LeishMANIAdb
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Cytochrome p450-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytochrome p450-like protein
Gene product:
cytochrome p450-like protein
Species:
Leishmania braziliensis
UniProt:
A4HIU1_LEIBR
TriTrypDb:
LbrM.30.3580 , LBRM2903_300043100
Length:
509

Annotations

LeishMANIAdb annotations

Homologous to endoplasmic reticulum-localized CYP enzymes of other Eukaryotes. . Most closely similar to sterol C-22 desaturase enzymes of higher plants.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HIU1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU1

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0008152 metabolic process 1 3
GO:0008202 steroid metabolic process 4 1
GO:0016125 sterol metabolic process 4 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004497 monooxygenase activity 3 11
GO:0005488 binding 1 11
GO:0005506 iron ion binding 6 11
GO:0016491 oxidoreductase activity 2 11
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 11
GO:0020037 heme binding 4 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046906 tetrapyrrole binding 3 11
GO:0046914 transition metal ion binding 5 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0008168 methyltransferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016741 transferase activity, transferring one-carbon groups 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 239 241 PF00675 0.206
CLV_NRD_NRD_1 252 254 PF00675 0.206
CLV_NRD_NRD_1 335 337 PF00675 0.312
CLV_NRD_NRD_1 429 431 PF00675 0.222
CLV_PCSK_KEX2_1 252 254 PF00082 0.261
CLV_PCSK_SKI1_1 120 124 PF00082 0.181
CLV_PCSK_SKI1_1 169 173 PF00082 0.157
CLV_PCSK_SKI1_1 257 261 PF00082 0.169
CLV_PCSK_SKI1_1 431 435 PF00082 0.235
DOC_CDC14_PxL_1 480 488 PF14671 0.538
DOC_CKS1_1 472 477 PF01111 0.479
DOC_CYCLIN_yCln2_LP_2 222 228 PF00134 0.406
DOC_CYCLIN_yCln2_LP_2 370 376 PF00134 0.418
DOC_MAPK_gen_1 137 146 PF00069 0.406
DOC_MAPK_gen_1 240 247 PF00069 0.458
DOC_MAPK_gen_1 430 439 PF00069 0.425
DOC_MAPK_MEF2A_6 150 158 PF00069 0.406
DOC_PP2B_LxvP_1 154 157 PF13499 0.406
DOC_PP2B_LxvP_1 222 225 PF13499 0.406
DOC_PP2B_LxvP_1 370 373 PF13499 0.418
DOC_PP2B_LxvP_1 481 484 PF13499 0.519
DOC_PP4_FxxP_1 411 414 PF00568 0.406
DOC_USP7_MATH_1 129 133 PF00917 0.418
DOC_USP7_MATH_1 138 142 PF00917 0.418
DOC_USP7_MATH_1 292 296 PF00917 0.435
DOC_USP7_MATH_1 31 35 PF00917 0.378
DOC_USP7_MATH_1 394 398 PF00917 0.388
DOC_WW_Pin1_4 176 181 PF00397 0.357
DOC_WW_Pin1_4 471 476 PF00397 0.467
DOC_WW_Pin1_4 49 54 PF00397 0.383
LIG_14-3-3_CanoR_1 140 144 PF00244 0.406
LIG_14-3-3_CanoR_1 473 483 PF00244 0.421
LIG_APCC_ABBA_1 379 384 PF00400 0.440
LIG_BIR_II_1 1 5 PF00653 0.302
