SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lorien protein

Species:

Leishmania braziliensis

UniProt:

A4HIT7_LEIBR

TriTrypDb:

LbrM.30.3540 , LBRM2903_300042700

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIT7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.574
CLV_NRD_NRD_1	148	150	PF00675	0.555
CLV_NRD_NRD_1	188	190	PF00675	0.703
CLV_NRD_NRD_1	245	247	PF00675	0.446
CLV_NRD_NRD_1	424	426	PF00675	0.449
CLV_PCSK_FUR_1	186	190	PF00082	0.565
CLV_PCSK_KEX2_1	145	147	PF00082	0.596
CLV_PCSK_KEX2_1	150	152	PF00082	0.555
CLV_PCSK_KEX2_1	185	187	PF00082	0.729
CLV_PCSK_KEX2_1	188	190	PF00082	0.692
CLV_PCSK_KEX2_1	245	247	PF00082	0.508
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.644
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.618
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.518
CLV_PCSK_PC7_1	146	152	PF00082	0.604
CLV_PCSK_SKI1_1	169	173	PF00082	0.589
CLV_PCSK_SKI1_1	198	202	PF00082	0.531
CLV_PCSK_SKI1_1	246	250	PF00082	0.423
CLV_PCSK_SKI1_1	262	266	PF00082	0.299
CLV_PCSK_SKI1_1	308	312	PF00082	0.282
CLV_PCSK_SKI1_1	380	384	PF00082	0.363
CLV_PCSK_SKI1_1	94	98	PF00082	0.536
DEG_APCC_DBOX_1	122	130	PF00400	0.391
DEG_APCC_DBOX_1	245	253	PF00400	0.479
DEG_APCC_DBOX_1	261	269	PF00400	0.304
DEG_APCC_DBOX_1	307	315	PF00400	0.295
DEG_APCC_DBOX_1	68	76	PF00400	0.477
DEG_Nend_UBRbox_3	1	3	PF02207	0.443
DEG_SCF_FBW7_2	83	89	PF00400	0.515
DOC_CKS1_1	83	88	PF01111	0.738
DOC_CYCLIN_RxL_1	305	315	PF00134	0.443
DOC_CYCLIN_RxL_1	377	384	PF00134	0.418
DOC_CYCLIN_yClb5_NLxxxL_5	280	289	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.532
DOC_MAPK_gen_1	245	251	PF00069	0.485
DOC_MAPK_gen_1	90	99	PF00069	0.500
DOC_MAPK_MEF2A_6	364	371	PF00069	0.367
DOC_MAPK_MEF2A_6	380	389	PF00069	0.348
DOC_PP2B_LxvP_1	289	292	PF13499	0.379
DOC_PP2B_LxvP_1	310	313	PF13499	0.305
DOC_PP4_FxxP_1	160	163	PF00568	0.505
DOC_PP4_FxxP_1	257	260	PF00568	0.419
DOC_USP7_MATH_1	173	177	PF00917	0.679
DOC_USP7_MATH_1	204	208	PF00917	0.723
DOC_USP7_MATH_1	24	28	PF00917	0.471
DOC_USP7_MATH_1	436	440	PF00917	0.615
DOC_USP7_MATH_1	467	471	PF00917	0.431
DOC_USP7_UBL2_3	542	546	PF12436	0.555
DOC_WW_Pin1_4	15	20	PF00397	0.615
DOC_WW_Pin1_4	215	220	PF00397	0.622
DOC_WW_Pin1_4	263	268	PF00397	0.287
DOC_WW_Pin1_4	301	306	PF00397	0.498
DOC_WW_Pin1_4	352	357	PF00397	0.379
DOC_WW_Pin1_4	41	46	PF00397	0.498
DOC_WW_Pin1_4	432	437	PF00397	0.673
DOC_WW_Pin1_4	536	541	PF00397	0.359
DOC_WW_Pin1_4	82	87	PF00397	0.668
