Putative calmodulin-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-related protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIS4_LEIBR

TriTrypDb:

LbrM.30.3400 , LBRM2903_300041000

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.305
CLV_C14_Caspase3-7	338	342	PF00656	0.542
CLV_C14_Caspase3-7	5	9	PF00656	0.636
CLV_NRD_NRD_1	421	423	PF00675	0.647
CLV_NRD_NRD_1	436	438	PF00675	0.462
CLV_NRD_NRD_1	454	456	PF00675	0.381
CLV_NRD_NRD_1	602	604	PF00675	0.530
CLV_NRD_NRD_1	701	703	PF00675	0.554
CLV_PCSK_FUR_1	699	703	PF00082	0.527
CLV_PCSK_KEX2_1	421	423	PF00082	0.647
CLV_PCSK_KEX2_1	436	438	PF00082	0.462
CLV_PCSK_KEX2_1	454	456	PF00082	0.324
CLV_PCSK_KEX2_1	602	604	PF00082	0.721
CLV_PCSK_KEX2_1	635	637	PF00082	0.642
CLV_PCSK_KEX2_1	701	703	PF00082	0.554
CLV_PCSK_KEX2_1	705	707	PF00082	0.570
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.611
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.371
CLV_PCSK_PC7_1	701	707	PF00082	0.351
CLV_PCSK_SKI1_1	166	170	PF00082	0.349
CLV_PCSK_SKI1_1	220	224	PF00082	0.522
CLV_PCSK_SKI1_1	231	235	PF00082	0.266
CLV_PCSK_SKI1_1	294	298	PF00082	0.439
CLV_PCSK_SKI1_1	358	362	PF00082	0.389
CLV_PCSK_SKI1_1	370	374	PF00082	0.344
CLV_PCSK_SKI1_1	709	713	PF00082	0.439
DEG_APCC_DBOX_1	293	301	PF00400	0.507
DEG_APCC_DBOX_1	349	357	PF00400	0.446
DEG_SPOP_SBC_1	620	624	PF00917	0.509
DOC_CYCLIN_RxL_1	355	363	PF00134	0.503
DOC_MAPK_gen_1	281	289	PF00069	0.411
DOC_MAPK_gen_1	701	712	PF00069	0.525
DOC_MAPK_HePTP_8	109	121	PF00069	0.415
DOC_MAPK_MEF2A_6	112	121	PF00069	0.423
DOC_MAPK_MEF2A_6	170	177	PF00069	0.393
DOC_MAPK_MEF2A_6	298	307	PF00069	0.445
DOC_PP1_RVXF_1	356	362	PF00149	0.442
DOC_PP1_RVXF_1	503	509	PF00149	0.344
DOC_PP1_RVXF_1	707	713	PF00149	0.501
DOC_PP4_FxxP_1	208	211	PF00568	0.447
DOC_PP4_FxxP_1	497	500	PF00568	0.522
DOC_PP4_FxxP_1	583	586	PF00568	0.518
DOC_USP7_MATH_1	128	132	PF00917	0.297
DOC_USP7_MATH_1	384	388	PF00917	0.361
DOC_USP7_MATH_1	596	600	PF00917	0.529
DOC_USP7_UBL2_3	166	170	PF12436	0.289
DOC_USP7_UBL2_3	679	683	PF12436	0.341
DOC_USP7_UBL2_3	705	709	PF12436	0.348
DOC_WW_Pin1_4	423	428	PF00397	0.536
DOC_WW_Pin1_4	479	484	PF00397	0.367
DOC_WW_Pin1_4	564	569	PF00397	0.645
DOC_WW_Pin1_4	582	587	PF00397	0.632
DOC_WW_Pin1_4	689	694	PF00397	0.584
LIG_14-3-3_CanoR_1	118	126	PF00244	0.425
LIG_14-3-3_CanoR_1	220	229	PF00244	0.515
LIG_14-3-3_CanoR_1	505	514	PF00244	0.385
LIG_14-3-3_CanoR_1	530	540	PF00244	0.710
