Leucine-rich repeat-containing protein 48

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Component of motile flagella protein 46

Species:

Leishmania braziliensis

UniProt:

A4HIV0_LEIBR

TriTrypDb:

LbrM.30.3670 , LBRM2903_300044100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0000164	protein phosphatase type 1 complex	5	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4HIV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIV0

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035304	regulation of protein dephosphorylation	7	1
GO:0035306	positive regulation of dephosphorylation	8	1
GO:0035307	positive regulation of protein dephosphorylation	8	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048870	cell motility	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	1
GO:0004864	protein phosphatase inhibitor activity	5	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	6	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.536
CLV_C14_Caspase3-7	325	329	PF00656	0.552
CLV_C14_Caspase3-7	548	552	PF00656	0.519
CLV_NRD_NRD_1	326	328	PF00675	0.480
CLV_NRD_NRD_1	335	337	PF00675	0.480
CLV_NRD_NRD_1	458	460	PF00675	0.606
CLV_NRD_NRD_1	498	500	PF00675	0.375
CLV_NRD_NRD_1	534	536	PF00675	0.559
CLV_NRD_NRD_1	57	59	PF00675	0.505
CLV_PCSK_FUR_1	324	328	PF00082	0.422
CLV_PCSK_FUR_1	498	502	PF00082	0.388
CLV_PCSK_FUR_1	531	535	PF00082	0.494
CLV_PCSK_KEX2_1	326	328	PF00082	0.422
CLV_PCSK_KEX2_1	335	337	PF00082	0.422
CLV_PCSK_KEX2_1	377	379	PF00082	0.662
CLV_PCSK_KEX2_1	458	460	PF00082	0.584
CLV_PCSK_KEX2_1	498	500	PF00082	0.390
CLV_PCSK_KEX2_1	533	535	PF00082	0.506
CLV_PCSK_KEX2_1	544	546	PF00082	0.353
CLV_PCSK_KEX2_1	57	59	PF00082	0.419
CLV_PCSK_KEX2_1	79	81	PF00082	0.404
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.662
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.397
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.294
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.521
CLV_PCSK_SKI1_1	163	167	PF00082	0.269
CLV_PCSK_SKI1_1	207	211	PF00082	0.330
CLV_PCSK_SKI1_1	226	230	PF00082	0.213
CLV_PCSK_SKI1_1	314	318	PF00082	0.501
CLV_PCSK_SKI1_1	448	452	PF00082	0.419
CLV_PCSK_SKI1_1	76	80	PF00082	0.456
CLV_PCSK_SKI1_1	88	92	PF00082	0.340
CLV_Separin_Metazoa	274	278	PF03568	0.477
DEG_APCC_DBOX_1	162	170	PF00400	0.532
DEG_APCC_DBOX_1	229	237	PF00400	0.557
DOC_ANK_TNKS_1	276	283	PF00023	0.469
DOC_CYCLIN_RxL_1	201	213	PF00134	0.462
DOC_MAPK_gen_1	419	427	PF00069	0.420
DOC_MAPK_gen_1	531	541	PF00069	0.285
DOC_MAPK_gen_1	54	65	PF00069	0.550
DOC_MAPK_MEF2A_6	421	429	PF00069	0.412
DOC_MAPK_MEF2A_6	534	543	PF00069	0.278
DOC_PP1_RVXF_1	199	206	PF00149	0.461
DOC_PP2B_LxvP_1	10	13	PF13499	0.430
DOC_USP7_MATH_1	372	376	PF00917	0.625
LIG_Actin_WH2_2	352	368	PF00022	0.355
LIG_APCC_ABBA_1	269	274	PF00400	0.568
LIG_APCC_ABBA_1	276	281	PF00400	0.457
LIG_Clathr_ClatBox_1	109	113	PF01394	0.507
LIG_Clathr_ClatBox_1	233	237	PF01394	0.439
LIG_Clathr_ClatBox_1	436	440	PF01394	0.477
LIG_FHA_1	156	162	PF00498	0.520
LIG_FHA_1	374	380	PF00498	0.608
LIG_FHA_1	519	525	PF00498	0.472
LIG_FHA_1	68	74	PF00498	0.411
LIG_FHA_2	143	149	PF00498	0.495
LIG_FHA_2	184	190	PF00498	0.536
LIG_FHA_2	268	274	PF00498	0.531
LIG_FHA_2	33	39	PF00498	0.536
LIG_FHA_2	339	345	PF00498	0.428
LIG_FHA_2	451	457	PF00498	0.334
LIG_FHA_2	488	494	PF00498	0.490
LIG_FHA_2	525	531	PF00498	0.474
