TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIT4_LEIBR

TriTrypDb:

LbrM.30.3500 , LBRM2903_300042100

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.363
CLV_C14_Caspase3-7	160	164	PF00656	0.389
CLV_C14_Caspase3-7	39	43	PF00656	0.503
CLV_MEL_PAP_1	59	65	PF00089	0.437
CLV_NRD_NRD_1	139	141	PF00675	0.481
CLV_NRD_NRD_1	186	188	PF00675	0.455
CLV_NRD_NRD_1	197	199	PF00675	0.518
CLV_NRD_NRD_1	281	283	PF00675	0.541
CLV_NRD_NRD_1	94	96	PF00675	0.369
CLV_PCSK_KEX2_1	15	17	PF00082	0.509
CLV_PCSK_KEX2_1	267	269	PF00082	0.488
CLV_PCSK_KEX2_1	94	96	PF00082	0.374
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.563
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.454
CLV_PCSK_SKI1_1	187	191	PF00082	0.406
CLV_PCSK_SKI1_1	210	214	PF00082	0.448
CLV_PCSK_SKI1_1	250	254	PF00082	0.444
CLV_PCSK_SKI1_1	268	272	PF00082	0.258
CLV_PCSK_SKI1_1	375	379	PF00082	0.469
CLV_PCSK_SKI1_1	48	52	PF00082	0.318
CLV_PCSK_SKI1_1	95	99	PF00082	0.329
DEG_APCC_DBOX_1	186	194	PF00400	0.476
DEG_APCC_KENBOX_2	314	318	PF00400	0.258
DOC_CKS1_1	341	346	PF01111	0.388
DOC_CYCLIN_RxL_1	45	54	PF00134	0.368
DOC_CYCLIN_yClb5_NLxxxL_5	69	77	PF00134	0.262
DOC_MAPK_MEF2A_6	69	77	PF00069	0.310
DOC_PP2B_LxvP_1	35	38	PF13499	0.304
DOC_PP2B_LxvP_1	58	61	PF13499	0.391
DOC_USP7_MATH_1	153	157	PF00917	0.426
DOC_USP7_MATH_1	383	387	PF00917	0.458
DOC_USP7_MATH_1	61	65	PF00917	0.454
DOC_USP7_UBL2_3	267	271	PF12436	0.499
DOC_WW_Pin1_4	133	138	PF00397	0.414
DOC_WW_Pin1_4	340	345	PF00397	0.429
LIG_14-3-3_CanoR_1	152	162	PF00244	0.305
LIG_14-3-3_CanoR_1	242	251	PF00244	0.473
LIG_14-3-3_CanoR_1	258	265	PF00244	0.346
LIG_14-3-3_CanoR_1	30	36	PF00244	0.497
LIG_14-3-3_CanoR_1	327	333	PF00244	0.302
LIG_APCC_ABBA_1	17	22	PF00400	0.403
LIG_APCC_ABBAyCdc20_2	16	22	PF00400	0.383
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BRCT_BRCA1_1	395	399	PF00533	0.477
LIG_CtBP_PxDLS_1	362	366	PF00389	0.300
LIG_FHA_1	114	120	PF00498	0.453
LIG_FHA_1	165	171	PF00498	0.452
LIG_FHA_1	239	245	PF00498	0.419
LIG_FHA_1	306	312	PF00498	0.434
LIG_FHA_1	347	353	PF00498	0.413
LIG_FHA_1	393	399	PF00498	0.563
LIG_FHA_1	81	87	PF00498	0.381
LIG_FHA_2	155	161	PF00498	0.375
LIG_FHA_2	24	30	PF00498	0.401
LIG_FHA_2	273	279	PF00498	0.476
LIG_FHA_2	341	347	PF00498	0.479
LIG_FHA_2	82	88	PF00498	0.449
LIG_LIR_Apic_2	368	374	PF02991	0.299
LIG_LIR_Gen_1	163	173	PF02991	0.399
LIG_LIR_Gen_1	83	93	PF02991	0.311
LIG_LIR_Nem_3	163	168	PF02991	0.315
LIG_LIR_Nem_3	182	186	PF02991	0.367
LIG_LIR_Nem_3	269	273	PF02991	0.488
LIG_LIR_Nem_3	316	321	PF02991	0.368
LIG_LIR_Nem_3	83	88	PF02991	0.315
LIG_MAD2	30	38	PF02301	0.448
LIG_NRBOX	212	218	PF00104	0.438
LIG_PDZ_Class_2	395	400	PF00595	0.527
LIG_SH2_CRK	122	126	PF00017	0.313
LIG_SH2_NCK_1	122	126	PF00017	0.455