LIG_14-3-3_CanoR_1	582	586	PF00244	0.520
LIG_14-3-3_CanoR_1	88	98	PF00244	0.300
LIG_Actin_WH2_2	19	37	PF00022	0.415
LIG_AP2alpha_1	361	365	PF02296	0.386
LIG_AP2alpha_1	711	715	PF02296	0.294
LIG_APCC_ABBA_1	334	339	PF00400	0.517
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BIR_III_2	363	367	PF00653	0.530
LIG_BRCT_BRCA1_1	44	48	PF00533	0.393
LIG_FHA_1	163	169	PF00498	0.381
LIG_FHA_1	288	294	PF00498	0.425
LIG_FHA_1	376	382	PF00498	0.462
LIG_FHA_1	536	542	PF00498	0.709
LIG_FHA_1	90	96	PF00498	0.335
LIG_FHA_2	120	126	PF00498	0.447
LIG_FHA_2	205	211	PF00498	0.532
LIG_FHA_2	221	227	PF00498	0.379
LIG_FHA_2	259	265	PF00498	0.522
LIG_FHA_2	286	292	PF00498	0.371
LIG_FHA_2	440	446	PF00498	0.527
LIG_FHA_2	465	471	PF00498	0.619
LIG_LIR_Apic_2	207	211	PF02991	0.566
LIG_LIR_Apic_2	563	568	PF02991	0.494
LIG_LIR_Apic_2	72	76	PF02991	0.277
LIG_LIR_Gen_1	131	138	PF02991	0.341
LIG_LIR_Gen_1	232	238	PF02991	0.287
LIG_LIR_Gen_1	36	44	PF02991	0.276
LIG_LIR_Gen_1	713	723	PF02991	0.392
LIG_LIR_Nem_3	131	136	PF02991	0.276
LIG_LIR_Nem_3	167	172	PF02991	0.264
LIG_LIR_Nem_3	232	237	PF02991	0.287
LIG_LIR_Nem_3	248	254	PF02991	0.241
LIG_LIR_Nem_3	638	644	PF02991	0.488
LIG_LIR_Nem_3	65	70	PF02991	0.303
LIG_LIR_Nem_3	675	680	PF02991	0.485
LIG_LIR_Nem_3	697	703	PF02991	0.491
LIG_LIR_Nem_3	713	718	PF02991	0.307
LIG_MAD2	358	366	PF02301	0.461
LIG_NRBOX	352	358	PF00104	0.287
LIG_PCNA_yPIPBox_3	491	505	PF02747	0.346
LIG_Pex14_2	292	296	PF04695	0.357
LIG_Pex14_2	361	365	PF04695	0.386
LIG_Pex14_2	397	401	PF04695	0.413
LIG_Pex14_2	711	715	PF04695	0.436
LIG_Pex14_2	94	98	PF04695	0.276
LIG_PTB_Apo_2	577	584	PF02174	0.517
LIG_SH2_CRK	565	569	PF00017	0.562
LIG_SH2_SRC	244	247	PF00017	0.272
LIG_SH2_SRC	479	482	PF00017	0.364
LIG_SH2_STAT5	244	247	PF00017	0.279
LIG_SH2_STAT5	457	460	PF00017	0.464
LIG_SH2_STAT5	479	482	PF00017	0.561
LIG_SH2_STAT5	609	612	PF00017	0.558
LIG_SH2_STAT5	671	674	PF00017	0.440
LIG_SH2_STAT5	681	684	PF00017	0.393
LIG_SH2_STAT5	73	76	PF00017	0.276
LIG_SH3_2	431	436	PF14604	0.503
LIG_SH3_3	140	146	PF00018	0.227
LIG_SH3_3	428	434	PF00018	0.511
LIG_SH3_3	477	483	PF00018	0.593
LIG_SH3_3	556	562	PF00018	0.742
LIG_SH3_3	592	598	PF00018	0.622
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.276
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.372
LIG_SUMO_SIM_anti_2	351	358	PF11976	0.295
LIG_SUMO_SIM_anti_2	445	451	PF11976	0.411
LIG_SUMO_SIM_par_1	18	25	PF11976	0.372
