Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIV7_LEIBR

TriTrypDb:

LbrM.30.3740 , LBRM2903_300044700

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HIV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.778
CLV_C14_Caspase3-7	806	810	PF00656	0.329
CLV_NRD_NRD_1	239	241	PF00675	0.396
CLV_NRD_NRD_1	311	313	PF00675	0.328
CLV_NRD_NRD_1	324	326	PF00675	0.498
CLV_NRD_NRD_1	411	413	PF00675	0.424
CLV_NRD_NRD_1	460	462	PF00675	0.371
CLV_PCSK_KEX2_1	223	225	PF00082	0.357
CLV_PCSK_KEX2_1	239	241	PF00082	0.345
CLV_PCSK_KEX2_1	269	271	PF00082	0.475
CLV_PCSK_KEX2_1	313	315	PF00082	0.382
CLV_PCSK_KEX2_1	323	325	PF00082	0.428
CLV_PCSK_KEX2_1	411	413	PF00082	0.445
CLV_PCSK_KEX2_1	462	464	PF00082	0.413
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.357
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.345
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.475
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.382
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.413
CLV_PCSK_PC7_1	235	241	PF00082	0.497
CLV_PCSK_SKI1_1	145	149	PF00082	0.252
CLV_PCSK_SKI1_1	279	283	PF00082	0.526
CLV_PCSK_SKI1_1	441	445	PF00082	0.495
CLV_PCSK_SKI1_1	501	505	PF00082	0.399
CLV_PCSK_SKI1_1	543	547	PF00082	0.276
CLV_PCSK_SKI1_1	723	727	PF00082	0.595
DEG_APCC_DBOX_1	269	277	PF00400	0.266
DEG_Nend_UBRbox_3	1	3	PF02207	0.749
DOC_CKS1_1	383	388	PF01111	0.322
DOC_CYCLIN_RxL_1	498	506	PF00134	0.731
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.227
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.688
DOC_CYCLIN_yCln2_LP_2	773	779	PF00134	0.428
DOC_MAPK_DCC_7	239	247	PF00069	0.405
DOC_MAPK_gen_1	223	229	PF00069	0.560
DOC_MAPK_gen_1	239	248	PF00069	0.437
DOC_MAPK_gen_1	269	276	PF00069	0.446
DOC_MAPK_gen_1	411	420	PF00069	0.522
DOC_MAPK_gen_1	767	775	PF00069	0.393
DOC_MAPK_HePTP_8	410	422	PF00069	0.449
DOC_MAPK_JIP1_4	634	640	PF00069	0.430
DOC_MAPK_MEF2A_6	145	153	PF00069	0.558
DOC_MAPK_MEF2A_6	239	247	PF00069	0.454
DOC_MAPK_MEF2A_6	413	422	PF00069	0.449
DOC_MAPK_MEF2A_6	768	777	PF00069	0.372
DOC_MAPK_RevD_3	448	463	PF00069	0.349
DOC_PP1_RVXF_1	334	340	PF00149	0.653
DOC_PP2B_LxvP_1	106	109	PF13499	0.610
DOC_PP2B_LxvP_1	177	180	PF13499	0.408
DOC_PP2B_LxvP_1	476	479	PF13499	0.687
DOC_PP2B_LxvP_1	773	776	PF13499	0.434
DOC_PP2B_PxIxI_1	704	710	PF00149	0.386
DOC_PP4_FxxP_1	178	181	PF00568	0.376
DOC_PP4_FxxP_1	3	6	PF00568	0.632
DOC_PP4_FxxP_1	780	783	PF00568	0.324
DOC_SPAK_OSR1_1	669	673	PF12202	0.240
DOC_USP7_MATH_1	17	21	PF00917	0.726
