Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIU8_LEIBR

TriTrypDb:

LbrM.30.3650 , LBRM2903_300043900

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	182	184	PF00082	0.560
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.560
CLV_PCSK_SKI1_1	13	17	PF00082	0.712
CLV_PCSK_SKI1_1	72	76	PF00082	0.693
DEG_APCC_DBOX_1	222	230	PF00400	0.775
DEG_Nend_UBRbox_2	1	3	PF02207	0.696
DEG_SCF_FBW7_1	109	114	PF00400	0.573
DOC_CDC14_PxL_1	42	50	PF14671	0.557
DOC_CKS1_1	285	290	PF01111	0.748
DOC_CKS1_1	291	296	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.746
DOC_PP2B_LxvP_1	48	51	PF13499	0.686
DOC_PP4_FxxP_1	153	156	PF00568	0.764
DOC_PP4_FxxP_1	196	199	PF00568	0.666
DOC_PP4_FxxP_1	208	211	PF00568	0.696
DOC_PP4_FxxP_1	241	244	PF00568	0.786
DOC_USP7_MATH_1	122	126	PF00917	0.681
DOC_USP7_MATH_1	127	131	PF00917	0.604
DOC_USP7_MATH_1	143	147	PF00917	0.790
DOC_USP7_MATH_1	156	160	PF00917	0.784
DOC_USP7_MATH_1	211	215	PF00917	0.616
DOC_USP7_MATH_2	156	162	PF00917	0.807
DOC_USP7_UBL2_3	215	219	PF12436	0.719
DOC_WW_Pin1_4	105	110	PF00397	0.710
DOC_WW_Pin1_4	111	116	PF00397	0.712
DOC_WW_Pin1_4	137	142	PF00397	0.758
DOC_WW_Pin1_4	159	164	PF00397	0.636
DOC_WW_Pin1_4	214	219	PF00397	0.750
DOC_WW_Pin1_4	240	245	PF00397	0.703
DOC_WW_Pin1_4	253	258	PF00397	0.613
DOC_WW_Pin1_4	262	267	PF00397	0.651
DOC_WW_Pin1_4	270	275	PF00397	0.490
DOC_WW_Pin1_4	284	289	PF00397	0.695
DOC_WW_Pin1_4	290	295	PF00397	0.695
DOC_WW_Pin1_4	46	51	PF00397	0.608
DOC_WW_Pin1_4	58	63	PF00397	0.714
LIG_14-3-3_CanoR_1	223	227	PF00244	0.776
LIG_14-3-3_CanoR_1	67	74	PF00244	0.817
LIG_APCC_ABBA_1	193	198	PF00400	0.640
LIG_BRCT_BRCA1_1	163	167	PF00533	0.783
LIG_deltaCOP1_diTrp_1	198	208	PF00928	0.711
LIG_eIF4E_1	317	323	PF01652	0.483
LIG_FHA_1	182	188	PF00498	0.698
LIG_FHA_1	297	303	PF00498	0.680
LIG_FHA_1	311	317	PF00498	0.679
LIG_LIR_Apic_2	150	156	PF02991	0.767
LIG_LIR_Apic_2	206	211	PF02991	0.751
LIG_LIR_Apic_2	239	244	PF02991	0.771
LIG_LIR_Gen_1	164	175	PF02991	0.773
LIG_LIR_Gen_1	25	36	PF02991	0.672
LIG_LIR_Nem_3	164	170	PF02991	0.743
LIG_LIR_Nem_3	25	31	PF02991	0.671
LIG_LIR_Nem_3	293	298	PF02991	0.655
LIG_MYND_1	320	324	PF01753	0.474
LIG_MYND_1	46	50	PF01753	0.560
LIG_NRBOX	80	86	PF00104	0.655
LIG_PCNA_yPIPBox_3	72	85	PF02747	0.626
LIG_SH2_CRK	298	302	PF00017	0.676
LIG_SH2_CRK	317	321	PF00017	0.597
LIG_SH2_CRK	342	346	PF00017	0.764
LIG_SH2_NCK_1	230	234	PF00017	0.704
LIG_SH2_NCK_1	317	321	PF00017	0.675
LIG_SH2_NCK_1	342	346	PF00017	0.762
LIG_SH2_SRC	342	345	PF00017	0.761
LIG_SH2_STAP1	230	234	PF00017	0.758
