XPG_I_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein mkt1, putative

Species:

Leishmania braziliensis

UniProt:

A4HIT1_LEIBR

TriTrypDb:

LbrM.30.3470 , LBRM2903_300041800

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIT1

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0010608	post-transcriptional regulation of gene expression	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0034248	regulation of amide metabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0017108	5'-flap endonuclease activity	7	1
GO:0048256	flap endonuclease activity	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.638
CLV_NRD_NRD_1	148	150	PF00675	0.469
CLV_NRD_NRD_1	166	168	PF00675	0.389
CLV_NRD_NRD_1	241	243	PF00675	0.367
CLV_NRD_NRD_1	270	272	PF00675	0.431
CLV_NRD_NRD_1	305	307	PF00675	0.394
CLV_NRD_NRD_1	333	335	PF00675	0.371
CLV_NRD_NRD_1	384	386	PF00675	0.542
CLV_NRD_NRD_1	86	88	PF00675	0.417
CLV_PCSK_FUR_1	331	335	PF00082	0.462
CLV_PCSK_KEX2_1	240	242	PF00082	0.398
CLV_PCSK_KEX2_1	270	272	PF00082	0.431
CLV_PCSK_KEX2_1	305	307	PF00082	0.397
CLV_PCSK_KEX2_1	333	335	PF00082	0.371
CLV_PCSK_KEX2_1	384	386	PF00082	0.542
CLV_PCSK_PC7_1	266	272	PF00082	0.431
CLV_PCSK_SKI1_1	101	105	PF00082	0.360
CLV_PCSK_SKI1_1	215	219	PF00082	0.321
CLV_PCSK_SKI1_1	25	29	PF00082	0.441
CLV_PCSK_SKI1_1	301	305	PF00082	0.404
CLV_PCSK_SKI1_1	338	342	PF00082	0.349
CLV_Separin_Metazoa	540	544	PF03568	0.362
CLV_Separin_Metazoa	84	88	PF03568	0.617
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.490
DOC_MAPK_DCC_7	385	395	PF00069	0.362
DOC_MAPK_DCC_7	435	444	PF00069	0.350
DOC_MAPK_FxFP_2	640	643	PF00069	0.362
DOC_MAPK_MEF2A_6	435	444	PF00069	0.350
DOC_MAPK_MEF2A_6	724	731	PF00069	0.430
DOC_PP1_RVXF_1	494	501	PF00149	0.352
DOC_PP2B_LxvP_1	311	314	PF13499	0.532
DOC_PP2B_LxvP_1	359	362	PF13499	0.484
DOC_PP4_FxxP_1	190	193	PF00568	0.543
DOC_PP4_FxxP_1	341	344	PF00568	0.537
DOC_PP4_FxxP_1	526	529	PF00568	0.362
DOC_PP4_FxxP_1	640	643	PF00568	0.276
DOC_SPAK_OSR1_1	154	158	PF12202	0.538
DOC_USP7_MATH_1	201	205	PF00917	0.432
DOC_USP7_MATH_1	324	328	PF00917	0.548
DOC_USP7_MATH_1	364	368	PF00917	0.337
DOC_USP7_MATH_1	386	390	PF00917	0.362
DOC_USP7_MATH_1	406	410	PF00917	0.381
DOC_USP7_MATH_1	511	515	PF00917	0.381
DOC_USP7_UBL2_3	21	25	PF12436	0.540
DOC_WW_Pin1_4	118	123	PF00397	0.681
DOC_WW_Pin1_4	340	345	PF00397	0.520
DOC_WW_Pin1_4	423	428	PF00397	0.345
DOC_WW_Pin1_4	68	73	PF00397	0.521
LIG_14-3-3_CanoR_1	295	303	PF00244	0.559
LIG_14-3-3_CanoR_1	622	627	PF00244	0.389
LIG_AP_GAE_1	249	255	PF02883	0.596
LIG_BRCT_BRCA1_1	187	191	PF00533	0.556
LIG_BRCT_BRCA1_1	41	45	PF00533	0.597