DOC_USP7_MATH_1	392	396	PF00917	0.398
DOC_USP7_MATH_1	527	531	PF00917	0.491
DOC_USP7_MATH_1	578	582	PF00917	0.425
DOC_USP7_MATH_1	59	63	PF00917	0.685
DOC_USP7_MATH_1	598	602	PF00917	0.212
DOC_USP7_MATH_1	744	748	PF00917	0.409
DOC_USP7_MATH_1	800	804	PF00917	0.259
DOC_USP7_MATH_1	849	853	PF00917	0.347
DOC_USP7_MATH_2	94	100	PF00917	0.600
DOC_WW_Pin1_4	382	387	PF00397	0.446
DOC_WW_Pin1_4	44	49	PF00397	0.694
DOC_WW_Pin1_4	583	588	PF00397	0.420
DOC_WW_Pin1_4	701	706	PF00397	0.339
LIG_14-3-3_CanoR_1	270	274	PF00244	0.451
LIG_14-3-3_CanoR_1	441	450	PF00244	0.205
LIG_14-3-3_CanoR_1	463	468	PF00244	0.660
LIG_14-3-3_CanoR_1	564	570	PF00244	0.395
LIG_14-3-3_CanoR_1	680	685	PF00244	0.344
LIG_14-3-3_CanoR_1	802	808	PF00244	0.350
LIG_14-3-3_CanoR_1	833	838	PF00244	0.337
LIG_APCC_ABBA_1	682	687	PF00400	0.388
LIG_BRCT_BRCA1_1	143	147	PF00533	0.547
LIG_BRCT_BRCA1_1	359	363	PF00533	0.408
LIG_BRCT_BRCA1_1	666	670	PF00533	0.268
LIG_EH1_1	243	251	PF00400	0.442
LIG_eIF4E_1	244	250	PF01652	0.443
LIG_eIF4E_1	419	425	PF01652	0.337
LIG_FHA_1	150	156	PF00498	0.386
LIG_FHA_1	168	174	PF00498	0.223
LIG_FHA_1	287	293	PF00498	0.405
LIG_FHA_1	35	41	PF00498	0.809
LIG_FHA_1	383	389	PF00498	0.453
LIG_FHA_1	442	448	PF00498	0.359
LIG_FHA_1	473	479	PF00498	0.676
LIG_FHA_1	569	575	PF00498	0.334
LIG_FHA_1	584	590	PF00498	0.389
LIG_FHA_1	783	789	PF00498	0.380
LIG_FHA_1	799	805	PF00498	0.282
LIG_FHA_1	816	822	PF00498	0.225
LIG_FHA_2	342	348	PF00498	0.535
LIG_FHA_2	466	472	PF00498	0.597
LIG_FHA_2	49	55	PF00498	0.756
LIG_FHA_2	731	737	PF00498	0.442
LIG_FHA_2	834	840	PF00498	0.321
LIG_FHA_2	842	848	PF00498	0.359
LIG_GBD_Chelix_1	205	213	PF00786	0.480
LIG_GBD_Chelix_1	425	433	PF00786	0.480
LIG_HP1_1	243	247	PF01393	0.227
LIG_LIR_Apic_2	125	129	PF02991	0.730
LIG_LIR_Gen_1	130	139	PF02991	0.559
LIG_LIR_Gen_1	170	179	PF02991	0.327
LIG_LIR_Gen_1	202	211	PF02991	0.282
LIG_LIR_Gen_1	289	297	PF02991	0.378
LIG_LIR_Gen_1	355	365	PF02991	0.506
LIG_LIR_Gen_1	405	410	PF02991	0.468
LIG_LIR_Gen_1	661	670	PF02991	0.322
LIG_LIR_Gen_1	803	811	PF02991	0.385
LIG_LIR_LC3C_4	289	293	PF02991	0.419
LIG_LIR_Nem_3	120	126	PF02991	0.732
LIG_LIR_Nem_3	130	134	PF02991	0.573
LIG_LIR_Nem_3	144	150	PF02991	0.541
LIG_LIR_Nem_3	170	174	PF02991	0.304
LIG_LIR_Nem_3	202	206	PF02991	0.309
LIG_LIR_Nem_3	289	293	PF02991	0.358
LIG_LIR_Nem_3	355	361	PF02991	0.557
LIG_LIR_Nem_3	387	393	PF02991	0.355
LIG_LIR_Nem_3	405	409	PF02991	0.245
LIG_LIR_Nem_3	502	507	PF02991	0.602
LIG_LIR_Nem_3	586	591	PF02991	0.385
