Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

T-complex protein 11, putative

Species:

Leishmania braziliensis

UniProt:

A4HIT0_LEIBR

TriTrypDb:

LbrM.30.3460 , LBRM2903_300041700

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIT0

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.641
CLV_C14_Caspase3-7	3	7	PF00656	0.737
CLV_C14_Caspase3-7	322	326	PF00656	0.661
CLV_NRD_NRD_1	133	135	PF00675	0.540
CLV_NRD_NRD_1	169	171	PF00675	0.780
CLV_NRD_NRD_1	282	284	PF00675	0.561
CLV_NRD_NRD_1	316	318	PF00675	0.571
CLV_NRD_NRD_1	374	376	PF00675	0.770
CLV_NRD_NRD_1	401	403	PF00675	0.541
CLV_NRD_NRD_1	404	406	PF00675	0.520
CLV_NRD_NRD_1	606	608	PF00675	0.420
CLV_NRD_NRD_1	617	619	PF00675	0.294
CLV_NRD_NRD_1	645	647	PF00675	0.415
CLV_NRD_NRD_1	711	713	PF00675	0.449
CLV_NRD_NRD_1	808	810	PF00675	0.475
CLV_NRD_NRD_1	92	94	PF00675	0.479
CLV_PCSK_FUR_1	402	406	PF00082	0.594
CLV_PCSK_KEX2_1	133	135	PF00082	0.468
CLV_PCSK_KEX2_1	292	294	PF00082	0.603
CLV_PCSK_KEX2_1	315	317	PF00082	0.581
CLV_PCSK_KEX2_1	374	376	PF00082	0.771
CLV_PCSK_KEX2_1	403	405	PF00082	0.523
CLV_PCSK_KEX2_1	617	619	PF00082	0.243
CLV_PCSK_KEX2_1	645	647	PF00082	0.413
CLV_PCSK_KEX2_1	711	713	PF00082	0.449
CLV_PCSK_KEX2_1	808	810	PF00082	0.363
CLV_PCSK_KEX2_1	91	93	PF00082	0.496
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.603
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.581
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.609
CLV_PCSK_SKI1_1	133	137	PF00082	0.548
CLV_PCSK_SKI1_1	189	193	PF00082	0.513
CLV_PCSK_SKI1_1	196	200	PF00082	0.529
CLV_PCSK_SKI1_1	227	231	PF00082	0.509
CLV_PCSK_SKI1_1	259	263	PF00082	0.626
CLV_PCSK_SKI1_1	292	296	PF00082	0.549
CLV_PCSK_SKI1_1	411	415	PF00082	0.479
CLV_PCSK_SKI1_1	467	471	PF00082	0.349
CLV_PCSK_SKI1_1	531	535	PF00082	0.470
CLV_PCSK_SKI1_1	624	628	PF00082	0.453
CLV_PCSK_SKI1_1	648	652	PF00082	0.385
CLV_PCSK_SKI1_1	712	716	PF00082	0.413
CLV_PCSK_SKI1_1	808	812	PF00082	0.365
CLV_PCSK_SKI1_1	858	862	PF00082	0.294
CLV_PCSK_SKI1_1	93	97	PF00082	0.483
DEG_APCC_DBOX_1	188	196	PF00400	0.508
DEG_APCC_DBOX_1	807	815	PF00400	0.475
DEG_APCC_DBOX_1	857	865	PF00400	0.449
DEG_APCC_DBOX_1	90	98	PF00400	0.474
DEG_SCF_FBW7_1	52	58	PF00400	0.540
DEG_SPOP_SBC_1	359	363	PF00917	0.807
DOC_CKS1_1	153	158	PF01111	0.486
DOC_CKS1_1	332	337	PF01111	0.800
DOC_CKS1_1	52	57	PF01111	0.617
DOC_CYCLIN_RxL_1	185	193	PF00134	0.521
DOC_CYCLIN_RxL_1	461	474	PF00134	0.309
