Putative casein kinase 1 isoform 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase 1 isoform 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HIT6_LEIBR

TriTrypDb:

LbrM.30.3520 , LBRM2903_300042300

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HIT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIT6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0007165	signal transduction	2	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0004674	protein serine/threonine kinase activity	4	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.701
CLV_NRD_NRD_1	220	222	PF00675	0.386
CLV_PCSK_KEX2_1	220	222	PF00082	0.386
CLV_PCSK_KEX2_1	23	25	PF00082	0.658
CLV_PCSK_KEX2_1	248	250	PF00082	0.424
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.673
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.424
CLV_PCSK_SKI1_1	156	160	PF00082	0.376
CLV_PCSK_SKI1_1	199	203	PF00082	0.359
CLV_PCSK_SKI1_1	257	261	PF00082	0.507
DEG_APCC_DBOX_1	220	228	PF00400	0.419
DEG_Nend_UBRbox_3	1	3	PF02207	0.615
DEG_SCF_FBW7_2	261	267	PF00400	0.360
DOC_CKS1_1	261	266	PF01111	0.356
DOC_CYCLIN_RxL_1	281	291	PF00134	0.472
DOC_MAPK_gen_1	23	30	PF00069	0.680
DOC_MAPK_gen_1	245	253	PF00069	0.426
DOC_MAPK_MEF2A_6	132	141	PF00069	0.386
DOC_PP1_RVXF_1	247	254	PF00149	0.428
DOC_PP1_RVXF_1	282	289	PF00149	0.462
DOC_SPAK_OSR1_1	33	37	PF12202	0.419
DOC_USP7_MATH_1	330	334	PF00917	0.787
DOC_USP7_MATH_1	337	341	PF00917	0.766
DOC_USP7_UBL2_3	128	132	PF12436	0.419
DOC_WW_Pin1_4	243	248	PF00397	0.461
DOC_WW_Pin1_4	260	265	PF00397	0.384
DOC_WW_Pin1_4	333	338	PF00397	0.731
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.383
LIG_BIR_III_4	329	333	PF00653	0.841
LIG_BRCT_BRCA1_1	284	288	PF00533	0.600
LIG_BRCT_BRCA1_1	355	359	PF00533	0.726
LIG_FHA_1	105	111	PF00498	0.467
LIG_FHA_1	275	281	PF00498	0.523
LIG_FHA_1	353	359	PF00498	0.763
LIG_FHA_1	89	95	PF00498	0.423
LIG_FHA_2	65	71	PF00498	0.268
LIG_GBD_Chelix_1	173	181	PF00786	0.467
LIG_LIR_Gen_1	105	114	PF02991	0.419
LIG_LIR_Gen_1	250	261	PF02991	0.478
LIG_LIR_Gen_1	313	323	PF02991	0.547
LIG_LIR_Nem_3	204	210	PF02991	0.386
LIG_LIR_Nem_3	238	244	PF02991	0.421
LIG_LIR_Nem_3	250	256	PF02991	0.508
LIG_LIR_Nem_3	277	282	PF02991	0.461
LIG_LIR_Nem_3	313	319	PF02991	0.501
LIG_LIR_Nem_3	47	52	PF02991	0.395
LIG_LIR_Nem_3	79	85	PF02991	0.360
LIG_PDZ_Class_3	386	391	PF00595	0.710
LIG_Pex14_2	45	49	PF04695	0.419
LIG_Rb_pABgroove_1	116	124	PF01858	0.268
LIG_SH2_PTP2	207	210	PF00017	0.386
LIG_SH2_SRC	147	150	PF00017	0.467
LIG_SH2_SRC	195	198	PF00017	0.521
LIG_SH2_STAP1	106	110	PF00017	0.467
LIG_SH2_STAP1	282	286	PF00017	0.497
LIG_SH2_STAP1	312	316	PF00017	0.547
LIG_SH2_STAT3	314	317	PF00017	0.505
LIG_SH2_STAT5	106	109	PF00017	0.375
LIG_SH2_STAT5	147	150	PF00017	0.404
LIG_SH2_STAT5	153	156	PF00017	0.363
LIG_SH2_STAT5	175	178	PF00017	0.386
LIG_SH2_STAT5	207	210	PF00017	0.386
LIG_SH2_STAT5	233	236	PF00017	0.390
LIG_SH2_STAT5	279	282	PF00017	0.482
LIG_SH2_STAT5	314	317	PF00017	0.561
LIG_SH2_STAT5	99	102	PF00017	0.430
LIG_SH3_3	331	337	PF00018	0.726
LIG_SUMO_SIM_anti_2	107	112	PF11976	0.521
LIG_SUMO_SIM_par_1	105	112	PF11976	0.473
LIG_TRAF2_2	273	278	PF00917	0.521
MOD_CDC14_SPxK_1	246	249	PF00782	0.467
MOD_CDK_SPK_2	243	248	PF00069	0.467
MOD_CDK_SPK_2	333	338	PF00069	0.585
MOD_CDK_SPxK_1	243	249	PF00069	0.467
MOD_CK1_1	15	21	PF00069	0.580
MOD_CK1_1	209	215	PF00069	0.467
MOD_CK1_1	333	339	PF00069	0.782
MOD_CK1_1	375	381	PF00069	0.540
MOD_CK2_1	319	325	PF00069	0.715
MOD_GlcNHglycan	301	304	PF01048	0.554