LIG_GBD_Chelix_1	383	391	PF00786	0.450
LIG_LIR_Gen_1	113	122	PF02991	0.460
LIG_LIR_Gen_1	270	280	PF02991	0.345
LIG_LIR_Gen_1	431	439	PF02991	0.368
LIG_LIR_Gen_1	493	502	PF02991	0.311
LIG_LIR_Nem_3	113	117	PF02991	0.460
LIG_LIR_Nem_3	118	122	PF02991	0.438
LIG_LIR_Nem_3	258	263	PF02991	0.449
LIG_LIR_Nem_3	270	275	PF02991	0.373
LIG_LIR_Nem_3	431	436	PF02991	0.366
LIG_LIR_Nem_3	493	497	PF02991	0.414
LIG_LIR_Nem_3	74	78	PF02991	0.373
LIG_PCNA_yPIPBox_3	405	419	PF02747	0.433
LIG_Pex14_2	451	455	PF04695	0.398
LIG_SH2_CRK	263	267	PF00017	0.461
LIG_SH2_GRB2like	140	143	PF00017	0.554
LIG_SH2_NCK_1	119	123	PF00017	0.536
LIG_SH2_NCK_1	263	267	PF00017	0.454
LIG_SH2_SRC	175	178	PF00017	0.554
LIG_SH2_STAP1	140	144	PF00017	0.554
LIG_SH2_STAT3	470	473	PF00017	0.670
LIG_SH2_STAT5	175	178	PF00017	0.447
LIG_SH2_STAT5	340	343	PF00017	0.547
LIG_SH2_STAT5	542	545	PF00017	0.482
LIG_SUMO_SIM_anti_2	407	414	PF11976	0.483
LIG_SUMO_SIM_anti_2	423	429	PF11976	0.285
LIG_SUMO_SIM_par_1	183	189	PF11976	0.536
LIG_SUMO_SIM_par_1	69	74	PF11976	0.487
LIG_TRAF2_1	251	254	PF00917	0.566
LIG_TRAF2_1	35	38	PF00917	0.435
LIG_TYR_ITIM	117	122	PF00017	0.536
LIG_UBA3_1	477	484	PF00899	0.544
LIG_WRC_WIRS_1	72	77	PF05994	0.507
MOD_CK1_1	151	157	PF00069	0.455
MOD_CK1_1	33	39	PF00069	0.624
MOD_CK1_1	349	355	PF00069	0.514
MOD_CK1_1	86	92	PF00069	0.452
MOD_CK2_1	183	189	PF00069	0.532
MOD_CK2_1	32	38	PF00069	0.442
MOD_CK2_1	428	434	PF00069	0.384
MOD_CK2_1	450	456	PF00069	0.293
MOD_CK2_1	487	493	PF00069	0.507
MOD_GlcNHglycan	25	28	PF01048	0.517
MOD_GlcNHglycan	462	465	PF01048	0.507
MOD_GSK3_1	151	158	PF00069	0.421
MOD_GSK3_1	460	467	PF00069	0.601
MOD_GSK3_1	516	523	PF00069	0.380
MOD_GSK3_1	67	74	PF00069	0.402
MOD_GSK3_1	82	89	PF00069	0.396
MOD_N-GLC_1	82	87	PF02516	0.424
MOD_NEK2_1	115	120	PF00069	0.459
MOD_NEK2_1	169	174	PF00069	0.481
MOD_NEK2_1	23	28	PF00069	0.471
MOD_NEK2_1	373	378	PF00069	0.690
MOD_NEK2_1	443	448	PF00069	0.438
MOD_NEK2_1	516	521	PF00069	0.391
MOD_NEK2_1	71	76	PF00069	0.400
MOD_PIKK_1	346	352	PF00454	0.427
MOD_PIKK_1	378	384	PF00454	0.592
MOD_PK_1	520	526	PF00069	0.531
MOD_PKA_1	544	550	PF00069	0.289
MOD_PKA_2	519	525	PF00069	0.436
MOD_PKA_2	544	550	PF00069	0.421
MOD_Plk_1	115	121	PF00069	0.472
MOD_Plk_1	169	175	PF00069	0.560
MOD_Plk_1	267	273	PF00069	0.314
MOD_Plk_1	82	88	PF00069	0.479
MOD_Plk_4	105	111	PF00069	0.493
MOD_Plk_4	135	141	PF00069	0.450
MOD_Plk_4	267	273	PF00069	0.314
MOD_Plk_4	450	456	PF00069	0.286
MOD_Plk_4	520	526	PF00069	0.514
MOD_Plk_4	67	73	PF00069	0.372
MOD_SUMO_for_1	510	513	PF00179	0.448
MOD_SUMO_rev_2	48	56	PF00179	0.597
TRG_ENDOCYTIC_2	119	122	PF00928	0.536
TRG_ENDOCYTIC_2	406	409	PF00928	0.390
TRG_ER_diArg_1	198	201	PF00400	0.472
TRG_ER_diArg_1	334	336	PF00400	0.459
TRG_ER_diArg_1	40	43	PF00400	0.544
TRG_ER_diArg_1	497	499	PF00400	0.390
TRG_ER_diArg_1	531	534	PF00400	0.426
TRG_ER_diArg_1	56	58	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB70	Leptomonas seymouri	70%	99%
A0A0S4JNZ9	Bodo saltans	39%	99%
A0A1X0P2D5	Trypanosomatidae	44%	100%
A0A3Q8IF34	Leishmania donovani	82%	100%
A0A422NMM2	Trypanosoma rangeli	43%	100%
A4I655	Leishmania infantum	82%	100%
A8IVX2	Chlamydomonas reinhardtii	26%	100%
C9ZRH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B1D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q6S4	Leishmania major	83%	100%
V5DNR7	Trypanosoma cruzi	43%	100%