LeishMANIAdb
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DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA ligase
Gene product:
DNA ligase I, putative
Species:
Leishmania braziliensis
UniProt:
A4HIT2_LEIBR
TriTrypDb:
LbrM.30.3480 , LBRM2903_300041900 *
Length:
776

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4HIT2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIT2

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006260 DNA replication 5 11
GO:0006266 DNA ligation 5 1
GO:0006271 DNA strand elongation involved in DNA replication 6 1
GO:0006273 lagging strand elongation 7 1
GO:0006281 DNA repair 5 12
GO:0006310 DNA recombination 5 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0003909 DNA ligase activity 4 12
GO:0003910 DNA ligase (ATP) activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016886 ligase activity, forming phosphoric ester bonds 3 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 342 346 PF00656 0.347
CLV_C14_Caspase3-7 569 573 PF00656 0.303
CLV_C14_Caspase3-7 603 607 PF00656 0.413
CLV_NRD_NRD_1 25 27 PF00675 0.731
CLV_NRD_NRD_1 273 275 PF00675 0.243
CLV_NRD_NRD_1 40 42 PF00675 0.675
CLV_NRD_NRD_1 497 499 PF00675 0.243
CLV_NRD_NRD_1 533 535 PF00675 0.243
CLV_NRD_NRD_1 67 69 PF00675 0.465
CLV_PCSK_KEX2_1 272 274 PF00082 0.243
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PB08 Leptomonas seymouri 74% 100%
A0A0S4JHN9 Bodo saltans 62% 100%
A0A1X0P2U4 Trypanosomatidae 63% 100%
A0A3Q8II77 Leishmania donovani 87% 100%
A0A422NMG1 Trypanosoma rangeli 66% 100%
A0B7F9 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 27% 100%
A0RWD6 Cenarchaeum symbiosum (strain A) 34% 100%
A1RTK4 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 34% 100%
A1RXA6 Thermofilum pendens (strain DSM 2475 / Hrk 5) 28% 100%
A1RY72 Thermofilum pendens (strain DSM 2475 / Hrk 5) 32% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS