Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIV4_LEIBR

TriTrypDb:

LbrM.30.3710 , LBRM2903_300044500

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.530
CLV_C14_Caspase3-7	227	231	PF00656	0.569
CLV_NRD_NRD_1	160	162	PF00675	0.377
CLV_NRD_NRD_1	177	179	PF00675	0.422
CLV_NRD_NRD_1	193	195	PF00675	0.528
CLV_NRD_NRD_1	246	248	PF00675	0.588
CLV_NRD_NRD_1	420	422	PF00675	0.539
CLV_NRD_NRD_1	61	63	PF00675	0.596
CLV_PCSK_KEX2_1	162	164	PF00082	0.468
CLV_PCSK_KEX2_1	192	194	PF00082	0.524
CLV_PCSK_KEX2_1	422	424	PF00082	0.578
CLV_PCSK_KEX2_1	61	63	PF00082	0.576
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.367
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.550
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.322
CLV_PCSK_PC7_1	418	424	PF00082	0.439
CLV_PCSK_SKI1_1	115	119	PF00082	0.565
CLV_PCSK_SKI1_1	133	137	PF00082	0.623
CLV_PCSK_SKI1_1	170	174	PF00082	0.479
CLV_PCSK_SKI1_1	2	6	PF00082	0.649
CLV_PCSK_SKI1_1	274	278	PF00082	0.447
CLV_PCSK_SKI1_1	295	299	PF00082	0.482
CLV_PCSK_SKI1_1	65	69	PF00082	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DOC_CYCLIN_RxL_1	418	431	PF00134	0.524
DOC_MAPK_gen_1	178	186	PF00069	0.501
DOC_MAPK_gen_1	353	362	PF00069	0.478
DOC_MAPK_gen_1	418	427	PF00069	0.425
DOC_MAPK_gen_1	61	72	PF00069	0.469
DOC_MAPK_gen_1	8	16	PF00069	0.427
DOC_MAPK_gen_1	95	102	PF00069	0.558
DOC_MAPK_MEF2A_6	10	18	PF00069	0.480
DOC_MIT_MIM_1	376	384	PF04212	0.344
DOC_PP2B_LxvP_1	319	322	PF13499	0.448
DOC_USP7_MATH_1	239	243	PF00917	0.594
DOC_USP7_MATH_1	296	300	PF00917	0.448
DOC_USP7_MATH_1	311	315	PF00917	0.341
DOC_USP7_MATH_1	63	67	PF00917	0.574
DOC_USP7_MATH_1	88	92	PF00917	0.614
DOC_USP7_UBL2_3	123	127	PF12436	0.482
DOC_USP7_UBL2_3	291	295	PF12436	0.574
LIG_14-3-3_CanoR_1	193	200	PF00244	0.597
LIG_14-3-3_CanoR_1	355	361	PF00244	0.401
LIG_APCC_ABBA_1	425	430	PF00400	0.344
LIG_EH1_1	303	311	PF00400	0.331
LIG_EH1_1	328	336	PF00400	0.528
LIG_FHA_1	119	125	PF00498	0.439
LIG_FHA_1	185	191	PF00498	0.570
LIG_FHA_1	357	363	PF00498	0.563
LIG_FHA_1	372	378	PF00498	0.453
LIG_FHA_1	387	393	PF00498	0.478
LIG_FHA_2	194	200	PF00498	0.535
LIG_FHA_2	262	268	PF00498	0.543
LIG_FHA_2	349	355	PF00498	0.500
LIG_FHA_2	377	383	PF00498	0.557
LIG_IRF3_LxIS_1	360	366	PF10401	0.342
LIG_LIR_Gen_1	201	210	PF02991	0.558
LIG_LIR_Gen_1	251	260	PF02991	0.348
LIG_LIR_Nem_3	201	207	PF02991	0.533
LIG_LIR_Nem_3	251	257	PF02991	0.347
LIG_LIR_Nem_3	52	56	PF02991	0.530
LIG_LIR_Nem_3	73	78	PF02991	0.592
LIG_LRP6_Inhibitor_1	202	208	PF00058	0.381
LIG_SH2_CRK	204	208	PF00017	0.426
LIG_SH2_CRK	254	258	PF00017	0.345
LIG_SH2_CRK	346	350	PF00017	0.486
LIG_SH2_CRK	75	79	PF00017	0.623
LIG_SH2_STAT5	254	257	PF00017	0.346
LIG_SH2_STAT5	58	61	PF00017	0.513
LIG_SH3_5	54	58	PF00018	0.441
LIG_SUMO_SIM_anti_2	359	364	PF11976	0.587
LIG_SUMO_SIM_par_1	182	187	PF11976	0.549
LIG_SUMO_SIM_par_1	307	315	PF11976	0.350
