C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIS5_LEIBR

TriTrypDb:

LbrM.30.3410 , LBRM2903_300041100

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.570
CLV_C14_Caspase3-7	66	70	PF00656	0.703
CLV_MEL_PAP_1	128	134	PF00089	0.542
CLV_NRD_NRD_1	143	145	PF00675	0.715
CLV_NRD_NRD_1	294	296	PF00675	0.808
CLV_NRD_NRD_1	330	332	PF00675	0.629
CLV_PCSK_KEX2_1	143	145	PF00082	0.715
CLV_PCSK_KEX2_1	197	199	PF00082	0.724
CLV_PCSK_KEX2_1	294	296	PF00082	0.808
CLV_PCSK_KEX2_1	330	332	PF00082	0.593
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.724
CLV_PCSK_SKI1_1	121	125	PF00082	0.558
CLV_PCSK_SKI1_1	331	335	PF00082	0.750
CLV_PCSK_SKI1_1	347	351	PF00082	0.570
CLV_PCSK_SKI1_1	539	543	PF00082	0.617
DEG_APCC_DBOX_1	538	546	PF00400	0.464
DEG_SCF_FBW7_1	114	119	PF00400	0.567
DEG_SPOP_SBC_1	42	46	PF00917	0.680
DEG_SPOP_SBC_1	470	474	PF00917	0.498
DEG_SPOP_SBC_1	48	52	PF00917	0.633
DEG_SPOP_SBC_1	62	66	PF00917	0.493
DOC_CKS1_1	478	483	PF01111	0.524
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.509
DOC_MAPK_DCC_7	144	154	PF00069	0.722
DOC_PP2B_LxvP_1	152	155	PF13499	0.723
DOC_PP2B_LxvP_1	453	456	PF13499	0.522
DOC_PP4_FxxP_1	266	269	PF00568	0.531
DOC_USP7_MATH_1	103	107	PF00917	0.688
DOC_USP7_MATH_1	110	114	PF00917	0.613
DOC_USP7_MATH_1	116	120	PF00917	0.537
DOC_USP7_MATH_1	269	273	PF00917	0.628
DOC_USP7_MATH_1	278	282	PF00917	0.543
DOC_USP7_MATH_1	305	309	PF00917	0.573
DOC_USP7_MATH_1	326	330	PF00917	0.747
DOC_USP7_MATH_1	41	45	PF00917	0.677
DOC_USP7_MATH_1	47	51	PF00917	0.629
DOC_USP7_MATH_1	471	475	PF00917	0.556
DOC_USP7_MATH_1	530	534	PF00917	0.706
DOC_USP7_MATH_1	62	66	PF00917	0.563
DOC_WW_Pin1_4	101	106	PF00397	0.548
DOC_WW_Pin1_4	112	117	PF00397	0.614
DOC_WW_Pin1_4	122	127	PF00397	0.675
DOC_WW_Pin1_4	147	152	PF00397	0.724
DOC_WW_Pin1_4	180	185	PF00397	0.697
DOC_WW_Pin1_4	230	235	PF00397	0.590
DOC_WW_Pin1_4	276	281	PF00397	0.613
DOC_WW_Pin1_4	297	302	PF00397	0.685
DOC_WW_Pin1_4	319	324	PF00397	0.717
DOC_WW_Pin1_4	338	343	PF00397	0.556
DOC_WW_Pin1_4	379	384	PF00397	0.688
DOC_WW_Pin1_4	444	449	PF00397	0.790
DOC_WW_Pin1_4	477	482	PF00397	0.607
DOC_WW_Pin1_4	73	78	PF00397	0.679
LIG_14-3-3_CanoR_1	121	126	PF00244	0.549
LIG_14-3-3_CanoR_1	131	136	PF00244	0.585
LIG_14-3-3_CanoR_1	143	151	PF00244	0.702
LIG_14-3-3_CanoR_1	249	259	PF00244	0.743
LIG_14-3-3_CanoR_1	365	373	PF00244	0.585
LIG_14-3-3_CanoR_1	388	398	PF00244	0.811
LIG_14-3-3_CanoR_1	442	448	PF00244	0.714
LIG_14-3-3_CanoR_1	492	498	PF00244	0.679
LIG_14-3-3_CanoR_1	511	519	PF00244	0.586