LIG_BRCT_BRCA1_1	496	500	PF00533	0.360
LIG_BRCT_BRCA1_1	585	589	PF00533	0.384
LIG_BRCT_BRCA1_1	646	650	PF00533	0.349
LIG_deltaCOP1_diTrp_1	410	420	PF00928	0.342
LIG_EH1_1	610	618	PF00400	0.381
LIG_eIF4E_1	202	208	PF01652	0.434
LIG_FHA_1	439	445	PF00498	0.401
LIG_FHA_1	465	471	PF00498	0.366
LIG_FHA_1	542	548	PF00498	0.279
LIG_FHA_1	59	65	PF00498	0.593
LIG_FHA_1	604	610	PF00498	0.344
LIG_FHA_1	651	657	PF00498	0.362
LIG_FHA_1	734	740	PF00498	0.435
LIG_FHA_1	81	87	PF00498	0.593
LIG_FHA_2	216	222	PF00498	0.578
LIG_FHA_2	271	277	PF00498	0.649
LIG_FHA_2	283	289	PF00498	0.482
LIG_FHA_2	528	534	PF00498	0.285
LIG_FHA_2	544	550	PF00498	0.244
LIG_FHA_2	660	666	PF00498	0.362
LIG_FHA_2	667	673	PF00498	0.301
LIG_LIR_Apic_2	188	193	PF02991	0.533
LIG_LIR_Apic_2	524	529	PF02991	0.362
LIG_LIR_Gen_1	226	235	PF02991	0.521
LIG_LIR_Gen_1	249	258	PF02991	0.592
LIG_LIR_Gen_1	272	281	PF02991	0.558
LIG_LIR_Gen_1	625	635	PF02991	0.368
LIG_LIR_Gen_1	688	699	PF02991	0.362
LIG_LIR_Gen_1	704	713	PF02991	0.287
LIG_LIR_Gen_1	74	82	PF02991	0.521
LIG_LIR_LC3C_4	549	554	PF02991	0.362
LIG_LIR_Nem_3	199	205	PF02991	0.517
LIG_LIR_Nem_3	226	230	PF02991	0.515
LIG_LIR_Nem_3	249	255	PF02991	0.596
LIG_LIR_Nem_3	272	277	PF02991	0.587
LIG_LIR_Nem_3	373	378	PF02991	0.298
LIG_LIR_Nem_3	408	414	PF02991	0.298
LIG_LIR_Nem_3	443	449	PF02991	0.408
LIG_LIR_Nem_3	497	503	PF02991	0.360
LIG_LIR_Nem_3	532	537	PF02991	0.266
LIG_LIR_Nem_3	625	631	PF02991	0.344
LIG_LIR_Nem_3	682	687	PF02991	0.322
LIG_LIR_Nem_3	688	694	PF02991	0.309
LIG_LIR_Nem_3	70	76	PF02991	0.523
LIG_LIR_Nem_3	704	708	PF02991	0.276
LIG_LIR_Nem_3	723	729	PF02991	0.421
LIG_LYPXL_S_1	725	729	PF13949	0.446
LIG_LYPXL_yS_3	726	729	PF13949	0.252
LIG_MLH1_MIPbox_1	187	191	PF16413	0.581
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.401
LIG_Pex14_1	413	417	PF04695	0.276
LIG_Pex14_1	585	589	PF04695	0.362
LIG_Pex14_2	100	104	PF04695	0.579
LIG_Pex14_2	151	155	PF04695	0.623
LIG_Pex14_2	349	353	PF04695	0.475
LIG_Pex14_2	500	504	PF04695	0.362
LIG_Pex14_2	642	646	PF04695	0.362
LIG_Pex14_2	687	691	PF04695	0.362
LIG_Pex14_2	730	734	PF04695	0.393
LIG_SH2_CRK	483	487	PF00017	0.390
LIG_SH2_CRK	534	538	PF00017	0.301
LIG_SH2_CRK	705	709	PF00017	0.381
LIG_SH2_CRK	76	80	PF00017	0.544
LIG_SH2_CRK	793	797	PF00017	0.553
LIG_SH2_GRB2like	37	40	PF00017	0.468
LIG_SH2_NCK_1	705	709	PF00017	0.381
LIG_SH2_NCK_1	76	80	PF00017	0.553
LIG_SH2_SRC	699	702	PF00017	0.362
LIG_SH2_SRC	793	796	PF00017	0.547
LIG_SH2_STAP1	243	247	PF00017	0.619
LIG_SH2_STAP1	37	41	PF00017	0.458
LIG_SH2_STAP1	82	86	PF00017	0.592
LIG_SH2_STAT3	37	40	PF00017	0.468
LIG_SH2_STAT5	181	184	PF00017	0.495