MOD_GlcNHglycan	339	342	PF01048	0.755
MOD_GlcNHglycan	343	346	PF01048	0.630
MOD_GlcNHglycan	362	365	PF01048	0.739
MOD_GlcNHglycan	55	58	PF01048	0.386
MOD_GSK3_1	197	204	PF00069	0.467
MOD_GSK3_1	319	326	PF00069	0.580
MOD_GSK3_1	333	340	PF00069	0.831
MOD_GSK3_1	348	355	PF00069	0.638
MOD_GSK3_1	368	375	PF00069	0.822
MOD_N-GLC_1	319	324	PF02516	0.473
MOD_N-GLC_1	375	380	PF02516	0.542
MOD_N-GLC_2	86	88	PF02516	0.386
MOD_NEK2_1	1	6	PF00069	0.801
MOD_NEK2_1	201	206	PF00069	0.386
MOD_NEK2_1	280	285	PF00069	0.427
MOD_NEK2_1	353	358	PF00069	0.739
MOD_NEK2_1	360	365	PF00069	0.762
MOD_NEK2_1	368	373	PF00069	0.571
MOD_NEK2_1	64	69	PF00069	0.326
MOD_PIKK_1	368	374	PF00454	0.641
MOD_PK_1	206	212	PF00069	0.386
MOD_PKA_2	185	191	PF00069	0.390
MOD_PKA_2	235	241	PF00069	0.331
MOD_PKA_2	330	336	PF00069	0.780
MOD_PKA_2	337	343	PF00069	0.759
MOD_PKA_2	348	354	PF00069	0.709
MOD_Plk_1	104	110	PF00069	0.521
MOD_Plk_4	104	110	PF00069	0.419
MOD_Plk_4	225	231	PF00069	0.423
MOD_Plk_4	354	360	PF00069	0.741
MOD_Plk_4	94	100	PF00069	0.443
MOD_ProDKin_1	243	249	PF00069	0.461
MOD_ProDKin_1	260	266	PF00069	0.390
MOD_ProDKin_1	333	339	PF00069	0.730
MOD_SUMO_for_1	158	161	PF00179	0.386
MOD_SUMO_for_1	62	65	PF00179	0.386
MOD_SUMO_rev_2	254	262	PF00179	0.557
TRG_ENDOCYTIC_2	106	109	PF00928	0.386
TRG_ENDOCYTIC_2	207	210	PF00928	0.386
TRG_ENDOCYTIC_2	316	319	PF00928	0.499
TRG_ENDOCYTIC_2	82	85	PF00928	0.386
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	42%	100%
A0A0N1HU44	Leptomonas seymouri	43%	100%
A0A0N1HU45	Leptomonas seymouri	73%	100%
A0A0N1I2H3	Leptomonas seymouri	39%	100%
A0A0N1IKB0	Leptomonas seymouri	34%	69%
A0A0S4IVY6	Bodo saltans	44%	95%
A0A0S4JA30	Bodo saltans	43%	100%
A0A0S4JN06	Bodo saltans	46%	100%
A0A0S4JP58	Bodo saltans	46%	92%
A0A0S4JU73	Bodo saltans	27%	82%
A0A0S4JXJ0	Bodo saltans	43%	100%
A0A1X0NIT3	Trypanosomatidae	44%	100%
A0A1X0NXJ1	Trypanosomatidae	41%	100%
A0A1X0NZS9	Trypanosomatidae	43%	88%
A0A1X0P176	Trypanosomatidae	59%	100%
A0A3Q8IJ66	Leishmania donovani	46%	100%
A0A3Q8ISA0	Leishmania donovani	81%	100%
A0A3S7WNZ6	Leishmania donovani	39%	100%
A0A3S7X0V1	Leishmania donovani	31%	69%
A0A3S7X8X3	Leishmania donovani	44%	100%
A0A422MSV5	Trypanosoma rangeli	41%	100%
A0A422NL83	Trypanosoma rangeli	45%	98%
A4H436	Leishmania braziliensis	38%	100%
A4HCD7	Leishmania braziliensis	22%	92%
A4HEI6	Leishmania braziliensis	43%	76%
A4HFV0	Leishmania braziliensis	32%	70%
A4HMD0	Leishmania braziliensis	44%	100%
A4HMD1	Leishmania braziliensis	46%	100%
A4HSC0	Leishmania infantum	39%	100%
A4I2Y4	Leishmania infantum	31%	69%
A4I638	Leishmania infantum	81%	100%
A4IAZ7	Leishmania infantum	44%	100%
A4IAZ8	Leishmania infantum	46%	100%
A7E3X2	Bos taurus	44%	86%
B9VVJ6	Trypanosoma brucei brucei	48%	100%
C6K3W8	Leptomonas seymouri	23%	74%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
C9ZNJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZNJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A1R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ADF5	Leishmania major	32%	70%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	69%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
E9B5Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
O15726	Plasmodium falciparum (isolate Dd2)	43%	100%
O74135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	89%
O76324	Drosophila melanogaster	46%	89%
O96999	Leishmania major	39%	100%
P23291	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	73%
P23292	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	72%