LIG_BIR_III_2 262 266 PF00653 0.461
LIG_BRCT_BRCA1_1 33 37 PF00533 0.602
LIG_CaM_IQ_9 244 259 PF13499 0.461
LIG_CtBP_PxDLS_1 180 184 PF00389 0.418
LIG_eIF4E_1 487 493 PF01652 0.470
LIG_EVH1_1 371 375 PF00568 0.406
LIG_FHA_1 108 114 PF00498 0.420
LIG_FHA_1 147 153 PF00498 0.418
LIG_FHA_1 195 201 PF00498 0.435
LIG_FHA_1 271 277 PF00498 0.461
LIG_FHA_1 313 319 PF00498 0.443
LIG_FHA_1 348 354 PF00498 0.406
LIG_FHA_1 455 461 PF00498 0.406
LIG_FHA_1 50 56 PF00498 0.383
LIG_FHA_1 85 91 PF00498 0.439
LIG_FHA_2 177 183 PF00498 0.501
LIG_FHA_2 273 279 PF00498 0.400
LIG_FHA_2 300 306 PF00498 0.412
LIG_FHA_2 322 328 PF00498 0.406
LIG_FHA_2 410 416 PF00498 0.461
LIG_FHA_2 92 98 PF00498 0.406
LIG_LIR_Apic_2 409 414 PF02991 0.418
LIG_LIR_Gen_1 141 151 PF02991 0.408
LIG_LIR_Gen_1 211 222 PF02991 0.445
LIG_LIR_Gen_1 34 45 PF02991 0.558
LIG_LIR_Gen_1 350 359 PF02991 0.418
LIG_LIR_Gen_1 457 467 PF02991 0.418
LIG_LIR_Gen_1 468 475 PF02991 0.473
LIG_LIR_Gen_1 81 90 PF02991 0.408
LIG_LIR_Nem_3 141 146 PF02991 0.408
LIG_LIR_Nem_3 153 158 PF02991 0.401
LIG_LIR_Nem_3 211 217 PF02991 0.459
LIG_LIR_Nem_3 231 237 PF02991 0.438
LIG_LIR_Nem_3 34 40 PF02991 0.555
LIG_LIR_Nem_3 350 354 PF02991 0.418
LIG_LIR_Nem_3 457 462 PF02991 0.427
LIG_LIR_Nem_3 468 472 PF02991 0.404
LIG_LIR_Nem_3 81 85 PF02991 0.408
LIG_LIR_Nem_3 87 92 PF02991 0.408
LIG_MYND_1 484 488 PF01753 0.430
LIG_Pex14_1 170 174 PF04695 0.406
LIG_Pex14_2 143 147 PF04695 0.406
LIG_Pex14_2 432 436 PF04695 0.406
LIG_SH2_CRK 214 218 PF00017 0.418
LIG_SH2_CRK 234 238 PF00017 0.425
LIG_SH2_CRK 351 355 PF00017 0.437
LIG_SH2_NCK_1 214 218 PF00017 0.418
LIG_SH2_NCK_1 351 355 PF00017 0.435
LIG_SH2_SRC 155 158 PF00017 0.406
LIG_SH2_SRC 227 230 PF00017 0.440
LIG_SH2_SRC 75 78 PF00017 0.501
LIG_SH2_STAP1 80 84 PF00017 0.435
LIG_SH2_STAT5 14 17 PF00017 0.235
LIG_SH2_STAT5 155 158 PF00017 0.406
LIG_SH2_STAT5 227 230 PF00017 0.406
LIG_SH2_STAT5 459 462 PF00017 0.418
LIG_SH2_STAT5 482 485 PF00017 0.458
LIG_SH3_1 369 375 PF00018 0.406
LIG_SH3_2 375 380 PF14604 0.418
LIG_SH3_3 223 229 PF00018 0.416
LIG_SH3_3 369 375 PF00018 0.406
LIG_SH3_3 7 13 PF00018 0.297
LIG_SUMO_SIM_anti_2 81 87 PF11976 0.383
LIG_TRAF2_1 157 160 PF00917 0.406
LIG_TRAF2_1 179 182 PF00917 0.501
LIG_TYR_ITIM 349 354 PF00017 0.435
LIG_UBA3_1 36 44 PF00899 0.551
MOD_CK1_1 314 320 PF00069 0.399
MOD_CK2_1 176 182 PF00069 0.501
MOD_CK2_1 272 278 PF00069 0.418
MOD_CK2_1 64 70 PF00069 0.452
MOD_GlcNHglycan 117 120 PF01048 0.246
MOD_GlcNHglycan 131 134 PF01048 0.208
MOD_GlcNHglycan 222 225 PF01048 0.261
MOD_GlcNHglycan 422 425 PF01048 0.232
MOD_GSK3_1 146 153 PF00069 0.418
MOD_GSK3_1 307 314 PF00069 0.404
MOD_GSK3_1 409 416 PF00069 0.494
MOD_N-GLC_1 205 210 PF02516 0.341
MOD_NEK2_1 139 144 PF00069 0.406