LIG_SH2_STAT5	351	354	PF00017	0.385
LIG_SH2_STAT5	417	420	PF00017	0.431
LIG_SH2_STAT5	465	468	PF00017	0.386
LIG_SH2_STAT5	494	497	PF00017	0.331
LIG_SH2_STAT5	503	506	PF00017	0.233
LIG_SH2_STAT5	519	522	PF00017	0.145
LIG_SH2_STAT5	654	657	PF00017	0.287
LIG_SH2_STAT5	76	79	PF00017	0.541
LIG_SH2_STAT5	82	85	PF00017	0.546
LIG_SH2_STAT5	92	95	PF00017	0.601
LIG_SH3_2	281	286	PF14604	0.647
LIG_SH3_3	119	125	PF00018	0.662
LIG_SH3_3	278	284	PF00018	0.634
LIG_SH3_3	354	360	PF00018	0.406
LIG_SH3_3	400	406	PF00018	0.381
LIG_SH3_3	474	480	PF00018	0.443
LIG_SH3_3	585	591	PF00018	0.282
LIG_SH3_3	749	755	PF00018	0.576
LIG_SH3_3	756	762	PF00018	0.575
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.590
LIG_SUMO_SIM_anti_2	549	556	PF11976	0.362
LIG_SUMO_SIM_par_1	535	540	PF11976	0.272
LIG_SUMO_SIM_par_1	61	68	PF11976	0.613
LIG_SxIP_EBH_1	572	583	PF03271	0.287
LIG_TRAF2_1	662	665	PF00917	0.362
LIG_TRFH_1	399	403	PF08558	0.475
LIG_TYR_ITIM	481	486	PF00017	0.454
LIG_TYR_ITIM	703	708	PF00017	0.475
LIG_UBA3_1	401	407	PF00899	0.449
LIG_WRC_WIRS_1	13	18	PF05994	0.560
LIG_WRC_WIRS_1	446	451	PF05994	0.539
LIG_WRC_WIRS_1	469	474	PF05994	0.527
LIG_WW_3	794	798	PF00397	0.730
MOD_CK1_1	15	21	PF00069	0.573
MOD_CK1_1	185	191	PF00069	0.449
MOD_CK1_1	231	237	PF00069	0.545
MOD_CK1_1	426	432	PF00069	0.546
MOD_CK1_1	5	11	PF00069	0.697
MOD_CK1_1	514	520	PF00069	0.327
MOD_CK1_1	74	80	PF00069	0.514
MOD_CK2_1	445	451	PF00069	0.479
MOD_CK2_1	454	460	PF00069	0.458
MOD_CK2_1	527	533	PF00069	0.328
MOD_CK2_1	659	665	PF00069	0.449
MOD_CK2_1	666	672	PF00069	0.409
MOD_GlcNHglycan	131	134	PF01048	0.562
MOD_GlcNHglycan	187	190	PF01048	0.379
MOD_GlcNHglycan	249	255	PF01048	0.529
MOD_GlcNHglycan	354	357	PF01048	0.388
MOD_GlcNHglycan	379	383	PF01048	0.449
MOD_GlcNHglycan	512	516	PF01048	0.384
MOD_GlcNHglycan	585	588	PF01048	0.342
MOD_GlcNHglycan	645	649	PF01048	0.388
MOD_GlcNHglycan	73	76	PF01048	0.511
MOD_GSK3_1	191	198	PF00069	0.544
MOD_GSK3_1	215	222	PF00069	0.277
MOD_GSK3_1	35	42	PF00069	0.547
MOD_GSK3_1	434	441	PF00069	0.522
MOD_GSK3_1	464	471	PF00069	0.493
MOD_GSK3_1	482	489	PF00069	0.208
MOD_GSK3_1	5	12	PF00069	0.686
MOD_GSK3_1	510	517	PF00069	0.374
MOD_GSK3_1	568	575	PF00069	0.338
MOD_GSK3_1	58	65	PF00069	0.504
MOD_GSK3_1	67	74	PF00069	0.202
MOD_GSK3_1	675	682	PF00069	0.449
MOD_N-GLC_1	136	141	PF02516	0.520
MOD_N-GLC_2	107	109	PF02516	0.492
MOD_N-GLC_2	580	582	PF02516	0.475
MOD_NEK2_1	182	187	PF00069	0.402
MOD_NEK2_1	257	262	PF00069	0.461
MOD_NEK2_1	352	357	PF00069	0.449
MOD_NEK2_1	377	382	PF00069	0.344
MOD_NEK2_1	454	459	PF00069	0.566
MOD_NEK2_1	541	546	PF00069	0.319
MOD_NEK2_1	603	608	PF00069	0.392
