Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HIU4_LEIBR

TriTrypDb:

LbrM.30.3610 , LBRM2903_300043400

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000245	spliceosomal complex assembly	7	1
GO:0007165	signal transduction	2	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0050684	regulation of mRNA processing	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065007	biological regulation	1	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	4
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.664
CLV_C14_Caspase3-7	581	585	PF00656	0.649
CLV_C14_Caspase3-7	587	591	PF00656	0.587
CLV_C14_Caspase3-7	683	687	PF00656	0.675
CLV_C14_Caspase3-7	700	704	PF00656	0.538
CLV_NRD_NRD_1	138	140	PF00675	0.409
CLV_NRD_NRD_1	25	27	PF00675	0.632
CLV_NRD_NRD_1	333	335	PF00675	0.471
CLV_NRD_NRD_1	343	345	PF00675	0.485
CLV_NRD_NRD_1	599	601	PF00675	0.573
CLV_PCSK_KEX2_1	16	18	PF00082	0.604
CLV_PCSK_KEX2_1	25	27	PF00082	0.582
CLV_PCSK_KEX2_1	332	334	PF00082	0.484
CLV_PCSK_KEX2_1	70	72	PF00082	0.491
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.588
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.582
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.517
CLV_PCSK_SKI1_1	157	161	PF00082	0.298
CLV_PCSK_SKI1_1	202	206	PF00082	0.246
CLV_PCSK_SKI1_1	26	30	PF00082	0.666
CLV_PCSK_SKI1_1	268	272	PF00082	0.279
CLV_PCSK_SKI1_1	325	329	PF00082	0.528
CLV_PCSK_SKI1_1	338	342	PF00082	0.546
CLV_PCSK_SKI1_1	345	349	PF00082	0.602
CLV_PCSK_SKI1_1	402	406	PF00082	0.264
CLV_PCSK_SKI1_1	491	495	PF00082	0.276
CLV_PCSK_SKI1_1	518	522	PF00082	0.353
CLV_PCSK_SKI1_1	635	639	PF00082	0.426
CLV_PCSK_SKI1_1	9	13	PF00082	0.741
DEG_APCC_DBOX_1	267	275	PF00400	0.279
DEG_SCF_FBW7_1	293	300	PF00400	0.357
DOC_ANK_TNKS_1	105	112	PF00023	0.672
DOC_CKS1_1	294	299	PF01111	0.357
DOC_MAPK_gen_1	178	186	PF00069	0.326
DOC_MAPK_gen_1	411	420	PF00069	0.264
DOC_MAPK_HePTP_8	408	420	PF00069	0.264
DOC_MAPK_MEF2A_6	411	420	PF00069	0.264
DOC_PP1_RVXF_1	158	165	PF00149	0.264
DOC_PP4_FxxP_1	30	33	PF00568	0.700
DOC_PP4_FxxP_1	308	311	PF00568	0.490
DOC_PP4_FxxP_1	526	529	PF00568	0.264
DOC_USP7_MATH_1	297	301	PF00917	0.458
DOC_USP7_MATH_1	33	37	PF00917	0.686
DOC_USP7_MATH_1	463	467	PF00917	0.414
DOC_USP7_MATH_1	602	606	PF00917	0.739
DOC_USP7_MATH_1	612	616	PF00917	0.597