DOC_MAPK_DCC_7	820	830	PF00069	0.417
DOC_MAPK_DCC_7	858	866	PF00069	0.562
DOC_MAPK_gen_1	461	471	PF00069	0.423
DOC_MAPK_gen_1	607	615	PF00069	0.470
DOC_MAPK_gen_1	645	653	PF00069	0.385
DOC_MAPK_gen_1	88	97	PF00069	0.469
DOC_MAPK_MEF2A_6	858	866	PF00069	0.562
DOC_MAPK_RevD_3	697	712	PF00069	0.417
DOC_PP1_RVXF_1	225	232	PF00149	0.477
DOC_PP1_RVXF_1	465	472	PF00149	0.223
DOC_PP1_RVXF_1	622	629	PF00149	0.454
DOC_PP1_RVXF_1	680	687	PF00149	0.344
DOC_PP1_RVXF_1	807	814	PF00149	0.344
DOC_PP2B_LxvP_1	53	56	PF13499	0.628
DOC_PP2B_LxvP_1	603	606	PF13499	0.475
DOC_USP7_MATH_1	174	178	PF00917	0.696
DOC_USP7_MATH_1	234	238	PF00917	0.685
DOC_USP7_MATH_1	323	327	PF00917	0.614
DOC_USP7_MATH_1	479	483	PF00917	0.416
DOC_USP7_MATH_1	704	708	PF00917	0.477
DOC_USP7_MATH_1	717	721	PF00917	0.389
DOC_WW_Pin1_4	152	157	PF00397	0.654
DOC_WW_Pin1_4	162	167	PF00397	0.766
DOC_WW_Pin1_4	201	206	PF00397	0.569
DOC_WW_Pin1_4	240	245	PF00397	0.777
DOC_WW_Pin1_4	253	258	PF00397	0.672
DOC_WW_Pin1_4	324	329	PF00397	0.709
DOC_WW_Pin1_4	331	336	PF00397	0.755
DOC_WW_Pin1_4	360	365	PF00397	0.760
DOC_WW_Pin1_4	366	371	PF00397	0.744
DOC_WW_Pin1_4	455	460	PF00397	0.413
DOC_WW_Pin1_4	51	56	PF00397	0.571
DOC_WW_Pin1_4	525	530	PF00397	0.449
DOC_WW_Pin1_4	547	552	PF00397	0.363
DOC_WW_Pin1_4	638	643	PF00397	0.279
LIG_14-3-3_CanoR_1	133	138	PF00244	0.560
LIG_14-3-3_CanoR_1	272	276	PF00244	0.542
LIG_14-3-3_CanoR_1	293	299	PF00244	0.528
LIG_14-3-3_CanoR_1	304	311	PF00244	0.420
LIG_14-3-3_CanoR_1	360	364	PF00244	0.543
LIG_14-3-3_CanoR_1	467	472	PF00244	0.410
LIG_14-3-3_CanoR_1	538	543	PF00244	0.443
LIG_14-3-3_CanoR_1	724	734	PF00244	0.418
LIG_14-3-3_CanoR_1	785	789	PF00244	0.302
LIG_Actin_WH2_2	644	662	PF00022	0.354
LIG_Actin_WH2_2	731	746	PF00022	0.389
LIG_Actin_WH2_2	807	822	PF00022	0.223
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BRCT_BRCA1_1	611	615	PF00533	0.344
LIG_BRCT_BRCA1_1	682	686	PF00533	0.312
LIG_Clathr_ClatBox_1	698	702	PF01394	0.449
LIG_Clathr_ClatBox_1	863	867	PF01394	0.464
LIG_EVH1_2	674	678	PF00568	0.449
LIG_FHA_1	139	145	PF00498	0.526
LIG_FHA_1	204	210	PF00498	0.500
LIG_FHA_1	243	249	PF00498	0.654
LIG_FHA_1	293	299	PF00498	0.544
LIG_FHA_1	325	331	PF00498	0.740
LIG_FHA_1	548	554	PF00498	0.430
LIG_FHA_1	598	604	PF00498	0.311
LIG_FHA_1	653	659	PF00498	0.492
LIG_FHA_1	694	700	PF00498	0.395
LIG_FHA_1	814	820	PF00498	0.387
LIG_FHA_1	830	836	PF00498	0.290
LIG_FHA_2	272	278	PF00498	0.568
LIG_FHA_2	305	311	PF00498	0.497