LIG_14-3-3_CanoR_1	9	17	PF00244	0.605
LIG_EVH1_1	181	185	PF00568	0.565
LIG_FHA_1	109	115	PF00498	0.731
LIG_FHA_1	230	236	PF00498	0.570
LIG_FHA_1	271	277	PF00498	0.553
LIG_FHA_1	312	318	PF00498	0.561
LIG_FHA_1	368	374	PF00498	0.567
LIG_FHA_1	477	483	PF00498	0.673
LIG_FHA_1	512	518	PF00498	0.539
LIG_FHA_1	66	72	PF00498	0.731
LIG_FHA_2	350	356	PF00498	0.731
LIG_LIR_Apic_2	265	269	PF02991	0.531
LIG_LIR_Apic_2	464	470	PF02991	0.569
LIG_LIR_Apic_2	516	522	PF02991	0.677
LIG_LIR_Apic_2	57	62	PF02991	0.549
LIG_LIR_Gen_1	546	552	PF02991	0.610
LIG_LIR_Nem_3	546	552	PF02991	0.689
LIG_MYND_1	151	155	PF01753	0.565
LIG_MYND_1	184	188	PF01753	0.587
LIG_NRBOX	212	218	PF00104	0.562
LIG_PAM2_1	86	98	PF00658	0.694
LIG_PDZ_Class_1	547	552	PF00595	0.452
LIG_SH2_CRK	200	204	PF00017	0.739
LIG_SH2_CRK	467	471	PF00017	0.580
LIG_SH2_CRK	495	499	PF00017	0.691
LIG_SH2_CRK	519	523	PF00017	0.683
LIG_SH2_NCK_1	463	467	PF00017	0.614
LIG_SH2_SRC	467	470	PF00017	0.487
LIG_SH2_STAP1	463	467	PF00017	0.614
LIG_SH2_STAT5	30	33	PF00017	0.655
LIG_SH2_STAT5	463	466	PF00017	0.611
LIG_SH2_STAT5	495	498	PF00017	0.679
LIG_SH3_1	396	402	PF00018	0.687
LIG_SH3_3	179	185	PF00018	0.714
LIG_SH3_3	228	234	PF00018	0.694
LIG_SH3_3	336	342	PF00018	0.670
LIG_SH3_3	373	379	PF00018	0.679
LIG_SH3_3	394	400	PF00018	0.816
LIG_SH3_4	162	169	PF00018	0.586
LIG_SUMO_SIM_par_1	479	486	PF11976	0.654
LIG_TRAF2_1	176	179	PF00917	0.581
LIG_WRC_WIRS_1	263	268	PF05994	0.810
LIG_WRC_WIRS_1	507	512	PF05994	0.704
LIG_WW_2	184	187	PF00397	0.560
MOD_CDK_SPxxK_3	338	345	PF00069	0.580
MOD_CK1_1	106	112	PF00069	0.682
MOD_CK1_1	218	224	PF00069	0.688
MOD_CK1_1	252	258	PF00069	0.764
MOD_CK1_1	281	287	PF00069	0.727
MOD_CK1_1	308	314	PF00069	0.666
MOD_CK1_1	329	335	PF00069	0.749
MOD_CK1_1	392	398	PF00069	0.764
MOD_CK1_1	472	478	PF00069	0.670
MOD_CK1_1	509	515	PF00069	0.687
MOD_CK1_1	51	57	PF00069	0.636
MOD_CK1_1	65	71	PF00069	0.608
MOD_CK1_1	76	82	PF00069	0.563
MOD_CK1_1	97	103	PF00069	0.659
MOD_CK2_1	173	179	PF00069	0.574
MOD_CK2_1	349	355	PF00069	0.731
MOD_CK2_1	530	536	PF00069	0.545
MOD_DYRK1A_RPxSP_1	230	234	PF00069	0.569
MOD_GlcNHglycan	105	108	PF01048	0.733
MOD_GlcNHglycan	138	141	PF01048	0.696
MOD_GlcNHglycan	207	210	PF01048	0.782
MOD_GlcNHglycan	213	216	PF01048	0.805
MOD_GlcNHglycan	222	226	PF01048	0.659
MOD_GlcNHglycan	25	29	PF01048	0.647
MOD_GlcNHglycan	254	257	PF01048	0.726
MOD_GlcNHglycan	276	279	PF01048	0.679
MOD_GlcNHglycan	281	284	PF01048	0.616
MOD_GlcNHglycan	32	35	PF01048	0.567
MOD_GlcNHglycan	391	394	PF01048	0.685
MOD_GlcNHglycan	88	91	PF01048	0.797
