR_1	360	364	PF00244	0.608
LIG_14-3-3_CanoR_1	402	411	PF00244	0.622
LIG_14-3-3_CanoR_1	44	51	PF00244	0.544
LIG_14-3-3_CanoR_1	495	502	PF00244	0.496
LIG_Actin_WH2_2	300	316	PF00022	0.425
LIG_Actin_WH2_2	51	69	PF00022	0.521
LIG_BIR_III_2	172	176	PF00653	0.548
LIG_BIR_III_2	370	374	PF00653	0.613
LIG_BIR_III_4	592	596	PF00653	0.611
LIG_BRCT_BRCA1_1	331	335	PF00533	0.552
LIG_BRCT_BRCA1_1	585	589	PF00533	0.458
LIG_deltaCOP1_diTrp_1	437	445	PF00928	0.591
LIG_eIF4E_1	550	556	PF01652	0.412
LIG_FHA_1	126	132	PF00498	0.574
LIG_FHA_1	213	219	PF00498	0.420
LIG_FHA_1	226	232	PF00498	0.449
LIG_FHA_1	285	291	PF00498	0.543
LIG_FHA_1	444	450	PF00498	0.701
LIG_FHA_1	557	563	PF00498	0.393
LIG_FHA_1	592	598	PF00498	0.485
LIG_FHA_2	114	120	PF00498	0.511
LIG_FHA_2	215	221	PF00498	0.390
LIG_FHA_2	227	233	PF00498	0.415
LIG_FHA_2	28	34	PF00498	0.597
LIG_FHA_2	403	409	PF00498	0.518
LIG_FHA_2	76	82	PF00498	0.602
LIG_Integrin_isoDGR_2	297	299	PF01839	0.620
LIG_LIR_Apic_2	603	608	PF02991	0.557
LIG_LIR_Gen_1	168	178	PF02991	0.415
LIG_LIR_Gen_1	215	224	PF02991	0.440
LIG_LIR_Gen_1	408	419	PF02991	0.433
LIG_LIR_Gen_1	6	16	PF02991	0.724
LIG_LIR_Nem_3	166	170	PF02991	0.432
LIG_LIR_Nem_3	191	197	PF02991	0.583
LIG_LIR_Nem_3	215	219	PF02991	0.422
LIG_LIR_Nem_3	332	338	PF02991	0.495
LIG_LIR_Nem_3	362	366	PF02991	0.604
LIG_LIR_Nem_3	408	414	PF02991	0.456
LIG_LIR_Nem_3	422	427	PF02991	0.412
LIG_LIR_Nem_3	569	575	PF02991	0.489
LIG_LIR_Nem_3	6	11	PF02991	0.723
LIG_LIR_Nem_3	61	66	PF02991	0.599
LIG_PCNA_yPIPBox_3	503	513	PF02747	0.580
LIG_Pex14_2	605	609	PF04695	0.543
LIG_SH2_CRK	171	175	PF00017	0.402
LIG_SH2_CRK	355	359	PF00017	0.434
LIG_SH2_CRK	411	415	PF00017	0.431
LIG_SH2_CRK	63	67	PF00017	0.492
LIG_SH2_NCK_1	171	175	PF00017	0.402
LIG_SH2_NCK_1	411	415	PF00017	0.582
LIG_SH2_SRC	374	377	PF00017	0.472
LIG_SH2_SRC	574	577	PF00017	0.522
LIG_SH2_STAP1	146	150	PF00017	0.554
LIG_SH2_STAP1	158	162	PF00017	0.325
LIG_SH2_STAP1	411	415	PF00017	0.582
LIG_SH2_STAP1	496	500	PF00017	0.657
LIG_SH2_STAP1	558	562	PF00017	0.387
LIG_SH2_STAP1	585	589	PF00017	0.569
LIG_SH2_STAT3	161	164	PF00017	0.389
LIG_SH2_STAT5	294	297	PF00017	0.569
LIG_SH2_STAT5	374	377	PF00017	0.472
LIG_SH2_STAT5	558	561	PF00017	0.389
LIG_SH2_STAT5	574	577	PF00017	0.412
LIG_SH3_3	100	106	PF00018	0.604
LIG_SH3_3	388	394	PF00018	0.439
LIG_SUMO_SIM_anti_2	329	335	PF11976	0.406
LIG_SUMO_SIM_par_1	217	223	PF11976	0.402
LIG_SUMO_SIM_par_1	245	252	PF11976	0.557
LIG_TRAF2_1	382	385	PF00917	0.590
MOD_CDC14_SPxK_1	265	268	PF00782	0.457
MOD_CDK_SPxK_1	262	268	PF00069	0.440
MOD_CK1_1	284	290	PF00069	0.576
MOD_CK1_1	306	312	PF00069	0.434
