Putative mago nashi-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mago nashi-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIU2_LEIBR

TriTrypDb:

LbrM.30.3590 , LBRM2903_300043200

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0035145	exon-exon junction complex	3	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	77	79	PF00082	0.217
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.217
CLV_PCSK_SKI1_1	143	147	PF00082	0.284
CLV_PCSK_SKI1_1	78	82	PF00082	0.297
DOC_CKS1_1	93	98	PF01111	0.497
DOC_MAPK_gen_1	98	108	PF00069	0.481
DOC_MAPK_MEF2A_6	101	108	PF00069	0.482
DOC_PP1_RVXF_1	144	151	PF00149	0.567
DOC_USP7_MATH_1	127	131	PF00917	0.570
DOC_USP7_MATH_1	151	155	PF00917	0.501
DOC_WW_Pin1_4	66	71	PF00397	0.501
DOC_WW_Pin1_4	8	13	PF00397	0.609
DOC_WW_Pin1_4	92	97	PF00397	0.497
LIG_Actin_WH2_2	35	51	PF00022	0.487
LIG_Actin_WH2_2	69	84	PF00022	0.410
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BRCT_BRCA1_1	153	157	PF00533	0.501
LIG_FHA_1	115	121	PF00498	0.487
LIG_FHA_1	130	136	PF00498	0.487
LIG_FHA_1	43	49	PF00498	0.590
LIG_Integrin_isoDGR_2	99	101	PF01839	0.287
LIG_LIR_Apic_2	90	96	PF02991	0.487
LIG_LIR_Gen_1	36	42	PF02991	0.487
LIG_LIR_Nem_3	36	40	PF02991	0.497
LIG_PTB_Apo_2	50	57	PF02174	0.567
LIG_PTB_Phospho_1	50	56	PF10480	0.567
LIG_SH2_CRK	139	143	PF00017	0.567
LIG_SH2_GRB2like	50	53	PF00017	0.539
LIG_SH2_STAT5	22	25	PF00017	0.481
LIG_SH2_STAT5	50	53	PF00017	0.552
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.501
MOD_CDK_SPxK_1	92	98	PF00069	0.354
MOD_CK1_1	114	120	PF00069	0.340
MOD_CK1_1	129	135	PF00069	0.340
MOD_CK1_1	27	33	PF00069	0.429
MOD_CK2_1	8	14	PF00069	0.610
MOD_CK2_1	85	91	PF00069	0.350
MOD_GlcNHglycan	26	29	PF01048	0.429
MOD_GSK3_1	114	121	PF00069	0.340
MOD_GSK3_1	40	47	PF00069	0.452
MOD_GSK3_1	8	15	PF00069	0.606
MOD_N-GLC_1	127	132	PF02516	0.232
MOD_N-GLC_1	51	56	PF02516	0.353
MOD_NEK2_1	108	113	PF00069	0.343
MOD_NEK2_2	151	156	PF00069	0.427
MOD_PIKK_1	15	21	PF00454	0.574
MOD_ProDKin_1	66	72	PF00069	0.360
MOD_ProDKin_1	8	14	PF00069	0.586
MOD_ProDKin_1	92	98	PF00069	0.354
MOD_SUMO_rev_2	69	79	PF00179	0.340
TRG_DiLeu_BaEn_1	131	136	PF01217	0.485
TRG_DiLeu_BaEn_1	75	80	PF01217	0.360
TRG_DiLeu_LyEn_5	75	80	PF01217	0.262
TRG_ENDOCYTIC_2	139	142	PF00928	0.360
TRG_ER_diLys_1	158	162	PF00400	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ5	Leptomonas seymouri	77%	97%
A0A0P0XB70	Oryza sativa subsp. japonica	48%	100%
A0A0S4JLH1	Bodo saltans	59%	77%
A0A1X0P189	Trypanosomatidae	71%	98%
A0A3S7X3Y3	Leishmania donovani	88%	100%
A0A422NMN3	Trypanosoma rangeli	70%	98%
A4I647	Leishmania infantum	88%	100%
B9ENE7	Salmo salar	52%	100%
C9ZRG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	97%
E9B1D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O23676	Arabidopsis thaliana	53%	100%
O42149	Xenopus laevis	53%	100%
O43037	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
O65806	Euphorbia lagascae	50%	100%
P49028	Drosophila melanogaster	50%	100%
P49029	Caenorhabditis elegans	54%	100%
P49030	Oryza sativa subsp. japonica	52%	100%
P50594	Gallus gallus	52%	100%
P61326	Homo sapiens	52%	100%
P61327	Mus musculus	52%	100%
Q0VC92	Bos taurus	52%	100%
Q27W02	Rattus norvegicus	52%	100%
Q3ZBV3	Bos taurus	52%	100%
Q4Q6T2	Leishmania major	91%	100%
Q55E21	Dictyostelium discoideum	45%	82%
Q566Y8	Danio rerio	52%	100%
Q96A72	Homo sapiens	52%	100%
Q9CQL1	Mus musculus	52%	100%