Tetratricopeptide repeat protein 39B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808), putative

Species:

Leishmania braziliensis

UniProt:

A4HIV5_LEIBR

TriTrypDb:

LbrM.30.3720 , LBRM2903_300044600

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HIV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.432
CLV_C14_Caspase3-7	499	503	PF00656	0.550
CLV_C14_Caspase3-7	510	514	PF00656	0.539
CLV_NRD_NRD_1	130	132	PF00675	0.201
CLV_NRD_NRD_1	137	139	PF00675	0.175
CLV_NRD_NRD_1	185	187	PF00675	0.230
CLV_NRD_NRD_1	293	295	PF00675	0.254
CLV_NRD_NRD_1	317	319	PF00675	0.222
CLV_NRD_NRD_1	368	370	PF00675	0.265
CLV_NRD_NRD_1	538	540	PF00675	0.327
CLV_NRD_NRD_1	575	577	PF00675	0.335
CLV_PCSK_FUR_1	291	295	PF00082	0.254
CLV_PCSK_KEX2_1	293	295	PF00082	0.240
CLV_PCSK_KEX2_1	470	472	PF00082	0.346
CLV_PCSK_KEX2_1	538	540	PF00082	0.327
CLV_PCSK_KEX2_1	575	577	PF00082	0.313
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.377
CLV_PCSK_SKI1_1	122	126	PF00082	0.276
CLV_PCSK_SKI1_1	132	136	PF00082	0.260
CLV_PCSK_SKI1_1	293	297	PF00082	0.217
CLV_PCSK_SKI1_1	328	332	PF00082	0.342
CLV_PCSK_SKI1_1	369	373	PF00082	0.271
CLV_PCSK_SKI1_1	470	474	PF00082	0.354
CLV_PCSK_SKI1_1	546	550	PF00082	0.318
CLV_Separin_Metazoa	46	50	PF03568	0.454
DEG_APCC_DBOX_1	292	300	PF00400	0.519
DEG_APCC_DBOX_1	368	376	PF00400	0.471
DEG_APCC_DBOX_1	78	86	PF00400	0.441
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DOC_CYCLIN_RxL_1	543	553	PF00134	0.554
DOC_CYCLIN_yClb5_NLxxxL_5	228	237	PF00134	0.288
DOC_MAPK_DCC_7	339	347	PF00069	0.428
DOC_MAPK_MEF2A_6	339	347	PF00069	0.428
DOC_PP2B_LxvP_1	276	279	PF13499	0.254
DOC_USP7_MATH_1	326	330	PF00917	0.519
DOC_USP7_MATH_1	519	523	PF00917	0.490
DOC_USP7_MATH_1	63	67	PF00917	0.571
DOC_USP7_MATH_1	88	92	PF00917	0.462
DOC_USP7_UBL2_3	125	129	PF12436	0.434
DOC_USP7_UBL2_3	132	136	PF12436	0.410
DOC_USP7_UBL2_3	140	144	PF12436	0.377
DOC_USP7_UBL2_3	212	216	PF12436	0.428
DOC_USP7_UBL2_3	470	474	PF12436	0.589
DOC_WW_Pin1_4	261	266	PF00397	0.217
DOC_WW_Pin1_4	423	428	PF00397	0.417
LIG_14-3-3_CanoR_1	328	333	PF00244	0.471
LIG_14-3-3_CanoR_1	57	61	PF00244	0.438
LIG_Actin_WH2_2	172	188	PF00022	0.441
LIG_BRCT_BRCA1_1	425	429	PF00533	0.428
LIG_CtBP_PxDLS_1	182	187	PF00389	0.484
LIG_eIF4E_1	161	167	PF01652	0.441
LIG_eIF4E_1	223	229	PF01652	0.269
LIG_FHA_1	150	156	PF00498	0.519
LIG_FHA_1	271	277	PF00498	0.254
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_2	112	118	PF00498	0.359
LIG_FHA_2	16	22	PF00498	0.698
LIG_FHA_2	73	79	PF00498	0.519
LIG_LIR_Apic_2	95	101	PF02991	0.484
LIG_LIR_Gen_1	221	231	PF02991	0.288
LIG_LIR_Gen_1	264	274	PF02991	0.221
LIG_LIR_Gen_1	484	494	PF02991	0.453
LIG_LIR_Gen_1	502	512	PF02991	0.454
LIG_LIR_Gen_1	59	68	PF02991	0.459