MOD_NEK2_1 146 151 PF00069 0.406
MOD_NEK2_1 299 304 PF00069 0.406
MOD_NEK2_1 357 362 PF00069 0.406
MOD_PIKK_1 192 198 PF00454 0.406
MOD_PIKK_1 307 313 PF00454 0.406
MOD_PIKK_1 84 90 PF00454 0.435
MOD_PKA_2 139 145 PF00069 0.406
MOD_PKA_2 251 257 PF00069 0.487
MOD_PKA_2 420 426 PF00069 0.357
MOD_Plk_1 107 113 PF00069 0.418
MOD_Plk_1 355 361 PF00069 0.452
MOD_Plk_2-3 347 353 PF00069 0.464
MOD_Plk_2-3 64 70 PF00069 0.452
MOD_Plk_4 139 145 PF00069 0.406
MOD_Plk_4 150 156 PF00069 0.406
MOD_Plk_4 194 200 PF00069 0.418
MOD_Plk_4 272 278 PF00069 0.418
MOD_Plk_4 299 305 PF00069 0.425
MOD_Plk_4 31 37 PF00069 0.416
MOD_Plk_4 316 322 PF00069 0.518
MOD_Plk_4 388 394 PF00069 0.421
MOD_Plk_4 399 405 PF00069 0.501
MOD_Plk_4 454 460 PF00069 0.418
MOD_Plk_4 482 488 PF00069 0.441
MOD_Plk_4 57 63 PF00069 0.438
MOD_Plk_4 64 70 PF00069 0.448
MOD_Plk_4 78 84 PF00069 0.400
MOD_ProDKin_1 176 182 PF00069 0.357
MOD_ProDKin_1 471 477 PF00069 0.462
MOD_ProDKin_1 49 55 PF00069 0.383
MOD_SUMO_for_1 503 506 PF00179 0.616
MOD_SUMO_rev_2 383 392 PF00179 0.460
MOD_SUMO_rev_2 423 433 PF00179 0.406
TRG_DiLeu_BaEn_1 264 269 PF01217 0.435
TRG_DiLeu_BaEn_2 16 22 PF01217 0.370
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.378
TRG_ENDOCYTIC_2 155 158 PF00928 0.406
TRG_ENDOCYTIC_2 214 217 PF00928 0.406
TRG_ENDOCYTIC_2 234 237 PF00928 0.425
TRG_ENDOCYTIC_2 351 354 PF00928 0.435
TRG_ENDOCYTIC_2 459 462 PF00928 0.435
TRG_ENDOCYTIC_2 80 83 PF00928 0.461
TRG_ER_diArg_1 251 253 PF00400 0.461
TRG_ER_diArg_1 341 344 PF00400 0.435
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.301
TRG_Pf-PMV_PEXEL_1 6 11 PF00026 0.590

Homologs

Protein Taxonomy Sequence identity Coverage
A0A098DJ84 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 26% 95%
A0A0B4KZX8 Maesa lanceolata 23% 100%
A0A0B4L1W8 Maesa lanceolata 24% 100%
A0A0N1I4H1 Leptomonas seymouri 22% 100%
A0A0N1P9B9 Leptomonas seymouri 86% 100%
A0A0S1TQ04 Salvia pomifera 22% 100%
A0A0S2II38 Kalopanax septemlobus 23% 100%
A0A0S4JHW8 Bodo saltans 70% 100%
A0A0U2U8U5 Barbarea vulgaris 22% 100%
A0A1I9Q5Z0 Platycodon grandiflorus 23% 100%
A0A1V1FNZ5 Emericella variicolor 29% 96%
A0A1X0NUW4 Trypanosomatidae 23% 100%
A0A1X0P1I7 Trypanosomatidae 75% 100%
A0A1Z3GBS4 Isodon rubescens 21% 100%
A0A3Q7HBJ5 Solanum lycopersicum 24% 100%
A0A3Q7HS74 Solanum lycopersicum 23% 100%
A0A3S5IRG8 Trypanosoma rangeli 71% 100%
A0A3S7WRS7 Leishmania donovani 22% 100%
A0A3S7X3X6 Leishmania donovani 91% 100%
A0A422NRN3 Trypanosoma rangeli 23% 100%
A0A517FNC5 Paris polyphylla 24% 100%
A0A517FND3 Trigonella foenum-graecum 23% 100%
A0A5A4DV62 Paris polyphylla 21% 100%
A2TEF2 Leishmania infantum 22% 100%
A2Z212 Oryza sativa subsp. indica 25% 100%