P29295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	79%
P34516	Caenorhabditis elegans	30%	100%
P35507	Bos taurus	41%	100%
P35508	Bos taurus	47%	94%
P39962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	75%
P40230	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	73%
P40233	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	88%
P40234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	90%
P40235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P40236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	98%
P42158	Arabidopsis thaliana	44%	87%
P42168	Caenorhabditis elegans	41%	100%
P42169	Caenorhabditis elegans	28%	100%
P48729	Homo sapiens	43%	100%
P48730	Homo sapiens	47%	94%
P49674	Homo sapiens	47%	94%
P54367	Drosophila melanogaster	44%	100%
P54644	Dictyostelium discoideum	23%	88%
P67827	Bos taurus	43%	100%
P67828	Oryctolagus cuniculus	43%	100%
P67829	Ovis aries	43%	100%
P67962	Gallus gallus	43%	100%
P67963	Xenopus laevis	43%	100%
P78368	Homo sapiens	45%	94%
P97633	Rattus norvegicus	43%	100%
P9WI62	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	23%	98%
P9WI63	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	98%
Q06486	Rattus norvegicus	47%	94%
Q20471	Caenorhabditis elegans	45%	79%
Q39050	Arabidopsis thaliana	47%	86%
Q4Q6U1	Leishmania major	78%	100%
Q4Q9T3	Leishmania major	42%	77%
Q4R9A9	Macaca fascicularis	45%	100%
Q4V3C8	Arabidopsis thaliana	26%	80%
Q54DF7	Dictyostelium discoideum	36%	79%
Q556Y4	Dictyostelium discoideum	49%	92%
Q5BP74	Xenopus laevis	47%	94%
Q5PRD4	Danio rerio	45%	93%
Q5R4V3	Pongo abelii	45%	86%
Q5RC72	Pongo abelii	47%	94%
Q5XF24	Arabidopsis thaliana	46%	84%
Q5ZJS0	Gallus gallus	45%	86%
Q5ZLL1	Gallus gallus	47%	94%
Q62761	Rattus norvegicus	42%	100%
Q62762	Rattus norvegicus	45%	94%
Q62763	Rattus norvegicus	45%	87%
Q6K9N1	Oryza sativa subsp. japonica	47%	84%
Q6NRT0	Xenopus laevis	43%	85%
Q6P3K7	Danio rerio	47%	96%
Q6P647	Xenopus tropicalis	47%	94%
Q6QNL9	Eimeria tenella	45%	100%
Q6QNM1	Toxoplasma gondii	47%	100%
Q7RBX5	Plasmodium yoelii yoelii	44%	100%
Q7T2E3	Danio rerio	47%	97%
Q7TYY6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	23%	98%
Q7ZUS1	Danio rerio	28%	92%
Q86AD7	Dictyostelium discoideum	24%	100%
Q86Y07	Homo sapiens	27%	77%
Q8BK63	Mus musculus	43%	100%
Q8BN21	Mus musculus	27%	78%
Q8BTH8	Mus musculus	45%	85%
Q8BVP5	Mus musculus	45%	94%
Q8C4X2	Mus musculus	45%	92%
Q8IHZ9	Plasmodium falciparum (isolate 3D7)	44%	100%
Q8LPI7	Arabidopsis thaliana	46%	94%
Q8LPJ1	Arabidopsis thaliana	44%	82%
Q8N752	Homo sapiens	44%	100%
Q8RWL6	Arabidopsis thaliana	21%	69%
Q8SQR2	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8SS96	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q8VYK9	Arabidopsis thaliana	44%	90%
Q8WQ99	Caenorhabditis elegans	44%	96%
Q91FD5	Invertebrate iridescent virus 6	28%	95%
Q93Z18	Arabidopsis thaliana	46%	94%
Q95PZ9	Caenorhabditis elegans	30%	100%
Q9CAI5	Arabidopsis thaliana	46%	84%
Q9DC28	Mus musculus	47%	94%
Q9FFH8	Arabidopsis thaliana	46%	82%
Q9HCP0	Homo sapiens	45%	93%
Q9J509	Fowlpox virus (strain NVSL)	27%	100%
Q9J523	Fowlpox virus (strain NVSL)	27%	100%
Q9JMK2	Mus musculus	47%	94%
Q9LSX4	Arabidopsis thaliana	46%	81%
Q9LW62	Arabidopsis thaliana	46%	88%
Q9NHE1	Leishmania major	46%	100%
Q9NHE2	Leishmania major	44%	100%
Q9XF67	Arabidopsis thaliana	26%	80%
Q9Y6M4	Homo sapiens	45%	87%
Q9ZUP4	Arabidopsis thaliana	46%	90%
Q9ZWB3	Arabidopsis thaliana	46%	83%
V5AIW9	Trypanosoma cruzi	42%	100%
V5BMQ3	Trypanosoma cruzi	60%	98%