LIG_LIR_Nem_3	219	225	PF02991	0.418
LIG_LIR_Nem_3	264	269	PF02991	0.249
LIG_LIR_Nem_3	273	278	PF02991	0.285
LIG_LIR_Nem_3	307	312	PF02991	0.417
LIG_LIR_Nem_3	366	371	PF02991	0.543
LIG_LIR_Nem_3	443	449	PF02991	0.485
LIG_LIR_Nem_3	484	490	PF02991	0.458
LIG_LIR_Nem_3	59	65	PF02991	0.459
LIG_MYND_1	437	441	PF01753	0.489
LIG_NRBOX	232	238	PF00104	0.194
LIG_PCNA_yPIPBox_3	168	179	PF02747	0.417
LIG_Pex14_1	189	193	PF04695	0.503
LIG_Pex14_1	37	41	PF04695	0.428
LIG_Pex14_2	149	153	PF04695	0.428
LIG_PTB_Apo_2	302	309	PF02174	0.541
LIG_PTB_Apo_2	311	318	PF02174	0.489
LIG_PTB_Apo_2	35	42	PF02174	0.484
LIG_PTB_Apo_2	52	59	PF02174	0.484
LIG_PTB_Apo_2	97	104	PF02174	0.359
LIG_PTB_Phospho_1	302	308	PF10480	0.541
LIG_PTB_Phospho_1	35	41	PF10480	0.484
LIG_PTB_Phospho_1	52	58	PF10480	0.484
LIG_RPA_C_Fungi	126	138	PF08784	0.173
LIG_SH2_CRK	193	197	PF00017	0.256
LIG_SH2_CRK	223	227	PF00017	0.254
LIG_SH2_CRK	368	372	PF00017	0.288
LIG_SH2_CRK	396	400	PF00017	0.283
LIG_SH2_CRK	98	102	PF00017	0.283
LIG_SH2_GRB2like	308	311	PF00017	0.269
LIG_SH2_GRB2like	312	315	PF00017	0.239
LIG_SH2_GRB2like	449	452	PF00017	0.316
LIG_SH2_GRB2like	507	510	PF00017	0.391
LIG_SH2_NCK_1	193	197	PF00017	0.269
LIG_SH2_SRC	161	164	PF00017	0.254
LIG_SH2_SRC	349	352	PF00017	0.269
LIG_SH2_STAP1	161	165	PF00017	0.254
LIG_SH2_STAP1	223	227	PF00017	0.200
LIG_SH2_STAP1	312	316	PF00017	0.254
LIG_SH2_STAP1	351	355	PF00017	0.397
LIG_SH2_STAP1	41	45	PF00017	0.364
LIG_SH2_STAP1	58	62	PF00017	0.201
LIG_SH2_STAT3	148	151	PF00017	0.330
LIG_SH2_STAT3	384	387	PF00017	0.254
LIG_SH2_STAT5	148	151	PF00017	0.330
LIG_SH2_STAT5	178	181	PF00017	0.254
LIG_SH2_STAT5	252	255	PF00017	0.256
LIG_SH2_STAT5	275	278	PF00017	0.286
LIG_SH2_STAT5	308	311	PF00017	0.257
LIG_SH2_STAT5	316	319	PF00017	0.250
LIG_SH2_STAT5	34	37	PF00017	0.173
LIG_SH2_STAT5	349	352	PF00017	0.272
LIG_SH2_STAT5	384	387	PF00017	0.282
LIG_SH2_STAT5	449	452	PF00017	0.320
LIG_TRAF2_1	114	117	PF00917	0.173
LIG_TRAF2_1	75	78	PF00917	0.173
LIG_UBA3_1	371	379	PF00899	0.316
LIG_UBA3_1	82	87	PF00899	0.255
MOD_CDK_SPK_2	423	428	PF00069	0.254
MOD_CK1_1	11	17	PF00069	0.595
MOD_CK1_1	4	10	PF00069	0.680
MOD_CK1_1	70	76	PF00069	0.301
MOD_CK1_1	91	97	PF00069	0.276
MOD_CK2_1	111	117	PF00069	0.321
MOD_CK2_1	476	482	PF00069	0.361
MOD_CK2_1	71	77	PF00069	0.269
MOD_GlcNHglycan	13	16	PF01048	0.581
MOD_GlcNHglycan	442	445	PF01048	0.408
MOD_GlcNHglycan	477	481	PF01048	0.398
MOD_GSK3_1	11	18	PF00069	0.589
MOD_GSK3_1	3	10	PF00069	0.689
MOD_GSK3_1	417	424	PF00069	0.361
MOD_GSK3_1	63	70	PF00069	0.323
MOD_GSK3_1	88	95	PF00069	0.348
MOD_N-GLC_1	304	309	PF02516	0.330
MOD_N-GLC_1	421	426	PF02516	0.352
MOD_N-GLC_1	559	564	PF02516	0.432
MOD_N-GLC_1	63	68	PF02516	0.308
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	149	154	PF00069	0.326