LIG_SUMO_SIM_par_1	358	364	PF11976	0.570
LIG_TRAF2_1	217	220	PF00917	0.576
LIG_TRAF2_1	324	327	PF00917	0.524
LIG_TRAF2_1	336	339	PF00917	0.461
LIG_TRAF2_1	391	394	PF00917	0.463
LIG_TRAF2_1	404	407	PF00917	0.460
LIG_UBA3_1	362	370	PF00899	0.491
LIG_UBA3_1	78	87	PF00899	0.567
LIG_WRC_WIRS_1	33	38	PF05994	0.629
MOD_CK1_1	361	367	PF00069	0.571
MOD_CK1_1	66	72	PF00069	0.578
MOD_CK2_1	151	157	PF00069	0.546
MOD_CK2_1	193	199	PF00069	0.439
MOD_CK2_1	261	267	PF00069	0.542
MOD_CK2_1	312	318	PF00069	0.549
MOD_CK2_1	321	327	PF00069	0.544
MOD_CK2_1	348	354	PF00069	0.525
MOD_CK2_1	363	369	PF00069	0.536
MOD_CK2_1	376	382	PF00069	0.580
MOD_CK2_1	434	440	PF00069	0.606
MOD_Cter_Amidation	59	62	PF01082	0.641
MOD_GlcNHglycan	365	368	PF01048	0.500
MOD_GlcNHglycan	38	41	PF01048	0.518
MOD_GSK3_1	118	125	PF00069	0.531
MOD_GSK3_1	296	303	PF00069	0.443
MOD_GSK3_1	32	39	PF00069	0.623
MOD_GSK3_1	371	378	PF00069	0.490
MOD_GSK3_1	435	442	PF00069	0.591
MOD_NEK2_1	118	123	PF00069	0.494
MOD_NEK2_1	312	317	PF00069	0.438
MOD_NEK2_1	36	41	PF00069	0.592
MOD_NEK2_1	363	368	PF00069	0.524
MOD_NEK2_1	434	439	PF00069	0.555
MOD_NEK2_1	49	54	PF00069	0.613
MOD_NEK2_2	63	68	PF00069	0.543
MOD_PIKK_1	321	327	PF00454	0.567
MOD_PIKK_1	402	408	PF00454	0.501
MOD_PIKK_1	88	94	PF00454	0.426
MOD_PK_1	358	364	PF00069	0.576
MOD_PK_1	68	74	PF00069	0.394
MOD_PKA_1	122	128	PF00069	0.536
MOD_PKA_1	192	198	PF00069	0.572
MOD_PKA_2	192	198	PF00069	0.554
MOD_PKA_2	211	217	PF00069	0.308
MOD_PKA_2	63	69	PF00069	0.578
MOD_Plk_1	12	18	PF00069	0.481
MOD_Plk_1	151	157	PF00069	0.582
MOD_Plk_1	252	258	PF00069	0.501
MOD_Plk_1	261	267	PF00069	0.551
MOD_Plk_4	211	217	PF00069	0.563
MOD_Plk_4	252	258	PF00069	0.346
MOD_Plk_4	32	38	PF00069	0.656
MOD_Plk_4	358	364	PF00069	0.535
MOD_SUMO_for_1	217	220	PF00179	0.405
MOD_SUMO_for_1	257	260	PF00179	0.488
MOD_SUMO_rev_2	109	117	PF00179	0.550
MOD_SUMO_rev_2	142	151	PF00179	0.711
MOD_SUMO_rev_2	166	172	PF00179	0.564
TRG_DiLeu_BaEn_2	112	118	PF01217	0.378
TRG_DiLeu_BaEn_2	31	37	PF01217	0.613
TRG_DiLeu_BaEn_4	219	225	PF01217	0.348
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.364
TRG_ENDOCYTIC_2	204	207	PF00928	0.507
TRG_ENDOCYTIC_2	254	257	PF00928	0.346
TRG_ENDOCYTIC_2	346	349	PF00928	0.442
TRG_ENDOCYTIC_2	75	78	PF00928	0.608
TRG_ER_diArg_1	161	164	PF00400	0.599
TRG_ER_diArg_1	61	64	PF00400	0.575
TRG_NES_CRM1_1	339	354	PF08389	0.412
TRG_NLS_MonoExtC_3	160	166	PF00514	0.362
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II28	Leptomonas seymouri	64%	100%
A0A0S4JDF0	Bodo saltans	26%	100%
A0A0S4JHV1	Bodo saltans	26%	72%
A0A1X0P1A4	Trypanosomatidae	40%	99%
A0A3Q8ISB1	Leishmania donovani	70%	100%
A0A422NMD4	Trypanosoma rangeli	36%	98%
A4I659	Leishmania infantum	71%	100%
C9ZRH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
E9B1E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q6S0	Leishmania major	69%	100%
V5B747	Trypanosoma cruzi	39%	98%