LIG_FHA_2	343	349	PF00498	0.733
LIG_FHA_2	442	448	PF00498	0.432
LIG_FHA_2	468	474	PF00498	0.482
LIG_FHA_2	639	645	PF00498	0.344
LIG_FHA_2	663	669	PF00498	0.449
LIG_FHA_2	689	695	PF00498	0.385
LIG_FHA_2	777	783	PF00498	0.351
LIG_FHA_2	794	800	PF00498	0.307
LIG_LIR_Apic_2	331	335	PF02991	0.762
LIG_LIR_Gen_1	309	318	PF02991	0.583
LIG_LIR_Gen_1	491	500	PF02991	0.420
LIG_LIR_Gen_1	668	678	PF02991	0.415
LIG_LIR_Gen_1	800	811	PF02991	0.365
LIG_LIR_Nem_3	220	225	PF02991	0.383
LIG_LIR_Nem_3	309	314	PF02991	0.574
LIG_LIR_Nem_3	491	495	PF02991	0.351
LIG_LIR_Nem_3	497	501	PF02991	0.302
LIG_LIR_Nem_3	668	673	PF02991	0.343
LIG_LIR_Nem_3	800	806	PF02991	0.365
LIG_LIR_Nem_3	856	860	PF02991	0.335
LIG_MYND_1	379	383	PF01753	0.615
LIG_NRBOX	464	470	PF00104	0.449
LIG_NRBOX	696	702	PF00104	0.344
LIG_Pex14_2	142	146	PF04695	0.514
LIG_Pex14_2	615	619	PF04695	0.475
LIG_SH2_CRK	299	303	PF00017	0.510
LIG_SH2_CRK	332	336	PF00017	0.761
LIG_SH2_NCK_1	332	336	PF00017	0.761
LIG_SH2_PTP2	113	116	PF00017	0.677
LIG_SH2_STAP1	225	229	PF00017	0.501
LIG_SH2_STAP1	419	423	PF00017	0.434
LIG_SH2_STAT3	225	228	PF00017	0.544
LIG_SH2_STAT5	113	116	PF00017	0.693
LIG_SH2_STAT5	147	150	PF00017	0.534
LIG_SH2_STAT5	210	213	PF00017	0.571
LIG_SH2_STAT5	332	335	PF00017	0.722
LIG_SH2_STAT5	386	389	PF00017	0.590
LIG_SH2_STAT5	408	411	PF00017	0.518
LIG_SH2_STAT5	511	514	PF00017	0.245
LIG_SH2_STAT5	594	597	PF00017	0.385
LIG_SH2_STAT5	679	682	PF00017	0.363
LIG_SH2_STAT5	803	806	PF00017	0.363
LIG_SH3_3	150	156	PF00018	0.417
LIG_SH3_3	376	382	PF00018	0.605
LIG_SH3_3	49	55	PF00018	0.562
LIG_SH3_3	668	674	PF00018	0.475
LIG_SH3_3	849	855	PF00018	0.381
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.447
LIG_SUMO_SIM_anti_2	696	702	PF11976	0.347
LIG_SUMO_SIM_par_1	579	586	PF11976	0.298
LIG_SUMO_SIM_par_1	696	702	PF11976	0.346
LIG_SUMO_SIM_par_1	862	868	PF11976	0.428
LIG_TRAF2_1	691	694	PF00917	0.344
LIG_TYR_ITIM	297	302	PF00017	0.501
LIG_UBA3_1	275	284	PF00899	0.359
LIG_WRC_WIRS_1	468	473	PF05994	0.371
LIG_WRC_WIRS_1	803	808	PF05994	0.364
LIG_WW_3	458	462	PF00397	0.223
MOD_CDC14_SPxK_1	256	259	PF00782	0.493
MOD_CDC14_SPxK_1	528	531	PF00782	0.449
MOD_CDK_SPK_2	324	329	PF00069	0.709
MOD_CDK_SPxK_1	253	259	PF00069	0.516
MOD_CDK_SPxK_1	455	461	PF00069	0.223
MOD_CDK_SPxK_1	525	531	PF00069	0.449
MOD_CDK_SPxxK_3	240	247	PF00069	0.744
MOD_CDK_SPxxK_3	638	645	PF00069	0.358
MOD_CK1_1	181	187	PF00069	0.486
MOD_CK1_1	217	223	PF00069	0.392