MOD_NEK2_1	650	655	PF00069	0.421
MOD_NEK2_1	666	671	PF00069	0.449
MOD_NEK2_1	67	72	PF00069	0.500
MOD_NEK2_2	173	178	PF00069	0.534
MOD_NEK2_2	324	329	PF00069	0.511
MOD_PIKK_1	182	188	PF00454	0.449
MOD_PIKK_1	364	370	PF00454	0.385
MOD_PIKK_1	426	432	PF00454	0.655
MOD_PK_1	572	578	PF00069	0.328
MOD_PKA_1	270	276	PF00069	0.541
MOD_PKA_2	270	276	PF00069	0.577
MOD_PKA_2	294	300	PF00069	0.516
MOD_PKA_2	621	627	PF00069	0.453
MOD_Plk_1	136	142	PF00069	0.484
MOD_Plk_1	173	179	PF00069	0.529
MOD_Plk_1	250	256	PF00069	0.489
MOD_Plk_1	378	384	PF00069	0.449
MOD_Plk_1	559	565	PF00069	0.468
MOD_Plk_2-3	223	229	PF00069	0.512
MOD_Plk_2-3	527	533	PF00069	0.449
MOD_Plk_2-3	701	707	PF00069	0.449
MOD_Plk_4	12	18	PF00069	0.463
MOD_Plk_4	231	237	PF00069	0.518
MOD_Plk_4	386	392	PF00069	0.351
MOD_Plk_4	39	45	PF00069	0.513
MOD_Plk_4	514	520	PF00069	0.400
MOD_Plk_4	572	578	PF00069	0.328
MOD_Plk_4	62	68	PF00069	0.493
MOD_Plk_4	630	636	PF00069	0.438
MOD_Plk_4	650	656	PF00069	0.425
MOD_Plk_4	679	685	PF00069	0.361
MOD_Plk_4	74	80	PF00069	0.439
MOD_ProDKin_1	118	124	PF00069	0.610
MOD_ProDKin_1	340	346	PF00069	0.391
MOD_ProDKin_1	423	429	PF00069	0.423
MOD_ProDKin_1	68	74	PF00069	0.388
MOD_SUMO_rev_2	15	22	PF00179	0.454
MOD_SUMO_rev_2	297	303	PF00179	0.543
MOD_SUMO_rev_2	97	103	PF00179	0.505
TRG_DiLeu_BaEn_1	299	304	PF01217	0.540
TRG_DiLeu_BaEn_1	533	538	PF01217	0.328
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.475
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.449
TRG_ENDOCYTIC_2	202	205	PF00928	0.291
TRG_ENDOCYTIC_2	351	354	PF00928	0.334
TRG_ENDOCYTIC_2	417	420	PF00928	0.460
TRG_ENDOCYTIC_2	446	449	PF00928	0.501
TRG_ENDOCYTIC_2	483	486	PF00928	0.424
TRG_ENDOCYTIC_2	534	537	PF00928	0.328
TRG_ENDOCYTIC_2	705	708	PF00928	0.457
TRG_ENDOCYTIC_2	726	729	PF00928	0.556
TRG_ENDOCYTIC_2	76	79	PF00928	0.378
TRG_ENDOCYTIC_2	82	85	PF00928	0.370
TRG_ER_diArg_1	239	242	PF00400	0.529
TRG_ER_diArg_1	304	306	PF00400	0.521
TRG_ER_diArg_1	331	334	PF00400	0.542
TRG_ER_diArg_1	383	385	PF00400	0.421
TRG_NES_CRM1_1	679	692	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	715	720	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P424	Leptomonas seymouri	75%	99%
A0A0S4JHW4	Bodo saltans	31%	100%
A0A1X0P1K6	Trypanosomatidae	36%	100%
A0A3Q8IF24	Leishmania donovani	95%	100%
A0A3R7MIQ4	Trypanosoma rangeli	36%	100%
A4I633	Leishmania infantum	95%	100%
C9ZRF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B1B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6U6	Leishmania major	94%	100%
Q587E3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	36%	100%
V5BX20	Trypanosoma cruzi	38%	100%