LIG_SH2_STAT3	304	307	PF00017	0.673
LIG_SH2_STAT5	298	301	PF00017	0.681
LIG_SH3_1	357	363	PF00018	0.683
LIG_SH3_2	62	67	PF14604	0.815
LIG_SH3_3	118	124	PF00018	0.782
LIG_SH3_3	148	154	PF00018	0.699
LIG_SH3_3	210	216	PF00018	0.665
LIG_SH3_3	241	247	PF00018	0.729
LIG_SH3_3	251	257	PF00018	0.692
LIG_SH3_3	271	277	PF00018	0.612
LIG_SH3_3	282	288	PF00018	0.632
LIG_SH3_3	303	309	PF00018	0.582
LIG_SH3_3	357	363	PF00018	0.626
LIG_SH3_3	59	65	PF00018	0.767
LIG_SH3_4	215	222	PF00018	0.801
LIG_TRAF2_1	93	96	PF00917	0.792
MOD_CDK_SPK_2	214	219	PF00069	0.804
MOD_CK1_1	114	120	PF00069	0.717
MOD_CK1_1	159	165	PF00069	0.801
MOD_CK1_1	214	220	PF00069	0.793
MOD_CK1_1	232	238	PF00069	0.662
MOD_CK1_1	258	264	PF00069	0.739
MOD_CK2_1	222	228	PF00069	0.702
MOD_DYRK1A_RPxSP_1	137	141	PF00069	0.554
MOD_GlcNHglycan	124	127	PF01048	0.798
MOD_GlcNHglycan	129	132	PF01048	0.740
MOD_GlcNHglycan	163	166	PF01048	0.745
MOD_GlcNHglycan	231	234	PF01048	0.698
MOD_GlcNHglycan	238	241	PF01048	0.698
MOD_GlcNHglycan	257	260	PF01048	0.617
MOD_GlcNHglycan	68	71	PF01048	0.682
MOD_GlcNHglycan	96	99	PF01048	0.788
MOD_GSK3_1	105	112	PF00069	0.735
MOD_GSK3_1	122	129	PF00069	0.629
MOD_GSK3_1	22	29	PF00069	0.689
MOD_GSK3_1	232	239	PF00069	0.675
MOD_GSK3_1	253	260	PF00069	0.698
MOD_GSK3_1	262	269	PF00069	0.672
MOD_GSK3_1	96	103	PF00069	0.776
MOD_N-GLC_1	236	241	PF02516	0.767
MOD_NEK2_1	222	227	PF00069	0.747
MOD_NEK2_1	229	234	PF00069	0.677
MOD_NEK2_1	330	335	PF00069	0.729
MOD_NEK2_1	66	71	PF00069	0.808
MOD_PIKK_1	109	115	PF00454	0.582
MOD_PIKK_1	330	336	PF00454	0.631
MOD_PIKK_1	8	14	PF00454	0.522
MOD_PIKK_1	96	102	PF00454	0.656
MOD_PKA_2	222	228	PF00069	0.775
MOD_PKA_2	66	72	PF00069	0.672
MOD_Plk_1	188	194	PF00069	0.730
MOD_Plk_1	236	242	PF00069	0.685
MOD_Plk_1	26	32	PF00069	0.568
MOD_ProDKin_1	105	111	PF00069	0.707
MOD_ProDKin_1	137	143	PF00069	0.760
MOD_ProDKin_1	159	165	PF00069	0.635
MOD_ProDKin_1	214	220	PF00069	0.749
MOD_ProDKin_1	240	246	PF00069	0.703
MOD_ProDKin_1	253	259	PF00069	0.612
MOD_ProDKin_1	262	268	PF00069	0.650
MOD_ProDKin_1	270	276	PF00069	0.489
MOD_ProDKin_1	284	290	PF00069	0.696
MOD_ProDKin_1	46	52	PF00069	0.610
MOD_ProDKin_1	58	64	PF00069	0.711
MOD_SUMO_rev_2	150	159	PF00179	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGN6	Leptomonas seymouri	52%	98%
A0A1X0P1I8	Trypanosomatidae	25%	94%
A0A3Q8IEJ9	Leishmania donovani	75%	99%
A0A422NME0	Trypanosoma rangeli	27%	98%
A4I653	Leishmania infantum	75%	99%
E9B1D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q6S6	Leishmania major	76%	99%