MOD_CK1_1	249	255	PF00069	0.806
MOD_CK1_1	57	63	PF00069	0.633
MOD_CK1_1	629	635	PF00069	0.468
MOD_CK1_1	865	871	PF00069	0.631
MOD_CK2_1	234	240	PF00069	0.652
MOD_CK2_1	271	277	PF00069	0.580
MOD_CK2_1	29	35	PF00069	0.539
MOD_CK2_1	304	310	PF00069	0.503
MOD_CK2_1	342	348	PF00069	0.677
MOD_CK2_1	441	447	PF00069	0.441
MOD_CK2_1	467	473	PF00069	0.415
MOD_CK2_1	638	644	PF00069	0.360
MOD_CK2_1	688	694	PF00069	0.385
MOD_CK2_1	778	784	PF00069	0.303
MOD_CK2_1	793	799	PF00069	0.393
MOD_CK2_1	853	859	PF00069	0.439
MOD_DYRK1A_RPxSP_1	360	364	PF00069	0.543
MOD_GlcNHglycan	2	5	PF01048	0.536
MOD_GlcNHglycan	219	222	PF01048	0.448
MOD_GlcNHglycan	235	239	PF01048	0.720
MOD_GlcNHglycan	248	251	PF01048	0.605
MOD_GlcNHglycan	35	39	PF01048	0.531
MOD_GlcNHglycan	660	663	PF01048	0.338
MOD_GlcNHglycan	719	722	PF01048	0.458
MOD_GlcNHglycan	78	81	PF01048	0.551
MOD_GSK3_1	162	169	PF00069	0.764
MOD_GSK3_1	174	181	PF00069	0.539
MOD_GSK3_1	210	217	PF00069	0.463
MOD_GSK3_1	234	241	PF00069	0.673
MOD_GSK3_1	242	249	PF00069	0.762
MOD_GSK3_1	279	286	PF00069	0.570
MOD_GSK3_1	300	307	PF00069	0.514
MOD_GSK3_1	354	361	PF00069	0.689
MOD_GSK3_1	450	457	PF00069	0.475
MOD_GSK3_1	51	58	PF00069	0.564
MOD_GSK3_1	64	71	PF00069	0.463
MOD_GSK3_1	654	661	PF00069	0.417
MOD_GSK3_1	725	732	PF00069	0.365
MOD_GSK3_1	776	783	PF00069	0.403
MOD_GSK3_1	784	791	PF00069	0.355
MOD_LATS_1	281	287	PF00433	0.395
MOD_N-GLC_1	268	273	PF02516	0.378
MOD_N-GLC_1	342	347	PF02516	0.675
MOD_N-GLC_1	455	460	PF02516	0.413
MOD_N-GLC_1	583	588	PF02516	0.475
MOD_N-GLC_1	820	825	PF02516	0.223
MOD_NEK2_1	214	219	PF00069	0.397
MOD_NEK2_1	279	284	PF00069	0.518
MOD_NEK2_1	339	344	PF00069	0.738
MOD_NEK2_1	358	363	PF00069	0.803
MOD_NEK2_1	582	587	PF00069	0.234
MOD_NEK2_1	626	631	PF00069	0.475
MOD_NEK2_1	652	657	PF00069	0.326
MOD_NEK2_1	658	663	PF00069	0.348
MOD_NEK2_1	680	685	PF00069	0.305
MOD_NEK2_1	743	748	PF00069	0.348
MOD_NEK2_1	750	755	PF00069	0.351
MOD_NEK2_1	813	818	PF00069	0.397
MOD_PIKK_1	117	123	PF00454	0.610
MOD_PIKK_1	128	134	PF00454	0.622
MOD_PIKK_1	147	153	PF00454	0.571
MOD_PIKK_1	250	256	PF00454	0.739
MOD_PIKK_1	441	447	PF00454	0.480
MOD_PIKK_1	725	731	PF00454	0.463
MOD_PIKK_1	750	756	PF00454	0.421
MOD_PKA_1	133	139	PF00069	0.524
MOD_PKA_1	283	289	PF00069	0.540
MOD_PKA_1	292	298	PF00069	0.550
MOD_PKA_2	133	139	PF00069	0.524
MOD_PKA_2	246	252	PF00069	0.792
MOD_PKA_2	271	277	PF00069	0.592
MOD_PKA_2	292	298	PF00069	0.498
