Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIS9_LEIBR

TriTrypDb:

LbrM.30.3450 , LBRM2903_300041600

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0005875	microtubule associated complex	2	16
GO:0030286	dynein complex	3	16
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1902494	catalytic complex	2	16
GO:1990904	ribonucleoprotein complex	2	13
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HIS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0008569	minus-end-directed microtubule motor activity	3	16
GO:0140657	ATP-dependent activity	1	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.637
CLV_NRD_NRD_1	289	291	PF00675	0.556
CLV_NRD_NRD_1	574	576	PF00675	0.416
CLV_PCSK_KEX2_1	267	269	PF00082	0.641
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.427
CLV_PCSK_SKI1_1	15	19	PF00082	0.564
CLV_PCSK_SKI1_1	194	198	PF00082	0.328
CLV_PCSK_SKI1_1	220	224	PF00082	0.243
CLV_PCSK_SKI1_1	331	335	PF00082	0.382
CLV_PCSK_SKI1_1	589	593	PF00082	0.419
DEG_APCC_DBOX_1	367	375	PF00400	0.528
DOC_CDC14_PxL_1	96	104	PF14671	0.407
DOC_CYCLIN_RxL_1	214	226	PF00134	0.544
DOC_CYCLIN_RxL_1	589	601	PF00134	0.457
DOC_MAPK_DCC_7	368	376	PF00069	0.525
DOC_MAPK_gen_1	150	158	PF00069	0.568
DOC_MAPK_gen_1	290	301	PF00069	0.570
DOC_MAPK_gen_1	575	583	PF00069	0.529
DOC_MAPK_MEF2A_6	368	376	PF00069	0.525
DOC_PP2B_LxvP_1	73	76	PF13499	0.503
DOC_SPAK_OSR1_1	353	357	PF12202	0.365
DOC_USP7_MATH_1	111	115	PF00917	0.482
DOC_USP7_MATH_1	192	196	PF00917	0.429
DOC_USP7_MATH_1	31	35	PF00917	0.470
DOC_USP7_MATH_1	562	566	PF00917	0.236
DOC_USP7_UBL2_3	179	183	PF12436	0.461
LIG_14-3-3_CanoR_1	15	20	PF00244	0.412
LIG_14-3-3_CanoR_1	200	209	PF00244	0.532
LIG_14-3-3_CanoR_1	237	243	PF00244	0.460
LIG_14-3-3_CanoR_1	458	464	PF00244	0.368
LIG_14-3-3_CanoR_1	63	73	PF00244	0.574
LIG_APCC_ABBA_1	185	190	PF00400	0.450
LIG_APCC_ABBAyCdc20_2	267	273	PF00400	0.675
LIG_APCC_Cbox_2	558	564	PF00515	0.360
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	388	392	PF00533	0.410
LIG_FHA_1	191	197	PF00498	0.484
LIG_FHA_1	35	41	PF00498	0.452
LIG_FHA_1	400	406	PF00498	0.357
LIG_FHA_1	415	421	PF00498	0.408
LIG_FHA_1	437	443	PF00498	0.397
LIG_FHA_1	448	454	PF00498	0.341
LIG_FHA_1	578	584	PF00498	0.410
LIG_FHA_1	590	596	PF00498	0.288
LIG_FHA_1	602	608	PF00498	0.315
LIG_FHA_2	16	22	PF00498	0.508
LIG_FHA_2	306	312	PF00498	0.566
LIG_FHA_2	394	400	PF00498	0.334
LIG_FHA_2	409	415	PF00498	0.442
LIG_FHA_2	489	495	PF00498	0.324
LIG_FHA_2	7	13	PF00498	0.444
LIG_FHA_2	75	81	PF00498	0.561
LIG_KLC1_Yacidic_2	154	159	PF13176	0.548
LIG_LIR_Apic_2	431	435	PF02991	0.371