LIG_LIR_Nem_3	659	663	PF02991	0.309
LIG_LIR_Nem_3	667	673	PF02991	0.325
LIG_LIR_Nem_3	683	688	PF02991	0.314
LIG_LIR_Nem_3	74	79	PF02991	0.635
LIG_LIR_Nem_3	803	808	PF02991	0.408
LIG_LIR_Nem_3	85	91	PF02991	0.549
LIG_NRBOX	150	156	PF00104	0.378
LIG_PCNA_PIPBox_1	213	222	PF02747	0.631
LIG_Pex14_2	195	199	PF04695	0.355
LIG_Pex14_2	627	631	PF04695	0.327
LIG_Pex14_2	724	728	PF04695	0.380
LIG_SH2_CRK	126	130	PF00017	0.717
LIG_SH2_CRK	280	284	PF00017	0.296
LIG_SH2_CRK	358	362	PF00017	0.562
LIG_SH2_CRK	480	484	PF00017	0.539
LIG_SH2_CRK	91	95	PF00017	0.591
LIG_SH2_GRB2like	787	790	PF00017	0.299
LIG_SH2_GRB2like	91	94	PF00017	0.703
LIG_SH2_NCK_1	126	130	PF00017	0.717
LIG_SH2_NCK_1	91	95	PF00017	0.720
LIG_SH2_PTP2	244	247	PF00017	0.227
LIG_SH2_PTP2	419	422	PF00017	0.358
LIG_SH2_PTP2	663	666	PF00017	0.390
LIG_SH2_SRC	121	124	PF00017	0.763
LIG_SH2_SRC	126	129	PF00017	0.483
LIG_SH2_SRC	647	650	PF00017	0.478
LIG_SH2_SRC	65	68	PF00017	0.754
LIG_SH2_SRC	663	666	PF00017	0.383
LIG_SH2_SRC	71	74	PF00017	0.665
LIG_SH2_SRC	807	810	PF00017	0.326
LIG_SH2_STAP1	169	173	PF00017	0.509
LIG_SH2_STAP1	27	31	PF00017	0.790
LIG_SH2_STAP1	280	284	PF00017	0.325
LIG_SH2_STAP1	35	39	PF00017	0.719
LIG_SH2_STAP1	374	378	PF00017	0.361
LIG_SH2_STAP1	765	769	PF00017	0.332
LIG_SH2_STAT3	275	278	PF00017	0.385
LIG_SH2_STAT3	374	377	PF00017	0.401
LIG_SH2_STAT3	79	82	PF00017	0.671
LIG_SH2_STAT5	150	153	PF00017	0.341
LIG_SH2_STAT5	156	159	PF00017	0.317
LIG_SH2_STAT5	169	172	PF00017	0.270
LIG_SH2_STAT5	194	197	PF00017	0.447
LIG_SH2_STAT5	200	203	PF00017	0.447
LIG_SH2_STAT5	236	239	PF00017	0.609
LIG_SH2_STAT5	244	247	PF00017	0.349
LIG_SH2_STAT5	275	278	PF00017	0.370
LIG_SH2_STAT5	296	299	PF00017	0.348
LIG_SH2_STAT5	35	38	PF00017	0.785
LIG_SH2_STAT5	402	405	PF00017	0.308
LIG_SH2_STAT5	419	422	PF00017	0.259
LIG_SH2_STAT5	496	499	PF00017	0.613
LIG_SH2_STAT5	663	666	PF00017	0.266
LIG_SH2_STAT5	741	744	PF00017	0.346
LIG_SH2_STAT5	76	79	PF00017	0.729
LIG_SH2_STAT5	787	790	PF00017	0.383
LIG_SH2_STAT5	807	810	PF00017	0.286
LIG_SH2_STAT5	819	822	PF00017	0.337
LIG_SH2_STAT5	840	843	PF00017	0.408
LIG_SH2_STAT5	91	94	PF00017	0.740
LIG_SH3_3	106	112	PF00018	0.647
LIG_SH3_3	177	183	PF00018	0.424
LIG_SH3_3	185	191	PF00018	0.431
LIG_SH3_3	252	258	PF00018	0.447
LIG_SH3_3	37	43	PF00018	0.774
LIG_SH3_3	380	386	PF00018	0.434
LIG_SH3_3	584	590	PF00018	0.417
LIG_SH3_3	643	649	PF00018	0.443
LIG_SUMO_SIM_anti_2	289	295	PF11976	0.462
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.546