MOD_PKA_2	300	306	PF00069	0.416
MOD_PKA_2	359	365	PF00069	0.543
MOD_PKA_2	537	543	PF00069	0.418
MOD_PKA_2	784	790	PF00069	0.413
MOD_PKB_1	91	99	PF00069	0.583
MOD_Plk_1	531	537	PF00069	0.374
MOD_Plk_1	583	589	PF00069	0.437
MOD_Plk_1	680	686	PF00069	0.327
MOD_Plk_1	693	699	PF00069	0.356
MOD_Plk_1	767	773	PF00069	0.382
MOD_Plk_4	138	144	PF00069	0.536
MOD_Plk_4	210	216	PF00069	0.507
MOD_Plk_4	271	277	PF00069	0.573
MOD_Plk_4	354	360	PF00069	0.783
MOD_Plk_4	467	473	PF00069	0.412
MOD_Plk_4	654	660	PF00069	0.332
MOD_Plk_4	680	686	PF00069	0.301
MOD_Plk_4	693	699	PF00069	0.366
MOD_Plk_4	704	710	PF00069	0.309
MOD_Plk_4	729	735	PF00069	0.370
MOD_Plk_4	743	749	PF00069	0.332
MOD_Plk_4	767	773	PF00069	0.329
MOD_Plk_4	813	819	PF00069	0.309
MOD_ProDKin_1	152	158	PF00069	0.662
MOD_ProDKin_1	162	168	PF00069	0.766
MOD_ProDKin_1	201	207	PF00069	0.567
MOD_ProDKin_1	240	246	PF00069	0.780
MOD_ProDKin_1	253	259	PF00069	0.665
MOD_ProDKin_1	324	330	PF00069	0.711
MOD_ProDKin_1	331	337	PF00069	0.756
MOD_ProDKin_1	360	366	PF00069	0.761
MOD_ProDKin_1	455	461	PF00069	0.413
MOD_ProDKin_1	51	57	PF00069	0.568
MOD_ProDKin_1	525	531	PF00069	0.449
MOD_ProDKin_1	547	553	PF00069	0.363
MOD_ProDKin_1	638	644	PF00069	0.279
MOD_SUMO_for_1	229	232	PF00179	0.592
MOD_SUMO_rev_2	193	200	PF00179	0.528
MOD_SUMO_rev_2	285	294	PF00179	0.624
MOD_SUMO_rev_2	406	415	PF00179	0.577
TRG_DiLeu_BaEn_1	694	699	PF01217	0.344
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.358
TRG_DiLeu_LyEn_5	859	864	PF01217	0.431
TRG_ENDOCYTIC_2	299	302	PF00928	0.503
TRG_ENDOCYTIC_2	419	422	PF00928	0.466
TRG_ENDOCYTIC_2	803	806	PF00928	0.328
TRG_ENDOCYTIC_2	857	860	PF00928	0.341
TRG_ER_diArg_1	133	135	PF00400	0.578
TRG_ER_diArg_1	26	29	PF00400	0.675
TRG_ER_diArg_1	316	318	PF00400	0.622
TRG_ER_diArg_1	402	405	PF00400	0.561
TRG_ER_diArg_1	483	486	PF00400	0.347
TRG_ER_diArg_1	616	618	PF00400	0.243
TRG_ER_diArg_1	645	648	PF00400	0.449
TRG_ER_diArg_1	808	810	PF00400	0.475
TRG_ER_diArg_1	91	93	PF00400	0.553
TRG_NES_CRM1_1	39	51	PF08389	0.591
TRG_NES_CRM1_1	769	784	PF08389	0.223
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ54	Leptomonas seymouri	63%	100%
A0A0S4JLJ6	Bodo saltans	29%	91%
A0A1X0P1B7	Trypanosomatidae	37%	100%
A0A3S7X411	Leishmania donovani	85%	100%
A0A422NMF0	Trypanosoma rangeli	37%	100%
A4I632	Leishmania infantum	84%	100%
C9ZRF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q6U7	Leishmania major	84%	100%
V5B765	Trypanosoma cruzi	38%	100%