DOC_USP7_UBL2_3	12	16	PF12436	0.621
DOC_USP7_UBL2_3	23	27	PF12436	0.654
DOC_USP7_UBL2_3	325	329	PF12436	0.491
DOC_USP7_UBL2_3	337	341	PF12436	0.455
DOC_USP7_UBL2_3	5	9	PF12436	0.628
DOC_USP7_UBL2_3	514	518	PF12436	0.277
DOC_USP7_UBL2_3	66	70	PF12436	0.528
DOC_WW_Pin1_4	293	298	PF00397	0.324
DOC_WW_Pin1_4	531	536	PF00397	0.392
DOC_WW_Pin1_4	537	542	PF00397	0.426
LIG_14-3-3_CanoR_1	316	324	PF00244	0.684
LIG_14-3-3_CanoR_1	344	348	PF00244	0.651
LIG_14-3-3_CanoR_1	665	674	PF00244	0.520
LIG_APCC_ABBA_1	239	244	PF00400	0.279
LIG_BRCT_BRCA1_1	614	618	PF00533	0.663
LIG_BRCT_BRCA1_1	78	82	PF00533	0.478
LIG_Clathr_ClatBox_1	271	275	PF01394	0.279
LIG_CtBP_PxDLS_1	473	477	PF00389	0.279
LIG_deltaCOP1_diTrp_1	378	386	PF00928	0.584
LIG_deltaCOP1_diTrp_1	429	438	PF00928	0.314
LIG_EH1_1	298	306	PF00400	0.424
LIG_eIF4E_1	198	204	PF01652	0.264
LIG_FHA_1	167	173	PF00498	0.264
LIG_FHA_1	403	409	PF00498	0.264
LIG_FHA_1	93	99	PF00498	0.480
LIG_FHA_2	121	127	PF00498	0.608
LIG_FHA_2	128	134	PF00498	0.475
LIG_FHA_2	318	324	PF00498	0.670
LIG_FHA_2	368	374	PF00498	0.601
LIG_FHA_2	375	381	PF00498	0.538
LIG_FHA_2	424	430	PF00498	0.266
LIG_FHA_2	581	587	PF00498	0.679
LIG_FHA_2	628	634	PF00498	0.511
LIG_FHA_2	636	642	PF00498	0.411
LIG_FHA_2	728	734	PF00498	0.650
LIG_Integrin_RGD_1	358	360	PF01839	0.659
LIG_LIR_Apic_2	410	416	PF02991	0.264
LIG_LIR_Apic_2	525	529	PF02991	0.279
LIG_LIR_Gen_1	179	186	PF02991	0.279
LIG_LIR_Gen_1	195	204	PF02991	0.235
LIG_LIR_Gen_1	384	394	PF02991	0.357
LIG_LIR_LC3C_4	55	59	PF02991	0.473
LIG_LIR_Nem_3	195	201	PF02991	0.291
LIG_LIR_Nem_3	254	258	PF02991	0.345
LIG_LIR_Nem_3	384	389	PF02991	0.481
LIG_LIR_Nem_3	400	404	PF02991	0.188
LIG_LIR_Nem_3	499	505	PF02991	0.208
LIG_LIR_Nem_3	549	554	PF02991	0.380
LIG_LIR_Nem_3	556	562	PF02991	0.423
LIG_Pex14_2	167	171	PF04695	0.264
LIG_PTB_Apo_2	150	157	PF02174	0.420
LIG_PTB_Apo_2	625	632	PF02174	0.542
LIG_PTB_Phospho_1	150	156	PF10480	0.424
LIG_PTB_Phospho_1	625	631	PF10480	0.547
LIG_Rb_pABgroove_1	233	241	PF01858	0.326
LIG_RPA_C_Fungi	150	162	PF08784	0.190
LIG_SH2_CRK	156	160	PF00017	0.330
LIG_SH2_CRK	255	259	PF00017	0.264
LIG_SH2_CRK	336	340	PF00017	0.449
LIG_SH2_CRK	559	563	PF00017	0.534
LIG_SH2_GRB2like	487	490	PF00017	0.348
LIG_SH2_NCK_1	193	197	PF00017	0.279
LIG_SH2_SRC	198	201	PF00017	0.264