LIG_LIR_Gen_1	307	316	PF02991	0.550
LIG_LIR_Gen_1	360	366	PF02991	0.487
LIG_LIR_LC3C_4	67	72	PF02991	0.592
LIG_LIR_Nem_3	360	365	PF02991	0.488
LIG_LIR_Nem_3	92	96	PF02991	0.523
LIG_Pex14_1	384	388	PF04695	0.333
LIG_Pex14_2	388	392	PF04695	0.458
LIG_PTB_Apo_2	422	429	PF02174	0.426
LIG_SH2_CRK	432	436	PF00017	0.511
LIG_SH2_CRK	5	9	PF00017	0.540
LIG_SH2_GRB2like	432	435	PF00017	0.396
LIG_SH2_NCK_1	432	436	PF00017	0.409
LIG_SH2_NCK_1	5	9	PF00017	0.382
LIG_SH2_PTP2	362	365	PF00017	0.354
LIG_SH2_SRC	432	435	PF00017	0.361
LIG_SH2_STAP1	119	123	PF00017	0.512
LIG_SH2_STAT3	188	191	PF00017	0.461
LIG_SH2_STAT5	157	160	PF00017	0.461
LIG_SH2_STAT5	188	191	PF00017	0.469
LIG_SH2_STAT5	348	351	PF00017	0.448
LIG_SH2_STAT5	362	365	PF00017	0.306
LIG_SH2_STAT5	560	563	PF00017	0.336
LIG_SH2_STAT5	570	573	PF00017	0.345
LIG_SH3_3	137	143	PF00018	0.453
LIG_SH3_3	226	232	PF00018	0.458
LIG_SH3_3	97	103	PF00018	0.656
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.461
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.517
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.464
LIG_SUMO_SIM_par_1	362	367	PF11976	0.343
LIG_SUMO_SIM_par_1	416	422	PF11976	0.495
LIG_TRAF2_1	411	414	PF00917	0.548
LIG_TRAF2_1	85	88	PF00917	0.571
LIG_WRC_WIRS_1	420	425	PF05994	0.426
LIG_WW_2	100	103	PF00397	0.664
MOD_CK1_1	261	267	PF00069	0.592
MOD_CK1_1	322	328	PF00069	0.691
MOD_CK1_1	336	342	PF00069	0.535
MOD_CK1_1	34	40	PF00069	0.353
MOD_CK1_1	387	393	PF00069	0.479
MOD_CK1_1	419	425	PF00069	0.402
MOD_CK1_1	565	571	PF00069	0.417
MOD_CK1_1	64	70	PF00069	0.632
MOD_CK2_1	15	21	PF00069	0.520
MOD_CK2_1	305	311	PF00069	0.575
MOD_CK2_1	393	399	PF00069	0.337
MOD_CK2_1	408	414	PF00069	0.440
MOD_CK2_1	6	12	PF00069	0.473
MOD_CK2_1	74	80	PF00069	0.455
MOD_CK2_1	81	87	PF00069	0.460
MOD_GlcNHglycan	114	117	PF01048	0.512
MOD_GlcNHglycan	311	315	PF01048	0.553
MOD_GlcNHglycan	359	362	PF01048	0.445
MOD_GlcNHglycan	439	442	PF01048	0.343
MOD_GlcNHglycan	443	446	PF01048	0.301
MOD_GlcNHglycan	447	450	PF01048	0.354
MOD_GlcNHglycan	564	567	PF01048	0.334
MOD_GlcNHglycan	86	91	PF01048	0.529
MOD_GlcNHglycan	96	99	PF01048	0.547
MOD_GSK3_1	190	197	PF00069	0.459
MOD_GSK3_1	319	326	PF00069	0.511
MOD_GSK3_1	437	444	PF00069	0.347
MOD_GSK3_1	484	491	PF00069	0.349
MOD_GSK3_1	516	523	PF00069	0.341
MOD_GSK3_1	545	552	PF00069	0.286
MOD_GSK3_1	82	89	PF00069	0.541
MOD_N-GLC_1	112	117	PF02516	0.424
MOD_N-GLC_1	406	411	PF02516	0.374
MOD_N-GLC_1	459	464	PF02516	0.451
MOD_N-GLC_1	64	69	PF02516	0.613
MOD_N-GLC_2	496	498	PF02516	0.518
MOD_NEK2_1	106	111	PF00069	0.634
MOD_NEK2_1	236	241	PF00069	0.457
