PAZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIS3_LEIBR

TriTrypDb:

LbrM.30.3390 , LBRM2903_300040900

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.429
CLV_NRD_NRD_1	153	155	PF00675	0.515
CLV_NRD_NRD_1	318	320	PF00675	0.567
CLV_PCSK_KEX2_1	153	155	PF00082	0.515
CLV_PCSK_KEX2_1	318	320	PF00082	0.596
CLV_PCSK_SKI1_1	121	125	PF00082	0.439
DEG_APCC_DBOX_1	200	208	PF00400	0.565
DEG_APCC_DBOX_1	218	226	PF00400	0.466
DEG_COP1_1	71	80	PF00400	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DOC_MAPK_gen_1	105	113	PF00069	0.456
DOC_MAPK_gen_1	153	159	PF00069	0.485
DOC_MAPK_gen_1	245	253	PF00069	0.373
DOC_PP2B_LxvP_1	140	143	PF13499	0.553
DOC_PP4_FxxP_1	280	283	PF00568	0.455
DOC_USP7_UBL2_3	226	230	PF12436	0.659
DOC_WW_Pin1_4	1	6	PF00397	0.575
DOC_WW_Pin1_4	11	16	PF00397	0.480
DOC_WW_Pin1_4	180	185	PF00397	0.447
DOC_WW_Pin1_4	279	284	PF00397	0.480
LIG_14-3-3_CanoR_1	153	158	PF00244	0.419
LIG_14-3-3_CanoR_1	201	205	PF00244	0.469
LIG_14-3-3_CanoR_1	32	38	PF00244	0.659
LIG_14-3-3_CanoR_1	7	12	PF00244	0.543
LIG_Actin_WH2_2	185	203	PF00022	0.425
LIG_BRCT_BRCA1_1	13	17	PF00533	0.565
LIG_FHA_1	125	131	PF00498	0.579
LIG_FHA_1	154	160	PF00498	0.471
LIG_FHA_1	195	201	PF00498	0.419
LIG_FHA_2	77	83	PF00498	0.500
LIG_LIR_Apic_2	10	15	PF02991	0.521
LIG_LIR_Apic_2	312	317	PF02991	0.463
LIG_LIR_Gen_1	183	192	PF02991	0.477
LIG_LIR_Nem_3	147	151	PF02991	0.507
LIG_LIR_Nem_3	173	179	PF02991	0.454
LIG_LIR_Nem_3	237	243	PF02991	0.350
LIG_LIR_Nem_3	79	83	PF02991	0.503
LIG_PCNA_PIPBox_1	259	268	PF02747	0.491
LIG_PCNA_yPIPBox_3	256	266	PF02747	0.341
LIG_Pex14_1	306	310	PF04695	0.453
LIG_Pex14_2	89	93	PF04695	0.610
LIG_SH2_CRK	176	180	PF00017	0.519
LIG_SH2_CRK	241	245	PF00017	0.460
LIG_SH2_PTP2	101	104	PF00017	0.479
LIG_SH2_PTP2	314	317	PF00017	0.460
LIG_SH2_SRC	176	179	PF00017	0.523
LIG_SH2_SRC	49	52	PF00017	0.562
LIG_SH2_STAP1	311	315	PF00017	0.462
LIG_SH2_STAP1	85	89	PF00017	0.497
LIG_SH2_STAT5	101	104	PF00017	0.504
LIG_SH2_STAT5	155	158	PF00017	0.477
LIG_SH2_STAT5	185	188	PF00017	0.513
LIG_SH2_STAT5	206	209	PF00017	0.398
LIG_SH2_STAT5	260	263	PF00017	0.397
LIG_SH2_STAT5	265	268	PF00017	0.429
LIG_SH2_STAT5	314	317	PF00017	0.500
LIG_SH2_STAT5	49	52	PF00017	0.562
LIG_SH2_STAT5	76	79	PF00017	0.533
LIG_SH2_STAT5	85	88	PF00017	0.524
LIG_SH3_1	226	232	PF00018	0.631
LIG_SH3_3	226	232	PF00018	0.521