A4H6N4 Leishmania braziliensis 22% 100%
A4I646 Leishmania infantum 91% 100%
A5BFI4 Vitis vinifera 23% 100%
A9QNE7 Solanum lycopersicum 25% 100%
B5BSX1 Glycyrrhiza uralensis 21% 100%
B8AV52 Oryza sativa subsp. indica 24% 100%
B8N2C8 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 24% 99%
B8NUK6 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 21% 99%
B8QHP3 Starmerella bombicola 24% 98%
D0A7D1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E1BHJ4 Bos taurus 24% 99%
E9ANQ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B1C9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9QY26 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 97%
F6H9N6 Vitis vinifera 24% 100%
G1UB11 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 98%
G3V7X8 Rattus norvegicus 26% 99%
H2DH17 Panax ginseng 25% 97%
I1GQE7 Brachypodium distachyon 25% 100%
I1RBR4 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 20% 97%
I1RE80 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 30% 95%
I1S2J5 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 23% 100%
I1S2M5 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 23% 98%
I7C6E8 Panax ginseng 23% 100%
I7CT85 Panax ginseng 25% 100%
K4CEE8 Solanum lycopersicum 24% 100%
K4CI52 Solanum lycopersicum 23% 100%
K7NBR2 Siraitia grosvenorii 26% 100%
O13820 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 94%
O14442 Uncinula necator 20% 97%
O18993 Callithrix jacchus 24% 100%
O23051 Arabidopsis thaliana 25% 100%
O43174 Homo sapiens 24% 100%
O46420 Sus scrofa 24% 100%
O48956 Sorghum bicolor 21% 99%
O55127 Mus musculus 24% 100%
O64697 Arabidopsis thaliana 37% 100%
O64698 Arabidopsis thaliana 35% 100%
O64989 Arabidopsis thaliana 21% 99%
O81077 Arabidopsis thaliana 23% 100%
O93323 Xenopus laevis 23% 100%
P08684 Homo sapiens 23% 100%
P10613 Candida albicans (strain SC5314 / ATCC MYA-2876) 20% 96%
P10614 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 96%
P22443 Rattus norvegicus 23% 100%
P24462 Homo sapiens 23% 100%
P33268 Macaca fascicularis 22% 100%
P49602 Ustilago maydis (strain 521 / FGSC 9021) 24% 91%
P50859 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 21% 95%
P51538 Rattus norvegicus 22% 100%
P51590 Rattus norvegicus 24% 100%
P54781 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 95%
P79739 Danio rerio 23% 100%
P93596 Triticum aestivum 23% 100%
P93846 Sorghum bicolor 24% 100%
P9WPM4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 22% 100%
P9WPM5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 22% 100%
Q05JG2 Oryza sativa subsp. japonica 26% 100%
Q08D50 Xenopus tropicalis 23% 100%
Q09J78 Oryza sativa subsp. indica 25% 100%
Q09J79 Oryza sativa subsp. indica 26% 100%
Q0J185 Oryza sativa subsp. japonica 25% 100%
