RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIU0_LEIBR

TriTrypDb:

LbrM.30.3570 , LBRM2903_300043000

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIU0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003747	translation release factor activity	5	3
GO:0005488	binding	1	3
GO:0008079	translation termination factor activity	4	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.355
CLV_C14_Caspase3-7	67	71	PF00656	0.446
CLV_NRD_NRD_1	142	144	PF00675	0.446
CLV_NRD_NRD_1	170	172	PF00675	0.333
CLV_NRD_NRD_1	204	206	PF00675	0.431
CLV_NRD_NRD_1	226	228	PF00675	0.643
CLV_NRD_NRD_1	333	335	PF00675	0.360
CLV_NRD_NRD_1	348	350	PF00675	0.539
CLV_NRD_NRD_1	372	374	PF00675	0.552
CLV_NRD_NRD_1	42	44	PF00675	0.532
CLV_NRD_NRD_1	442	444	PF00675	0.483
CLV_NRD_NRD_1	461	463	PF00675	0.503
CLV_NRD_NRD_1	7	9	PF00675	0.577
CLV_NRD_NRD_1	94	96	PF00675	0.496
CLV_PCSK_FUR_1	199	203	PF00082	0.463
CLV_PCSK_FUR_1	346	350	PF00082	0.265
CLV_PCSK_FUR_1	94	98	PF00082	0.511
CLV_PCSK_KEX2_1	142	144	PF00082	0.446
CLV_PCSK_KEX2_1	170	172	PF00082	0.347
CLV_PCSK_KEX2_1	201	203	PF00082	0.421
CLV_PCSK_KEX2_1	204	206	PF00082	0.415
CLV_PCSK_KEX2_1	226	228	PF00082	0.582
CLV_PCSK_KEX2_1	333	335	PF00082	0.462
CLV_PCSK_KEX2_1	348	350	PF00082	0.476
CLV_PCSK_KEX2_1	37	39	PF00082	0.526
CLV_PCSK_KEX2_1	41	43	PF00082	0.514
CLV_PCSK_KEX2_1	442	444	PF00082	0.457
CLV_PCSK_KEX2_1	461	463	PF00082	0.619
CLV_PCSK_KEX2_1	7	9	PF00082	0.577
CLV_PCSK_KEX2_1	93	95	PF00082	0.480
CLV_PCSK_KEX2_1	96	98	PF00082	0.525
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.569
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.523
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.580
CLV_PCSK_PC7_1	199	205	PF00082	0.439
CLV_PCSK_PC7_1	329	335	PF00082	0.242
CLV_PCSK_PC7_1	38	44	PF00082	0.504
CLV_PCSK_SKI1_1	174	178	PF00082	0.326
CLV_PCSK_SKI1_1	208	212	PF00082	0.458
CLV_PCSK_SKI1_1	333	337	PF00082	0.468
CLV_PCSK_SKI1_1	360	364	PF00082	0.403
CLV_PCSK_SKI1_1	419	423	PF00082	0.436
DEG_APCC_DBOX_1	364	372	PF00400	0.406
DEG_APCC_DBOX_1	80	88	PF00400	0.389
DEG_Nend_UBRbox_3	1	3	PF02207	0.571
DOC_CYCLIN_RxL_1	170	178	PF00134	0.243
DOC_MAPK_gen_1	105	114	PF00069	0.598
DOC_MAPK_gen_1	159	168	PF00069	0.426
DOC_MAPK_gen_1	170	181	PF00069	0.207
DOC_MAPK_gen_1	223	233	PF00069	0.572
DOC_MAPK_gen_1	442	452	PF00069	0.536
DOC_MAPK_gen_1	7	13	PF00069	0.590
DOC_MAPK_gen_1	81	89	PF00069	0.464
DOC_MAPK_HePTP_8	156	168	PF00069	0.442
DOC_MAPK_MEF2A_6	159	168	PF00069	0.423
DOC_MAPK_MEF2A_6	174	181	PF00069	0.347
DOC_MAPK_MEF2A_6	388	396	PF00069	0.375
DOC_MAPK_MEF2A_6	443	452	PF00069	0.480