LIG_SUMO_SIM_par_1	186	192	PF11976	0.455
LIG_SUMO_SIM_par_1	331	339	PF11976	0.405
LIG_SUMO_SIM_par_1	445	451	PF11976	0.378
LIG_TRAF2_1	122	125	PF00917	0.436
LIG_TRAF2_1	196	199	PF00917	0.276
LIG_TRAF2_1	27	30	PF00917	0.449
LIG_TRAF2_1	393	396	PF00917	0.548
LIG_TRAF2_1	50	53	PF00917	0.341
LIG_TRAF2_1	69	72	PF00917	0.164
LIG_TRFH_1	687	691	PF08558	0.543
LIG_WRC_WIRS_1	293	298	PF05994	0.444
LIG_WRC_WIRS_1	398	403	PF05994	0.496
MOD_CDK_SPK_2	564	569	PF00069	0.561
MOD_CK1_1	131	137	PF00069	0.464
MOD_CK1_1	259	265	PF00069	0.369
MOD_CK1_1	279	285	PF00069	0.440
MOD_CK1_1	4	10	PF00069	0.532
MOD_CK1_1	415	421	PF00069	0.529
MOD_CK1_1	426	432	PF00069	0.682
MOD_CK1_1	439	445	PF00069	0.579
MOD_CK1_1	535	541	PF00069	0.666
MOD_CK1_1	624	630	PF00069	0.601
MOD_CK1_1	704	710	PF00069	0.532
MOD_CK2_1	119	125	PF00069	0.432
MOD_CK2_1	186	192	PF00069	0.301
MOD_CK2_1	193	199	PF00069	0.251
MOD_CK2_1	204	210	PF00069	0.369
MOD_CK2_1	220	226	PF00069	0.387
MOD_CK2_1	257	263	PF00069	0.582
MOD_CK2_1	390	396	PF00069	0.491
MOD_CK2_1	397	403	PF00069	0.487
MOD_CK2_1	464	470	PF00069	0.638
MOD_CK2_1	47	53	PF00069	0.393
MOD_CK2_1	552	558	PF00069	0.648
MOD_CK2_1	689	695	PF00069	0.486
MOD_CK2_1	87	93	PF00069	0.297
MOD_Cter_Amidation	600	603	PF01082	0.533
MOD_GlcNHglycan	123	129	PF01048	0.530
MOD_GlcNHglycan	178	181	PF01048	0.276
MOD_GlcNHglycan	283	286	PF01048	0.533
MOD_GlcNHglycan	326	329	PF01048	0.447
MOD_GlcNHglycan	403	407	PF01048	0.532
MOD_GlcNHglycan	428	431	PF01048	0.738
MOD_GlcNHglycan	438	441	PF01048	0.394
MOD_GlcNHglycan	534	537	PF01048	0.697
MOD_GlcNHglycan	554	557	PF01048	0.757
MOD_GlcNHglycan	574	577	PF01048	0.454
MOD_GlcNHglycan	623	626	PF01048	0.618
MOD_GSK3_1	124	131	PF00069	0.581
MOD_GSK3_1	254	261	PF00069	0.428
MOD_GSK3_1	275	282	PF00069	0.383
MOD_GSK3_1	348	355	PF00069	0.465
MOD_GSK3_1	412	419	PF00069	0.504
MOD_GSK3_1	422	429	PF00069	0.592
MOD_GSK3_1	526	533	PF00069	0.751
MOD_GSK3_1	560	567	PF00069	0.725
MOD_GSK3_1	603	610	PF00069	0.662
MOD_GSK3_1	620	627	PF00069	0.618
MOD_GSK3_1	631	638	PF00069	0.627
MOD_N-GLC_1	131	136	PF02516	0.221
MOD_N-GLC_1	530	535	PF02516	0.511
MOD_N-GLC_1	542	547	PF02516	0.472
MOD_N-GLC_2	111	113	PF02516	0.438
MOD_NEK2_1	193	198	PF00069	0.281
MOD_NEK2_1	254	259	PF00069	0.331
MOD_NEK2_1	292	297	PF00069	0.569
MOD_NEK2_1	34	39	PF00069	0.341
MOD_NEK2_1	372	377	PF00069	0.490
MOD_NEK2_1	397	402	PF00069	0.487
MOD_NEK2_1	541	546	PF00069	0.604