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.150
LIG_SUMO_SIM_anti_2	751	759	PF11976	0.354
LIG_SUMO_SIM_par_1	558	563	PF11976	0.241
LIG_SUMO_SIM_par_1	671	677	PF11976	0.386
LIG_SUMO_SIM_par_1	751	759	PF11976	0.325
LIG_TYR_ITIM	148	153	PF00017	0.513
LIG_TYR_ITIM	356	361	PF00017	0.623
LIG_TYR_ITIM	478	483	PF00017	0.538
LIG_WRC_WIRS_1	139	144	PF05994	0.579
LIG_WRC_WIRS_1	200	205	PF05994	0.288
LIG_WW_1	128	131	PF00397	0.686
MOD_CK1_1	405	411	PF00069	0.492
MOD_CK1_1	563	569	PF00069	0.428
MOD_CK1_1	633	639	PF00069	0.414
MOD_CK1_1	714	720	PF00069	0.370
MOD_CK1_1	748	754	PF00069	0.423
MOD_CK1_1	803	809	PF00069	0.389
MOD_CK1_1	825	831	PF00069	0.280
MOD_CK2_1	341	347	PF00069	0.533
MOD_CK2_1	465	471	PF00069	0.599
MOD_CK2_1	48	54	PF00069	0.741
MOD_CMANNOS	298	301	PF00535	0.408
MOD_GlcNHglycan	600	603	PF01048	0.520
MOD_GlcNHglycan	747	750	PF01048	0.669
MOD_GlcNHglycan	751	754	PF01048	0.635
MOD_GlcNHglycan	761	764	PF01048	0.585
MOD_GlcNHglycan	769	772	PF01048	0.555
MOD_GlcNHglycan	798	801	PF01048	0.616
MOD_GSK3_1	23	30	PF00069	0.785
MOD_GSK3_1	34	41	PF00069	0.747
MOD_GSK3_1	357	364	PF00069	0.507
MOD_GSK3_1	378	385	PF00069	0.401
MOD_GSK3_1	392	399	PF00069	0.322
MOD_GSK3_1	44	51	PF00069	0.669
MOD_GSK3_1	527	534	PF00069	0.587
MOD_GSK3_1	615	622	PF00069	0.351
MOD_GSK3_1	626	633	PF00069	0.410
MOD_GSK3_1	730	737	PF00069	0.367
MOD_GSK3_1	744	751	PF00069	0.445
MOD_GSK3_1	796	803	PF00069	0.330
MOD_GSK3_1	807	814	PF00069	0.307
MOD_N-GLC_1	167	172	PF02516	0.368
MOD_N-GLC_1	54	59	PF02516	0.582
MOD_N-GLC_1	578	583	PF02516	0.599
MOD_N-GLC_1	598	603	PF02516	0.411
MOD_N-GLC_1	656	661	PF02516	0.588
MOD_N-GLC_1	745	750	PF02516	0.623
MOD_N-GLC_1	793	798	PF02516	0.607
MOD_N-GLC_1	822	827	PF02516	0.627
MOD_N-GLC_2	829	831	PF02516	0.578
MOD_NEK2_1	167	172	PF00069	0.381
MOD_NEK2_1	199	204	PF00069	0.342
MOD_NEK2_1	286	291	PF00069	0.408
MOD_NEK2_1	357	362	PF00069	0.518
MOD_NEK2_1	472	477	PF00069	0.668
MOD_NEK2_1	531	536	PF00069	0.640
MOD_NEK2_1	562	567	PF00069	0.492
MOD_NEK2_1	615	620	PF00069	0.317
MOD_NEK2_1	745	750	PF00069	0.357
MOD_NEK2_1	798	803	PF00069	0.335
MOD_NEK2_1	841	846	PF00069	0.403
MOD_NEK2_2	499	504	PF00069	0.552
MOD_NEK2_2	734	739	PF00069	0.249
MOD_PIKK_1	48	54	PF00454	0.798
MOD_PIKK_1	563	569	PF00454	0.327
MOD_PIKK_1	57	63	PF00454	0.725
MOD_PIKK_1	615	621	PF00454	0.363
MOD_PIKK_1	793	799	PF00454	0.375
MOD_PK_1	307	313	PF00069	0.472
MOD_PKA_1	269	275	PF00069	0.450
MOD_PKA_1	463	469	PF00069	0.660
MOD_PKA_1	767	773	PF00069	0.403
MOD_PKA_2	269	275	PF00069	0.270