LIG_14-3-3_CanoR_1	115	122	PF00244	0.485
LIG_14-3-3_CanoR_1	130	134	PF00244	0.491
LIG_14-3-3_CanoR_1	198	203	PF00244	0.659
LIG_14-3-3_CanoR_1	344	349	PF00244	0.289
LIG_Actin_WH2_2	282	298	PF00022	0.432
LIG_Actin_WH2_2	526	544	PF00022	0.460
LIG_BIR_III_2	95	99	PF00653	0.550
LIG_EVH1_1	160	164	PF00568	0.498
LIG_FHA_1	157	163	PF00498	0.598
LIG_FHA_1	366	372	PF00498	0.287
LIG_FHA_1	480	486	PF00498	0.571
LIG_FHA_1	553	559	PF00498	0.648
LIG_FHA_2	24	30	PF00498	0.682
LIG_FHA_2	392	398	PF00498	0.449
LIG_FHA_2	42	48	PF00498	0.537
LIG_FHA_2	53	59	PF00498	0.483
LIG_FHA_2	86	92	PF00498	0.704
LIG_FHA_2	98	104	PF00498	0.564
LIG_GBD_Chelix_1	374	382	PF00786	0.313
LIG_LIR_Apic_2	14	19	PF02991	0.483
LIG_LIR_Apic_2	159	163	PF02991	0.508
LIG_LIR_Apic_2	255	260	PF02991	0.415
LIG_LIR_Apic_2	321	327	PF02991	0.363
LIG_LIR_Apic_2	422	427	PF02991	0.388
LIG_LIR_Nem_3	215	220	PF02991	0.497
LIG_LIR_Nem_3	266	272	PF02991	0.296
LIG_LIR_Nem_3	397	402	PF02991	0.352
LIG_MAD2	542	550	PF02301	0.473
LIG_MYND_1	73	77	PF01753	0.501
LIG_NRBOX	306	312	PF00104	0.247
LIG_PCNA_yPIPBox_3	504	518	PF02747	0.371
LIG_Pex14_1	517	521	PF04695	0.283
LIG_SH2_CRK	16	20	PF00017	0.617
LIG_SH2_CRK	424	428	PF00017	0.388
LIG_SH2_CRK	545	549	PF00017	0.392
LIG_SH2_GRB2like	340	343	PF00017	0.434
LIG_SH2_STAP1	196	200	PF00017	0.498
LIG_SH2_STAT3	521	524	PF00017	0.444
LIG_SH2_STAT5	340	343	PF00017	0.479
LIG_SH2_STAT5	472	475	PF00017	0.503
LIG_SH2_STAT5	531	534	PF00017	0.490
LIG_SH3_1	151	157	PF00018	0.625
LIG_SH3_1	424	430	PF00018	0.388
LIG_SH3_3	151	157	PF00018	0.770
LIG_SH3_3	158	164	PF00018	0.623
LIG_SH3_3	197	203	PF00018	0.679
LIG_SH3_3	205	211	PF00018	0.584
LIG_SH3_3	261	267	PF00018	0.334
LIG_SH3_3	343	349	PF00018	0.343
LIG_SH3_3	424	430	PF00018	0.388
LIG_SH3_3	70	76	PF00018	0.621
LIG_SH3_3	78	84	PF00018	0.611
LIG_SUMO_SIM_anti_2	554	562	PF11976	0.559
LIG_SUMO_SIM_par_1	367	373	PF11976	0.345
LIG_SUMO_SIM_par_1	374	379	PF11976	0.434
LIG_SUMO_SIM_par_1	554	562	PF11976	0.568
LIG_TRAF2_1	179	182	PF00917	0.684
LIG_TRAF2_1	44	47	PF00917	0.549
LIG_TRFH_1	263	267	PF08558	0.306
LIG_TYR_ITIM	543	548	PF00017	0.362
MOD_CDC14_SPxK_1	355	358	PF00782	0.531
MOD_CDC14_SPxK_1	539	542	PF00782	0.339
MOD_CDK_SPxK_1	352	358	PF00069	0.518
MOD_CDK_SPxK_1	536	542	PF00069	0.470
MOD_CDK_SPxxK_3	263	270	PF00069	0.245
MOD_CDK_SPxxK_3	301	308	PF00069	0.464
MOD_CK1_1	117	123	PF00069	0.479
MOD_CK1_1	215	221	PF00069	0.612
MOD_CK1_1	435	441	PF00069	0.602
MOD_CK2_1	15	21	PF00069	0.610