MOD_NEK2_1	260	265	PF00069	0.600
MOD_NEK2_1	304	309	PF00069	0.564
MOD_NEK2_1	310	315	PF00069	0.498
MOD_NEK2_1	319	324	PF00069	0.489
MOD_NEK2_1	428	433	PF00069	0.361
MOD_NEK2_1	447	452	PF00069	0.352
MOD_NEK2_1	473	478	PF00069	0.364
MOD_NEK2_1	520	525	PF00069	0.323
MOD_NEK2_1	526	531	PF00069	0.319
MOD_NEK2_1	577	582	PF00069	0.491
MOD_NEK2_2	238	243	PF00069	0.461
MOD_PIKK_1	387	393	PF00454	0.479
MOD_PIKK_1	473	479	PF00454	0.418
MOD_PIKK_1	501	507	PF00454	0.260
MOD_PIKK_1	540	546	PF00454	0.352
MOD_PIKK_1	64	70	PF00454	0.565
MOD_PKA_2	166	172	PF00069	0.503
MOD_PKA_2	236	242	PF00069	0.469
MOD_PKA_2	293	299	PF00069	0.669
MOD_PKA_2	466	472	PF00069	0.362
MOD_Plk_1	112	118	PF00069	0.484
MOD_Plk_1	304	310	PF00069	0.551
MOD_Plk_1	384	390	PF00069	0.373
MOD_Plk_1	406	412	PF00069	0.366
MOD_Plk_1	413	419	PF00069	0.398
MOD_Plk_1	459	465	PF00069	0.479
MOD_Plk_1	526	532	PF00069	0.357
MOD_Plk_1	577	583	PF00069	0.524
MOD_Plk_1	64	70	PF00069	0.643
MOD_Plk_2-3	305	311	PF00069	0.582
MOD_Plk_2-3	82	88	PF00069	0.649
MOD_Plk_4	305	311	PF00069	0.589
MOD_Plk_4	400	406	PF00069	0.351
MOD_Plk_4	459	465	PF00069	0.404
MOD_Plk_4	488	494	PF00069	0.323
MOD_Plk_4	565	571	PF00069	0.406
MOD_Plk_4	598	604	PF00069	0.401
MOD_SUMO_for_1	151	154	PF00179	0.533
MOD_SUMO_for_1	282	285	PF00179	0.714
MOD_SUMO_rev_2	86	96	PF00179	0.612
TRG_DiLeu_BaEn_2	304	310	PF01217	0.545
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.411
TRG_ENDOCYTIC_2	362	365	PF00928	0.338
TRG_ENDOCYTIC_2	5	8	PF00928	0.542
TRG_ER_diArg_1	242	245	PF00400	0.532
TRG_NES_CRM1_1	545	558	PF08389	0.440
TRG_NLS_MonoExtC_3	289	294	PF00514	0.581
TRG_NLS_MonoExtC_3	507	512	PF00514	0.453
TRG_NLS_MonoExtN_4	290	295	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S6	Leptomonas seymouri	83%	100%
A0A0N1PCL0	Leptomonas seymouri	28%	70%
A0A0S4J7X8	Bodo saltans	28%	83%
A0A0S4JKZ2	Bodo saltans	48%	93%
A0A1X0P1Y1	Trypanosomatidae	52%	99%
A0A1X0P3P9	Trypanosomatidae	28%	80%
A0A3R7KEX8	Trypanosoma rangeli	27%	82%
A0A3S7X3V5	Leishmania donovani	89%	100%
A0A3S7X707	Leishmania donovani	28%	71%
A0A422NMN1	Trypanosoma rangeli	52%	100%
A4HLS7	Leishmania braziliensis	27%	71%
A4I631	Leishmania infantum	89%	100%
A4I986	Leishmania infantum	28%	71%
C9ZRE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
D0A6A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
E9B1B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B453	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
Q4Q6U8	Leishmania major	88%	100%
Q9GRN2	Leishmania major	28%	71%
V5DNT3	Trypanosoma cruzi	52%	100%
V5DQD1	Trypanosoma cruzi	27%	82%