MOD_PKA_2	352	358	PF00069	0.475
MOD_PKA_2	563	569	PF00069	0.417
MOD_PKA_2	714	720	PF00069	0.293
MOD_PKA_2	832	838	PF00069	0.325
MOD_PKB_1	461	469	PF00069	0.627
MOD_Plk_1	167	173	PF00069	0.367
MOD_Plk_1	23	29	PF00069	0.809
MOD_Plk_1	527	533	PF00069	0.536
MOD_Plk_1	54	60	PF00069	0.637
MOD_Plk_1	578	584	PF00069	0.414
MOD_Plk_1	656	662	PF00069	0.384
MOD_Plk_1	811	817	PF00069	0.288
MOD_Plk_1	822	828	PF00069	0.278
MOD_Plk_2-3	122	128	PF00069	0.749
MOD_Plk_2-3	23	29	PF00069	0.815
MOD_Plk_4	138	144	PF00069	0.557
MOD_Plk_4	149	155	PF00069	0.323
MOD_Plk_4	204	210	PF00069	0.388
MOD_Plk_4	269	275	PF00069	0.392
MOD_Plk_4	286	292	PF00069	0.230
MOD_Plk_4	341	347	PF00069	0.544
MOD_Plk_4	352	358	PF00069	0.541
MOD_Plk_4	402	408	PF00069	0.293
MOD_Plk_4	492	498	PF00069	0.686
MOD_Plk_4	626	632	PF00069	0.379
MOD_Plk_4	633	639	PF00069	0.327
MOD_Plk_4	680	686	PF00069	0.341
MOD_Plk_4	714	720	PF00069	0.345
MOD_Plk_4	72	78	PF00069	0.716
MOD_Plk_4	815	821	PF00069	0.336
MOD_Plk_4	833	839	PF00069	0.382
MOD_ProDKin_1	382	388	PF00069	0.448
MOD_ProDKin_1	44	50	PF00069	0.695
MOD_ProDKin_1	583	589	PF00069	0.417
MOD_ProDKin_1	701	707	PF00069	0.335
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.480
TRG_DiLeu_BaLyEn_6	702	707	PF01217	0.419
TRG_ENDOCYTIC_2	131	134	PF00928	0.589
TRG_ENDOCYTIC_2	150	153	PF00928	0.190
TRG_ENDOCYTIC_2	175	178	PF00928	0.353
TRG_ENDOCYTIC_2	194	197	PF00928	0.415
TRG_ENDOCYTIC_2	200	203	PF00928	0.399
TRG_ENDOCYTIC_2	244	247	PF00928	0.344
TRG_ENDOCYTIC_2	280	283	PF00928	0.290
TRG_ENDOCYTIC_2	296	299	PF00928	0.250
TRG_ENDOCYTIC_2	358	361	PF00928	0.520
TRG_ENDOCYTIC_2	419	422	PF00928	0.307
TRG_ENDOCYTIC_2	480	483	PF00928	0.710
TRG_ENDOCYTIC_2	663	666	PF00928	0.315
TRG_ER_diArg_1	311	314	PF00400	0.594
TRG_ER_diArg_1	322	325	PF00400	0.685
TRG_ER_diArg_1	410	412	PF00400	0.639
TRG_ER_diArg_1	721	724	PF00400	0.455
TRG_NLS_Bipartite_1	223	243	PF00514	0.561
TRG_NLS_MonoCore_2	460	465	PF00514	0.638
TRG_NLS_MonoExtC_3	238	243	PF00514	0.568
TRG_NLS_MonoExtN_4	461	466	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	686	690	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB4	Leptomonas seymouri	67%	100%
A0A1X0P1U6	Trypanosomatidae	47%	100%
A0A3S7X3Y7	Leishmania donovani	79%	100%
A0A422NAB6	Trypanosoma rangeli	45%	100%
A4I5Z7	Leishmania infantum	79%	100%
C9ZRI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B1E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q6R8	Leishmania major	78%	100%
V5BX06	Trypanosoma cruzi	45%	100%