LIG_SH2_STAT5	143	146	PF00017	0.439
LIG_SH2_STAT5	284	287	PF00017	0.588
LIG_SH3_1	198	204	PF00018	0.428
LIG_SH3_3	156	162	PF00018	0.279
LIG_SH3_3	198	204	PF00018	0.407
LIG_SH3_3	338	344	PF00018	0.417
LIG_SH3_3	350	356	PF00018	0.355
LIG_SUMO_SIM_anti_2	343	349	PF11976	0.415
LIG_SUMO_SIM_par_1	166	171	PF11976	0.444
LIG_SUMO_SIM_par_1	294	301	PF11976	0.325
LIG_SUMO_SIM_par_1	307	314	PF11976	0.321
LIG_SUMO_SIM_par_1	319	325	PF11976	0.335
LIG_SUMO_SIM_par_1	343	349	PF11976	0.373
LIG_SUMO_SIM_par_1	48	54	PF11976	0.408
MOD_CDK_SPxxK_3	133	140	PF00069	0.356
MOD_CK1_1	171	177	PF00069	0.453
MOD_CK1_1	81	87	PF00069	0.432
MOD_CK2_1	23	29	PF00069	0.463
MOD_CK2_1	272	278	PF00069	0.477
MOD_CK2_1	340	346	PF00069	0.469
MOD_CK2_1	81	87	PF00069	0.452
MOD_Cter_Amidation	265	268	PF01082	0.420
MOD_GlcNHglycan	288	291	PF01048	0.549
MOD_GlcNHglycan	386	389	PF01048	0.495
MOD_GlcNHglycan	80	83	PF01048	0.379
MOD_GSK3_1	164	171	PF00069	0.378
MOD_GSK3_1	238	245	PF00069	0.525
MOD_GSK3_1	254	261	PF00069	0.278
MOD_GSK3_1	282	289	PF00069	0.526
MOD_GSK3_1	305	312	PF00069	0.381
MOD_N-GLC_1	20	25	PF02516	0.416
MOD_N-GLC_1	286	291	PF02516	0.471
MOD_N-GLC_1	363	368	PF02516	0.356
MOD_N-GLC_2	128	130	PF02516	0.481
MOD_NEK2_1	168	173	PF00069	0.432
MOD_NEK2_1	20	25	PF00069	0.483
MOD_NEK2_1	238	243	PF00069	0.440
MOD_NEK2_1	259	264	PF00069	0.510
MOD_NEK2_1	363	368	PF00069	0.432
MOD_NEK2_1	392	397	PF00069	0.534
MOD_NEK2_1	51	56	PF00069	0.431
MOD_PIKK_1	120	126	PF00454	0.382
MOD_PIKK_1	282	288	PF00454	0.542
MOD_PIKK_1	51	57	PF00454	0.368
MOD_PKA_1	282	288	PF00069	0.580
MOD_PKA_2	238	244	PF00069	0.316
MOD_PKA_2	326	332	PF00069	0.355
MOD_PKA_2	61	67	PF00069	0.441
MOD_Plk_1	20	26	PF00069	0.416
MOD_Plk_1	363	369	PF00069	0.322
MOD_Plk_2-3	179	185	PF00069	0.476
MOD_Plk_4	168	174	PF00069	0.455
MOD_Plk_4	212	218	PF00069	0.450
MOD_Plk_4	305	311	PF00069	0.382
MOD_Plk_4	81	87	PF00069	0.410
MOD_ProDKin_1	133	139	PF00069	0.411
MOD_ProDKin_1	340	346	PF00069	0.426
MOD_SUMO_rev_2	264	273	PF00179	0.296
MOD_SUMO_rev_2	34	43	PF00179	0.332
MOD_SUMO_rev_2	8	17	PF00179	0.419
TRG_DiLeu_BaEn_1	316	321	PF01217	0.256
TRG_ENDOCYTIC_2	122	125	PF00928	0.314
TRG_ER_diArg_1	16	19	PF00400	0.473
TRG_ER_diArg_1	93	95	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P422	Leptomonas seymouri	72%	100%
A0A0S4JKF4	Bodo saltans	35%	95%
A0A1X0P1J7	Trypanosomatidae	39%	97%
A0A3Q8IF79	Leishmania donovani	88%	100%
A0A422NMP4	Trypanosoma rangeli	39%	97%
A4I636	Leishmania infantum	88%	100%
C9ZRF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B1C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q0P5H9	Bos taurus	23%	91%
Q4Q6U3	Leishmania major	88%	100%
Q5BK48	Rattus norvegicus	24%	91%
Q8N0Z6	Homo sapiens	24%	91%
Q99LG4	Mus musculus	23%	91%
V5DNS8	Trypanosoma cruzi	43%	100%