Q12664 Penicillium italicum 22% 99%
Q16850 Homo sapiens 24% 100%
Q1JPY5 Danio rerio 24% 100%
Q1T7C2 Solanum lycopersicum 35% 100%
Q27519 Caenorhabditis elegans 22% 98%
Q2MJ20 Medicago truncatula 23% 100%
Q42569 Arabidopsis thaliana 22% 100%
Q43147 Solanum lycopersicum 24% 100%
Q43246 Zea mays 24% 98%
Q4PJW3 Bos taurus 22% 100%
Q4Q6T3 Leishmania major 90% 100%
Q4QGX0 Leishmania major 22% 100%
Q4R8S6 Macaca fascicularis 24% 100%
Q4WK25 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 31% 98%
Q4WNT5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 99%
Q50EK0 Picea sitchensis 25% 100%
Q50EK1 Picea sitchensis 24% 100%
Q50EK5 Pinus taeda 23% 100%
Q50EK6 Pinus taeda 22% 100%
Q50LE0 Solanum lycopersicum 22% 100%
Q54SK0 Dictyostelium discoideum 21% 100%
Q55EK2 Dictyostelium discoideum 37% 96%
Q59990 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 100%
Q5IZM4 Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) 23% 100%
Q5RE72 Pongo abelii 24% 100%
Q5VRM7 Oryza sativa subsp. japonica 24% 100%
Q64464 Mus musculus 22% 100%
Q64654 Rattus norvegicus 22% 100%
Q69F95 Phaseolus vulgaris 23% 100%
Q6EIG3 Danio rerio 24% 100%
Q6F4F5 Oryza sativa subsp. japonica 24% 100%
Q6JD68 Taxus canadensis 24% 100%
Q6JTJ0 Taxus cuspidata 26% 100%
Q6V0L0 Homo sapiens 23% 98%
Q6WG30 Taxus cuspidata 25% 100%
Q6WNQ8 Medicago truncatula 21% 100%
Q6ZDE3 Oryza sativa subsp. japonica 25% 100%
Q759W0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 21% 96%
Q7XU38 Oryza sativa subsp. japonica 24% 99%
Q7Z1V1 Trypanosoma cruzi (strain CL Brener) 24% 100%
Q811W2 Mus musculus 25% 99%
Q84KI1 Taxus cuspidata 24% 100%
Q8GSQ1 Oryza sativa subsp. japonica 25% 100%
Q8K0C4 Mus musculus 23% 100%
Q8N118 Homo sapiens 24% 100%
Q8W4T9 Taxus cuspidata 24% 100%
Q92088 Oncorhynchus mykiss 22% 100%
Q940V4 Arabidopsis thaliana 25% 100%
Q949P1 Arabidopsis thaliana 24% 100%
Q9AXH9 Hordeum vulgare 24% 100%
Q9AXM6 Taxus cuspidata 24% 100%
Q9C5Y2 Arabidopsis thaliana 25% 100%
Q9CA60 Arabidopsis thaliana 21% 100%
Q9FH76 Arabidopsis thaliana 26% 100%
Q9JMA7 Mus musculus 22% 100%
Q9K498 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 24% 100%
Q9LJK2 Arabidopsis thaliana 24% 100%
Q9NR63 Homo sapiens 24% 99%
Q9PUB4 Gallus gallus 23% 100%
Q9SHG5 Arabidopsis thaliana 22% 98%
Q9V4U9 Drosophila melanogaster 25% 100%
Q9V674 Drosophila melanogaster 23% 97%
Q9V675 Drosophila melanogaster 24% 98%
Q9V9L1 Drosophila melanogaster 23% 99%
Q9VB31 Drosophila melanogaster 22% 100%
Q9ZV28 Arabidopsis thaliana 37% 100%
Q9ZV29 Arabidopsis thaliana 37% 100%
V5BSB7 Trypanosoma cruzi 72% 100%
V5C1C6 Trypanosoma cruzi 24% 100%
X2EVQ5 Tanacetum parthenium 20% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS