Putative zinc finger-domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger CCCH domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HIU3_LEIBR

TriTrypDb:

LbrM.30.3600 , LBRM2903_300043300

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	50	56	PF00089	0.664
CLV_NRD_NRD_1	165	167	PF00675	0.511
CLV_NRD_NRD_1	175	177	PF00675	0.512
CLV_PCSK_KEX2_1	165	167	PF00082	0.564
CLV_PCSK_KEX2_1	175	177	PF00082	0.563
CLV_PCSK_KEX2_1	52	54	PF00082	0.680
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.352
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.680
CLV_PCSK_SKI1_1	141	145	PF00082	0.540
CLV_PCSK_SKI1_1	190	194	PF00082	0.447
CLV_PCSK_SKI1_1	210	214	PF00082	0.279
CLV_Separin_Metazoa	260	264	PF03568	0.523
DEG_SPOP_SBC_1	238	242	PF00917	0.700
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.515
DOC_MAPK_MEF2A_6	147	154	PF00069	0.423
DOC_PP2B_LxvP_1	89	92	PF13499	0.442
DOC_USP7_MATH_1	114	118	PF00917	0.742
DOC_USP7_MATH_1	202	206	PF00917	0.630
DOC_USP7_MATH_1	238	242	PF00917	0.690
DOC_USP7_UBL2_3	177	181	PF12436	0.336
DOC_WW_Pin1_4	105	110	PF00397	0.535
DOC_WW_Pin1_4	13	18	PF00397	0.614
DOC_WW_Pin1_4	203	208	PF00397	0.523
DOC_WW_Pin1_4	21	26	PF00397	0.674
DOC_WW_Pin1_4	96	101	PF00397	0.614
LIG_14-3-3_CanoR_1	116	124	PF00244	0.728
LIG_14-3-3_CanoR_1	78	83	PF00244	0.378
LIG_Actin_WH2_2	185	202	PF00022	0.539
LIG_APCC_ABBA_1	150	155	PF00400	0.423
LIG_deltaCOP1_diTrp_1	214	223	PF00928	0.550
LIG_eIF4E_1	130	136	PF01652	0.541
LIG_eIF4E_1	22	28	PF01652	0.681
LIG_FAT_LD_1	132	140	PF03623	0.530
LIG_FHA_1	110	116	PF00498	0.585
LIG_FHA_1	97	103	PF00498	0.640
LIG_FHA_2	156	162	PF00498	0.507
LIG_FHA_2	226	232	PF00498	0.573
LIG_FHA_2	247	253	PF00498	0.449
LIG_LIR_Apic_2	232	238	PF02991	0.463
LIG_LIR_Nem_3	137	143	PF02991	0.428
LIG_LIR_Nem_3	44	50	PF02991	0.705
LIG_MYND_1	100	104	PF01753	0.666
LIG_MYND_1	25	29	PF01753	0.748
LIG_NRBOX	131	137	PF00104	0.537
LIG_PCNA_yPIPBox_3	157	166	PF02747	0.415
LIG_SH2_CRK	235	239	PF00017	0.481
LIG_SH2_NCK_1	235	239	PF00017	0.481
LIG_SH2_PTP2	22	25	PF00017	0.627
LIG_SH2_PTP2	47	50	PF00017	0.674
LIG_SH2_STAT5	130	133	PF00017	0.553
LIG_SH2_STAT5	22	25	PF00017	0.638
LIG_SH2_STAT5	235	238	PF00017	0.564
LIG_SH2_STAT5	47	50	PF00017	0.705
LIG_SH3_3	118	124	PF00018	0.581
LIG_SH3_3	15	21	PF00018	0.631
LIG_SH3_3	45	51	PF00018	0.720
LIG_SH3_3	89	95	PF00018	0.605
LIG_SH3_3	98	104	PF00018	0.650
LIG_UBA3_1	135	141	PF00899	0.521
LIG_WRC_WIRS_1	220	225	PF05994	0.549
MOD_CDK_SPxxK_3	109	116	PF00069	0.671
MOD_CDK_SPxxK_3	203	210	PF00069	0.550
MOD_CDK_SPxxK_3	96	103	PF00069	0.673
MOD_CK1_1	13	19	PF00069	0.557
MOD_CK2_1	155	161	PF00069	0.511
MOD_CK2_1	202	208	PF00069	0.467
MOD_CK2_1	219	225	PF00069	0.385
MOD_GlcNHglycan	126	129	PF01048	0.564
MOD_GlcNHglycan	254	257	PF01048	0.661
MOD_GSK3_1	105	112	PF00069	0.618
MOD_GSK3_1	124	131	PF00069	0.546
MOD_GSK3_1	221	228	PF00069	0.499
MOD_GSK3_1	233	240	PF00069	0.507
MOD_GSK3_1	56	63	PF00069	0.457
MOD_GSK3_1	9	16	PF00069	0.606
MOD_N-GLC_1	156	161	PF02516	0.423
MOD_N-GLC_1	8	13	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	115	120	PF00069	0.693
MOD_PIKK_1	115	121	PF00454	0.741
MOD_PIKK_1	179	185	PF00454	0.532
MOD_PKA_2	115	121	PF00069	0.747
MOD_Plk_1	156	162	PF00069	0.420
MOD_Plk_4	23	29	PF00069	0.637
MOD_ProDKin_1	105	111	PF00069	0.534
MOD_ProDKin_1	13	19	PF00069	0.614
MOD_ProDKin_1	203	209	PF00069	0.520
MOD_ProDKin_1	21	27	PF00069	0.678
MOD_ProDKin_1	96	102	PF00069	0.617
MOD_SUMO_rev_2	174	182	PF00179	0.577
MOD_SUMO_rev_2	204	212	PF00179	0.517
TRG_DiLeu_BaEn_1	208	213	PF01217	0.449
TRG_ENDOCYTIC_2	140	143	PF00928	0.433
TRG_ENDOCYTIC_2	47	50	PF00928	0.674
TRG_ER_diArg_1	164	166	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I028	Leptomonas seymouri	81%	100%
A0A1X0P164	Trypanosomatidae	40%	93%
A0A3Q8IFW3	Leishmania donovani	90%	99%
A0A3R7M044	Trypanosoma rangeli	41%	100%
A4I648	Leishmania infantum	90%	99%
C9ZRG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
E9B1D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q6T1	Leishmania major	89%	100%
V5DNR8	Trypanosoma cruzi	40%	100%