MOD_CK1_1	326	332	PF00069	0.394
MOD_CK2_1	113	119	PF00069	0.497
MOD_CK2_1	379	385	PF00069	0.540
MOD_CK2_1	402	408	PF00069	0.512
MOD_CK2_1	75	81	PF00069	0.605
MOD_Cter_Amidation	121	124	PF01082	0.464
MOD_Cter_Amidation	150	153	PF01082	0.577
MOD_GlcNHglycan	283	286	PF01048	0.577
MOD_GlcNHglycan	477	480	PF01048	0.772
MOD_GlcNHglycan	496	499	PF01048	0.348
MOD_GlcNHglycan	5	8	PF01048	0.638
MOD_GSK3_1	375	382	PF00069	0.602
MOD_GSK3_1	39	46	PF00069	0.629
MOD_GSK3_1	403	410	PF00069	0.627
MOD_GSK3_1	433	440	PF00069	0.490
MOD_NEK2_1	317	322	PF00069	0.616
MOD_NEK2_1	338	343	PF00069	0.417
MOD_NEK2_1	66	71	PF00069	0.465
MOD_NEK2_2	359	364	PF00069	0.608
MOD_PIKK_1	338	344	PF00454	0.566
MOD_PKA_1	43	49	PF00069	0.619
MOD_PKA_2	204	210	PF00069	0.406
MOD_PKA_2	303	309	PF00069	0.456
MOD_PKA_2	359	365	PF00069	0.611
MOD_PKA_2	43	49	PF00069	0.619
MOD_PKA_2	443	449	PF00069	0.601
MOD_PKA_2	494	500	PF00069	0.526
MOD_PKA_2	66	72	PF00069	0.495
MOD_PKB_1	123	131	PF00069	0.466
MOD_PKB_1	473	481	PF00069	0.777
MOD_Plk_1	292	298	PF00069	0.419
MOD_Plk_1	375	381	PF00069	0.608
MOD_Plk_1	407	413	PF00069	0.562
MOD_Plk_1	417	423	PF00069	0.540
MOD_Plk_1	556	562	PF00069	0.498
MOD_Plk_2-3	272	278	PF00069	0.478
MOD_Plk_2-3	407	413	PF00069	0.618
MOD_Plk_4	226	232	PF00069	0.425
MOD_Plk_4	284	290	PF00069	0.481
MOD_Plk_4	326	332	PF00069	0.418
MOD_Plk_4	33	39	PF00069	0.624
MOD_Plk_4	58	64	PF00069	0.588
MOD_ProDKin_1	220	226	PF00069	0.568
MOD_ProDKin_1	262	268	PF00069	0.440
MOD_ProDKin_1	27	33	PF00069	0.618
MOD_SUMO_rev_2	270	280	PF00179	0.417
TRG_DiLeu_BaEn_1	14	19	PF01217	0.709
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.477
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.580
TRG_ENDOCYTIC_2	171	174	PF00928	0.384
TRG_ENDOCYTIC_2	194	197	PF00928	0.562
TRG_ENDOCYTIC_2	355	358	PF00928	0.429
TRG_ENDOCYTIC_2	411	414	PF00928	0.542
TRG_ENDOCYTIC_2	63	66	PF00928	0.484
TRG_ER_diArg_1	123	125	PF00400	0.479
TRG_ER_diArg_1	152	155	PF00400	0.577
TRG_ER_diArg_1	186	189	PF00400	0.424
TRG_ER_diArg_1	195	198	PF00400	0.420
TRG_ER_diArg_1	441	444	PF00400	0.602
TRG_ER_diArg_1	472	475	PF00400	0.766
TRG_ER_diArg_1	621	623	PF00400	0.552
TRG_NES_CRM1_1	107	119	PF08389	0.603
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	451	456	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NZ81	Trypanosomatidae	47%	92%
A0A1X0NZU3	Trypanosomatidae	46%	93%
A0A1X0P2J1	Trypanosomatidae	48%	96%
A4H9A6	Leishmania braziliensis	100%	100%
A4HEK5	Leishmania braziliensis	99%	68%
A4HIQ7	Leishmania braziliensis	100%	66%
A4HJX9	Leishmania braziliensis	99%	82%
A4HM37	Leishmania braziliensis	99%	69%