DOC_MAPK_NFAT4_5	174	182	PF00069	0.365
DOC_MAPK_RevD_3	80	94	PF00069	0.308
DOC_USP7_MATH_1	239	243	PF00917	0.539
DOC_USP7_MATH_1	279	283	PF00917	0.540
DOC_USP7_MATH_1	321	325	PF00917	0.438
DOC_USP7_MATH_1	421	425	PF00917	0.629
DOC_WW_Pin1_4	235	240	PF00397	0.418
DOC_WW_Pin1_4	309	314	PF00397	0.301
DOC_WW_Pin1_4	381	386	PF00397	0.285
DOC_WW_Pin1_4	401	406	PF00397	0.351
DOC_WW_Pin1_4	455	460	PF00397	0.602
LIG_14-3-3_CanoR_1	101	109	PF00244	0.543
LIG_14-3-3_CanoR_1	142	152	PF00244	0.431
LIG_14-3-3_CanoR_1	205	211	PF00244	0.463
LIG_14-3-3_CanoR_1	333	343	PF00244	0.448
LIG_14-3-3_CanoR_1	349	355	PF00244	0.484
LIG_14-3-3_CanoR_1	393	399	PF00244	0.312
LIG_14-3-3_CanoR_1	442	452	PF00244	0.398
LIG_Actin_WH2_2	335	350	PF00022	0.373
LIG_BRCT_BRCA1_1	110	114	PF00533	0.352
LIG_BRCT_BRCA1_1	14	18	PF00533	0.728
LIG_BRCT_BRCA1_2	110	116	PF00533	0.454
LIG_CSL_BTD_1	271	274	PF09270	0.483
LIG_FHA_1	101	107	PF00498	0.366
LIG_FHA_1	144	150	PF00498	0.386
LIG_FHA_1	187	193	PF00498	0.301
LIG_FHA_1	258	264	PF00498	0.389
LIG_FHA_1	436	442	PF00498	0.367
LIG_FHA_1	447	453	PF00498	0.584
LIG_FHA_2	19	25	PF00498	0.568
LIG_LIR_Apic_2	107	113	PF02991	0.434
LIG_LIR_Gen_1	337	347	PF02991	0.507
LIG_LIR_Nem_3	107	112	PF02991	0.434
LIG_LIR_Nem_3	161	166	PF02991	0.368
LIG_LIR_Nem_3	271	276	PF02991	0.384
LIG_LIR_Nem_3	337	342	PF02991	0.403
LIG_Pex14_1	14	18	PF04695	0.428
LIG_Pex14_1	391	395	PF04695	0.472
LIG_Pex14_2	163	167	PF04695	0.367
LIG_Pex14_2	339	343	PF04695	0.309
LIG_REV1ctd_RIR_1	117	125	PF16727	0.363
LIG_REV1ctd_RIR_1	411	420	PF16727	0.358
LIG_RPA_C_Fungi	165	177	PF08784	0.419
LIG_RPA_C_Insects	165	180	PF08784	0.475
LIG_SH2_CRK	110	114	PF00017	0.446
LIG_SH2_CRK	395	399	PF00017	0.453
LIG_SH2_CRK	75	79	PF00017	0.398
LIG_SH2_NCK_1	110	114	PF00017	0.497
LIG_SH2_SRC	308	311	PF00017	0.498
LIG_SH2_STAT5	118	121	PF00017	0.364
LIG_SH2_STAT5	212	215	PF00017	0.557
LIG_SH2_STAT5	302	305	PF00017	0.306
LIG_SUMO_SIM_par_1	9	16	PF11976	0.635
LIG_TRAF2_1	249	252	PF00917	0.351
LIG_TYR_ITSM	105	112	PF00017	0.448
LIG_UBA3_1	86	93	PF00899	0.476
MOD_CDC14_SPxK_1	458	461	PF00782	0.490
MOD_CDK_SPxK_1	455	461	PF00069	0.486
MOD_CDK_SPxxK_3	309	316	PF00069	0.302
MOD_CDK_SPxxK_3	381	388	PF00069	0.277
MOD_CDK_SPxxK_3	401	408	PF00069	0.354
MOD_CDK_SPxxK_3	455	462	PF00069	0.490
MOD_CK1_1	104	110	PF00069	0.557
MOD_CK1_1	16	22	PF00069	0.566
MOD_CK1_1	280	286	PF00069	0.335
MOD_CK1_1	375	381	PF00069	0.307
MOD_CK1_1	446	452	PF00069	0.519
MOD_CK1_1	453	459	PF00069	0.578
MOD_CK2_1	309	315	PF00069	0.327
MOD_CK2_1	394	400	PF00069	0.453
MOD_GlcNHglycan	153	156	PF01048	0.415
MOD_GlcNHglycan	241	244	PF01048	0.523