MOD_NEK2_1	166	171	PF00069	0.173
MOD_NEK2_1	174	179	PF00069	0.269
MOD_NEK2_1	382	387	PF00069	0.292
MOD_NEK2_1	67	72	PF00069	0.270
MOD_NEK2_1	92	97	PF00069	0.319
MOD_NEK2_2	218	223	PF00069	0.288
MOD_NEK2_2	351	356	PF00069	0.397
MOD_PK_1	235	241	PF00069	0.348
MOD_PKA_1	470	476	PF00069	0.419
MOD_PKA_2	470	476	PF00069	0.360
MOD_PKA_2	56	62	PF00069	0.283
MOD_Plk_1	149	155	PF00069	0.313
MOD_Plk_1	285	291	PF00069	0.291
MOD_Plk_1	304	310	PF00069	0.284
MOD_Plk_1	559	565	PF00069	0.437
MOD_Plk_1	63	69	PF00069	0.397
MOD_Plk_1	7	13	PF00069	0.504
MOD_Plk_2-3	111	117	PF00069	0.279
MOD_Plk_4	174	180	PF00069	0.269
MOD_Plk_4	191	197	PF00069	0.269
MOD_Plk_4	218	224	PF00069	0.288
MOD_Plk_4	235	241	PF00069	0.288
MOD_Plk_4	270	276	PF00069	0.254
MOD_Plk_4	304	310	PF00069	0.287
MOD_Plk_4	351	357	PF00069	0.260
MOD_Plk_4	411	417	PF00069	0.304
MOD_Plk_4	507	513	PF00069	0.354
MOD_Plk_4	519	525	PF00069	0.320
MOD_Plk_4	63	69	PF00069	0.312
MOD_ProDKin_1	261	267	PF00069	0.254
MOD_ProDKin_1	423	429	PF00069	0.254
MOD_SUMO_rev_2	204	213	PF00179	0.356
MOD_SUMO_rev_2	510	519	PF00179	0.456
TRG_DiLeu_BaEn_1	338	343	PF01217	0.254
TRG_DiLeu_BaEn_1	78	83	PF01217	0.173
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.313
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.349
TRG_ENDOCYTIC_2	192	195	PF00928	0.254
TRG_ENDOCYTIC_2	223	226	PF00928	0.254
TRG_ENDOCYTIC_2	275	278	PF00928	0.270
TRG_ENDOCYTIC_2	312	315	PF00928	0.254
TRG_ENDOCYTIC_2	368	371	PF00928	0.254
TRG_ENDOCYTIC_2	396	399	PF00928	0.348
TRG_ENDOCYTIC_2	487	490	PF00928	0.363
TRG_ER_diArg_1	291	294	PF00400	0.306
TRG_ER_diArg_1	537	539	PF00400	0.392
TRG_ER_diArg_1	574	576	PF00400	0.458
TRG_NLS_MonoExtC_3	127	132	PF00514	0.353
TRG_NLS_MonoExtN_4	125	132	PF00514	0.355
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.254
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.173
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD2	Leptomonas seymouri	80%	99%
A0A0S4JLL5	Bodo saltans	58%	100%
A0A1X0P173	Trypanosomatidae	64%	100%
A0A3Q8ICA6	Leishmania donovani	86%	100%
A0A3S5IRG7	Trypanosoma rangeli	64%	100%
A1A5Y5	Danio rerio	26%	100%
A2ACP1	Mus musculus	23%	100%
A4I660	Leishmania infantum	86%	100%
C9ZRI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
D3ZC96	Rattus norvegicus	22%	95%
E9B1E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q0VGK2	Rattus norvegicus	24%	100%
Q1LXE6	Danio rerio	22%	100%
Q28D40	Xenopus tropicalis	23%	100%
Q28DB0	Xenopus tropicalis	22%	99%
Q4Q6R9	Leishmania major	85%	99%
Q5VTQ0	Homo sapiens	20%	86%
Q5XHH9	Xenopus laevis	23%	100%
Q8BYY4	Mus musculus	22%	95%
Q8N584	Homo sapiens	22%	100%
Q8VE09	Mus musculus	22%	100%
Q95LT8	Macaca fascicularis	21%	92%
V5BMN7	Trypanosoma cruzi	64%	100%