MOD_GlcNHglycan	96	99	PF01048	0.774
MOD_GSK3_1	106	113	PF00069	0.631
MOD_GSK3_1	205	212	PF00069	0.561
MOD_GSK3_1	248	255	PF00069	0.672
MOD_GSK3_1	270	277	PF00069	0.552
MOD_GSK3_1	281	288	PF00069	0.592
MOD_GSK3_1	305	312	PF00069	0.651
MOD_GSK3_1	313	320	PF00069	0.598
MOD_GSK3_1	363	370	PF00069	0.547
MOD_GSK3_1	388	395	PF00069	0.773
MOD_GSK3_1	43	50	PF00069	0.618
MOD_GSK3_1	472	479	PF00069	0.683
MOD_GSK3_1	482	489	PF00069	0.614
MOD_GSK3_1	493	500	PF00069	0.647
MOD_GSK3_1	502	509	PF00069	0.516
MOD_GSK3_1	60	67	PF00069	0.586
MOD_GSK3_1	69	76	PF00069	0.599
MOD_GSK3_1	80	87	PF00069	0.530
MOD_GSK3_1	97	104	PF00069	0.710
MOD_N-GLC_1	218	223	PF02516	0.712
MOD_N-GLC_2	127	129	PF02516	0.542
MOD_NEK2_1	248	253	PF00069	0.782
MOD_NEK2_1	309	314	PF00069	0.595
MOD_NEK2_1	367	372	PF00069	0.590
MOD_NEK2_1	437	442	PF00069	0.824
MOD_NEK2_1	461	466	PF00069	0.663
MOD_NEK2_1	497	502	PF00069	0.678
MOD_NEK2_1	510	515	PF00069	0.553
MOD_NEK2_1	84	89	PF00069	0.527
MOD_PIKK_1	116	122	PF00454	0.596
MOD_PIKK_1	167	173	PF00454	0.634
MOD_PIKK_1	187	193	PF00454	0.577
MOD_PIKK_1	401	407	PF00454	0.645
MOD_PIKK_1	423	429	PF00454	0.565
MOD_PIKK_1	502	508	PF00454	0.691
MOD_PKA_2	130	136	PF00069	0.542
MOD_PKA_2	142	148	PF00069	0.706
MOD_PKA_2	158	164	PF00069	0.840
MOD_PKA_2	229	235	PF00069	0.729
MOD_PKA_2	248	254	PF00069	0.636
MOD_PKA_2	329	335	PF00069	0.592
MOD_PKA_2	510	516	PF00069	0.535
MOD_Plk_4	313	319	PF00069	0.588
MOD_Plk_4	431	437	PF00069	0.719
MOD_Plk_4	493	499	PF00069	0.737
MOD_Plk_4	513	519	PF00069	0.523
MOD_Plk_4	70	76	PF00069	0.531
MOD_ProDKin_1	101	107	PF00069	0.549
MOD_ProDKin_1	112	118	PF00069	0.614
MOD_ProDKin_1	122	128	PF00069	0.674
MOD_ProDKin_1	147	153	PF00069	0.726
MOD_ProDKin_1	180	186	PF00069	0.697
MOD_ProDKin_1	230	236	PF00069	0.590
MOD_ProDKin_1	276	282	PF00069	0.613
MOD_ProDKin_1	297	303	PF00069	0.689
MOD_ProDKin_1	319	325	PF00069	0.717
MOD_ProDKin_1	338	344	PF00069	0.555
MOD_ProDKin_1	379	385	PF00069	0.690
MOD_ProDKin_1	444	450	PF00069	0.793
MOD_ProDKin_1	477	483	PF00069	0.602
MOD_ProDKin_1	73	79	PF00069	0.679
TRG_DiLeu_BaEn_1	536	541	PF01217	0.502
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.569
TRG_ENDOCYTIC_2	200	203	PF00928	0.585
TRG_ENDOCYTIC_2	495	498	PF00928	0.679
TRG_ER_diArg_1	293	295	PF00400	0.661
TRG_ER_diArg_1	344	347	PF00400	0.741

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEI9	Leishmania donovani	63%	88%
A4I621	Leishmania infantum	63%	88%
E9B1B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	87%
Q4Q6V2	Leishmania major	67%	100%