MOD_GlcNHglycan	31	34	PF01048	0.472
MOD_GlcNHglycan	352	355	PF01048	0.426
MOD_GlcNHglycan	423	426	PF01048	0.560
MOD_GlcNHglycan	445	448	PF01048	0.590
MOD_GlcNHglycan	453	456	PF01048	0.658
MOD_GlcNHglycan	49	52	PF01048	0.438
MOD_GlcNHglycan	66	69	PF01048	0.592
MOD_GSK3_1	104	111	PF00069	0.582
MOD_GSK3_1	12	19	PF00069	0.639
MOD_GSK3_1	158	165	PF00069	0.353
MOD_GSK3_1	235	242	PF00069	0.574
MOD_GSK3_1	375	382	PF00069	0.397
MOD_GSK3_1	417	424	PF00069	0.557
MOD_GSK3_1	446	453	PF00069	0.689
MOD_GSK3_1	96	103	PF00069	0.646
MOD_N-GLC_1	379	384	PF02516	0.445
MOD_N-GLC_1	47	52	PF02516	0.496
MOD_NEK2_1	12	17	PF00069	0.573
MOD_NEK2_1	18	23	PF00069	0.544
MOD_NEK2_1	47	52	PF00069	0.637
MOD_PIKK_1	187	193	PF00454	0.301
MOD_PIKK_1	243	249	PF00454	0.442
MOD_PIKK_1	277	283	PF00454	0.386
MOD_PK_1	108	114	PF00069	0.421
MOD_PKA_1	37	43	PF00069	0.512
MOD_PKA_1	64	70	PF00069	0.459
MOD_PKA_1	96	102	PF00069	0.629
MOD_PKA_2	37	43	PF00069	0.515
MOD_PKA_2	372	378	PF00069	0.512
MOD_PKA_2	441	447	PF00069	0.518
MOD_PKA_2	96	102	PF00069	0.594
MOD_Plk_1	126	132	PF00069	0.421
MOD_Plk_1	356	362	PF00069	0.520
MOD_Plk_4	13	19	PF00069	0.675
MOD_Plk_4	162	168	PF00069	0.391
MOD_Plk_4	268	274	PF00069	0.494
MOD_ProDKin_1	235	241	PF00069	0.418
MOD_ProDKin_1	309	315	PF00069	0.299
MOD_ProDKin_1	381	387	PF00069	0.278
MOD_ProDKin_1	401	407	PF00069	0.347
MOD_ProDKin_1	455	461	PF00069	0.606
MOD_SUMO_for_1	414	417	PF00179	0.479
MOD_SUMO_rev_2	366	375	PF00179	0.300
MOD_SUMO_rev_2	50	59	PF00179	0.546
MOD_SUMO_rev_2	67	74	PF00179	0.509
TRG_DiLeu_BaEn_1	55	60	PF01217	0.309
TRG_DiLeu_BaEn_4	126	132	PF01217	0.459
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.550
TRG_ENDOCYTIC_2	109	112	PF00928	0.456
TRG_ENDOCYTIC_2	395	398	PF00928	0.444
TRG_ENDOCYTIC_2	44	47	PF00928	0.673
TRG_ENDOCYTIC_2	75	78	PF00928	0.510
TRG_ER_diArg_1	142	144	PF00400	0.461
TRG_ER_diArg_1	201	204	PF00400	0.433
TRG_ER_diArg_1	332	334	PF00400	0.368
TRG_ER_diArg_1	345	348	PF00400	0.277
TRG_ER_diArg_1	41	43	PF00400	0.526
TRG_ER_diArg_1	441	443	PF00400	0.473
TRG_ER_diArg_1	80	83	PF00400	0.423
TRG_ER_diArg_1	94	97	PF00400	0.503
TRG_NLS_MonoExtC_3	94	100	PF00514	0.600
TRG_NLS_MonoExtN_4	93	99	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ29	Leptomonas seymouri	59%	100%
A0A0S4JPR1	Bodo saltans	33%	86%
A0A1X0P2E4	Trypanosomatidae	39%	98%
A0A3R7MQL4	Trypanosoma rangeli	43%	97%
A0A3S7X3Z9	Leishmania donovani	80%	100%
A4I645	Leishmania infantum	81%	100%
C9ZRG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	99%
E9B1C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q6T4	Leishmania major	81%	100%
V5BX14	Trypanosoma cruzi	40%	95%