LIG_SH2_STAP1	127	131	PF00017	0.544
LIG_SH2_STAP1	193	197	PF00017	0.288
LIG_SH2_STAP1	424	428	PF00017	0.298
LIG_SH2_STAP1	592	596	PF00017	0.598
LIG_SH2_STAT5	166	169	PF00017	0.264
LIG_SH2_STAT5	224	227	PF00017	0.298
LIG_SH2_STAT5	631	634	PF00017	0.523
LIG_SH3_3	55	61	PF00018	0.536
LIG_SUMO_SIM_anti_2	279	286	PF11976	0.279
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.478
LIG_SUMO_SIM_anti_2	458	467	PF11976	0.264
LIG_SUMO_SIM_par_1	244	251	PF11976	0.264
LIG_TRAF2_1	340	343	PF00917	0.594
LIG_TYR_ITIM	500	505	PF00017	0.409
LIG_UBA3_1	301	306	PF00899	0.395
LIG_UBA3_1	527	532	PF00899	0.190
MOD_CDK_SPK_2	293	298	PF00069	0.279
MOD_CDK_SPxxK_3	531	538	PF00069	0.298
MOD_CK1_1	189	195	PF00069	0.409
MOD_CK1_1	300	306	PF00069	0.515
MOD_CK1_1	35	41	PF00069	0.631
MOD_CK1_1	372	378	PF00069	0.703
MOD_CK1_1	397	403	PF00069	0.264
MOD_CK1_1	423	429	PF00069	0.190
MOD_CK1_1	534	540	PF00069	0.190
MOD_CK1_1	585	591	PF00069	0.640
MOD_CK1_1	594	600	PF00069	0.709
MOD_CK1_1	84	90	PF00069	0.540
MOD_CK2_1	104	110	PF00069	0.720
MOD_CK2_1	127	133	PF00069	0.524
MOD_CK2_1	189	195	PF00069	0.409
MOD_CK2_1	245	251	PF00069	0.281
MOD_CK2_1	367	373	PF00069	0.629
MOD_CK2_1	374	380	PF00069	0.579
MOD_CK2_1	453	459	PF00069	0.303
MOD_CK2_1	574	580	PF00069	0.632
MOD_CK2_1	627	633	PF00069	0.545
MOD_CK2_1	727	733	PF00069	0.650
MOD_CMANNOS	171	174	PF00535	0.264
MOD_GlcNHglycan	188	191	PF01048	0.264
MOD_GlcNHglycan	571	577	PF01048	0.650
MOD_GlcNHglycan	679	682	PF01048	0.510
MOD_GlcNHglycan	83	86	PF01048	0.544
MOD_GSK3_1	100	107	PF00069	0.750
MOD_GSK3_1	293	300	PF00069	0.393
MOD_GSK3_1	323	330	PF00069	0.538
MOD_GSK3_1	420	427	PF00069	0.253
MOD_GSK3_1	580	587	PF00069	0.649
MOD_GSK3_1	588	595	PF00069	0.663
MOD_GSK3_1	673	680	PF00069	0.609
MOD_GSK3_1	697	704	PF00069	0.696
MOD_GSK3_1	734	741	PF00069	0.636
MOD_N-GLC_1	230	235	PF02516	0.327
MOD_N-GLC_1	602	607	PF02516	0.712
MOD_N-GLC_1	627	632	PF02516	0.540
MOD_N-GLC_2	396	398	PF02516	0.264
MOD_NEK2_1	1	6	PF00069	0.733
MOD_NEK2_1	225	230	PF00069	0.302
MOD_NEK2_1	327	332	PF00069	0.469
MOD_NEK2_1	394	399	PF00069	0.264
MOD_NEK2_1	420	425	PF00069	0.190
MOD_NEK2_1	627	632	PF00069	0.540
MOD_NEK2_1	81	86	PF00069	0.665
MOD_PIKK_1	327	333	PF00454	0.484
MOD_PIKK_1	698	704	PF00454	0.743
MOD_PKA_2	343	349	PF00069	0.694
MOD_PKA_2	361	367	PF00069	0.791