LIG_SH3_3	280	286	PF00018	0.496
LIG_SUMO_SIM_anti_2	190	197	PF11976	0.519
LIG_TRAF2_1	255	258	PF00917	0.440
LIG_TYR_ITIM	146	151	PF00017	0.528
LIG_TYR_ITIM	99	104	PF00017	0.462
LIG_UBA3_1	117	124	PF00899	0.429
LIG_WRC_WIRS_1	77	82	PF05994	0.582
MOD_CDC14_SPxK_1	4	7	PF00782	0.432
MOD_CDK_SPxK_1	1	7	PF00069	0.596
MOD_CK1_1	103	109	PF00069	0.594
MOD_CK1_1	169	175	PF00069	0.512
MOD_CK1_1	38	44	PF00069	0.560
MOD_CK2_1	104	110	PF00069	0.492
MOD_CK2_1	146	152	PF00069	0.507
MOD_CK2_1	279	285	PF00069	0.459
MOD_GlcNHglycan	147	151	PF01048	0.527
MOD_GSK3_1	100	107	PF00069	0.484
MOD_GSK3_1	153	160	PF00069	0.510
MOD_GSK3_1	166	173	PF00069	0.448
MOD_GSK3_1	32	39	PF00069	0.658
MOD_GSK3_1	50	57	PF00069	0.506
MOD_GSK3_1	7	14	PF00069	0.550
MOD_NEK2_1	157	162	PF00069	0.435
MOD_NEK2_1	166	171	PF00069	0.521
MOD_NEK2_1	194	199	PF00069	0.448
MOD_NEK2_1	200	205	PF00069	0.487
MOD_NEK2_1	30	35	PF00069	0.649
MOD_NEK2_1	302	307	PF00069	0.549
MOD_NEK2_1	50	55	PF00069	0.445
MOD_PIKK_1	36	42	PF00454	0.595
MOD_PK_1	100	106	PF00069	0.538
MOD_PKA_1	153	159	PF00069	0.485
MOD_PKA_2	153	159	PF00069	0.485
MOD_PKA_2	200	206	PF00069	0.483
MOD_Plk_1	68	74	PF00069	0.543
MOD_Plk_4	166	172	PF00069	0.473
MOD_Plk_4	249	255	PF00069	0.437
MOD_Plk_4	302	308	PF00069	0.521
MOD_Plk_4	7	13	PF00069	0.534
MOD_ProDKin_1	1	7	PF00069	0.577
MOD_ProDKin_1	11	17	PF00069	0.478
MOD_ProDKin_1	180	186	PF00069	0.452
MOD_ProDKin_1	279	285	PF00069	0.487
MOD_SUMO_for_1	225	228	PF00179	0.675
MOD_SUMO_for_1	255	258	PF00179	0.455
TRG_AP2beta_CARGO_1	237	247	PF09066	0.309
TRG_ENDOCYTIC_2	101	104	PF00928	0.464
TRG_ENDOCYTIC_2	148	151	PF00928	0.499
TRG_ENDOCYTIC_2	176	179	PF00928	0.485
TRG_ENDOCYTIC_2	185	188	PF00928	0.460
TRG_ENDOCYTIC_2	241	244	PF00928	0.405
TRG_ER_diArg_1	135	138	PF00400	0.528
TRG_ER_diArg_1	153	155	PF00400	0.446
TRG_ER_diArg_1	219	222	PF00400	0.533
TRG_ER_diArg_1	317	319	PF00400	0.578
TRG_NES_CRM1_1	115	129	PF08389	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYP4	Leptomonas seymouri	86%	100%
A0A0S4KFH5	Bodo saltans	64%	99%
A0A1X0P2F6	Trypanosomatidae	80%	99%
A0A3S5H7N9	Leishmania donovani	94%	100%
A4I619	Leishmania infantum	94%	100%
C9ZRE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	99%
E9B1B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q6V4	Leishmania major	93%	100%
V5DNT8	Trypanosoma cruzi	76%	84%