MOD_NEK2_1	643	648	PF00069	0.592
MOD_PIKK_1	209	215	PF00454	0.526
MOD_PIKK_1	263	269	PF00454	0.449
MOD_PIKK_1	596	602	PF00454	0.721
MOD_PIKK_1	607	613	PF00454	0.642
MOD_PKA_1	421	427	PF00069	0.648
MOD_PKA_1	436	442	PF00069	0.407
MOD_PKA_1	635	641	PF00069	0.488
MOD_PKA_1	701	707	PF00069	0.471
MOD_PKA_2	119	125	PF00069	0.432
MOD_PKA_2	34	40	PF00069	0.379
MOD_PKA_2	42	48	PF00069	0.291
MOD_PKA_2	421	427	PF00069	0.648
MOD_PKA_2	436	442	PF00069	0.652
MOD_PKA_2	581	587	PF00069	0.518
MOD_PKA_2	631	637	PF00069	0.661
MOD_PKA_2	673	679	PF00069	0.522
MOD_PKA_2	701	707	PF00069	0.546
MOD_PKA_2	87	93	PF00069	0.300
MOD_PKB_1	699	707	PF00069	0.467
MOD_Plk_1	124	130	PF00069	0.529
MOD_Plk_1	131	137	PF00069	0.354
MOD_Plk_1	225	231	PF00069	0.531
MOD_Plk_1	263	269	PF00069	0.425
MOD_Plk_1	591	597	PF00069	0.551
MOD_Plk_2-3	339	345	PF00069	0.562
MOD_Plk_4	171	177	PF00069	0.335
MOD_Plk_4	204	210	PF00069	0.563
MOD_Plk_4	225	231	PF00069	0.443
MOD_Plk_4	34	40	PF00069	0.436
MOD_Plk_4	352	358	PF00069	0.436
MOD_Plk_4	372	378	PF00069	0.458
MOD_Plk_4	397	403	PF00069	0.526
MOD_Plk_4	560	566	PF00069	0.547
MOD_ProDKin_1	423	429	PF00069	0.538
MOD_ProDKin_1	479	485	PF00069	0.361
MOD_ProDKin_1	564	570	PF00069	0.646
MOD_ProDKin_1	582	588	PF00069	0.633
MOD_ProDKin_1	689	695	PF00069	0.579
MOD_SUMO_for_1	682	685	PF00179	0.376
TRG_AP2beta_CARGO_1	713	722	PF09066	0.334
TRG_DiLeu_BaEn_1	329	334	PF01217	0.498
TRG_DiLeu_BaEn_1	352	357	PF01217	0.285
TRG_DiLeu_BaEn_1	502	507	PF01217	0.363
TRG_DiLeu_BaEn_1	714	719	PF01217	0.422
TRG_DiLeu_BaEn_4	124	130	PF01217	0.412
TRG_DiLeu_BaEn_4	29	35	PF01217	0.419
TRG_ENDOCYTIC_2	251	254	PF00928	0.360
TRG_ENDOCYTIC_2	681	684	PF00928	0.351
TRG_ER_diArg_1	117	120	PF00400	0.358
TRG_ER_diArg_1	313	316	PF00400	0.508
TRG_ER_diArg_1	435	437	PF00400	0.491
TRG_ER_diArg_1	453	455	PF00400	0.432
TRG_ER_diArg_1	700	702	PF00400	0.551
TRG_ER_diArg_1	722	725	PF00400	0.531
TRG_NES_CRM1_1	167	181	PF08389	0.199
TRG_NES_CRM1_1	267	280	PF08389	0.459
TRG_NES_CRM1_1	469	481	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.443
TRG_PTS1	722	725	PF00515	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB40	Leptomonas seymouri	57%	100%
A0A0S4JKD9	Bodo saltans	42%	100%
A0A1X0P1B1	Trypanosomatidae	41%	100%
A0A3R7R5F4	Trypanosoma rangeli	40%	100%
A0A3S7X3V3	Leishmania donovani	72%	100%
A4I620	Leishmania infantum	72%	100%
E9B1B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q6V3	Leishmania major	72%	100%