MOD_PKA_2	41	47	PF00069	0.640
MOD_PKA_2	672	678	PF00069	0.663
MOD_Plk_1	585	591	PF00069	0.522
MOD_Plk_1	627	633	PF00069	0.495
MOD_Plk_2-3	580	586	PF00069	0.810
MOD_Plk_2-3	691	697	PF00069	0.809
MOD_Plk_2-3	734	740	PF00069	0.718
MOD_Plk_4	166	172	PF00069	0.264
MOD_Plk_4	245	251	PF00069	0.280
MOD_Plk_4	297	303	PF00069	0.448
MOD_Plk_4	343	349	PF00069	0.531
MOD_Plk_4	641	647	PF00069	0.583
MOD_Plk_4	76	82	PF00069	0.475
MOD_ProDKin_1	293	299	PF00069	0.324
MOD_ProDKin_1	531	537	PF00069	0.392
MOD_SUMO_for_1	287	290	PF00179	0.264
MOD_SUMO_for_1	340	343	PF00179	0.533
MOD_SUMO_rev_2	194	204	PF00179	0.282
MOD_SUMO_rev_2	281	289	PF00179	0.279
MOD_SUMO_rev_2	321	327	PF00179	0.506
MOD_SUMO_rev_2	342	347	PF00179	0.526
MOD_SUMO_rev_2	593	602	PF00179	0.635
MOD_SUMO_rev_2	690	700	PF00179	0.526
MOD_SUMO_rev_2	718	727	PF00179	0.509
TRG_DiLeu_BaEn_1	343	348	PF01217	0.586
TRG_DiLeu_BaEn_1	53	58	PF01217	0.460
TRG_DiLeu_BaEn_1	662	667	PF01217	0.428
TRG_DiLeu_BaEn_2	521	527	PF01217	0.279
TRG_DiLeu_BaEn_4	622	628	PF01217	0.552
TRG_DiLeu_BaEn_4	669	675	PF01217	0.628
TRG_DiLeu_LyEn_5	60	65	PF01217	0.483
TRG_DiLeu_LyEn_5	662	667	PF01217	0.472
TRG_ENDOCYTIC_2	143	146	PF00928	0.351
TRG_ENDOCYTIC_2	156	159	PF00928	0.264
TRG_ENDOCYTIC_2	181	184	PF00928	0.291
TRG_ENDOCYTIC_2	198	201	PF00928	0.198
TRG_ENDOCYTIC_2	255	258	PF00928	0.314
TRG_ENDOCYTIC_2	336	339	PF00928	0.502
TRG_ENDOCYTIC_2	401	404	PF00928	0.268
TRG_ENDOCYTIC_2	502	505	PF00928	0.409
TRG_ENDOCYTIC_2	559	562	PF00928	0.466
TRG_ER_diArg_1	332	334	PF00400	0.519
TRG_NLS_Bipartite_1	16	30	PF00514	0.672
TRG_NLS_MonoCore_2	67	72	PF00514	0.468
TRG_NLS_MonoExtC_3	24	29	PF00514	0.662
TRG_NLS_MonoExtC_3	516	521	PF00514	0.322
TRG_NLS_MonoExtC_3	67	73	PF00514	0.648
TRG_NLS_MonoExtN_4	23	30	PF00514	0.664
TRG_NLS_MonoExtN_4	514	521	PF00514	0.322
TRG_NLS_MonoExtN_4	66	72	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H8	Leptomonas seymouri	80%	100%
A0A0S4JMD1	Bodo saltans	55%	96%
A0A1X0P1B0	Trypanosomatidae	60%	100%
A0A3R7KF70	Trypanosoma rangeli	58%	100%
A0A3S7X404	Leishmania donovani	84%	99%
A4I649	Leishmania infantum	83%	99%
C9ZRG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B1D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4Q6T0	Leishmania major	84%	100%
V5B752	Trypanosoma cruzi	64%	100%