Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIS8_LEIBR

TriTrypDb:

LbrM.30.3440 , LBRM2903_300041500

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.509
CLV_NRD_NRD_1	193	195	PF00675	0.386
CLV_NRD_NRD_1	221	223	PF00675	0.394
CLV_NRD_NRD_1	58	60	PF00675	0.381
CLV_PCSK_KEX2_1	193	195	PF00082	0.386
CLV_PCSK_KEX2_1	221	223	PF00082	0.309
CLV_PCSK_PC7_1	189	195	PF00082	0.371
CLV_PCSK_SKI1_1	59	63	PF00082	0.404
CLV_Separin_Metazoa	56	60	PF03568	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.362
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.438
DOC_MAPK_DCC_7	59	68	PF00069	0.288
DOC_MAPK_gen_1	105	113	PF00069	0.378
DOC_MAPK_HePTP_8	57	69	PF00069	0.279
DOC_MAPK_MEF2A_6	105	113	PF00069	0.383
DOC_MAPK_MEF2A_6	60	69	PF00069	0.287
DOC_PP1_RVXF_1	62	69	PF00149	0.415
DOC_PP4_FxxP_1	68	71	PF00568	0.399
DOC_USP7_MATH_1	143	147	PF00917	0.628
DOC_USP7_MATH_1	78	82	PF00917	0.473
DOC_WW_Pin1_4	137	142	PF00397	0.482
LIG_14-3-3_CanoR_1	186	196	PF00244	0.288
LIG_14-3-3_CanoR_1	29	33	PF00244	0.418
LIG_Actin_WH2_2	175	191	PF00022	0.370
LIG_Actin_WH2_2	48	66	PF00022	0.272
LIG_APCC_ABBA_1	1	6	PF00400	0.416
LIG_APCC_ABBA_1	51	56	PF00400	0.326
LIG_BRCT_BRCA1_1	175	179	PF00533	0.309
LIG_FHA_1	153	159	PF00498	0.582
LIG_FHA_1	16	22	PF00498	0.445
LIG_FHA_1	29	35	PF00498	0.344
LIG_FHA_2	140	146	PF00498	0.492
LIG_LIR_Apic_2	31	35	PF02991	0.396
LIG_LIR_Gen_1	176	187	PF02991	0.290
LIG_LIR_Gen_1	49	58	PF02991	0.325
LIG_LIR_Gen_1	6	16	PF02991	0.364
LIG_LIR_Nem_3	176	182	PF02991	0.363
LIG_LIR_Nem_3	49	54	PF02991	0.334
LIG_LIR_Nem_3	6	12	PF02991	0.357
LIG_MAD2	133	141	PF02301	0.464
LIG_NRBOX	57	63	PF00104	0.343
LIG_SH2_PTP2	100	103	PF00017	0.397
LIG_SH2_PTP2	32	35	PF00017	0.335
LIG_SH2_STAT3	89	92	PF00017	0.496
LIG_SH2_STAT5	100	103	PF00017	0.562
LIG_SH2_STAT5	197	200	PF00017	0.335
LIG_SH2_STAT5	32	35	PF00017	0.385
LIG_SH3_3	135	141	PF00018	0.445
LIG_SH3_3	177	183	PF00018	0.444
LIG_SH3_3	98	104	PF00018	0.401
LIG_TRAF2_1	147	150	PF00917	0.530
LIG_UBA3_1	106	110	PF00899	0.345
LIG_UBA3_1	62	70	PF00899	0.301
LIG_WW_3	102	106	PF00397	0.417
MOD_CAAXbox	231	234	PF01239	0.386
MOD_CDK_SPxxK_3	137	144	PF00069	0.440
MOD_CK1_1	81	87	PF00069	0.497
MOD_CK2_1	143	149	PF00069	0.519
MOD_CK2_1	41	47	PF00069	0.349
MOD_GSK3_1	139	146	PF00069	0.582
MOD_GSK3_1	152	159	PF00069	0.507
MOD_GSK3_1	24	31	PF00069	0.366
MOD_GSK3_1	79	86	PF00069	0.535
MOD_NEK2_1	111	116	PF00069	0.411
MOD_NEK2_1	24	29	PF00069	0.370
MOD_NEK2_1	41	46	PF00069	0.327
MOD_NEK2_1	83	88	PF00069	0.755
MOD_PIKK_1	156	162	PF00454	0.472
MOD_PKA_2	111	117	PF00069	0.285
MOD_PKA_2	143	149	PF00069	0.519
MOD_PKA_2	217	223	PF00069	0.495
MOD_PKA_2	28	34	PF00069	0.415
MOD_Plk_1	41	47	PF00069	0.340
MOD_Plk_2-3	145	151	PF00069	0.527
MOD_Plk_2-3	42	48	PF00069	0.277
MOD_Plk_4	28	34	PF00069	0.351
MOD_Plk_4	84	90	PF00069	0.653
MOD_ProDKin_1	137	143	PF00069	0.493
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.403
TRG_ENDOCYTIC_2	16	19	PF00928	0.312
TRG_ENDOCYTIC_2	9	12	PF00928	0.396
TRG_ENDOCYTIC_2	99	102	PF00928	0.548
TRG_ER_diArg_1	221	224	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I1	Leptomonas seymouri	56%	100%
A0A3Q8IJQ2	Leishmania donovani	76%	100%
A4I630	Leishmania infantum	76%	100%
E9B1B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q6U9	Leishmania major	74%	100%