MOD_CK2_1	204	210	PF00069	0.665
MOD_CK2_1	391	397	PF00069	0.459
MOD_CK2_1	41	47	PF00069	0.543
MOD_CK2_1	436	442	PF00069	0.667
MOD_CK2_1	52	58	PF00069	0.521
MOD_CK2_1	551	557	PF00069	0.547
MOD_CK2_1	85	91	PF00069	0.691
MOD_CK2_1	97	103	PF00069	0.421
MOD_Cter_Amidation	147	150	PF01082	0.527
MOD_GlcNHglycan	191	194	PF01048	0.667
MOD_GlcNHglycan	26	29	PF01048	0.569
MOD_GlcNHglycan	289	292	PF01048	0.442
MOD_GlcNHglycan	389	392	PF01048	0.469
MOD_GSK3_1	173	180	PF00069	0.637
MOD_GSK3_1	215	222	PF00069	0.605
MOD_GSK3_1	280	287	PF00069	0.341
MOD_GSK3_1	365	372	PF00069	0.437
MOD_GSK3_1	387	394	PF00069	0.482
MOD_GSK3_1	432	439	PF00069	0.692
MOD_GSK3_1	532	539	PF00069	0.491
MOD_GSK3_1	58	65	PF00069	0.457
MOD_N-GLC_1	52	57	PF02516	0.576
MOD_NEK2_1	285	290	PF00069	0.400
MOD_NEK2_1	335	340	PF00069	0.395
MOD_NEK2_1	479	484	PF00069	0.372
MOD_NEK2_2	467	472	PF00069	0.458
MOD_PIKK_1	519	525	PF00454	0.429
MOD_PKA_2	114	120	PF00069	0.526
MOD_PKA_2	129	135	PF00069	0.516
MOD_PKB_1	69	77	PF00069	0.485
MOD_Plk_1	369	375	PF00069	0.304
MOD_Plk_1	449	455	PF00069	0.503
MOD_Plk_1	479	485	PF00069	0.420
MOD_Plk_1	52	58	PF00069	0.495
MOD_Plk_4	106	112	PF00069	0.623
MOD_Plk_4	335	341	PF00069	0.387
MOD_Plk_4	370	376	PF00069	0.401
MOD_ProDKin_1	15	21	PF00069	0.613
MOD_ProDKin_1	215	221	PF00069	0.619
MOD_ProDKin_1	263	269	PF00069	0.289
MOD_ProDKin_1	301	307	PF00069	0.484
MOD_ProDKin_1	352	358	PF00069	0.380
MOD_ProDKin_1	41	47	PF00069	0.492
MOD_ProDKin_1	432	438	PF00069	0.673
MOD_ProDKin_1	536	542	PF00069	0.358
MOD_ProDKin_1	82	88	PF00069	0.667
MOD_SUMO_for_1	328	331	PF00179	0.486
MOD_SUMO_for_1	503	506	PF00179	0.430
TRG_ENDOCYTIC_2	269	272	PF00928	0.341
TRG_ENDOCYTIC_2	545	548	PF00928	0.383
TRG_ER_diArg_1	151	154	PF00400	0.644
TRG_ER_diArg_1	186	189	PF00400	0.515
TRG_ER_diArg_1	512	515	PF00400	0.450
TRG_ER_diArg_1	69	72	PF00400	0.605
TRG_NES_CRM1_1	301	316	PF08389	0.281
TRG_NES_CRM1_1	397	410	PF08389	0.423
TRG_NLS_Bipartite_1	139	154	PF00514	0.693
TRG_NLS_MonoCore_2	184	189	PF00514	0.519
TRG_NLS_MonoCore_2	424	429	PF00514	0.505
TRG_NLS_MonoExtC_3	148	153	PF00514	0.655
TRG_NLS_MonoExtC_3	184	189	PF00514	0.519
TRG_NLS_MonoExtN_4	146	153	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I181	Leptomonas seymouri	55%	96%
A0A0S4JLR1	Bodo saltans	29%	100%
A0A1X0P185	Trypanosomatidae	37%	100%
A0A3R7KHL3	Trypanosoma rangeli	35%	100%
C9ZRF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AHK2	Leishmania infantum	78%	95%
V5BSC2	Trypanosoma cruzi	37%	100%