Putative CYC2-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CYC2-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIU9_LEIBR

TriTrypDb:

LbrM.30.3660 , LBRM2903_300044000

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU9

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	12
GO:0001932	regulation of protein phosphorylation	7	12
GO:0019220	regulation of phosphate metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031399	regulation of protein modification process	6	12
GO:0042325	regulation of phosphorylation	7	12
GO:0043549	regulation of kinase activity	5	12
GO:0045859	regulation of protein kinase activity	6	12
GO:0050789	regulation of biological process	2	12
GO:0050790	regulation of catalytic activity	3	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051174	regulation of phosphorus metabolic process	5	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0051338	regulation of transferase activity	4	12
GO:0051726	regulation of cell cycle	4	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0065009	regulation of molecular function	2	12
GO:0071900	regulation of protein serine/threonine kinase activity	7	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0019900	kinase binding	4	12
GO:0019901	protein kinase binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.258
CLV_PCSK_KEX2_1	94	96	PF00082	0.258
CLV_PCSK_SKI1_1	110	114	PF00082	0.219
CLV_PCSK_SKI1_1	150	154	PF00082	0.277
CLV_PCSK_SKI1_1	172	176	PF00082	0.297
CLV_PCSK_SKI1_1	74	78	PF00082	0.302
CLV_PCSK_SKI1_1	95	99	PF00082	0.257
DEG_APCC_DBOX_1	109	117	PF00400	0.258
DOC_CYCLIN_RxL_1	104	114	PF00134	0.217
DOC_PP1_RVXF_1	229	235	PF00149	0.384
DOC_PP4_FxxP_1	233	236	PF00568	0.649
DOC_WW_Pin1_4	137	142	PF00397	0.221
DOC_WW_Pin1_4	205	210	PF00397	0.526
DOC_WW_Pin1_4	79	84	PF00397	0.301
LIG_14-3-3_CanoR_1	110	120	PF00244	0.243
LIG_14-3-3_CanoR_1	6	16	PF00244	0.401
LIG_14-3-3_CanoR_1	74	79	PF00244	0.294
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BRCT_BRCA1_1	53	57	PF00533	0.281
LIG_Clathr_ClatBox_1	155	159	PF01394	0.416
LIG_FHA_1	112	118	PF00498	0.249
LIG_FHA_1	70	76	PF00498	0.413
LIG_FHA_2	138	144	PF00498	0.322
LIG_FHA_2	187	193	PF00498	0.488
LIG_FHA_2	206	212	PF00498	0.500
LIG_LIR_Gen_1	130	141	PF02991	0.273
LIG_LIR_Gen_1	166	174	PF02991	0.441
LIG_LIR_Nem_3	130	136	PF02991	0.268
LIG_LIR_Nem_3	166	170	PF02991	0.301
LIG_Rb_pABgroove_1	147	155	PF01858	0.166
LIG_SH2_CRK	167	171	PF00017	0.298
LIG_SH2_NCK_1	133	137	PF00017	0.246
LIG_SH2_SRC	133	136	PF00017	0.316
LIG_SH2_STAP1	71	75	PF00017	0.277
LIG_SH2_STAT5	23	26	PF00017	0.269
LIG_SH2_STAT5	71	74	PF00017	0.302
LIG_SH2_STAT5	92	95	PF00017	0.269
LIG_SH3_3	41	47	PF00018	0.457
MOD_CDK_SPK_2	137	142	PF00069	0.277
MOD_CK1_1	11	17	PF00069	0.326
MOD_CK1_1	186	192	PF00069	0.541
MOD_CK1_1	200	206	PF00069	0.504
MOD_CK2_1	186	192	PF00069	0.433
MOD_GlcNHglycan	10	13	PF01048	0.452
MOD_GlcNHglycan	198	202	PF01048	0.646
MOD_GlcNHglycan	32	35	PF01048	0.472
MOD_GSK3_1	186	193	PF00069	0.455
MOD_GSK3_1	196	203	PF00069	0.450
MOD_GSK3_1	7	14	PF00069	0.386
MOD_NEK2_1	111	116	PF00069	0.208
MOD_NEK2_1	204	209	PF00069	0.663
MOD_NEK2_1	30	35	PF00069	0.469
MOD_NEK2_1	40	45	PF00069	0.486
MOD_NEK2_2	128	133	PF00069	0.387
MOD_PIKK_1	192	198	PF00454	0.522
MOD_PKA_1	69	75	PF00069	0.316
MOD_Plk_1	160	166	PF00069	0.406
MOD_Plk_1	172	178	PF00069	0.304
MOD_Plk_4	128	134	PF00069	0.294
MOD_Plk_4	166	172	PF00069	0.362
MOD_Plk_4	40	46	PF00069	0.497
MOD_Plk_4	74	80	PF00069	0.302
MOD_ProDKin_1	137	143	PF00069	0.221
MOD_ProDKin_1	205	211	PF00069	0.528
MOD_ProDKin_1	79	85	PF00069	0.301
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.337
TRG_ENDOCYTIC_2	133	136	PF00928	0.240
TRG_ENDOCYTIC_2	167	170	PF00928	0.294
TRG_ER_diArg_1	3	6	PF00400	0.446
TRG_ER_diArg_1	93	95	PF00400	0.277
TRG_NES_CRM1_1	154	166	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRS5	Leptomonas seymouri	65%	100%
A0A0S4JHS7	Bodo saltans	48%	75%
A0A1X0P2T0	Trypanosomatidae	48%	100%
A0A3Q8IJQ6	Leishmania donovani	73%	93%
A0A3R7RLR0	Trypanosoma rangeli	48%	100%
A4I654	Leishmania infantum	72%	93%
C9ZRH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B1D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	96%
Q4Q6S5	Leishmania major	72%	100%
Q9M205	Arabidopsis thaliana	29%	100%
V5BSB4	Trypanosoma cruzi	46%	100%